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22 results on '"Turcant, Alain"'

1. Voriconazole pharmacokinetics in experimental models of disseminated scedosporiosis: Effect of infection and cyclosporine dosing regimen on voriconazole disposition

Author

Lelièvre, Bénédicte, Abbara, Chadi, Chao de La Barca, Juan Manuel, Godon, Charlotte, Legras, Pierre, Turcant, Alain, Bouchara, Jean-Philippe, Diquet, Bertrand, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Biologie Neurovasculaire et Mitochondriale Intégrée (BNMI), and Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2015

5. Dosage de la metformine par chromatographie liquide en mode Hilic couplée à la spectrométrie de masse en tandem: application à 5 cas d'acidose lactique

Author

Férec, Séverine, Lelièvre, Bénédicte, Lagarce, Laurence, Bretaudeau, M., Turcant, Alain, Diquet, Bertrand, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Département de Pharmacologie-Toxicologie [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), and PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

6. Pharmacokinetic analysis of pralidoxime after its intramuscular injection alone or in combination with atropine-avizafone in healthy volunteers

Author

Abbara, Chadi, Rousseau, J.-M., Lelièvre, Bénédicte, Turcant, Alain, Lallement, Guy, Férec, Séverine, Bardot, Isabelle, Diquet, Bertrand, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
neurotoxic agents, Pralidoxime, [SDV]Life Sciences [q-bio], Pharmacokinetics, bioavailability
Abstract

International audience; BACKGROUND AND PURPOSETreatment of organophosphate poisoning with pralidoxime needs to be improved. Here we have studied the pharmacokinetics of pralidoxime after its intramuscular injection alone or in combination with avizafone and atropine using an auto-injector device.EXPERIMENTAL APPROACHThe study was conducted in an open, randomized, single-dose, two-way, cross-over design. At each period, each subject received either intramuscular injections of pralidoxime (700mg), or two injections of the combination: pralidoxime (350mg), atropine (2mg), avizafone (20mg). Pralidoxime concentrations were quantified using a validated LC/MS-MS method. Two approaches were used to analyse these data: (i) a non-compartmental approach; and (ii) a compartmental modelling approach.KEY RESULTSThe injection of pralidoxime combination with atropine and avizafone provided a higher pralidoxime maximal concentration than that obtained after the injection of pralidoxime alone (out of bioequivalence range), while pralidoxime AUC values were equivalent. Pralidoxime concentrations reached their maximal value earlier after the injection of the combination. According to Akaike and to goodness of fit criteria, the best model describing the pharmacokinetics of pralidoxime was a two-compartment with a zero-order absorption model. When avizafone and atropine were injected with pralidoxime, the best model describing pralidoxime pharmacokinetics becomes a two-compartment with a first-order absorption model.CONCLUSIONS AND IMPLICATIONSThe two approaches, non-compartmental and compartmental, showed that the administration of avizafone and atropine with pralidoxime results in a faster absorption into the general circulation and higher maximal concentrations, compared with the administration of pralidoxime alone.

Published
2010

7. Intoxications aiguës par le pentobarbital: un vieux produit toujours d'actualité

Author

Turcant, Alain, Lelièvre, Bénédicte, Boels, David, Lagarce, Laurence, Diquet, Bertrand, Cano, Y., Rodrigues-Monteiro, A., Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Département de Pharmacologie-Toxicologie [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), and PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

8. Mise au point du dosage du strontium dans l'eau et le sang: comparaison de deux techniques (ICP-AES, ICP-MS) et application en cas de noyade

Author

Huby, A., Lelièvre, Bénédicte, Mauras, Y., Le Bouil, Anne, Rougé-Maillart, Clotilde, Diquet, Bertrand, Turcant, Alain, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), and Centre Jean Bodin : Recherche Juridique et Politique (CJB)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

9. Pharmacokinetics of secnidazole in healthy volunteers after single oral dose

Author

Lelièvre, Bénédicte, Abbara, Chadi, Férec, Séverine, Turcant, Alain, Diquet, Bertrand, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Résumé publié dans : Fundamental & Clinical Pharmacology, avril 2010, 24(Suppl. 1): p. 55-56. doi:10.1111/j.1472-8206.2010.00819.x; National audience; Introduction: Secnidazole is an anti infective agent which belongs to the 5-nitroimidazole class.Method: The objective of the trial was to characterize the pharmacokinetics of secnidazole after oral administration of a 2g dose, as microgranules formulation in healthy subjects. Blood samples were collected before, 1, 2, 3, 6, 9, 12, 24, 36, 48, 72, 96, 120, 168 and 240 h after dosing. Urines were collected in 24-h-fractions for the first five days and in 48 h-fraction for the last sample. The cumulative urinary excretion was captured for each subject from urine concentration (lg/L). Pharmacokinetic parameters were obtained by a non-compartmental approach (WinNonlin Pharsight). The assay was performed by ultra-performance liquid chromatography coupled with mass spectrometry detection (UPLC-MS/MS, Quattro Premier, Waters) after simple protein precipitation of 50 lL plasma sample. Chromatographic separation was done on a C18 Acquity column (50 mm · 2.1 mm, id 1.7 lm, Waters), in isocratic mode (80% water/0.1% formic acid and 20% acetonitrile). Ornidazole was used as internal standard. The detection was operated in positive mode and multiple reaction monitoring was used for quantification (186 > 128 ion transition for secnidazole). The lower limit of quantification was 10 and 100 lg/L for plasma and urine samples respectively.Results: Sixteen subjects (8 female, 8 male) were included. Population characteristics such as: age ranged from 23 to 50 years (mean ± SD: 38 ± 9.2 years), weight ranged from 51 to 90 Kg (mean ± SD = 64.6 ± 10.1 Kg) and body mass index (BMI) ranged from 19.9 to 24.2 Kg/m 2 (mean ± SD = 21.9 ± 1.5 Kg/m 2 ;). Secnidazole exposure achieved a maximal concentration (Cmax) with a mean of 37.9 ± 8.5 mg/L (range 20–56 mg/L) and at a median time associated with the Cmax (Tmax) of 6 h (range 3–6 h). The area under the curve to the last measurable time (AUC0_t) and the total area under the curve (AUC0_¥) were 1281.9 ± 416.4 mg h/L and 1304.2 ± 444.1 mg h/L (mean ± SD) respectively.The Cl/F and V/F were 1.7 ± 0.5 L/h and 40.2 ± 9.2 L respectively and the elimination half-life (t1/2) was 17.5 ± 4.3 h (mean ± SD). The mean amount of secnidazole excreted in the 168-h urine collection was 310.47 mg (15.5% of the administered dose). For example, for the subject number 5, the observed parameters are: Cmax 37.3 mg/L, Tmax 3 h, AUC0_¥ 1029.5 mg h/L and t1/2 15.6 h.Conclusion: After a 2 g single oral dose, secnidazole presents a good absorption profile and relatively long elimination half life ensuring probable sufficient exposure with once a day administration.

Published
2010

10. Eczéma de contact au diméthylfumarate : intérêt de l'analyse toxicologique

Author

Bretaudeau, M., Avenel-Audran, M., Laurence, Lagarce, Lelièvre, Bénédicte, Turcant, Alain, Département de Pharmacologie-Toxicologie [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 10/2009

Published
2009

13. Usage abusif de benfluorex

Author

Cherel, A., Perroux, D., Auclair, V., Courtecuisse, A., Turcant, Alain, Roberge, C., Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 01/2009

Published
2009

14. Pharmacokinetic analysis of diazepam liberation from avizafone in healthy volunteers : Non-compartmental approach and compartmental modeling

Author

Abbara, Chadi, Lelièvre, Bénédicte, Rousseau, J.-M., Comets, Emmanualle, Bardot, Isabelle, Turcant, Alain, Diquet, Bertrand, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Génie industriel alimentaire (GENIAL), and Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National Agronomique Paris-Grignon (INA P-G)-Ecole Nationale Supérieure des Industries Agricoles et alimentaires

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 04/2009

Published
2009

16. Pharmacokinetics of secnidazole after single oral dose in healthy volunteers

Author

Diquet, Bertrand, Lelièvre, Bénédicte, Abbara, Chadi, Turcant, Alain, Bergman, J.-F., Simoneau, G., Brauman, M., Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2009

21. Imputabilité en toxicologie postmortem : exemple d'un travail sur la pholcodine

Author

Eysseric, H., Saviuc, P., Gaulier, Jean-Michel, Pépin, G., Dumestre-Toulet, V., Millan, N., Bevalot, F., Alvarez, J.-C., Saussereau, E., Ghysel, M.-H., Turcant, Alain, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 10/2008

Published
2008

22. Involvement of pholcodine in the cause of death in 127 forensic cases in France

Author

Eysseric, H., Saviuc, P., Gaulier, Jean-Michel, Pépin, G., Dumestre-Toulet, V., Millan, N., Bevalot, F., Alvarez, J.-C., Saussereau, E., Ghysel, M.-H., Turcant, Alain, Service de Pharmacologie, toxicologie et pharmacovigilance [CHU Limoges], CHU Limoges, Groupe Hospitalier du Havre, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 2008

Published
2008

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