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Your search keyword '"Zou, Xiangang"' showing total 18 results
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18 results on '"Zou, Xiangang"'

1. LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer

Author

Anstee, Joanne E., Feehan, Karen T., Opzoomer, James W., Dean, Isaac, Muller, Henrike P., Bahri, Meriem, Cheung, Tik Shing, Liakath-Ali, Kifayathullah, Liu, Ziyan, Choy, Desmond, Caron, Jonathan, Sosnowska, Dominika, Beatson, Richard, Muliaditan, Tamara, An, Zhengwen, Gillett, Cheryl E., Lan, Guocheng, Zou, Xiangang, Watt, Fiona M., Ng, Tony, Burchell, Joy M., Kordasti, Shahram, Withers, David R., Lawrence, Toby, and Arnold, James N.

Published
2023
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3. Establishment of porcine and human expanded potential stem cells

Author

Gao, Xuefei, Nowak-Imialek, Monika, Chen, Xi, Chen, Dongsheng, Herrmann, Doris, Ruan, Degong, Chen, Andy Chun Hang, Eckersley-Maslin, Melanie A., Ahmad, Shakil, Lee, Yin Lau, Kobayashi, Toshihiro, Ryan, David, Zhong, Jixing, Zhu, Jiacheng, Wu, Jian, Lan, Guocheng, Petkov, Stoyan, Yang, Jian, Antunes, Liliana, Campos, Lia S., Fu, Beiyuan, Wang, Shengpeng, Yong, Yu, Wang, Xiaomin, Xue, Song-Guo, Ge, Liangpeng, Liu, Zuohua, Huang, Yong, Nie, Tao, Li, Peng, Wu, Donghai, Pei, Duanqing, Zhang, Yi, Lu, Liming, Yang, Fengtang, Kimber, Susan J., Reik, Wolf, Zou, Xiangang, Shang, Zhouchun, Lai, Liangxue, Surani, Azim, Tam, Patrick P. L., Ahmed, Asif, Yeung, William Shu Biu, Teichmann, Sarah A., Niemann, Heiner, and Liu, Pentao

Published
2019
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4. Establishment of mouse expanded potential stem cells

Author

Yang, Jian, Ryan, David J., Wang, Wei, Tsang, Jason Cheuk-Ho, Lan, Guocheng, Masaki, Hideki, Gao, Xuefei, Antunes, Liliana, Yu, Yong, Zhu, Zhexin, Wang, Juexuan, Kolodziejczyk, Aleksandra A., Campos, Lia S., Wang, Cui, Yang, Fengtang, Zhong, Zhen, Fu, Beiyuan, Eckersley-Maslin, Melanie A., Woods, Michael, Tanaka, Yosuke, Chen, Xi, Wilkinson, Adam C., Bussell, James, White, Jacqui, Ramirez-Solis, Ramiro, Reik, Wolf, Göttgens, Berthold, Teichmann, Sarah A., Tam, Patrick P. L., Nakauchi, Hiromitsu, Zou, Xiangang, Lu, Liming, and Liu, Pentao

Subjects
Stem cells -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Jian Yang [1]; David J. Ryan [1]; Wei Wang [1]; Jason Cheuk-Ho Tsang [1]; Guocheng Lan [2]; Hideki Masaki [3]; Xuefei Gao [1]; Liliana Antunes [1]; Yong Yu [1]; [...]

Published
2017
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14. Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.

Author

Espana-Agusti, Judit, Zou, Xiangang, Wong, Kim, Fu, Beiyuan, Yang, Fengtang, Tuveson, David A., Adams, David J., and Matakidou, Athena

Subjects
*EPITHELIAL cells, *KIDNEY physiology, *GENE targeting, *LABORATORY mice, *SPATIOTEMPORAL processes
Abstract

Genetically relevant mouse models need to recapitulate the hallmarks of human disease by permitting spatiotemporal gene targeting. This is especially important for replicating the biology of complex diseases like cancer, where genetic events occur in a sporadic fashion within developed somatic tissues. Though a number of renal tubule targeting mouse lines have been developed their utility for the study of renal disease is limited by lack of inducibility and specificity. In this study we describe the generation and characterisation of two novel mouse lines directing CreERT2 expression to renal tubular epithelia. The Pax8-CreERT2 transgenic line uses the mouse Pax8 promoter to direct expression of CreERT2 to all renal tubular compartments (proximal and distal tubules as well as collecting ducts) whilst the Slc22a6-CreERT2 knock-in line utilises the endogenous mouse Slc22a6 locus to specifically target the epithelium of proximal renal tubules. Both lines show high organ and tissue specificity with no extrarenal activity detected. To establish the utility of these lines for the study of renal cancer biology, Pax8-CreERT2 and Slc22a6-CreERT2 mice were crossed to conditional Vhl knockout mice to induce long-term renal tubule specific Vhl deletion. These models exhibited renal specific activation of the hypoxia inducible factor pathway (a VHL target). Our results establish Pax8-CreERT2 and Slc22a6-CreERT2 mice as valuable tools for the investigation and modelling of complex renal biology and disease. [ABSTRACT FROM AUTHOR]

Published
2016
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15. Silencing of the immunoglobulin heavy chain locus by removal of all eight constant-region genes in a 200-kb region

Author

Ren, Liming, Zou, Xiangang, Smith, Jennifer A., and Brüggemann, Marianne

Subjects
*NUCLEIC acids, *GENETIC regulation, *RODENTS, *IMMUNOGLOBULINS
Abstract

Silencing or removal of individual C (constant)-region genes and/or adjacent control sequences did not generate fully deficient Ig (immunoglobulin)− mice. A reason is that different C genes share many functional tasks and most importantly are individually capable of ensuring lymphocyte differentiation. Nevertheless, incomplete arrests in B-cell development were found, most pronounced at the onset of H-chain expression. Here we show that removal of 200 kb accommodating all C genes, Cμ–Cδ–Cγ3–Cγ1–Cγ2b–Cγ2a–Cε–Cα, stops antibody production. For this two loxP targeting constructs were introduced into the most 5′ C gene and the distal α 3′ enhancer. Cre–loxP-mediated in vivo deletion was accompanied by extensive germ-line mosaicism, which could be separated by breeding. Homozygous C-gene deletion mice did not express Ig H or L chains and flow cytometry revealed a complete block in B-cell development. However, C-gene removal did not affect DNA rearrangement processes following locus activation, as recombination efficacy appears to be similar to what is found in normal mice. [Copyright &y& Elsevier]

Published
2004
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18. Mechanism of sperm-egg recognition during subzonal (perivitalline space) insemination.

Author

Dayuan, Chen, Miao, Du, Zou Xiangang, Song Xiangfen, Sun Qingyuan, Duan Chongwen, Zhuang Dazhong, and Liu Hui

Subjects
SPERM-ovum interactions
Abstract

Discusses the mechanism of sperm-egg recognition during subzonal (perivitelline space) insemination, with reference to a study conducted on the issue. Details on three existing kinds of microinsemination techniques; Methodology used to conduct the study; Results of the study.

Published
1996

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