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Your search keyword '"Lieubeau, Blandine"' showing total 10 results
Start Over Author "Lieubeau, Blandine" Topic [sdv]life sciences [q-bio]
10 results on '"Lieubeau, Blandine"'

1. Identification of biological variables associated with robustness of piglets at weaning

Author

Buchet, Arnaud, MERLOT, Elodie, Mormède, Pierre, Terenina, Elena, Lieubeau, Blandine, MIGNOT, Grégoire, Hervé, J., Leblanc-Maridor, Mily, Belloc, Catherine, Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] (PEGASE), AGROCAMPUS OUEST-Institut National de la Recherche Agronomique (INRA), Cooperl Arcatlantique, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), IECM, Institut National de la Recherche Agronomique (INRA), Ecole Nationale Vétérinaire Agroalimentaire et de l'Alimentation Nantes Atlantique (ONIRIS), Université Bretagne Loire (UBL), UMR 1300 Biologie, Epidémiologie et Analyse du Risque, Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Biologie, Epidémiologie et Analyse du Risque (BioEpAR)-Santé animale (S.A.), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes

Subjects
integumentary system, sevrage, marqueur biologique, animal diseases, weaning, [SDV]Life Sciences [q-bio], immunologie, sucking pig, robustness, porcelet, robustesse, biological markers
Abstract

The robustness of a piglet at weaning can be seen as its ability to express optimal growth without any health problems and regardless of weaning conditions. The identification of the level of the robustness of piglets at weaning could allow implementing targeted cares and treatments. The aim of this study was to identify some biological markers measured around weaning that could be associated with the growth of the piglet after weaning. Blood variables (n=62) describing immunity, stress, oxidative status and metabolism were measured at 26 and 33 days of age on piglets (n=288) from 16 commercial farms selected with contrasting sanitary statuses (deteriorated: SS- or good: SS+). The sanitary status of the farm was significantly associated with 37 of 67 variables measured (P

Published
2018

2. Divergent selection on adrenocortical activity modulates immune traits in pig

Author

Lieubeau, Blandine, Hervé, Julie, Haurogné, Karine, Bacou, Elodie, Allard, Marie, Billon, Yvon, Terenina, Elena, Bach, Jean-Marie, Mormède, Pierre, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), and Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

3. Long term muscle repair and clinical efficacy in duchenne muscular dystrophy dogs induced by systemic delivery of allogenic muscle stem (MuStem) cells

Author

Rouger, Karl, Larcher, Thibaut, Dubreil, Laurence, Deschamps, Jack-Yves, Fromes, Y., Le Guiner, C., Jouvion, Grégory, Delorme, B., Lieubeau, Blandine, Ledevin, Mireille, Zuber, Céline, Leroux, Isabelle, Guigand, Lydie, Le Rumeur, E., Cherel, Yan, Développement et Pathologie du Tissu Musculaire (DPTM), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Nantes, Généthon, Vecteurs viraux et transfert de gènes in vivo, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris], ESPRI-EA3855, Institut National de la Santé et de la Recherche Médicale (INSERM), Faculté de Médecine, Université Francois Rabelais [Tours], MacoPharma Tourcoing, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Interactions cellulaires et moléculaires (ICM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UNIV-RENNES), Institut Pasteur [Paris] (IP), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes - Faculté de Médecine (UR Médecine), and Université de Rennes (UR)

Subjects
clinical efficacy, allogenic muscle stem, [SDV]Life Sciences [q-bio], dog, Duchenne Muscular Dystrophy, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2011

4. Long-term clinical improvement and tissue remodelling in Duchenne Muscular Dystrophy (DMD) dogs after systemic delivery of allogenic Muscle Stem (MuStem) cells

Author

Larcher, Thibaut, Cherel, Yan, Dubreil, Laurence, Deschamps, Jack-Yves, Le Guiner, Caroline, Jouvion, Gregory, Delorme, Bruno, Lieubeau, Blandine, Ledevin, Mireille, Zuber, Céline, Leroux, Isabelle, Guigand, Lydie, Le Rumeur, Elisabeth, Rouger, Karl, Développement et Pathologie du Tissu Musculaire (DPTM), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Nantes, LUNAM Université [Nantes Angers Le Mans], Vecteurs viraux et transfert de gènes in vivo, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Nantes (CHU Nantes), Institut Pasteur [Paris] (IP), MacoPharma Tourcoing, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Interactions cellulaires et moléculaires (ICM), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes - Faculté de Médecine (UR Médecine), Université de Rennes (UR), Institut Pasteur [Paris], Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine, and Université de Rennes (UNIV-RENNES)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2011

5. Caractérisation des cellules dendritiques canines différenciées à partir des monocytes du sang périphérique

Author

Ibisch, Catherine, Lieubeau, Blandine, Pradal, Gilbert, Bach, Jean-Marie, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes, Université de Nantes (UN), and Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA)

Subjects
ULTRASTRUCTURE, CELLULE DENDRITIQUE, [SDV]Life Sciences [q-bio], CULTURE CELLULAIRE, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2006

6. Functional canine dendritic cells generated in vitro from peripheral blood mononuclear cells (PBMC) : Structural and functional characterization

Author

Ibisch, Catherine, Bach, Jean-Marie, Lieubeau, Blandine, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes, and Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], IMMUNOLOGIE, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2005

7. Ultrastructural markers expressed in cultured canine dendritic cells and laminated bodies found in Langerhans cells : similarities and differences

Author

Ibisch, Catherine, Lieubeau, Blandine, Pradal, Gilbert, Bach, Jean-Marie, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Université de Nantes (UN), and Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes

Subjects
LYMPHOCYTE, LANGERHANS CELL, [SDV]Life Sciences [q-bio], DENDRITIC CELL, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2004

8. Induction of tolerance by recipient immature dendritic cells in porcine islet cell xenotransplantation in mouse

Author

Lieubeau, Blandine, Potiron, N., Kadri, N., Saï, Pierre, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), and Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes

Subjects
health care facilities, manpower, and services, [SDV]Life Sciences [q-bio], education, social sciences, DENDRITIC CELLS, geographic locations, health care economics and organizations, ComputingMilieux_MISCELLANEOUS
Abstract

s of the Seventh Congress of the International Xenotransplantation Association - Glasgow, 2003; International audience

Published
2003

9. β2-adrenoreceptor stimulation dampens the LPS-induced M1 polarization in pig macrophages

Author

Karine Haurogné, Jean-Marie Bach, Marie Allard, Julie Hervé, Grégoire Mignot, Elodie Bacou, Blandine Lieubeau, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Hervé, Julie, Lieubeau, Blandine, and Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes

Subjects
Lipopolysaccharides, 0301 basic medicine, medicine.medical_specialty, Swine, Macrophage, [SDV]Life Sciences [q-bio], Immunology, Adrenoreceptor, beta 2-agonist, Pig, Stimulation, Biology, 03 medical and health sciences, Catecholamines, 0302 clinical medicine, Immune system, Anti-Infective Agents, Internal medicine, medicine, Animals, Secretion, Interleukin 8, Adrenergic beta-2 Receptor Agonists, Innate immune system, Tumor Necrosis Factor-alpha, Macrophages, Interleukin-8, Immunity, Innate, Interleukin-10, Up-Regulation, Interleukin 10, 030104 developmental biology, Endocrinology, Tumor necrosis factor alpha, Receptors, Adrenergic, beta-2, 030217 neurology & neurosurgery, Developmental Biology
Abstract

The cross-talk between sympatho-adreno-medullar axis and innate immunity players was mainly studied in rodents. In intensive husbandry, pigs are exposed to multiple stressors inducing repeated releases of catecholamines that bind to adrenoreceptors (AR) on target cells. Among adrenoreceptors, the (beta 2-AR is largely expressed by immune cells including macrophages. We report herein on the effects of catecholamines, through (beta 2-AR stimulation, on pig macrophage functions activated by LPS. beta 2-AR stimulation of porcine macrophages prevented the LPS-induced increase in TINF alpha and IL-8 secretion while increasing IL-10 secretion. In contrast, treatment with a beta 2-agonist had no effect on anti-microbial functions. Lastly, beta 2-AR stimulation of macrophages reduced the expression of genes up regulated by LPS. Altogether, we demonstrated that (beta 2-AR stimulation of porcine macrophages prevented polarization towards a pro-inflammatory phenotype. Since porcine macrophages are a suitable model for human macrophages, our results might be relevant to appreciate catecholamine effects on human macrophages.

Published
2017

10. Beta 2-adrenergic stimulation of dendritic cells favors IL-10 secretion by CD4(+) T cells

Author

Julie Hervé, Elodie Bacou, Blandine Lieubeau, Sylvie Pogu, Karine Haurogné, Jean-Marie Bach, Marie Allard, Grégoire Mignot, Hervé, Julie, Lieubeau, Blandine, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), and Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA)

Subjects
CD4-Positive T-Lymphocytes, Lipopolysaccharides, 0301 basic medicine, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Dendritic cell, CD4(+) T lymphocyte, Salbutamol, beta 2-adrenergic receptor, IL-10, popilation, cultures, induction, Lymphocyte Activation, Immunotherapy, Adoptive, Mice, 0302 clinical medicine, Cytotoxic T cell, Cells, Cultured, Mice, Knockout, biology, Chemistry, Cell Differentiation, Interleukin-10, 3. Good health, Cell biology, Interleukin 10, medicine.anatomical_structure, T cell, Immunology, 03 medical and health sciences, Antigen, medicine, Animals, Humans, Albuterol, Antigen-presenting cell, Adrenergic beta-2 Receptor Agonists, Cell Proliferation, CD40, Dendritic Cells, Immunotherapy, Coculture Techniques, Mice, Inbred C57BL, 030104 developmental biology, biology.protein, Receptors, Adrenergic, beta-2, 030215 immunology
Abstract

International audience; Adrenergic receptor agonists and antagonists are extensively used as drugs in medicine for a broad spectrum of indications. We examined the consequences of beta 2-adrenergic stimulation of murine dendritic cells (DCs) on CD4(+) T cell activation. We demonstrated in vitro that treatment of LPS-matured DCs with the beta 2-agonist salbutamol reduced their ability to trigger OT-II T cell proliferation specific for ovalbumin antigen. Salbutamol also induced a decrease in MHC class II molecule expression by DC through Gi protein activation. Co-culture of CD4(+) T cells with salbutamol-conditioned mature DC impaired TNF alpha and IL-6 secretion while preserving IL-10 production by T cells. Using a vaccination protocol in mice, we showed that salbutamol favored IL-10-producing CD4(+) T cells. None of these effects was observed when working with beta 2-adrenoreceptor deficient mice. Finally, we suggest that beta 2-adrenergic stimulation of DC could be an interesting way to shape CD4(+) T cell responses for the purposes of immunotherapy.

Published
2017

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