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To ease the long-term contradiction between the supply and demand of water resources in Hebei Province, the system dynamics method was used to construct a supply-demand model of water resources in Hebei Province. Based on factors in the studied area including economic development level and water resources utilization, five different development scenarios were designed (status quo continuation scenario W1, economic development scenario W2, water conservation scenario W3, pollution control scenario W4, and coordinated development scenario W5). Water demand in Hebei Province from 2022 to 2050 was thus predicted. According to the results, ①the total water demand shows an increasing trend under the five scenarios, with average values of 23.947, 25.851, 21.553, 23.947 and 23.295 billion m3 respectively; ②all five scenarios are in a state of water shortage, with an average shortage degree of 0.243 8, 0.302 6, 0.137 5, 0.146 7 and 0.129 0 respectively; ③ the average value of agricultural water demand, under the five scenarios, accounts for the largest proportion of the average value of total water demand, with 46.57%, 43.14%, 45.72%, 46.57%, and 43.85% respectively. Therefore, agricultural water use efficiency improvement plays an important role in reducing water consumption.

Northern Goshawk Optimization (NGO) is an efficient optimization algorithm, but it has the drawbacks of easily falling into local optima and slow convergence. Aiming at these drawbacks, an improved NGO algorithm named the Multi-Strategy Improved Northern Goshawk Optimization (MSINGO) algorithm was proposed by adding the cubic mapping strategy, a novel weighted stochastic difference mutation strategy, and weighted sine and cosine optimization strategy to the original NGO. To verify the performance of MSINGO, a set of comparative experiments were performed with five highly cited and six recently proposed metaheuristic algorithms on the CEC2017 test functions. Comparative experimental results show that in the vast majority of cases, MSINGO's exploitation ability, exploration ability, local optimal avoidance ability, and scalability are superior to those of competitive algorithms. Finally, six real world engineering problems demonstrated the merits and potential of MSINGO. [ABSTRACT FROM AUTHOR]

The Kangxi Southern Inspection Tours strengthened the Qing Dynasty's control over Jiangnan Buddhism, thereby promoting the standardization and officialization of Jiangnan temples and externalizing imperial power through images and physical space. Taking Jinshan Temple as an example, this study combines spatial analysis of architecture and image analysis used by art historians to examine the transformation between physical and pictorial spaces in Jinshan Temple, revealing the spatial operation of imperial power. The intervention of imperial power sparked the space reconstruction of Jinshan Temple through a process of "merger-occupation-infiltration-adjustment". Thus, the control measures of Kangxi are revealed, including the emphasis on the geographical significance of the temple, space occupation of royal buildings, change in landscape, and the adaptation of monks by adjusting their imagination of the sacred space. By determining the spatial reconstruction, we observe that the spatial strategy of power reflects Kangxi's religious attitude toward Buddhism of "neither promoting nor suppressing, but treating it reasonably" 朕惟置之焉能有無之間, which may enrich our understanding of the influence of Kangxi's Southern Inspection Tours on Jiangnan's religious space. [ABSTRACT FROM AUTHOR]

Covalent organic framework (COF) membranes with tunable ordered channels and free organic groups hold great promise in molecular separations owing to the synergy of physical and chemical microenvironments. Herein, we develop a defect engineering strategy to fabricate COF membranes for efficient CO2 separation. Abundant amino groups are in situ generated on the COF nanosheets arising from the missing‐linker defects during the reactive assembly of amine monomer and mixed aldehyde monomers. The COF nanosheets are assembled to fabricate COF membranes. Amino groups, as the CO2 facilitated transport carriers, along with ordered channels endow COF membrane with high CO2 permeances exceeding 300 GPU and excellent separation selectivity of 80 for CO2/N2, and 54 for CO2/CH4 mixed gas under humidified state. Our defect engineering strategy offers a facile approach to generating free organic functional groups in COF membranes and other organic framework membranes for diverse chemical separations. [ABSTRACT FROM AUTHOR]

The Parkinson's Disease Progressive Neuroimaging Initiative (PDPNI) is a longitudinal observational clinical study. In PDPNI, the clinical and imaging data of patients diagnosed with Parkinsonian syndromes and Idiopathic rapid eye movement sleep behavior disorder (RBD) were longitudinally followed every two years, aiming to identify progression biomarkers of Parkinsonian syndromes through functional imaging modalities including FDG-PET, DAT-PET imaging, ASL MRI, and fMRI, as well as the treatment conditions, clinical symptoms, and clinical assessment results of patients. From February 2012 to March 2019, 224 subjects (including 48 healthy subjects and 176 patients with confirmed PDS) have been enrolled in PDPNI. The detailed clinical information and clinical assessment scores of all subjects were collected by neurologists from Huashan Hospital, Fudan University. All subjects enrolled in PDPNI were scanned with 18F-FDG PET, 11C-CFT PET, and MRI scan sequence. All data were collected in strict accordance with standardized data collection protocols. [ABSTRACT FROM AUTHOR]

Columnar jointed basalts (CJB) are featured by the joint network of discontinuities, which is hard for geotechnical design and construction. Therefore, investigating the mechanical behaviors of CJB is significant for the long-term use of the engineering structures. In this paper, field research studies, such as the rigid bearing plate tests and acoustic tests, were employed, to obtain the deformation modulus and the acoustic velocity of columnar jointed basalts, and the formula expressed by deformation modulus and acoustic velocity was then established, which would be a useful guidance for the site operation. Based on the monitoring and testing data of CJB, several numerical simulation models with different joint angles and weak thickness were built to further discuss the mechanical behaviors of CJB. The numerical simulation results show that the joint angle of 30° ∼ 60° presents weak antipressure abilities, for the shearing slipping force and interformational sliding are remarkable in them. Besides, the small material property difference is helpful for the compressive strength of rock masses. After adopting the most unfavorable joint angle and width to model the tunneling process in CJB, it suggests that it is easily damaged along the directions of rock joints in CJB when constructing in tunnels. [ABSTRACT FROM AUTHOR]

Background: Intracranial artery atherosclerotic stenosis (ICAS) is among the causes of intracranial large artery occlusion (LVO). The optimal treatment strategy for patients with ischemic stroke due to ICAS-related LVO remains unclear. In this retrospective case series, we discussed our experience with direct angioplasty as frontline therapy for ICAS-related LVO. Methods: We extracted data for patients who had a known pre-existing ICAS and undergone direct angioplasty as frontline therapy for ICAS-related LVO in the anterior circulation at our institution between January 2019 and December 2019. We analysed procedural details, the degree of reperfusion, functional outcomes, and complications. Successful reperfusion was defined as a modified Treatment in Cerebral Ischemia (mTICI) score of 2 b − 3. Functional outcomes at 90 days were assessed using modified Rankin Scale (mRS) scores (good outcome: mRS of 0–2). Results: We analysed data for five patients (mean age: 51.6 ± 11 years). The mean time from symptom onset to recanalization was 371 ± 38.6 min. Occlusions involved the first segment of the middle cerebral artery in four patients and the intracranial internal carotid artery in one patient. Successful reperfusion was achieved in four (80%) patients. The remaining patient (20%) underwent intracranial stenting as rescue therapy, achieving a final mTICI of 2a. No re-occlusion was observed on follow-up images. Four patients (80%) achieved good outcomes at 90 days. There were no cases of symptomatic intracranial hemorrhage, although asymptomatic intracranial haemorrhage was observed in one patient. Conclusion: Direct angioplasty may represent an alternative treatment strategy in patients with acute ischemic stroke due to known ICAS-related LVO. [ABSTRACT FROM AUTHOR]

A novel superhydrophobic composite fabric was prepared by polydopamine-induced growth of ZIF-8 nanocrystals (PZIF-8) and subsequent modification with polydimethylsiloxane (PDMS). Compared to traditional medical textiles, Cotton/PZIF-8/PDMS has rapid photothermal antimicrobial properties in the near infrared and sustainable self-cleaning capabilities. [Display omitted] • Superhydrophobic self-cleaning Cotton/PZIF-8/PDMS was successfully synthesized. • The composite fabric has excellent synergistic photothermal conversion performance. • The composite fabric has efficient antimicrobial activity and long-lasting properties. Inspired by mussels, a novel superhydrophobic composite fabric with photothermal antibacterial and self-cleaning properties was prepared by polydopamine induced growth of ZIF-8 nanocrystals (PZIF-8) and subsequent modification with polydimethylsiloxane (PDMS). The composite fabric showed self-cleaning property with a water contact angle (WCA) of 153.1° and excellent photothermal antibacterial activity against E. coli and S. aureus under near-infrared (NIR) light irradiation. Polydopamine acts as an adhesive and photothermal agent (PTA), which can bind ZIF-8 nanocrystals on cotton fabric firmly and kill E. coli and S. aureus synergistically with ZIF-8. The composite fabric can withstand five cycles of laundering and 100 cm of friction without obvious WCA decline. Consequently, the durable multifunctional composite fabric may have great potential in medical protection applications. [ABSTRACT FROM AUTHOR]

Objectives-Elevated protein O-GlcNAcylation could benefit cell survival and promote organ functional recovery. Thiamet-G (O-GlcNAcase inhibitor) could upregulate protein O-GlcNAcylation level to improve dyskinesia in models of neurodegenerative diseases without any obvious detrimental side-effects. Therefore, we conducted this study to investigate the effects of protein O-GlcNAcylation upregulation by Thiamet-G on the spinal cord injury (SCI) in rats. Methods-We randomly assigned 74 rats to three groups: sham-operated group (Sham) with no lesion (n = 22), injured control group (SCI+SS) with saline solution (n = 26), and Thiamet-G treated group (SCI+Thiamet-G) (n = 26). We assessed Locomotor behavior using the Basso, Beattice, and Bresnahan (BBB) scale and evaluated histopathological alterations by morphometry and histochemistry. We also assessed potential inflammatory effects by microglia/macrophages immunohistochemistry, and potential apoptosis effects by caspase-3 western blot. Results-Thiamet-G treatment improved hindlimb motor functional recovery by inducing elevated protein O-GlcNAcylation, and mitigated the severity, reduced the lesion size and promoted the structural recovery of the injured spinal cord. Thiamet-G treatment also inhibited microglia/macrophages infiltration at the injury sites and the caspase-3 mediated apoptosis pathway. Discussion-We conclude that Thiamet-G induced elevated protein O-GlcNAcylation to ameliorate acute SCI, which could provide a potential novel therapeutic approach for SCI treatment. [ABSTRACT FROM AUTHOR]

Ferroptosis contributes to brain injury after germinal matrix hemorrhage (GMH). Mitochondrial ferritin (FTMT), a novel mitochondrial outer membrane protein, reduces oxidative stress in neurodegenerative diseases. In vitro, Deferiprone has been shown to upregulate FTMT. However, the effects of FTMT upregulation by Deferiprone on neuronal ferroptosis after GMH and its underlying mechanism has not been investigated. In our study, 389 Sprague-Dawley rat pups of postnatal day 7 were used to establish a collagenase-induced GMH model and an iron-overload model of intracerebral FeCl2 injection. The brain expressions of FTMT, N-myc downstream-regulated gene-1 (NDGR1), Yes-associated protein (YAP), ferroptosis-related molecules including transferrin receptor (TFR) and acyl-CoA synthase long-chain family member 4 (ACSL4) were increased after GMH. FTMT agonist Deferiprone improved neurological deficits and hydrocephalus after GMH. Deferiprone or Adenovirus-FTMT enhanced YAP phosphorylation at the Ser127 site and attenuated ferroptosis, which was reversed by NDRG1 CRISPR Knockout. Iron overload induced neuronal ferroptosis and neurological deficits, which were improved by YAP CRISPR Knockout. Collectively, FTMT upregulation by Deferiprone reduced neuronal ferroptosis and neurological deficits via the NDRG1/YAP signaling pathway after GMH. Deferiprone may serve as a potential non-invasive treatment for GMH patients. [ABSTRACT FROM AUTHOR]

• Morphology control achieved via Zr:Ce and metal-to-ligand ratio adjustments. • Polydopamine-coated tips enhance protein coupling and minimize reagent use. • MOVE immunosensor achieved economical, rapid, and accurate rapid testing. • Enrofloxacin facilitated with one-step reaction and UV–Vis readout. Ensuring the safety of animal-derived foods requires the reliable and swift identification of enrofloxacin residues to monitor the presence of antibiotics. In this regard, we synthesized, tuned, and investigated the optical properties of a bimetallic metal–organic framework (Ce/Zr-UiO 66). The investigation was facilitated by employing a polydopamine-coated pipette tip with high adsorption efficiency, serving as an immunoreactive carrier. Subsequently, an immunofunctionalized variant of Ce/Zr-UiO 66, referred to as Ce/Zr-UiO 66@ Bovine serum albumin-enrofloxacin, was developed as an optical probe for the rapid and sensitive identification of enrofloxacin across a variety of samples. The method can accurately detect enrofloxacin at concentrations as low as 0.12 ng/mL, with a determination time of under 15 min; furthermore, it demonstrates exceptional efficacy when applied to food, environmental, and clinical samples. The implementation of this methodology offers a valuable means for cost-effective, rapid, and on-site enrofloxacin determination. [ABSTRACT FROM AUTHOR]

Design and fabrication of phosphoric acid (PA)-doped polybenzimidazole (PBI) membranes with high proton conductivity, mechanical property and phosphoric acid retention stability has been a critical challenge. In this study, a sulfonated ionic covalent organic framework (SCOF) was in-situ synthesized in the polybenzimidazole matrix. The high-density sulfonic groups and ordered channel structure of SCOF rendered the as-prepared composite membrane high proton conductivity under low phosphoric acid doping level. Additionally, the introduction of SCOF helped to immobilize the phosphoric acid, thus effectively reducing its loss and improving the acid retention stability. The acid-base interaction formed between the sulfonic acid and imidazole groups act as ionic crosslinkers, which significantly enhanced the mechanical-dimensional stability of composite membranes. As a result, the PA-PBI/SCOF composite membrane exhibited a high proton conductivity up to 542.1 mS cm−1 at 80 °C, 100 % RH and 134.1 mS cm−1 at 30 °C, 50 % RH, as well as a high mechanical strength up to 64.0 MPa (PA uptake: 67.47 %). This in-situ synthesis strategy offers a promising new approach to fabricate covalent organic framework-based composite membranes for various applications. [Display omitted] • A sulfonated covalent organic framework (SCOF) was in-situ synthesized in polybenzimidazole matrix to prepare composite membranes. • The as-prepared composite membrane exhibited high mechanical strength, proton conductivity and phosphoric acid retention stability. • The composite membrane showed comparable performance in electrochemical hydrogen compression and proton exchange membrane fuel cell. [ABSTRACT FROM AUTHOR]

Semiconducting Cu 4 Mn 2 Te 4 , consisting of nontoxic elements only, attracts increasing attentions as a promising thermoelectric material due to its low lattice thermal conductivity. This work focuses on systematic investigation of thermoelectric properties for Cu 4 Mn 2 Te 4 to assess its potential for thermoelectric applications. Hall carrier concentration ranging from 9 × 10 20  cm −3 to 16 × 10 20  cm −3 is obtained by various dopants, which enables a reasonable assessment of electronic transport properties by a single parabolic band model with acoustic scattering. The lowest lattice thermal conductivity of ∼0.4 W/m-K at high temperature is obtained, which presumably results from weak bonding for Cu and large number (20) of atoms in primitive cell. As a result, a peak zT of 0.6 is realized here. On the basis of the model, a peak zT as high as 1.0 is achievable for this compound when the Hall carrier concentration is reduced to 3–4 × 10 20  cm −3 . This work not only demonstrates Cu 4 Mn 2 Te 4 as a potentially high-performance thermoelectric material, but also provides a well understanding of its underlying physical parameters. [ABSTRACT FROM AUTHOR]