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Your search keyword '"Zhou, Jun-Su"' showing total 14 results
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14 results on '"Zhou, Jun-Su"'

10. cis‐Clerodane Diterpenoids with Structural Diversity and Anti‐inflammatory Activity from Tinospora crispa.

Author

You, Jin‐Qiu, Liu, Yi‐Nan, Zhou, Jun‐Su, Sun, Xin‐Yu, Lei, Chun, Mu, Qing, Li, Jing‐Ya, and Hou, Ai‐Jun

Abstract

Comprehensive Summary: Twelve new cis‐clerodane diterpenoids, designated as crispinoids A—L (1—12), together with three known analogues (13—15), were isolated from Tinospora crispa. Their structures were fully assigned by comprehensive spectroscopic techniques, single‐crystal X‐ray diffraction experiments, and electronic circular dichroism (ECD) analyses. The isolated clerodanes displayed diverse heterocyclic frameworks including 6/6/6‐, 6/5/6/6‐, 6/6/5‐, 6/6‐, and 6/5/6‐fused ring systems. Some of the isolates showed ATP‐citrate lyase (ACLY) and nuclear factor kappa B (NF‐κB) pathway inhibition. The NF‐κB inhibitors further suppressed the lipopolysaccharide (LPS)‐induced inflammatory responses in RAW 264.7 cells. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Rearranged Dichapetalin‐Type Triterpenoids with Cytotoxic Activity from Dichapetalum gelonioides.

Author

Gao, Xin‐Hua, Wang, Xi‐Yuan, Zhou, Jun‐Su, Zhang, Yan, Liu, Hong‐Chun, Zhou, Bin, and Yue, Jian‐Min

Subjects
TRITERPENOIDS, CELL lines, CANCER cells
Abstract

Comprehensive Summary: Dichagelinoids A—C (1—3), three unusual dichapetalin‐type triterpenoids, together with two biogenetically related derivatives dichagelinoids D and E (4 and 5) were isolated and characterized by solid data from Dichapetalum gelonioides. Compounds 1—3 possess a common rearranged C ring and different C6—C2 modified motifs at the A rings. Biological evaluation revealed that compounds 1—3 showed distinct cytotoxic activity against the tested human cancer cell lines. [ABSTRACT FROM AUTHOR]

Published
2022
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