1. Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs
- Author
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Nagl, Veronika, Grenier, Bertrand, PINTON, Philippe, Ruczizka, Ursula, Dippel, Maximiliane, Bünger, Moritz, Oswald, Isabelle P., SOLER-VASCO, Laura, Oswald, Isabelle, Soler, Laura, Biomin Research Center, Biosynthèse & Toxicité des Mycotoxines (ToxAlim-BioToMyc), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Veterinary Medicine [Vienna] (Vetmeduni), This project received funding from the ANR grant ExpoMycoPig (ANR-17-Carn012) and the Austrian Research Promotion Agency (FFG, Frontrunner program line, grant number 866384, and ANR-17-CARN-0012,ExpoMycoPig
- Subjects
medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,[SDV]Life Sciences [q-bio] ,Sus scrofa ,Adipokine ,030209 endocrinology & metabolism ,Carbohydrate metabolism ,Peptide hormone ,Toxicology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,mycotoxins ,medicine ,estrogen ,Animals ,Endocrine system ,adipokines ,030304 developmental biology ,0303 health sciences ,Adiponectin ,Chemistry ,fungi ,zearalenone ,Metabolism ,3. Good health ,Endocrinology ,Endocrine disruptor ,Medicine ,Female ,Resistin ,metabolism - Abstract
International audience; Zearalenone (ZEN) is a mycotoxin classified as an endocrine disruptor. Many endocrine disruptors are also metabolic disruptors able to modulate energy balance and inflammatory processes in a process often involving a family of protein hormones known as adipokines. The aim of our study was to elucidate the role of ZEN as metabolic disruptor in pigs by investigating the changes in energy balance and adipokines levels in response to different treatment diets. To this end, weaned piglets (n = 10/group) were exposed to either basal feed or feed contaminated with 680 and 1620 µg/kg ZEN for 28 days. Serum samples collected at days 7 and 21 were subjected to biochemistry analysis, followed by determination of adipokine levels using a combined approach of protein array and ELISA. Results indicate that ZEN has an impact on lipid and glucose metabolism that was different depending on the dose and time of exposure. In agreement with these changes, ZEN altered circulating adipokines concentrations, inducing significant changes in adiponectin, resistin, and fetuin B. Our results suggest that ZEN may function as a natural metabolism-disrupting chemical.
- Published
- 2021
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