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161 results on '"Zhao, Ruifang"'

2. Chloroplast and whole-genome sequencing shed light on the evolutionary history and phenotypic diversification of peanuts

Author

Zheng, Zheng, Sun, Ziqi, Qi, Feiyan, Fang, Yuanjin, Lin, Ke, Pavan, Stefano, Huang, Bingyan, Dong, Wenzhao, Du, Pei, Tian, Mengdi, Shi, Lei, Xu, Jing, Han, Suoyi, Liu, Hua, Qin, Li, Zhang, Zhongxin, Dai, Xiaodong, Miao, Lijuan, Zhao, Ruifang, Wang, Juan, Liao, Yanlin, Li, Alun, Ruan, Jue, Delvento, Chiara, Aiese Cigliano, Riccardo, Maliepaard, Chris, Bai, Yuling, Visser, Richard G. F., and Zhang, Xinyou

Published
2024
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7. A telomere-to-telomere genome assembly of the cultivated peanut

Author

Wang, Xiaobo, Sun, Ziqi, Qi, Feiyan, Zhou, Zhiyuan, Du, Pei, Shi, Lei, Dong, Wenzhao, Huang, Bingyan, Han, Suoyi, Pavan, Stefano, Zhang, Meng, Cui, Mengjie, Xu, Jing, Liu, Hua, Qin, Li, Zhang, Zhongxin, Dai, Xiaodong, Gao, Wei, Miao, Lijuan, Zhao, Ruifang, Wang, Juan, Wang, Mengmeng, Zhi, Chenyang, Hu, Yaojun, Zhao, Huanhuan, Chen, Linjie, Jin, Xiaodong, Sun, Yanhui, Zheng, Zheng, and Zhang, Xinyou

Published
2025
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21. Status and influencing factors of frailty in hospitalized patients with chronic heart failure: A cross‐sectional study.

Author

Tang, Miaoyan, Zhao, Ruifang, and Lv, Qiaoxia

Subjects
*RISK assessment, *CROSS-sectional method, *HEALTH self-care, *PHOBIAS, *MALNUTRITION, *VENTRICULAR ejection fraction, *T-test (Statistics), *RECEIVER operating characteristic curves, *RESEARCH funding, *FRAIL elderly, *HOSPITAL care, *QUESTIONNAIRES, *STATISTICAL sampling, *SCIENTIFIC observation, *HEMOGLOBINS, *MULTIPLE regression analysis, *HEART failure, *AGE distribution, *PEPTIDE hormones, *MANN Whitney U Test, *DESCRIPTIVE statistics, *SURVEYS, *LOW density lipoproteins, *CONVALESCENCE, *ONE-way analysis of variance, *STATISTICS, *BODY movement, *ALBUMINS, *DATA analysis software, *DISEASE risk factors
Abstract

Objectives: To investigate the frailty status of inpatients with chronic heart failure (CHF) and analyse its influencing factors, so as to provide evidence for the early identification of high‐risk groups and frailty management. Background: Early identification of frailty can guide the development and implementation of holistic and individualized treatment plans. However, at present, the frailty of patients with CHF has not attracted enough attention. Design: A cross‐sectional study. Methods: From June 2022 to June 2023, a convenience sample of 256 participants were recruited at a hospital in China. Multivariate logistic regression analysis was used to explore the influencing factors of frailty in patients with CHF, and an ROC curve was drawn to determine the cut‐off values for each influencing factor. STROBE checklist guides the reporting of the manuscript. Results: A total of 270 questionnaires were sent out during the survey, and 256 valid questionnaires were ultimately recovered, resulting in an effective recovery rate of 94.8%. The incidence of frailty in hospitalized patients with CHF was 68.75%. Multivariable logistic regression analysis showed that age, self‐care ability, nutritional risk, Kinesiophobia and NT‐proBNP were risk factors for frailty, while albumin and LVEF were protective factors. Conclusion: Multidimensional frailty was prevalent in hospitalized patients with CHF. Medical staff should take measures as early as possible from the aspects of exercise, nutrition, psychology and disease to delay the occurrence and development of frailty and reduce the occurrence of clinical adverse events caused by frailty. Relevance to Clinical Practice: This study emphasizes the importance of the early identification of multidimensional frailty and measures can be taken to delay the occurrence and development of frailty through exercise, nutrition, psychology and disease treatment. Patient or Public Contribution: Patients contributed through sharing their information required for the case report form and filling out questionnaires. [ABSTRACT FROM AUTHOR]

Published
2025
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28. X‐ray‐ultraviolet–visible‐near‐infrared photoresponses realized in a lead‐free hybrid perovskite ferroelectric through light‐induced ferro‐pyro‐phototronic effect.

Author

Fu, Dongying, Ma, Yanli, Wu, Shufang, Pan, Lin, Wang, Qi, Zhao, Ruifang, Zhang, Xian‐Ming, and Luo, Junhua

Subjects
BAND gaps, FERROELECTRIC crystals, SINGLE crystals, LIGHT absorption, DETECTION limit
Abstract

Due to the built‐in electric field induced by spontaneous polarization in hybrid perovskite (HP) ferroelectrics, the devices based on them exhibit excellent performance in self‐powered photodetection. However, most of the self‐powered photodetector are made of lead‐based HP ferroelectrics and have a relatively narrow photoresponse waveband. Although lead‐free HPs solve the problem of lead toxicity, their optoelectronic performance is inferior to that of lead‐based HPs and photoresponse waveband is limited by its optical band gap, which hinders their further application. To solve this problem, herein, a lead‐free HP ferroelectric (HDA)BiI5 (HDA is hexane‐1,6‐diammonium) with large spontaneous polarization shows an enhanced photocurrent and achieves x‐ray‐ultraviolet–visible‐near‐infrared (x‐ray‐UV–Vis–NIR) photoresponse through the ferro‐pyro‐phototronic (FPP) effect. The ferroelectric, pyroelectric, and photovoltaic characteristics coupled together in a single‐phase (HDA)BiI5 ferroelectric is an effective way to improve the performance of the devices. What is particularly attractive is that the FPP effect not only improves the optoelectronic performance of (HDA)BiI5, but also achieves broadband photoresponses beyond its optical absorption range. Especially, the current boosting with an exceptional contrast of ~1100% and 2400% under 520 and 637 nm, respectively, which is associated with FPP effect. Meanwhile, single crystal self‐powered photodetector based on (HDA)BiI5 also exhibit significant FPP effects even under high‐energy x‐ray, which owns an outstanding sensitivity of 170.7 μC Gy−1 cm−2 and a lower detection limit of 266 nGy s−1 at 0 V bias. Therefore, it is of great significance to study the coupling of multiple physical effects and improve device performance based on lead‐free HP ferroelectrics. [ABSTRACT FROM AUTHOR]

Published
2024
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33. The challenge and opportunity of gut microbiota‐targeted nanomedicine for colorectal cancer therapy.

Author

Wei, Yaohua, Shen, Feng, Song, Huidong, Zhao, Ruifang, Feng, Weiyue, Pan, Yue, Li, Xiaobo, Yu, Huanling, Familiari, Giuseppe, Relucenti, Michela, Aschner, Michael, Shi, Hanping, Chen, Rui, Nie, Guangjun, and Chen, Hanqing

Subjects
MEDICAL sciences, GUT microbiome, FECAL microbiota transplantation, TREATMENT effectiveness, TECHNOLOGICAL innovations, WESTERN diet
Abstract

This article discusses the potential of using nanotechnology to modulate the gut microbiota in colorectal cancer (CRC) therapy. It explains the association between specific microbiomes and CRC initiation and progression, as well as their impact on treatment outcomes. The article explores various strategies for modulating the gut microbiota, such as antibiotics, fecal microbiota transplants, probiotics, prebiotics, and diet modifications. It suggests that nanotechnology can offer targeted approaches for manipulating the gut microbiota in CRC therapy, but further research is needed to develop effective delivery systems for bacteria-targeting medicines. The article also highlights challenges that need to be addressed in the use of nanomedicine for CRC management. Overall, nanomedicine shows promise in modulating the gut microbiota for CRC therapy. [Extracted from the article]

Published
2024
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47. Chondrocyte membrane–coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis.

Author

Deng, Ronghui, Zhao, Ruifang, Zhang, Zining, Chen, Yang, Yang, Meng, Lin, Yixuan, Ye, Jing, Li, Nan, Qin, Hao, Yan, Xin, Shi, Jian, Yuan, Fuzhen, Song, Shitang, Xu, Zijie, Song, Yifan, Fu, Jiangnan, Xu, Bingbing, Nie, Guangjun, and Yu, Jia-Kuo

Subjects
CARTILAGE, CHARCOT joints, ANTERIOR cruciate ligament, KNEE joint, ARTICULAR cartilage, DRUG efficacy, GLYCOLIC acid
Abstract

Osteoarthritis (OA) is a chronic joint disease characterized by progressive degeneration of articular cartilage. A challenge in the development of disease-modifying drugs is effective delivery to chondrocytes. The unique structure of the joint promotes rapid clearance of drugs through synovial fluid, and the dense and avascular cartilage extracellular matrix (ECM) limits drug penetration. Here, we show that poly(lactide-co-glycolic acid) nanoparticles coated in chondrocyte membranes (CM-NPs) were preferentially taken up by rat chondrocytes ex vivo compared with uncoated nanoparticles. Internalization of the CM-NPs was mediated primarily by E-cadherin, clathrin-mediated endocytosis, and micropinocytosis. These CM-NPs adhered to the cartilage ECM in rat knee joints in vivo and penetrated deeply into the cartilage matrix with a residence time of more than 34 days. Simulated synovial fluid clearance studies showed that CM-NPs loaded with a Wnt pathway inhibitor, adavivint (CM-NPs-Ada), delayed the catabolic metabolism of rat and human chondrocytes and cartilage explants under inflammatory conditions. In a surgical model of rat OA, drug-loaded CM-NPs effectively restored gait, attenuated periarticular bone remodeling, and provided chondroprotection against cartilage degeneration. OA progression was also mitigated by CM-NPs-Ada in a canine model of anterior cruciate ligament transection. These results demonstrate the feasibility of using chondrocyte membrane–coated nanoparticles to improve the pharmacokinetics and efficacy of anti-OA drugs. Editor's summary: Osteoarthritis (OA) lacks effective disease-modifying treatments partially because of the difficulty of delivering drugs to dense and avascular cartilage tissue. Here, Deng et al. disguised drug-carrying nanoparticles with chondrocyte membranes to increase the interaction of the nanoparticles with cartilage. These membrane-coated nanoparticles retained critical chondrocyte proteins that supported cell and matrix interactions in explanted rat and human cartilage. These nanoparticles were retained in rat knee in vivo for at least 34 days. In rat and canine models of injury-induced OA, release of a Wnt-pathway inhibitor from these nanoparticles improved cartilage and subchondral bone morphology. These findings support the further development of chondrocyte-mimicking particles for cartilage drug delivery and OA therapy. —Molly Ogle [ABSTRACT FROM AUTHOR]

Published
2024
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