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BACKGROUND: Silver dressings have good anti-infective effect, but there is still a lack of evidence from randomized controlled studies on the efficacy of silver dressings in the treatment of chronic infected wounds. OBJECTIVE: To systematically evaluate the efficacy of silver dressings in the treatment of chronic infected wounds. METHODS: Databases of PubMed, Cochrane Library, EMbase, Web of science, CNKI, CBM, WanFang and Baidu Scholar were searched for the randomized controlled trials reporting the efficacy of silver dressings on chronic infected wounds published before August 2018. Literature screening, data extraction and quality assessment were conducted by two researchers, and a meta-analysis was performed on RevMan 5.3 software. RESULTS AND CONCLUSION: Nine randomized controlled trials including 1 268 patients were enrolled. The trial group was treated with silver dressings, and the control group was treated with dialginate dressings, conventional dressings, foam dressings, general dressings, sterile gauze, vaseline gauze, sterilized gauze or povidone iodine gauze. The meta-analysis results showed that compared with the control group, the wound healing rate in the trial group was increased [OR=4.53, 95%CI (2.87, 7.15), P < 0.000 01], the rate of wound area reduction was increased [MD=8.90, 95%CI (2.05, 15.76), P=0.01], the times of dressing change was decreased [MD=-8.91, 95%CI (-14.33, -3.48), P=0.001], and the debridement time was shortened [MD=-8.92, 95%CI (-10.03, -7.81), P < 0.000 01]. To conclude, silver dressings can promote healing of chronic infected wounds. [ABSTRACT FROM AUTHOR]

BACKGROUND: Various kinds of dressings for diabetic foot have been developed, among which, silver dressing has been widely used, but no conclusion has been reached yet. OBJECTIVE: To evaluate the effects of silver dressing in the treatment of diabetic foot ulcers by a Meta-analysis. METHODS: A systematic search of literatures in PubMed, Embase, Elsevier, CNKI, CBM, VIP and WanFang from inception to March 2018 was conducted. The quality of the literatures was appraised and data were extracted by two researchers independently. Meta-analysis was then conducted for the included literatures. RESULTS AND CONCLUSION: A total of 7 randomized controlled trials involving 642 patients were included. The meta-analysis results showed that the wound healing rate of silver dressing group was significantly higher than that of the other dressing groups [odds ratio (OR)=2.34, 95% confidence interval (CI) (1.57, 3.48), P < 0.000 1], epithelial formation time was significantly shorter than that of other dressing groups [mean difference (MD)=-2.22, 95% CI (-2.77, -1.66), P < 0.000 01], occurrence time of granulation tissue was significantly shorter than that of the other dressing groups[MD=-2.84, 95% CI (-3.26, -2.41), P < 0.000 01], wound healing time was significantly shorter than that of the other dressing groups [MD=-11.13, 95% CI (-19.87, -2.39), P=0.01]. Overall, silver dressing can promote the healing of diabetic foot ulcers. [ABSTRACT FROM AUTHOR]