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Frank Barry, Ivan Martin, Thomas W. Bauer, Cecilia Pascual-Garrido, Christian Jorgensen, Scott A. Rodeo, George F. Muschler, Constance R. Chu, Jérôme Guicheux, Pamela Gehron Robey, Nicolas S. Piuzzi, Massimo Dominici, Stéphane Maddens, M. A.R.C. Long, J. O.H.N. Barrett, David Karli, Richard McFarland, Johnny Huard, Laurie R. Goodrich, Daniel J. Weiss, Department of Orthopedic Surgery [Cleveland, Ohio, USA], Cleveland Clinic, Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Department of Medical and Surgical Sciences for Children and Adults [Modena, Italy] (Laboratory of Cellular Therapy), Università degli Studi di Modena e Reggio Emilia (UNIMORE), MTF Biologics, Edison [New Jersey, USA], Adult Reconstruction-Adolescent and Young Adult Hip Service [St. Louis, Missouri, USA] (School of Medicine), Washington University in Saint Louis (WUSTL), Orthopaedic Soft Tissue Research Program [New York, NY, USA], Hospital for Special Surgery, Department of Orthopaedic Surgery [Houston, TX, USA], The University of Texas Health Science Center at Houston (UTHealth), Steadman Philippon Research Institute, Regenerative Medicine and Skeleton research lab (RMeS), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale [CHU Nantes] (PHU4 - OTONN), Centre hospitalier universitaire de Nantes (CHU Nantes), Advanced Regenerative Manufacturing Institute [Manchester, NH, USA], Standards Coordinating Body, Department of Clinical Sciences [Fort Collins, CO, USA] (Orthopaedic Research Center), Colorado State University [Fort Collins] (CSU), Vetbiobank [Marcy l’Etoile, France], Department of Health and Human Services [Bethesda, MD, USA] (Skeletal Biology Section ), National Institutes of Health [Bethesda] (NIH), Department of Pathology and Laboratory Medicine [New-York, NY, USA], Stem Cell Allogeneic Transplant Section [Bethesda, MD, USA], Regenerative Medicine Institute [Galway, Ireland], National University of Ireland [Galway] (NUI Galway), Greyledge Technologies - LLC [Vail, CO, USA], Department of Orthopaedic Surgery [Stanford], Stanford Medicine, Stanford University-Stanford University, Veterans Affairs Palo Alto Health Care System [Palo Alto, CA, USA], University of Vermont [Burlington], Department of Biomedicine [Basel], University Hospital Basel [Basel], Unité thérapeutique d'immunologie clinique et des maladies ostéoarticulaires [Hôpital Lapeyronie, Montpellier], Hôpital Lapeyronie [Montpellier] (CHU), The authors thanks both the ISCT and the sponsors of the First Signature Series Symposium 'Cellular Therapies for Orthopaedics and Musculoskeletal Disease Proven and Unproven Therapies–Promise, Facts and Fantasy,' May 2, 2018, Montreal, Canada: Greyledge Technologies (Edwards, Colorado), MTF Biologics (Edison, New Jersey), Orthofix (Lewisville, Texas), MEdXcell (Lausanne, Switzerland), Osiris Therapeutics (Columbia, Maryland) and Angiocrine Bioscience (San Diego, California). Additionally this work was supported, in part, by the DIR, NIDCR, a part of the Intramural Research Program (IRP), NIH, DHHS (to P.G.R., ZIA DE000380)., Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Regenerative Medicine and Skeleton (RMeS), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Jehan, Frederic, Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and University of Vermont College of Medicine [Burlington, VT, USA]