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Pancreatic cancer, with the characteristics of insidious onset, easy metastasis, chemotherapy resistance and poor prognosis, is a common malignant tumor of the digestive system. Early diagnosis and treatment of pancreatic cancer is one of the major problems in modern medicine, and there is an urgent need to find new diagnostic, prognostic biomarkers and therapeutic targets. MicroRNA (miRNA) is a small non-coding RNA which can regulate the expression of various genes. miRNAs have wide abnormal expressions in pancreatic cancer, and are closely related to the occurrence and development of pancreatic cancer. Thereby, miRNAs have the potential to become new diagnostic, prognostic and predictive biomarkers and therapeutic targets of pancreatic cancer. Many studies have initially shown that miRNAs have the application value in the diagnosis, treatment and prognosis evaluation of pancreatic cancer, but there are still some difficulties in the practical application and promotion. The mechanisms of miRNAs in pancreatic cancer remain to be further studied. [ABSTRACT FROM AUTHOR]

Neutrolphil to lymphocyte ratio（NLR）has been found to be associated with clinic pathological characteristics of many tumors as Immune evaluation index.NLR is concered by researchers for its easy to detect, repeatable, and cheap price. Many studies about breast cancer, colorectal cancer, lung cancer, gastric cancer have revealed the relationship between highly recurrence rate or death rate and NLR. So the study on NLR has great value in diagnose, treatment and prognosis of tumor patient. The mechanism may be related to the promoting effect of neutrophils on tumor and the tumor inhibition of lymphocytes. And the NLR and other inflammatory indexes such as platelet count （Platelet count）, Glasgow outcome score （Glasgow Prognostic, Score, GPS） and carcinoembryonic antigen CEA （carcino-embryonic antigen CEA）, AFP （alpha fetoprotein alpha -fetoprotein, FP or AFP） can be combined for cancer prognosis prediction. As a new indicator, NLR also has shortcomings and deficiencies. This article reviews the applications of NLR in tumors of different systems and the relationship with other diagnose index. [ABSTRACT FROM AUTHOR]

目的 探讨迈之灵治疗中心性浆液性脉络膜视网膜病变(CSC)的临床疗效及光学相干断层成 像(OCT)对 CSC诊疗的价值. 方法 将2017年1月至2020年1月该院眼科收治的36例(36眼)CSC患者采 用随机单盲方法分为研究组和对照组,每组18例(18眼). 对照组给予视网膜激光治疗,研究组在视网膜激光 治疗基础上加用迈之灵(每次2片、每天2次)口服,2组患者均随访12周. 比较2组患者治疗4、12周后总有 效率,并通过 OCT 检查比较2组患者治疗前后视网膜神经上皮和(或)色素上皮脱离范围的变化. 结果 研究 组患者治疗12周后总有效率[94.44%(17/18)]明显高于对照组 [72.22%(13/18)],差异有统计学意义(P< 0.05). 研究组患者治疗4、12周视网膜脱离面积分别减小(126.79±16.63)、(198.52±11.3)μm ²,对照组患者 治疗4、12周视网膜脱离面积分别减小(85.54±12.23)、(134.38±10.11)μm ²,2组患者治疗4、12周视网膜脱 离面积比较,差异均有统计学意义(P<0.05)。2组患者治疗过程中均未出现明显不良反应. 结论 迈之灵联 合视网膜激光治疗 CSC患者可缩短病程、提高治疗有效率. OCT 能客观、定量地进行黄斑部细微结构的测量 和分析,对 CSC的诊断和疗效评价均具有重要价值. [ABSTRACT FROM AUTHOR]

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