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Objective To investigate the association between transversal psoas thickness index(TPTI) and nutritional risk in patients with liver cirrhosis or hepatocellular carcinoma(HCC).Methods The patients with liver cirrhosis or HCC who were admitted to Tianjin Third Central Hospital from January 2018 to January 2019 and underwent abdominal CT examination were enrolled,and according to the inclusion and exclusion criteria,the patients were screened and divided into liver cirrhosis group and HCC group.The patients with liver cirrhosis or HCC were divided into nutritional risk group and non-nutritional risk group according to the results of Nutritional Risk Screening 2002.Related clinical data,including body height,body weight,liver function,and TPTI were collected.The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups,and the chi-square test and the trend chi-square test were used for comparison of categorical data between two groups.A logistic regression analysis was used to analyze the factors for nutritional risk in patients with liver cirrhosis or HCC.Results A total of 151 patients were enrolled in this study,with 95 patients in the liver cirrhosis group and 56 patients in the HCC group.The incidence rates of nutritional risk in patients with Child-Pugh class A/B/C liver cirrhosis were 61.2%,80.6%,and 86.7%,respectively,and those in patients with Child-Pugh A/B/C HCC were 44.4%,84.6%,and 85.7%,respectively.The trend chi-square test and the Spearman correlation analysis showed that the incidence rate of nutritional risk tended to increase with the reduction in liver function reserve in patients with liver cirrhosis or HCC(χ2=5.051,P=0.025;r=0.388,P=0.003).For the patients with liver cirrhosis or HCC,the nutritional risk group had a significantly lower TPTI than the non-nutritional risk group(both P<0.05).For the patients in the liver cirrhosis group,after adjustment for albumin level in the logistic regression model,the higher the TPTI value,the lower the possibility of nutritional risk in patients(odds ratio=0.766,95% confidence interval:0.642-0.915).Conclusion The incidence rate of nutritional risk in patients with liver cirrhosis or HCC tends to increase with the reduction in liver function reserve.For patients with liver cirrhosis,the higher the TPTI value,the lower the possibility of nutritional risk;for patients with HCC,those with nutritional risk have a lower TPTI value. [ABSTRACT FROM AUTHOR]

As the disease progresses, there is a significant change in the body composition of patients with liver cirrhosis, and sarcopenia is one of the common complications in liver cirrhosis, especially in decompensated cirrhosis. About 30% —70% of patients with liver cirrhosis have sarcopenia, which greatly affects patients’ survival and is closely associated with the development of hepatic encephalopathy. Sarcopenia may also increase the risk of infection. Sarcopenia and muscle fatty degeneration can be used as poor prognostic indicators of hepatocellular carcinoma and may increase the risk of recurrence of liver cancer. This article reviews the research advances in the definition of sarcopenia, the association of sarcopenia with liver cirrhosis, arid assessment and clinical management of sarcopenia. [ABSTRACT FROM AUTHOR]