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OBJECTIVE: To probe into the effects of Danggui Buxue decoction combined with circling moxibustion on glomerular filtration function, vascular calcification, intestinal endotoxin level and hepcidin-25, β-hydroxybutyrate (β-HB) in patients with chronic kidney disease(CKD) 3-5 non-dialysis diabetes nephropathy complicated with renal anemia. METHODS: A total of 102 patients with CKD 3-5 non-dialysis diabetes nephropathy complicated with renal anemia admitted into nephropathy and rheumatology department of the hospital from Dec. 2021 to Feb. 2023 were extracted and divided into the research group and control group by random number table method, with 51 patients in each group. On the basis of routine treatment (diet control, moderate exercise, oral rosastatin), the control group was treated with circling moxibustion, while the research group received Danggui Buxue decoction on the basis of the control group. Both groups were treated continuously for 3 months. After treatment, the efficacy of two groups was analyzed, and the glomerular filtration function, vascular calcification score, peripheral blood lipopolysaccharide (LPS), interleukin-6 (IL-6), hepcidin-25 and β-HB levels were compared between two groups. RESULTS: The total effective rate of the research group was 96. 08% (49 / 51), significantly higher than that 84. 31% ( 43 / 51) of the control group, the difference was statistically significant (P<0. 05). Compared with the control group, patients in the research group after treatment had higher glomerular filtration rate, lower abdominal aortic vascular calcification score, lower LPS, IL-6, hepcidin-25 and β-HB levels in peripheral blood, and higher hemoglobin, ferritin, transferrin saturation and transferrin contents in peripheral blood, the differences were statistically significant ( P < 0. 05 ). CONCLUSIONS: The efficacy of Danggui Buxue decoction combined with circling moxibustion for improving anemia in patients with CKD 3-5 non-dialysis diabetes nephropathy complicated with renal anemia is significant, which can improve the glomerular filtration function and reduce the degree of vascular calcification, the mechanism may be related to reducing the level of lipopolysaccharide and regulating the level of hepcidin-25 and β-HB. [ABSTRACT FROM AUTHOR]