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11 results on '"Ecole Natl Super Mines Gardanne"'

1. Integrating flexible electronics for pulsed electric field delivery in a vascularized 3D glioblastoma model

Author

David Moreau, Martin Baca, Gerwin Dijk, Attila Kaszás, Marie C. Lefevre, Rodney P. O'Connor, École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT), Ecole Natl Super Mines Gardanne, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and ANR-18-CE19-0029,FIDELGLIO,Dispositifs bioélectroniques flexibles et implantables pour l'amélioration du traitement du Glioblastome par impulsions électriques(2018)

Subjects
[SDV.BIO]Life Sciences [q-bio]/Biotechnology, Materials science, TK7800-8360, [SDV]Life Sciences [q-bio], Brain tumor, Tumor cells, 02 engineering and technology, 03 medical and health sciences, Electric field, Cell integrity, medicine, General Materials Science, Electrical and Electronic Engineering, Materials of engineering and construction. Mechanics of materials, 030304 developmental biology, 0303 health sciences, Spheroid, 021001 nanoscience & nanotechnology, medicine.disease, Flexible electronics, 3. Good health, Multiphoton fluorescence microscope, TA401-492, Electronics, 0210 nano-technology, Biomedical engineering, Glioblastoma
Abstract

Glioblastoma is a highly aggressive brain tumor, very invasive and thus difficult to eradicate with standard oncology therapies. Bioelectric treatments based on pulsed electric fields have proven to be a successful method to treat cancerous tissues. However, they rely on stiff electrodes, which cause acute and chronic injuries, especially in soft tissues like the brain. Here we demonstrate the feasibility of delivering pulsed electric fields with flexible electronics using an in ovo vascularized tumor model. We show with fluorescence widefield and multiphoton microscopy that pulsed electric fields induce vasoconstriction of blood vessels and evoke calcium signals in vascularized glioblastoma spheroids stably expressing a genetically encoded fluorescence reporter. Simulations of the electric field delivery are compared with the measured influence of electric field effects on cell membrane integrity in exposed tumor cells. Our results confirm the feasibility of flexible electronics as a means of delivering intense pulsed electric fields to tumors in an intravital 3D vascularized model of human glioblastoma.

Published
2021
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2. An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo

Author

Sahika Inal, George G. Malliaras, Christopher M. Proctor, Adam Williamson, Ilke Uguz, Vincenzo F. Curto, Andrea Slézia, University of Cambridge [UK] (CAM), Ecole Natl Super Mines Gardanne, Columbia University [New York], University of Szeged [Szeged], Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), King Abdullah University of Science and Technology (KAUST), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), European Project: 716867,ERC, Williamson, Adam, INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE - - Amidex2011 - ANR-11-IDEX-0001 - IDEX - VALID, Epilepsy Controlled with Electronic Neurotransmitter Delivery - ERC - 716867 - INCOMING, Proctor, Christopher [0000-0002-2066-1354], Malliaras, George [0000-0002-4582-8501], and Apollo - University of Cambridge Repository

Subjects
Electrophoresis, Male, Computer science, [SDV]Life Sciences [q-bio], Microfluidics, Biomedical Engineering, 02 engineering and technology, bioelectronics, General Biochemistry, Genetics and Molecular Biology, Biomaterials, 03 medical and health sciences, Mice, 0302 clinical medicine, Drug Delivery Systems, In vivo, medicine, Animals, Electrocorticography, gamma-Aminobutyric Acid, ComputingMilieux_MISCELLANEOUS, Bioelectronics, medicine.diagnostic_test, electrophoretic, neuroengineering, Brain, Neural engineering, Equipment Design, Microfluidic Analytical Techniques, 021001 nanoscience & nanotechnology, [SDV] Life Sciences [q-bio], Brain implant, Ion pump, Drug delivery, drug delivery, 0210 nano-technology, 030217 neurology & neurosurgery, Biomedical engineering
Abstract

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The challenge of treating neurological disorders has motivated the development of implantable devices that can deliver treatment when and where it is needed. This study presents a novel brain implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.

Published
2019
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3. NeuroRoots, a bio-inspired, seamless Brain Machine Interface device for long-term recording

Author

Jolien Pas, Eric T. Zhao, Sukhdeep Singh, Andreas Schober, Gerwin Dijk, Marc Ferro, Mary J. Donahue, Alex Gonzalez, Lisa M. Giocomo, Nicholas A. Melosh, Andrea Slézia, Uta Fernekorn, Georges Malliaras, Christopher M. Proctor, Adam Williamson, Stanford University, University of Cambridge [UK] (CAM), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Natl Super Mines Gardanne, M.F. was supported by US National Institutes of Health Grants ( 1R21EY026365 - 01 ) and the Stanford NeuroTechnology Initiative (NTI) . C.P. acknowledges funding from a Whitaker International Scholar Grant administered by the U.S. Institute for International Education as well as funding from the University of Cambridge Borysiewicz Biomedical Fellowship program. A.W. acknowledges funding fr om the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 716867), and European Project: 716867,ERC

Subjects
Cardiomyocytes, Computer science, Organ-on-a-Chip, [SDV]Life Sciences [q-bio], 02 engineering and technology, Biological tissue, 021001 nanoscience & nanotechnology, Organ-on-a-chip, P19 Stem Cells, 03 medical and health sciences, Electrophysiology, 0302 clinical medicine, Long period, Hepatocytes, 0210 nano-technology, 030217 neurology & neurosurgery, Biomedical engineering, Brain–computer interface
Abstract

Minimally invasive electrodes of cellular scale that approach a bio-integrative level of neural recording could enable the development of scalable brain machine interfaces that stably interface with the same neural populations over long period of time.In this paper, we designed and created NeuroRoots, a bio-mimetic multi-channel implant sharing similar dimension (10µm wide, 1.5µm thick), mechanical flexibility and spatial distribution as axon bundles in the brain. A simple approach of delivery is reported based on the assembly and controllable immobilization of the electrode onto a 35µm microwire shuttle by using capillarity and surface-tension in aqueous solution. Once implanted into targeted regions of the brain, the microwire was retracted leaving NeuroRoots in the biological tissue with minimal surgical footprint and perturbation of existing neural architectures within the tissue. NeuroRoots was implanted using a platform compatible with commercially available electrophysiology rigs and with measurements of interests in behavioral experiments in adult rats freely moving into maze. We demonstrated that NeuroRoots electrodes reliably detected action potentials for at least 7 weeks and the signal amplitude and shape remained relatively constant during long-term implantation.This research represents a step forward in the direction of developing the next generation of seamless brain-machine interface to study and modulate the activities of specific sub-populations of neurons, and to develop therapies for a plethora of neurological diseases.

Published
2018
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4. A bilayered PVA/PLGA-bioresorbable shuttle to improve the implantation of flexible neural probes

Author

George G. Malliaras, Rodney P. O'Connor, Antoine Ghestem, Christophe Bernard, Jolien Pas, Vincenzo F. Curto, Attila Kaszás, Adam Williamson, Pascale P. Quilichini, Andrea Slézia, Alexandra L. Rutz, Mary J. Donahue, Ecole des Mines de Saint-Etienne - CMP (CMP -EMSE), EMSE, Electrical Engineering Division, university of Cambridge, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), European Project: 732032,BrainCom, European Project: 716867,ERC, European Project: 625372,EC:FP7:PEOPLE,FP7-PEOPLE-2013-IEF,IMAGINE(2015), Quilichini, Pascale, High-density cortical implants for cognitive neuroscience and rehabilitation of speech using brain-computer interfaces - BrainCom - 732032 - INCOMING, Epilepsy Controlled with Electronic Neurotransmitter Delivery - ERC - 716867 - INCOMING, Imaging Interneurons in Epilepsy - IMAGINE - - EC:FP7:PEOPLE2015-09-01 - 2017-08-31 - 625372 - VALID, Malliaras, George [0000-0002-4582-8501], Apollo - University of Cambridge Repository, Ecole Natl Super Mines Gardanne, University of Cambridge [UK] (CAM), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT), Williamson, Adam, and INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE - - Amidex2011 - ANR-11-IDEX-0001 - IDEX - VALID

Subjects
Male, Vinyl alcohol, Materials science, Biocompatibility, [SPI] Engineering Sciences [physics], [SDV]Life Sciences [q-bio], Biomedical Engineering, Biocompatible Materials, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Mice, [SPI]Engineering Sciences [physics], Parylene, Polylactic Acid-Polyglycolic Acid Copolymer, Absorbable Implants, Electric Impedance, Animals, chemistry.chemical_classification, Bioelectronics, technology, industry, and agriculture, Brain, Polymer, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Molding (decorative), Electrodes, Implanted, Mice, Inbred C57BL, [SDV] Life Sciences [q-bio], PLGA, chemistry, Polyvinyl Alcohol, 0210 nano-technology, Layer (electronics), Biomedical engineering
Abstract

© 2018 IOP Publishing Ltd. Objective. Neural electrophysiology is often conducted with traditional, rigid depth probes. The mechanical mismatch between these probes and soft brain tissue is unfavorable for tissue interfacing. Making probes compliant can improve biocompatibility, but as a consequence, they become more difficult to insert into the brain. Therefore, new methods for inserting compliant neural probes must be developed. Approach. Here, we present a new bioresorbable shuttle based on the hydrolytically degradable poly(vinyl alcohol) (PVA) and poly(lactic-co-glycolic acid) (PLGA). We show how to fabricate the PVA/PLGA shuttles on flexible and thin parylene probes. The method consists of PDMS molding used to fabricate a PVA shuttle aligned with the probe and to also impart a sharp tip necessary for piercing brain tissue. The PVA shuttle is then dip-coated with PLGA to create a bi-layered shuttle. Main results. While single layered PVA shuttles are able to penetrate agarose brain models, only limited depths were achieved and repositioning was not possible due to the fast degradation. We demonstrate that a bilayered approach incorporating a slower dissolving PLGA layer prolongs degradation and enables facile insertion for at least several millimeters depth. Impedances of electrodes before and after shuttle preparation were characterized and showed that careful deposition of PLGA is required to maintain low impedance. Facilitated by the shuttles, compliant parylene probes were also successfully implanted into anaesthetized mice and enabled the recording of high quality local field potentials. Significance. This work thereby presents a solution towards addressing a key challenge of implanting compliant neural probes using a two polymer system. PVA and PLGA are polymers with properties ideal for translation: commercially available, biocompatible with FDA-approved uses and bioresorbable. By presenting new ways to implant compliant neural probes, we can begin to fully evaluate their chronic biocompatibility and performance compared to traditional, rigid electronics.

Published
2018
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5. Inkjet-Printed PEDOT:PSS Electrodes on Paper for Electrocardiography

Author

George G. Malliaras, Jozina B. De Graaf, Timothée Roberts, Eloise Bihar, Thierry Hervé, Mohamed Saadaoui, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), EMSE-CMP, Ecole Nationale Supérieure des Mines de Saint-Etienne, Centre Microélectronique de Provenc (EMSE-CMP), Ministère du Redressement productif-Ministère du Redressement productif, Ecole Nationale Supérieure des Mines de Saint-Etienne, Centre Microélectronique de Provence (EMSE-CMP), Ecole Natl Super Mines, Dept Bioelect, Ecole Natl Super Mines Gardanne, and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Paper, Materials science, Polymers, [SDV]Life Sciences [q-bio], Biomedical Engineering, Pharmaceutical Science, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biomaterials, Electrocardiography, [SPI]Engineering Sciences [physics], PEDOT:PSS, medicine, Humans, Electrodes, medicine.diagnostic_test, business.industry, Bridged Bicyclo Compounds, Heterocyclic, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Printed electronics, Electrode, Printing, Optoelectronics, 0210 nano-technology, business
Abstract

International audience; Inkjet-printed PEDOT:PSS electrodes are shown to record cutaneous electrophysiological signals such as electrocardiograms via a simple finger-to-electrode contact. The recordings are of high quality and show no deterioration over a 3 month period, paving the way for the development of the next generation of low-cost, convenient-to-use healthcare monitoring devices.

Published
2017
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6. Simultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays

Author

Eileen Pedraza, Sylvie Renaud, Ariana Villarroel Marquez, Antoine Pirog, Jochen Lang, Dimitrios A. Koutsouras, Eric Cloutet, George G. Malliaras, Matthieu Raoux, Romain Perrier, Ecole Nationale Supérieure des Mines de Saint-Etienne, Centre Microélectronique de Provence (EMSE-CMP), Ecole Nationale Supérieure des Mines de Saint-Etienne, Centre Microélectronique de Provenc (EMSE-CMP), Ministère du Redressement productif-Ministère du Redressement productif, Chimie et Biologie des Membranes et des Nanoobjets (CBMN), École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Team 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies, Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Laboratoire de l'intégration, du matériau au système (IMS), Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), Ecole Natl Super Mines, Dept Bioelect, Ecole Natl Super Mines Gardanne, and Université de Bordeaux (UB)-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Materials science, [SDV]Life Sciences [q-bio], Bioengineering, Nanotechnology, Biosensing Techniques, 02 engineering and technology, Local field potential, Low frequency, Noise (electronics), Membrane Potentials, Biomaterials, Islets of Langerhans, 03 medical and health sciences, PEDOT:PSS, Electric Impedance, medicine, Electrodes, Bioelectronics, Pancreatic islets, Diabetes, Pancreatic beta-cells, 021001 nanoscience & nanotechnology, 030104 developmental biology, medicine.anatomical_structure, [CHIM.POLY]Chemical Sciences/Polymers, Mechanics of Materials, Electrode, Islets, 0210 nano-technology, Biosensor, Biomedical engineering
Abstract

International audience; Continuous and long-term monitoring of cellular and micro-organ activity is required for new insights intophysiology and novel technologies such as Organs-on-Chip. Moreover, recent advances in stem cell technologyand especially in the field of diabetes call for non-invasive approaches in quality testing of the large quantities ofsurrogate pancreatic islets to be generated. Electrical activity of such a micro-organ results in single cell actionpotentials (APs) of high frequency and in low frequency changes in local field potentials (slow potentials or SPs),reflecting coupled cell activity and overall organ physiology. Each of them is indicative of different physiologicalstages in islet activation. Action potentials in islets are of small amplitude and very difficult to detect. The use ofPEDOT:PSS to coat metal electrodes is expected to reduce noise and results in a frequency-dependent change inimpedance, as shown here. Whereas detection of high-frequency APs improves, low frequency SPs are less welldetected which is, however, an acceptable trade off in view of the strong amplitude of SPs. Using a dedicatedsoftware, recorded APs and SPs can be automatically diagnosed and analyzed. Concomitant capture of the twosignals will considerably increase the diagnostic power of monitoring islets and islet surrogates in fundamentalresearch as well as drug screening or the use of islets as biosensors.

Published
2017
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7. High-performance transistors for bioelectronics through tuning of channel thickness

Author

Christophe Bernard, Jean-Michel Badier, Pierre Leleux, Róisín M. Owens, Dion Khodagholy, Jonathan Rivnay, Georgios Malliaras, Christian Bénar, Dimitrios A. Koutsouras, Marc Ferro, Xenofon Strakosas, Marc Ramuz, Adam Williamson, Michele Sessolo, Williamson, Adam, Blanc 2013 - Multifunctional implantable probes based on conducting polymer devices - - PolyProbe2013 - ANR-13-BSV5-0019 - Blanc 2013 - VALID, Département Bioélectronique (BEL-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-CMP-GC, Ecole Natl Super Mines Gardanne, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported through grants by the Agence Nationale de la Recherche (MUSIC, PolyProbe), region Provence-Alpes-Cote d'Azur, the Fondation pour la Recherche Medicale, the Marie Curie ITN OLIMPIA, and Orthogonal Inc. J.R. and M.S. acknowledge a Marie Curie postdoctoral fellowship, and D.K. acknowledges a Simons Foundation postdoctoral fellowship., ANR-13-BSV5-0019,PolyProbe,Multifunctional implantable probes based on conducting polymer devices(2013), Owens, Roisin [0000-0001-7856-2108], Malliaras, George [0000-0002-4582-8501], and Apollo - University of Cambridge Repository

Subjects
Fabrication, Materials science, Transconductance, [SDV]Life Sciences [q-bio], Nanotechnology, 02 engineering and technology, Electrolyte, bioelectronics, 010402 general chemistry, 01 natural sciences, law.invention, PEDOT:PSS, law, Research Articles, Organic electronics, Bioelectronics, Multidisciplinary, Transistor, SciAdv r-articles, 021001 nanoscience & nanotechnology, equipment and supplies, 0104 chemical sciences, [SDV] Life Sciences [q-bio], Medicine, Molecular Electronics, electrochemical transistors, 0210 nano-technology, Organic electrochemical transistor, Research Article
Abstract

Transistors with tunable transconductance allow high-quality recordings of human brain rhythms., Despite recent interest in organic electrochemical transistors (OECTs), sparked by their straightforward fabrication and high performance, the fundamental mechanism behind their operation remains largely unexplored. OECTs use an electrolyte in direct contact with a polymer channel as part of their device structure. Hence, they offer facile integration with biological milieux and are currently used as amplifying transducers for bioelectronics. Ion exchange between electrolyte and channel is believed to take place in OECTs, although the extent of this process and its impact on device characteristics are still unknown. We show that the uptake of ions from an electrolyte into a film of poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) leads to a purely volumetric capacitance of 39 F/cm3. This results in a dependence of the transconductance on channel thickness, a new degree of freedom that we exploit to demonstrate high-quality recordings of human brain rhythms. Our results bring to the forefront a transistor class in which performance can be tuned independently of device footprint and provide guidelines for the design of materials that will lead to state-of-the-art transistor performance.

Published
2015
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8. Localized Neuron Stimulation with Organic Electrochemical Transistors on Delaminating Depth Probes

Author

George G. Malliaras, Adam Williamson, Pascale P. Quilichini, Esma Ismailova, Jonathan Rivnay, Thomas Doublet, Pierre Leleux, Christophe Bernard, Gergely Katona, Balázs Rózsa, Attila Kaszás, Marc Ferro, Williamson, Adam, Blanc 2013 - Multifunctional implantable probes based on conducting polymer devices - - PolyProbe2013 - ANR-13-BSV5-0019 - Blanc 2013 - VALID, INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE - - Amidex2011 - ANR-11-IDEX-0001 - IDEX - VALID, Targets and biomarkers for antiepileptogenesis - EPITARGET - - EC:FP7:HEALTH2013-11-01 - 2018-10-31 - 602102 - VALID, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Natl Super Mines Gardanne, Département Bioélectronique (BEL-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-CMP-GC, Pázmány Péter Catholic University, Hungarian Academy of Sciences, A.W., A.K., M.F., P.L., and E.I., contributed equally to this work. This work was funded by the European Union's Seventh Framework Programme (FP7/2007-2013) under Grant Agreement No. 602102 (EPITARGET), the A*MIDEX project MIDOE (A_M-AAP-ID-13-24-130531-16.31-BERNARD-HLS), the ANR through the project PolyProbe (ANR-13-BSV5-0019-01), the Fondation pour la Recherche Medicale under Grant Agreement No. DBS20131128446, Fondation de l'Avenir, the Region PACA, Orthogonal, Inc., and Microvitae Technologies. A.K. was sponsored by the Fondation pour la Recherche Medicale postdoctoral fellowship under Grant Agreement No. SPF20130526842. J.R. was supported by Marie Curie Postdoctoral Fellowship. The authors thank Gaelle Rondeau and the staff of the clean room at CMP for technical support during the devices fabrication. Finally, A.W. sincerely thanks Robert Charles Williamson for inspiration., ANR-13-BSV5-0019,PolyProbe,Multifunctional implantable probes based on conducting polymer devices(2013), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), and European Project: 602102,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,EPITARGET(2013)

Subjects
Materials science, Mechanical Engineering, [SDV]Life Sciences [q-bio], Transistor, Nanotechnology, equipment and supplies, Electrochemistry, law.invention, Delamination process, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, PEDOT:PSS, Mechanics of Materials, law, Feature (computer vision), medicine, General Materials Science, Neuron, ComputingMilieux_MISCELLANEOUS
Abstract

Organic electrochemical transistors are integrated on depth probes to achieve localized electrical stimulation of neurons. The probes feature a mechanical delamination process which leaves only a 4 μm thick film with embedded transistors inside the brain. This considerably reduces probe invasiveness and correspondingly improves future brain-machine interfaces.

Published
2015
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9. Fully Printed Electrodes on Stretchable Textiles for Long-Term Electrophysiology

Author

Thierry Hervé, Ana Sanchez-Sanchez, Eloise Bihar, George G. Malliaras, David Mecerreyes, Esma Ismailova, Timothée Roberts, Mehmet Isik, Mohamed Saadaoui, Jozina B. De Graaf, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Ecole Nationale Supérieure des Mines de Saint-Etienne, Centre Microélectronique de Provence (EMSE-CMP), Ecole Nationale Supérieure des Mines de Saint-Etienne, Centre Microélectronique de Provenc (EMSE-CMP), Ministère du Redressement productif-Ministère du Redressement productif, EMSE-CMP, Univ Basque Country UPV EHU, Joxe Mari Korta Ctr, POLYMAT, Univ Basque Country, Ecole Natl Super Mines, Dept Bioelect, Ecole Natl Super Mines Gardanne, and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Conductive polymer, Textile, Materials science, business.industry, [SDV]Life Sciences [q-bio], education, technology, industry, and agriculture, Cardiac activity, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Industrial and Manufacturing Engineering, 0104 chemical sciences, [SPI]Engineering Sciences [physics], chemistry.chemical_compound, chemistry, Mechanics of Materials, Electrode, Ionic liquid, General Materials Science, 0210 nano-technology, business, Textile electrodes
Abstract

International audience; Fully printed electrodes consisting of a conducting polymer and an ionic liquid gel are fabricated on a stretchable textile. They are shown to record cardiac activity while the wearer is moving and for long periods of time, paving the way for the development of low-cost devices for continuous health monitoring.

Published
2017
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10. Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Author

Adam Williamson, Christopher M. Proctor, Andrea Slézia, George G. Malliaras, Attila Kaszás, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Szeged [Szeged], University of Cambridge Hearing Group, University of Cambridge [UK] (CAM), Ecole Natl Super Mines Gardanne, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), European Project: 716867,ERC, and European Project: 625372,EC:FP7:PEOPLE,FP7-PEOPLE-2013-IEF,IMAGINE(2015)

Subjects
medicine.medical_specialty, General Immunology and Microbiology, business.industry, General Chemical Engineering, General Neuroscience, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 4-Aminopyridine, Hippocampus, Drug resistance, Inhibitory postsynaptic potential, medicine.disease, General Biochemistry, Genetics and Molecular Biology, 3. Good health, Epilepsy, Drug delivery, medicine, Neurosurgery, business, Neurostimulation, Neuroscience, ComputingMilieux_MISCELLANEOUS, medicine.drug
Abstract

Epilepsy is a group of neurological disorders which affects millions of people worldwide. Although treatment with medication is helpful in 70% of the cases, serious side effects affect the quality of life of patients. Moreover, a high percentage of epileptic patients are drug resistant; in their case, neurosurgery or neurostimulation are necessary. Therefore, the major goal of epilepsy research is to discover new therapies which are either capable of curing epilepsy without side effects or preventing recurrent seizures in drug-resistant patients. Neuroengineering provides new approaches by using novel strategies and technologies to find better solutions to cure epileptic patients at risk. As a demonstration of a novel experimental protocol in an acute mouse model of epilepsy, a direct in situ electrophoretic drug delivery system is used. Namely, a neural probe incorporating a microfluidic ion pump (µFIP) for on-demand drug delivery and simultaneous recording of local neural activity is implanted and demonstrated to be capable of controlling 4-aminopyridine-induced (4AP-induced) seizure-like event (SLE) activity. The γ-aminobutyric acid (GABA) concentration is kept in the physiological range by the precise control of GABA delivery to reach an antiepileptic effect in the seizure focus but not to cause overinhibition-induced rebound bursts. The method allows both the detection of pathological activity and intervention to stop seizures by delivering inhibitory neurotransmitters directly to the epileptic focus with precise spatiotemporal control. As a result of the developments to the experimental method, SLEs can be induced in a highly localized manner that allows seizure control by the precisely tuned GABA delivery at the seizure onset.

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11. Noninvasive Stimulation of Peripheral Nerves using Temporally‐Interfering Electrical Fields

Author

Boris Botzanowski, Mary J. Donahue, Malin Silverå Ejneby, Alessandro L. Gallina, Ibrahima Ngom, Florian Missey, Emma Acerbo, Donghak Byun, Romain Carron, Antonino M. Cassarà, Esra Neufeld, Viktor Jirsa, Peder S. Olofsson, Eric Daniel Głowacki, Adam Williamson, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Natl Super Mines Gardanne, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), APHM, Hôpital de la Timone, Service de Neurochirurgie Fonctionnelle et Stéréotaxique, Foundation for Research on Information Technologies in Society (IT’IS), This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (A.W. grant agreement No. 716867, E.D.G. grant agreement No. 949191). E.D.G. acknowledges funding from the City Council of Brno, Czech Republic. M.J.D acknowledges funding from the European Research Council (834677 'e-NeuroPharma' ERC-2018-ADG). P.S.O. and A.L.G. were funded by MedTechLabs and the Swedish Research Council., European Project: 834677,e-NeuroPharma, European Project: 716867,ERC, and European Project: 949191,OPTEL-MED

Subjects
Biomaterials, Mice, bioelectronic medicines, electrical stimulation, flexible electronics, neurostimulation, temporal interference, transcutaneous, [SDV]Life Sciences [q-bio], Transcutaneous Electric Nerve Stimulation, Biophysics, Biomedical Engineering, Animals, Pharmaceutical Science, Sciatic Nerve, Electric Stimulation, Biofysik
Abstract

Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high-frequency sine-wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 - 4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on-skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically-approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques. Funding Agencies|European Research Council (ERC) under the European Union [716867, 949191]; City Council of Brno, Czech Republic; European Research Council [834677]; Swedish Research Council; MedTechLabs

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