1. Diacylglyceride kinases, sphingosine kinases and NAD kinases: distant relatives of 6-phosphofructokinases
- Author
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Liliane Assairi, Anne-Marie Gilles, Gilles Labesse, Dominique Douguet, Centre de Biochimie Structurale [Montpellier] (CBS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Chimie Structurale des Macromolécules (CSM), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Diacylglycerol Kinase ,Cell biology ,Evolution ,Phosphofructokinase-1 ,Extracellular signal-regulated kinases ,Amino Acid Motifs ,Molecular Sequence Data ,[CHIM.THER]Chemical Sciences/Medicinal Chemistry ,Biochemistry ,03 medical and health sciences ,chemistry.chemical_compound ,diacylglyceride kinases ,NAD kinases ,Amino Acid Sequence ,Phosphofructokinases ,Phosphorylation ,Molecular Biology ,030304 developmental biology ,0303 health sciences ,biology ,Sphingosine ,Kinase ,030302 biochemistry & molecular biology ,6-phosphofructokinases ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,Phosphotransferases (Alcohol Group Acceptor) ,Structural biology ,chemistry ,sphingosine kinases ,Mitogen-activated protein kinase ,biology.protein ,NAD+ kinase ,[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,Allosteric Site ,[CHIM.CHEM]Chemical Sciences/Cheminformatics - Abstract
International audience; Diacylglyceride kinases, sphingosine kinases, NAD kinases and 6-phosphofructokinases are thought to be related despite large evolution of their sequences. Discovery of a common signature has led to the suggestion that they possess a similar phosphate-donor-binding site and a similar phosphorylation mechanism. The substrate- and allosteric-binding sites are much more divergent and their delineation remains to be determined experimentally.
- Published
- 2002
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