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Objective To systematically assess the application value of vitamin D supplements in the treatment of chronic obstructive pulmonary disease (COPD) to provide evidence-based reference for clinical treatment. Methods The Medline, EM Base, PubMed, Cochrane library, CNKI, VIP database and Wan Fang databases were retrieved by entering the key words. The included randomized controlled trails (RCTs) were performed the literature quality assessment and analyzed by adopting the Rev Man 5.2 software. Results Eleven randomized controlled trials (RCTs) were included, including 1 357 patients. The meta analysis results demonstrated that FEV1% in the observation group was significantly increased compared with the control group, the merge effect size mean difference (MD) of FEV1% (95% CI) was 9.78[7.30, 12.26] with statistical difference (Z=7.73, P<0.01); FEV1/FVC was also increased compared with the control group, the merge effect size MD (95% CI) was 0.09 [1.63, 18.55] with statistical difference (Z=2.34, P=0.02); the CAT scores in the observation group was significantly decreased compared with the control group, the merge effect size MD (95% CI) of CAT score was-5.16 [-5.81, -4.52] with statistical difference (Z=15.78, P<0.00001); the sputum amount in the observation group was decreased compared with the control group,the merge effect size MD (95%) of sputum amount was-6.60 [-7.27, -5.93] with statistical difference (Z=19.39, P<0.01; the serum 25 (OH) D level in the observation group was significantly increased compared with the control group, its merge effect size MD (95% CI) was 13.87 [11.84, 15.90] with statistical difference (Z=13.37, P<0.01). Conclusion Supplementing vitamin D can better improve the pulmonary function and health status, reduces the clinical symptoms and increases the level of serum 25 (OH) D. But due to the limitation of included RCT quality and design methodology, this conclusion needs the large samples and high quality RCT to be further verified. [ABSTRACT FROM AUTHOR]

Objective To observe the effect and security of Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration in the adjuvant therapy of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty patients with AECOPD in the Second Affiliated Hospital of Chongqing Medical University from October to Decem-ber 2015 were selected as the research subjects and randomly divided into the conventional treatment group (32 cases) and the Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration group (experimental group, 28 cases). The effect and safety of the Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration in treating AECOPD were analyzed. The clinical curative effect and occurrence rate of adverse reactions were compared between the two groups. The efficacy and safety of Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration in treating this disease were analyzed. Results The hospitalization time and disappearance time of clinical symptoms and signs in the experimental group were shorter than those in the conventional treatment group, moreover the treatment total effective rate was 96.43%(27/28),which was higher than 78.13%(25/32) in the conventional treatment group;in the comparison of the sputum character on 1,2 3 d after treatment in the two groups, the sputum expectoration volume in the experimental group was increased compared with the conventional treatment group, sputum dry mass/wet mass and viscosity were decreased compared with the con-ventional treatment group, the differences were statistically significant(P<0.05);PaCO2 and PaO2 on 3,7 d after treatment in the experimental group were significantly improved compared with the conventional treatment group, the difference was statistically significant(P<0.05);the two groups had no adverse reactions occurrence during the treatment process. Conclusion The Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration as an adjuvant therapy of AECOPD has definite effect, safety and reliability. [ABSTRACT FROM AUTHOR]