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4 results on '"Abbes Benmerache"'

1. 6''-O-acetylisospinosin, a new C-glycosylflavone and known compounds from the aerial parts of Cladanthus mixtus

Author

Ahmed Kabouche, Zahia Kabouche, Abbes Benmerache, Laurence Voutquenne-Nazabadioko, Dominique Harakat, Abdulmagid Alabdul Magid, Université Mentouri Constantine [Algérie] (UMC), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), and Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Stereochemistry, Plant Science, 01 natural sciences, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, flavonoid, quinic acid derivative, Spectral data, biology, phenolic acid, 010405 organic chemistry, Organic Chemistry, Cladanthus mixtus, Phenolic acid, Carbon-13 NMR, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, biology.organism_classification, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, chemistry, [CHIM.OTHE]Chemical Sciences/Other, Two-dimensional nuclear magnetic resonance spectroscopy, Heteronuclear single quantum coherence spectroscopy
Abstract

A new C-glycosylflavone, identified as 6"'-O-acetylisospinosin (1), was isolated from the aerial parts of Cladanthus mixtus together with 30 known compounds. The structures of these compounds were established by interpretation of their spectral data, mainly UV, 1D and 2D NMR spectroscopic methods including (1H and 13C NMR, COSY, ROESY, HSQC and HMBC experiments), ESI-MS, and by comparison with the literature data.

Published
2019
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2. Isolation and characterisation of cytotoxic compounds from Euphorbia clementei Boiss

Author

Zahia Kabouche, Jane Hubert, Laurence Voutquenne-Nazabadioko, Ahmed Kabouche, Hamid Morjani, Abbes Benmerache, Amira Labed, Abdulmagid Alabdul Magid, Université Mentouri Constantine [Algérie] (UMC), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Matrice extracellulaire et dynamique cellulaire - UMR 7369 (MEDyC), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), and Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Latex, Stereochemistry, HL60, HL-60 Cells, Plant Science, Mass spectrometry, 01 natural sciences, Biochemistry, Plant Roots, Analytical Chemistry, chemistry.chemical_compound, Inhibitory Concentration 50, Euphorbia, Humans, Euphorbia clementei, [CHIM]Chemical Sciences, Cytotoxicity, cytotoxic activity, biology, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Euphorbiaceae, diterpenoids, Carbon-13 NMR, triterpenoids, biology.organism_classification, Antineoplastic Agents, Phytogenic, Phorbols, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, chemistry, Diterpene, Diterpenes, Drug Screening Assays, Antitumor, K562 Cells, Two-dimensional nuclear magnetic resonance spectroscopy, Heteronuclear single quantum coherence spectroscopy
Abstract

International audience; A new phorbol-type diterpene ester, 4,20-dideoxy-4α-phorbol-12β-acetate-13α-isobutyrate, in addition to 11 known compounds were isolated from the latex and roots of Euphorbia clementei Boiss. Structure elucidation was performed by comprehensive 1D and 2D NMR analyses (1H and 13C NMR, COSY, ROESY, HSQC and HMBC experiments), mass spectrometry (HR-ESI-MS) and by comparison with literature data. The inhibitory activity of all isolated compounds was evaluated against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia K562 cell lines and seven of these compounds exhibited a weak cytotoxicity with IC50 values ranging from 40 to 97 μM.

Published
2017
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3. Chemical composition, antioxidant and antibacterial activities of Tamarix balansae J. Gay aerial parts

Author

Zahia Kabouche, Mounira Benteldjoune, Djemaa Berrehal, Ahmed Kabouche, Abdulmagid Alabdul Magid, Abbes Benmerache, Laurence Voutquenne-Nazabadioko, Amin Abedini, Sophie Gangloff, Université Mentouri Constantine [Algérie] (UMC), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Biomatériaux et inflammation en site osseux - EA 4691 (BIOS), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), Université frères Mentouri Constantine I (UMC), Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), and Alabdul Magid, Abdulmagid

Subjects
DPPH, antioxidant activity, Ether, Microbial Sensitivity Tests, Plant Science, 01 natural sciences, Biochemistry, Antioxidants, Enterococcus faecalis, Analytical Chemistry, chemistry.chemical_compound, Phenols, antibacterial activity, Staphylococcus epidermidis, [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, Organic chemistry, Food science, Afzelin, Bacteria, Molecular Structure, biology, Plant Extracts, Tamaricaceae, 010405 organic chemistry, Organic Chemistry, Free Radical Scavengers, Plant Components, Aerial, biology.organism_classification, Anti-Bacterial Agents, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Tamarix balansae, chemistry, flavonoids, Kaempferol, Antibacterial activity, Quercetin
Abstract

A previously undescribed phenolic sulphate ester, potassium 34-dihydroxy-3-methoxybenzoic acid methyl ester-5-sulphate (1), along with nine known flavonoids, kaempferol-3-O-potassium sulphate-4′,7-dimethyl ether (2), kaempferol-4′,7-dimethyl ether (3), rhamnocitrin-3-O-potassium sulphate (4), rhamnocitrin (5), kaempferol (6), quercetin (7), afzelin (8), quercetin-3-O-α-l-rhamnopyranoside (9) and luteolin-3′-O-potassium sulphate (10) were isolated from the aerial parts of Tamarix balansae. Structures elucidation was performed by comprehensive 1D and 2D NMR analyses, mass spectrometry and by comparison with literature data. The antibacterial assay against Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa bacteria showed a good activity for 2, 3, 7 and 9, with MICs ranging from 62.5 to 250 μg/mL. The abilities of these compounds to scavenge the DPPH were evaluated. Compounds 1, 7, 9 and 10 exhibited a good antiradical activity potential with IC50 values ranging from 3.0 to 115.5 μg/mL, compared with ascorbic acid (IC50 7.4 μg/mL) which was used as positive control.

Published
2017
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4. Chemical composition, antibacterial, antioxidant and tyrosinase inhibitory activities of glycosides from aerial parts of Eryngium tricuspidatum L

Author

Zahia Kabouche, Amin Abedini, Abbes Benmerache, Ahmed Kabouche, Djemaa Berrehal, Abdulmagid Alabdul Magid, Laurence Voutquenne-Nazabadioko, Dominique Harakat, Souhila Messaili, Université Mentouri Constantine [Algérie] (UMC), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), and Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Antioxidant, Stereochemistry, DPPH, medicine.medical_treatment, Tyrosinase, Plant Science, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 01 natural sciences, Biochemistry, chemistry.chemical_compound, medicine, chemistry.chemical_classification, Apiaceae, biology, 010405 organic chemistry, Glycoside, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Antioxidant activity tyrosinase inhibitory activity, chemistry, Eryngium tricuspidatum, Antibacterial activity, Quercetin, Agronomy and Crop Science, Two-dimensional nuclear magnetic resonance spectroscopy, Biotechnology
Abstract

International audience; Two new phenolic glucosides, together with six known compounds, were isolated from the aerial part of Eryngium tricuspidatum L. (Apiaceae). The structures of the new compounds were established as 2-hydroxy- 3,5-dimethyl-acetophenon-4-O-β-d-glucopyranoside (1) and 2,3-dimethyl-4-hydroxymethylphenyl-1-hydroxymethyl-O-β-d-glucopyranoside (2) on the basis of detailed spectroscopic data including MS, 1D, and 2D NMR. The antibacterial, tyrosinase inhibitory and DPPH radical scavenging activities of hydromethanolic extract, fractions, and the eight isolated compounds were evaluated. The antibacterial assay showed a moderate activity for magnolioside (4) against Staphylococcus aureus CIP 53.154. Compound 7 (quercetin 3-O-β-d-glucopyranosyl-(1 → 6)-O-β-d-galactopyranoside) had moderate DPPH radical scavenging activity whereas compounds 2 exhibited good inhibitory effect against mushroom tyrosinase.

Published
2016
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