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Objective To assess whether a lifestyle intervention starting in early pregnancy can reduce the incidence of gestational diabetes mellitus (GDM) among Chinese women with high risk factors. Methods Between January 2020 and September 2021, women at gestational age of 6-15 weeks with high risk factors [body mass index (BMI) of 24-35 kg/m2 or a family history of diabetes] in 4 urban districts and 3 suburban districts of Tianjin were recruited as an intervention cohort. During the same period, the high-risk pregnant women who received routine maternal management from two of the above districts, one in urban and the other in suburban district, were retrospectively enrolled as a control cohort through the hospital system information. Women in the intervention cohort received a combination of online and offline lifestyle intervention (nutrition, exercise, and weight control). At the baseline survey, information including age, family history of diabetes, gestational age, and fasting plasma glucose (FPG) level were collected at the baseline survey. The height and body weight were recorded, and BMI was calculated. All pregnant women underwent two-step GDM screening at gestational age of 24-28 weeks. The comparison between the two cohorts was performed using the t test or the χ2 test. Logistic regression model was used to evaluate the effect of lifestyle intervention on GDM incidence. Results Finally, 106 and 2 348 patients were included in the intervention and control cohorts, respectively. There were statistically significant differences between the two cohorts in gestational age, family history of diabetes proportion, gestational age and FPG level at the baseline survey (P<0.05). At gestational age of 24-28 weeks, the incidence of GDM in the intervention and control cohorts was 19.8% (21/106) and 29.6% (696/2 348), respectively (P=0.029), with a relative risk reduction of 33%. Multivariate logistic regression analysis showed that the risk of GDM was significantly lower in the intervention cohort than that in the control cohort, with an OR and 95% confidence interval of 0.41 (0.24-0.69). Conclusion Lifestyle intervention (nutrition, exercise, and weight control) starting in early pregnancy can reduce the incidence of GDM in pregnant women with high risk factors. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 观察替格瑞洛口服对合并糖尿病的不稳定型心绞痛经皮冠状动脉介入术（ＰＣＩ）治疗患者血清炎症因子水平的影响。方法 １２４例合并糖尿病的不稳定型心绞痛患者随机分为观察组和对照组各６２例，两组均 行ＰＣＩ。观察组术前３ｄ口服负荷剂量（１８０ｍｇ）替格瑞洛，随后给予维持剂量（９０ｍｇ），２次／ｄ，维持６个月；对照组术前３ｄ口服负荷剂量（３００ｍｇ）氯吡格雷，随后给予维持剂量（７５ｍｇ），１次／ｄ，维持６个月；其余治疗措施相同。 比较两组手术前后外周血循环内皮细胞（ＣＥＣ）及血清ＣＤ４０配体（ＣＤ４０Ｌ）、ＩＬ-６、高敏Ｃ反应蛋白（ｈｓ-ＣＲＰ）。结果 与同组术前比较，两组术后１２ｈ的ＣＥＣ增加，ＣＤ４０Ｌ、ＩＬ-６、ｈｓ-ＣＲＰ水平升高；与同组术后１２ｈ比较，两组术后１ 个月ＣＥＣ减少，ＣＤ４０Ｌ、ＩＬ-６、ｈｓ-ＣＲＰ水平降低；与对照组比较，观察组术后１、６个月ＣＥＣ减少，ＣＤ４０Ｌ、ＩＬ-６、ｈｓ-ＣＲＰ 水平降低；Ｐ均＜０．０５。结论 合并糖尿病的不稳定型心绞痛ＰＣＩ治疗患者替格瑞洛应用后血清炎症因子水平下降，其对血管起到保护作用。 [ABSTRACT FROM AUTHOR]