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Outcomes after photodynamic therapy (PDT) in 33 patients with basal cell skin cancer Т3-Т4N0M0 primary stage are represented in the article. The irradiation was performed distantly 3h after intravenous injection of photosensitizer photolon with dose 0.8-1.0 mg/kg; light dose accounted for 200-400 J/cm2. Distant PDT was applied as monotherapy or in combination with electrochemical lysis, radiotherapy or interstitial PDT. 84.6% of patients with Т3N0M0 stage basal cell skin carcinoma had complete regression, 15.4% of patients – partial regression. The treatment for Т4N0M0 stage basal cell skin carcinoma was palliative and in 100% of cases it allows to shrink the tumor (defined as partial tumor regression), retard the progression time, improve quality of life. Interstitial PDT and electrochemical lysis improved the efficacy of distant PDT (increased volume of tumor destruction) and, thus, allowed to decrease treatment period. Combination of PDT with radiotherapy allowed to decrease radiation dose for 20-30% and, thus, to decrease the risk of radiation-induced complications.

Purpose: to design the new combined technique of endoresection with intraoperative intraocular electrochemical lysis at the tumor destruction stage for large posterior intraocular tumors.Methods: 3 patients (3 eyes) with large choroidal melanomas t3N0M0 (tumor thickness — 8-10 mm, base diameter — 13-15 mm, juxtapapillary localization). Mean age was 55.4 years old. Endoresection with intraoperational intraocular electrochemical lysis of the tumor was performed. Electrochemical lysis was performed with use of the technical unit ECU 300 (Soering, Germany) and the original method of combined intratumoral positioning of two platinum electrodes: anode and cathode.Results: the tumor was removal completely in all 3 cases. the anatomical retinal reattachment was reached in all patients. Sclera was safe in all 3 cases. Visual acuity was not changed (NLP). At the place of the removal tumor a surgical choroidal coloboma without pigmentation all over scleral bed and periphery was shown in all cases in distant postoperative period (from 1.5 to 3 years). No local recurrences or metastasis were revealed in all patients.Conclusion: Further investigations in clinical group are necessarily to determinate the real possibilities of the combined method and the indications for endoresection with intraoperative intraocular electrochemical lysis for large intraocular tumors.

In experiment on fresh enucleated eyes with large tumors it was shown that a new method of electrochemical lysis with original combined positioning of electrodes for intraocular tumors treatment provides a minimal traumatic impact and total destruction of tumor tissue at electrodes encirclement. Superficial electrode allows to aim the electrochemical destruction at hole tumor basis. the combination of the both superficial and intratumoral electrodes gives an opportunity to minimize a scleral injury in tumor basis scleral projection. Further examination on alteration of both intratumoral electrode injection depth and quantity of electricity in combinationwith bioimpedancemetry might it possible for regulation of morphological changes in tumor structure.

Electrochemical lysis is investigated to be used in miniinvasive treatment of thyroid nodules. Histological operative preparations of thyroid nodules (n = 20) helped to work out a model of electrochemical lysis optimal regimens. The results of this experiment were verified by usage of experimental animals.

PURPOSE To examine morphologic effects produced by electrochemical ablation on the structures of human uveal melanoma. MATERIALS AND METHODS The Electrochemical lysis (ECL) method was offered to patient K (58-year-old man) suffering from a large choroidal melanoma (T3N0M0) (prominence of 12.8 mm, tumor base diameter of 15 x 18 mm). ECL of the tumor was performed at the amperage of 20 mA within 20 minutes. RESULTS ECL resulted in necrosis of a significant portion of the tumor. A large portion of the tumor showed necrosis and third- and fourth-grade pathomorphism. Necrotic segments of the tumor demonstrated extensive areas of cell debris, destroyed stroma, and blood corpuscles resulted from hemorrhages that had occurred due to vascular damage. The process of the tumor necrosis was accompanied by reactive inflammation characterized by mild lymphocyte infiltration of the choroidal stroma, by infiltration of numerous monocyte- and macrophage-type cells, and also by ectasia and hyperemia of the intrinsic tumor vessels with destruction of vascular walls. CONCLUSION Our study indicates that subtotal necrosis of a large-sized choroidal melanoma can be achieved as a result of a single procedure of ECL. It seems reasonable to continue our study on a larger clinical material, which will help us to determine the real potential of the method described above and to develop a list of clinical indications for ECL in ophthalmology [ABSTRACT FROM AUTHOR]