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Start Over Author "Staub, Christophe" Topic [sdv.bdlr]life sciences [q-bio]/reproductive biology
8 results on '"Staub, Christophe"'

1. Evaluation of salivary metabolome and steroidome for the identification of biomarkers of the pubertal stage of maturity in gilts

Author

Goudet-Guitton, Ghylène, Nadal-Desbarats, Lydie, Lière, Philippe, Douet, Cécile, SAVOIE, Jonathan, STAUB, Christophe, Venturi, Eric, Ferchaud, Stéphane, Maupertuis, Florence, ROINSARD, Antoine, BOULOT, Sylviane, Prunier, Armelle, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), Imagerie et cerveau, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), U 1195, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Sud (Paris 11), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (Unité Expérimentale de Physiologie Animale de l‘Orfrasiére - UE PAO), Institut National de la Recherche Agronomique (INRA), UE 1372 Génétique, Expérimentation et Système Innovants, Institut National de la Recherche Agronomique (INRA)-Génétique animale (G.A.)-Physiologie Animale et Systèmes d'Elevage (PHASE), Institut National de la Recherche Agronomique (INRA)-Génétique, Expérimentation et Système Innovants (GenESI), Chambre d'agriculture de la Loire Atlantique (CDA), Institut Technique de l'Agriculture Biologique (ITAB), Institut du Porc, Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] (PEGASE), AGROCAMPUS OUEST-Institut National de la Recherche Agronomique (INRA), Crédit Incitatif PHASE, Agribio4, CIAB, INRA, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Génétique, Expérimentation et Système Innovants (GenESI), Institut du Porc (IFIP), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université François Rabelais (Tours). Tours, FRA. Centre National de la Recherche Scientifique (CNRS), FRA., Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
pig, saliva, puberty, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, porcine, steroidome, sexual maturity, femelle, maturité sexuelle, biomarker, metabolome, porcin, biomarqueur
Abstract

Evaluation of salivary metabolome and steroidome for the identification of biomarkers of the pubertal stage of maturity in gilts. 2. Journées du GdR 3606 Repro

Published
2017

2. Local immunization impacts the response of dairy cows to Escherichia coli mastitis

Author

Herry, Vincent, Gitton, Christophe, Tabouret, Guillaume, Répérant, Maryline, Forge, Laurine, Tasca, Christian, Gilbert, Florence B., Guitton, Edouard, Barc, Céline, Staub, Christophe, Smith, David G. E., Germon, Pierre, Foucras, Gilles, Rainard, Pascal, Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Plateforme d'Infectiologie Expérimentale (PFIE), Institut National de la Recherche Agronomique (INRA), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University [Edinburgh] (HWU), 'Investissements d’avenir' grant managed by Agence Nationale de la Recherche under the reference ANR-11-EQPX-0003, European Project: 291815, Institut National de la Recherche Agronomique (INRA)-Université de Tours, Infectiologie Animale et Santé Publique - IASP (Nouzilly, France), Plateforme d'Infectiologie Expérimentale (PFIE - INRA UE 1277), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (Unité Expérimentale de Physiologie Animale de l‘Orfrasiére - UE PAO), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), and European Project: 291815,EC:FP7:KBBE,FP7-ERANET-2011-RTD,ANIHWA(2012)

Subjects
mammary gland, mammite bovine, Science, Immunology, réponse immunitaire, Article, Random Allocation, Immunologie, Biologie de la reproduction, Animals, dairy cows, Mastitis, Bovine, Reproductive Biology, dairy cattle, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, immunologic reactions, bovin laitier, vache laitière, Cytokines, Medicine, glande mammaire, [SDV.IMM]Life Sciences [q-bio]/Immunology, Cattle, Female, Immunization, escherichia coli, bovine mastitis
Abstract

Remerciements :Jean-Luc Touzé and Eric Venturi for help in performing ultrasonography; International audience; Current vaccines to Escherichia coli mastitis have shown some albeit limited efficacy. Their mode of action has not been documented, and immune responses protecting the mammary gland against E. coli are not completely understood. To improve our knowledge of mammary gland immune protection, cows immunized either intramuscularly or intramammarily with the E. coli P4 were submitted to a homologous mastitis challenge. A third group of mock-immunized cows serve as challenge controls. Local immunization modified favorably the course of infection, by improving bacterial clearance while limiting inflammation. Systemic clinical signs and reduction in milk secretion were also contained. This occurred with a modification of the cytokine profile, such as an increase in IFN-γ and a reduction in TNF-α concentrations in milk. Concentrations of IL-17A and IL-22 increased in milk at the onset of the inflammatory response and remained high up to the elimination of bacteria, but concentrations did not differ between groups. Accelerated bacteriological cure was not linked to an increase in the initial efficiency of phagocytosis in milk. Results support the idea that antibodies did not play a major role in the improvement, and that cell-mediated immunity is the key to understanding E. coli vaccine-induced protection of the mammary gland.

Published
2017

3. Sex determination and egg quality evalutation in the Eurasian perch, Perca fluviatilis, using ultrasonography

Author

Schaerlinger, Bérénice, Staub, Christophe, Touze, Jean-Luc, CHARDARD, Dominique, Krauss, Daniel, LeDore, Yannick, Alix, Maud, Fontaine, Pascal, Institut National de la Recherche Agronomique (INRA), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Research Ministry, INRA, Department PHASE, Lorraine region, Università Politecnica delle Marche. ITA., Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

4. Apoptosis during the initiation of equine spermatogenesis

Author

Staub, Christophe, Heninger, N.L., Donnely, C.L., Forrest, D.W., Blanchard, T.L., Love, C.C., Varner, Dickson D., Johnson, L., Department of Veterinary Anatomy and Public Health, Texas A&M University System, Department of Animal Science, Texas A&M University [College Station], Department of Large Animal Medicine and Surgery, Link Equine Research Endowment, and International Society of Equine Reproduction (ISER). INT.

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], 03 medical and health sciences, 030219 obstetrics & reproductive medicine, 0302 clinical medicine, Food Animals, Equine, 0402 animal and dairy science, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, Animal Science and Zoology, 04 agricultural and veterinary sciences, Small Animals, 040201 dairy & animal science, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2002

5. Proteome analysis and genome-wide regulatory motif prediction identify novel potentially sex-hormone regulated proteins in rat efferent ducts

Author

Trépos-Pouplard, Mélanie, Lardenois, Aurélie, Staub, Christophe, Guitton, Nathalie, Dorval-Coiffec, Isabelle, Pineau, Charles, Primig, Michael, Jégou, Bernard, Trépos, Mélanie, Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), IMV Technologies, Plate-forme protéomique [Rennes], Plateforme Génomique Santé Biogenouest®, Biogenouest Proteomics Core Facility, Ministère de l’Enseignement, de la Recherche et de la Technologie, Inserm Avenir grant No R07216NS, Conseil Régional de Bretagne, European Project: 212844,EC:FP7:ENV,FP7-ENV-2007-1,DEER(2008), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Forgeron, Christine, and Developmental effects of environment on reproductive health - DEER - - EC:FP7:ENV2008-05-01 - 2012-04-30 - 212844 - VALID

Subjects
Epididymis, Male, oestrogen response elements, Rete Testis, Proteome, Tumor Protein, Translationally-Controlled 1, Estrogens, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, androgen, Response Elements, Rats, Rats, Sprague-Dawley, androgene response elements, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Androgens, efferent ducts, Animals, Electrophoresis, Gel, Two-Dimensional, rat, oestrogen, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology, Genome-Wide Association Study
Abstract

International audience; The efferent ducts are a series of tubules that conduct sperm from the rete testis to the epididymis. They absorb most fluid and proteins originating from the rete testis during concentration of spermatozoa prior to their entry into the epididymis. Proteome analysis of micro-dissected efferent duct samples from adult rats was combined with genome-wide computational prediction of conserved hormone response elements to identify factors likely regulated by oestrogens and androgens. We identified 165 proteins and found subsets of the promoters controlling their corresponding genes to contain androgen- and oestrogen response elements (ARE/EREs) at similar frequencies. Moreover, EREs were significantly enriched among the loci identified compared with their genome-wide occurrence. The expression and localization of Anxa6, Ckb, Krt19, Park7, Pdzk1 and Tpt1 in the efferent ducts and other related hormone controlled tissues was further validated at the RNA or protein level. This study identifies many novel proteins predicted to play roles in sperm maturation and male fertility and provides significant computational evidence that the efferent ducts express genes transcriptionally controlled by sex hormones.

Published
2010

6. Expression of estrogen receptor ESR1 and its 46-kDa variant in the gubernaculum testis

Author

Staub, Christophe, Rauch, Michel, Ferrière, François, Trépos, Mélanie, Dorval-Coiffec, Isabelle, Saunders, Philippa T, Cobellis, Gilda, Flouriot, Gilles, Saligaut, Christian, Jégou, Bernard, Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Interactions cellulaires et moléculaires (ICM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), INSERM, Ministère de la Recherche et Ministère de la Santé, EDEN European program, contract number QLK4-CT-2002-00603, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, endocrine system, MESH: Rats, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Rats, Sprague-Dawley, MESH: Protein Isoforms, Rats, Sprague-Dawley, developmental biology, estradiol receptor, androgen receptor, Testis, MESH: Gene Expression Regulation, Developmental, Animals, Estrogen Receptor beta, Protein Isoforms, MESH: Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Estrogen Receptor alpha, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, MESH: Estrogen Receptor beta, MESH: Testis, MESH: Alternative Splicing, Estrogen Receptor alpha, Gene Expression Regulation, Developmental, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, MESH: Male, Rats, body regions, Alternative Splicing, Receptors, Androgen, MESH: Receptors, Androgen, Female, MESH: Female, male reproductive tract
Abstract

Michel Rauch and François Ferrière : these authors contributed equally to this work; International audience; Testicular descent corresponds to migration of the testis from the abdominal cavity to the scrotum and is essential for proper functioning of the testis. Recent advances in the characterization of estrogen receptor (ESR) subtypes and isoforms in various tissues prompted us to study ESRs within the gubernaculum testis, a structure involved in testicular descent. In the rat gubernaculum, we searched for ESR alpha (Esr1) and beta (Esr2) and for the androgen receptor (Ar), androgens being known to regulate testicular descent. Reverse transcription-polymerase chain reaction (RT-PCR) revealed that Esr1, Esr2, and Ar mRNAs were all expressed in the gubernaculum. Using PEETA (Primer extension, Electrophoresis, Elution, Tailing, and Amplification), we established that all Esr1 leader exons, previously identified in other organs, such as the uterus and pituitary, were transcribed in the gubernaculum, with the major form being O/B. The RNA protection assays, RT-PCR, and Western blot experiments revealed that isoform-specific mRNA transcripts generated by alternative splicing of the C-leader sequence on coding exons 1 and 2 of the Esr1 gene gave the 46- and 66-kDa ESR1 proteins. The ESR1 and AR proteins were found to colocalize in the parenchymal cells of the gubernaculum early in development, whereas AR also was strongly expressed in the muscular cells, both during fetal and postnatal life. The ESR2 protein was weakly expressed, principally in the muscular cells, but only once testicular descent had occurred. The levels of the 46-kDa ESR1 variant (ER46) exceeded those of the 66-kDa ESR1 form (ER66) at periods when the gubernaculum developed. Conversely, the 66-kDa form appears to predominate clearly when the gubernaculum growth was low or completed. The possible role of estrogens on the modulation of the androgen-dependent growth of the gubernaculum and, more widely, on testicular descent is discussed.

Published
2005

7. Apoptosis as a mechanism of germ cell loss in mature stallions

Author

Heninger, N., Staub, Christophe, Blanchard, T., Varner, D., Love, C., Forrest, D., Johnson, L., Department of Animal Science, Texas A&M University [College Station], Department of Veterinary Anatomy and Public Health, Texas A&M University System, and Department of Large Animal Medicine and Surgery

Subjects
Reproductive Biology, apoptose, cellule germinale, Biologie de la reproduction, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, étalon, équin, spermatogénèse
Abstract

Article suite au Congrès : 8th International Symposium on Equine Reproduction. 22-26 July 2002, Fort Collins, USA; International audience

Published
2002

8. Granulocyte-macrophage colony-stimulating factor reduces testicular germ apoptosis in vitro

Author

Donnelly, C., Staub, Christophe, Forrest, D., Varner, D., Blanchard, T., Love, C., Johnson, L., ProdInra, Migration, Department of Animal Science, Texas A&M University [College Station], Department of Veterinary Anatomy and Public Health, Texas A&M University System, and Department of Large Animal Medicine and Surgery

Subjects
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology
Abstract

Article suite au Congrès : 8th International Symposium on Equine Reproduction. 22-26 July 2002, Fort Collins, USA; International audience

Published
2002

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