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Ionic conductors are important materials for sensing devices owing to their excellent stretchability, conductivity, and transparency. However, it is extremely challenging to simultaneously achieve high tensile strength, fracture strain, and toughness in a dry ion conductor. In view of this, an acrylic acid (AA) and poly(ethylene glycol) dimethacrylate (PEGMA) based dry ion conductor (ISPSIC) with ultra-high mechanical performance is developed by an efficient one-pot method. By utilizing PEGMA to construct microphase-separated regions within the polymer network of the traditional poly(AA--ChCl) type supramolecular deep eutectic polymer, the ISPSIC can enhance the tensile strength of the dry ion conductor by 252.74% with only 0.43% PEGMA content, with no loss of tensile strain. Benefiting from the advantages of the in situ microphase-separation structure, this dry ion conductor exhibits remarkably high tensile strength (77.77 MPa), tensile strain (505.43%), toughness (232.70 MJ m-3), transparency (>90%), and electrical conductivity (6.7 x 10-5 S m-1). Notably, the relative resistance variations of the ISPSIC are greater than 800% and can be electrohealed up to 98.5% within 0.03 s. This work provides a reliable method for further tuning the microstructure and high performance of ionic conductors during polymerization. [ABSTRACT FROM AUTHOR]

Urban forest parks serve as significant venues for tourists' leisure and recreation. The experiences and perceptions of tourists in these parks considerably influence their attitudes and behaviors. While numerous studies have investigated the functions and values of urban forest parks at a macro level, the mechanisms influencing tourists' perceived values and their environmentally responsible behavior at a micro level remain under explored. This research used structural equation modeling (SEM) to test the association between tourists' perceived values and their environmentally responsible behavior, including the mediating functions of tourists' satisfaction and their subjective well-being. 502 valid questionnaires in total were obtained from Changpoling National Forest Park in Guiyang City, Guizhou, China, for this case study. The results show that there are some variances in the impact of the dimensions of tourists' perceived value on environmentally responsible behavior, in which service quality, resource quality, and emotional value impose a pronounced positive effect on environmentally responsible behavior, tourism costs impose a pronounced negative effect on environmentally responsible behavior, and the activity experience does not exert a pronounced effect on environmentally responsible behavior. Satisfaction and subjective well-being have a mediating function during the process of positive influence of tourists' perceived value on their environmentally responsible behavior and serve as partial mediators, and the significant positive influence of satisfaction on subjective well-being as well as subjective well-being on environmentally responsible behavior are verified. This research can help better explain the mechanism of the effect of tourists' perceived value exerted on environmental responsibility behavior in nature-based tourism destinations, and also has a guiding and reference significance for the sustainable development of urban forest parks. [ABSTRACT FROM AUTHOR]

Anthocyanin is one important nutrition composition in Tartary buckwheat (Fagopyrum tataricum) sprouts, a component missing in its seeds. Although anthocyanin biosynthesis requires light, the mechanism of light-induced anthocyanin accumulation in Tartary buckwheat is unclear. Here, comparative transcriptome analysis of Tartary buckwheat sprouts under light and dark treatments and biochemical approaches were performed to identify the roles of one B-box protein BBX22 and ELONGATED HYPOCOTYL 5 (HY5). The overexpression assay showed that FtHY5 and FtBBX22 could both promote anthocyanin synthesis in red-flower tobacco. Additionally, FtBBX22 associated with FtHY5 to form a complex that activates the transcription of MYB transcription factor genes FtMYB42 and FtDFR, leading to anthocyanin accumulation. These findings revealed the regulation mechanism of light-induced anthocyanin synthesis and provide excellent gene resources for breeding high-quality Tartary buckwheat. [ABSTRACT FROM AUTHOR]

Bilateral diffuse metastatic lung adenocarcinoma (BLDM‐LUAD) is a special imaging pattern of lung adenocarcinoma (LUAD). We retrospectively assessed survival outcomes and co‐mutation characteristics of BLDM‐LUAD patients harboring epidermal growth factor receptor (EGFR) mutations who were treated with EGFR‐yrosine kinase inhibitors (TKIs). From May 2016 to May 2021, among 458 patients who submitted samples for next generation sequencing (NGS) detection in 1125 patients with non‐small‐cell lung cancer (NSCLC), and 44 patients were diagnosed as BLDM‐LUAD. In order to analyze the survival outcomes of BLDM‐LUAD patients harboring EGFR mutations who were treated with EGFR‐TKIs, the factors age, gender, smoking history, hydrothorax, site of EGFR mutations and EGFR‐TKIs treatment were adjusted using propensity score‐matching (PSM). The Kaplan‐Meier survival curves and log‐rank test were used to analyze progression‐free survival (PFS) and overall survival (OS). The co‐mutation characteristics of BLDM‐LUAD patients harboring EGFR mutations were analyzed by NGS panels. 64 patients with advanced lung adenocarcinoma harboring EGFR mutations and first‐line treatment of EGFR‐TKIs were successfully matched. BLDM‐LUAD (n = 32) have significantly longer median PFS than control group (n = 32) (mPFS: 14 vs 6.2 months; p =.002) and insignificantly longer median OS than control group (mOS: 45 vs 25 months; p =.052). The patients with BLDM‐LUAD have the higher frequency of EGFR mutation than control group (84.1% vs 62.0%) before PSM. The co‐mutation genes kirsten rat sarcoma viral oncogene homolog (KRAS) (9.4%), ataxia telangiectasia‐mutated (ATM) (7.4%) and mesenchymal‐epithelial transition (MET) (3.1%) only appeared in the control group after PSM. The BLDM‐LUAD harboring EGFR mutations was associated with a favorable prognosis to EGFR‐TKI. [ABSTRACT FROM AUTHOR]

In this paper, cationic organic montmorillonites (OMts) were prepared by dry, semi-dry, and wet methods. The structures and properties of these OMts according to the modification methods were studied. By the characterization of XRD, TG-DTA, lipophilicity, and thixotropy, the results showed that cationic OMt prepared by wet method with sufficient surfactants had better properties, including contact angle, swelling capacity, thixotropic loop area, and thermal stability compared with cationic OMt prepared by dry and semi-dry methods. Attention should be paid that with low ratio amount of surfactants used, cationic OMt prepared by the semi-dry method had favorable properties compared with cationic OMt prepared by wet method, and it had the potential to be applied in industrial field due to its environment-friendly and modification efficiency characteristics.