Search

Objective To investigate the status quo of self-care self-efficacy among patients with digestive tract cancer, and to explore its influencing factors, in order to provide a basis for making self-management programs for patients with digestive tract cancer. Methods A total of 443 patients with digestive tract tumors admitted to three Grade-A hospitals in Hubei Province from October 2021 to September 2022 were selected as subjects. Convenience sampling method was used to investigate the Chinese version of Strategies Used by People to Promote Health(SUPPH), Social Support Rate Scale(SSRS) and Medical Coping Modes Questionnaire(MCMQ). Results The SUPPH score was (75. 91±15. 64). Gender, place of residence, family per capita monthly income, children, social support and coping style were the main factors affecting the self-management efficacy of patients with digestive tract tumors (P＜0. 05). Conclusion The self-management efficacy of patients with digestive tract tumors is at a medium to low level. Higher level of social support is associated with stronger self-management efficacy of patients. Positive coping style is helpful to improve the self-management efficacy of patients. (目的 了解消化道肿瘤患者自我管理效能感水平现状, 探索其影响因素, 以期为消化道肿瘤患者针对性制定自我管理项目内容提供依据。方法 选取2021年10月—2022年9月湖北省三家三甲医院收治的443例消化道肿瘤患者作为研究对象, 采用便利抽样法, 使用中文版癌症自我管理效能感(SUPPH)、社会支持量表(SSRS)和医学应对方式问卷(MCMQ)进行调查。结果 患者的SUPPH得分为(75. 91±15. 64)分; 性别、居住地、家庭人均月收入、子女情况、社会支持及应对方式是影响消化道肿瘤患者自我管理效能感的主要因素(P

[Display omitted] • DZSM improves cognition by facilitating LTP. • DZSM regulates the NMDA receptor-mediated Ca2+/CaMKII pathway. • Flavonoids and caffeoyl compounds are active components of DZSM. • Scu is promising to treat cognitive deficits. [ABSTRACT FROM AUTHOR]

[Objectives] Volatile Organic Compounds (VOC) should be efficiently controlled in vessel cabins to ensure the crew's health and navigation safety. As an important parameter, research on release rate of VOCs in cabins is required. [Methods] This paper develops a method to investigate this parameter of a ship's cabin based on methods used in other closed indoor environments. A typical vessel cabin is sampled with Tenax TA tubes and analyzed by Automated Thermal Desorption-Gas Chromatography-Mass Spectrometry (ATD-GC/MS). The lumped mode is used and the release rate of Benzene, Toluene, Ethylbenzene and Xylene (BTEX), the typical representatives of VOCs, is obtained both in closed and ventilated conditions. [Results] The results show that the content of xylene and Total Volatile Organic Compounds (TVOC) exceed the indoor environment standards in ventilated conditions. The BTEX release rate is similar in both conditions except for the benzene. [Conclusions] This research builds a method to measure the release rate of VOCs, providing references for pollution character evaluation and ventilation and purification system design.

The ionized field should be controlled in order to insure the environmental friendliness of high voltage direct current (HVDC) transmission lines. Different with traditional HVDC transmission lines, the metal return lines is first employed in Zhangbei ±500kV flexible HVDC lines. In this paper, the characteristics of ionized field with and without metal return lines are calculated on the basis of numerical method with Deutsch’s assumption. The influence factors, i.e. roughness coefficient, distance between metal return line and height of the metal return line, are analysed in detail. The results show that the metal return lines will have a shield effect on the ionized field on the ground. The distribution of ionized field is nearly independent on the height of metal return line. The shielding effect of the metal return line mainly contributes to the projection position of the metal return line. The presented results can give instructions for the design and control of the ionized field level of flexible HVDC lines with metal return lines.

Mitochondrial bioenergetic deficits and their resulting glucose hypometabolism are the key pathophysiological modulators that promote neurodegeneration. However, there are no specific potential molecules that have been identified to treat neurological diseases by regulating energy metabolism and repairing mitochondrial damage. Pyruvate dehydrogenase (PDH) complex (PDC), which can be phosphorylated by pyruvate dehydrogenase kinase (PDK), is the gate‐keeping enzyme for mitochondrial glucose oxidation. In this study, a small‐molecule scutellarin (SG) is discovered that can significantly alleviate the neuropathological changes in hippocampal CA1 of cerebral hypoperfusion model rats, rescued the morphological changes of abnormal mitochondria, and restored mitochondrial homeostasis. Mitochondrial proteomics, energy metabolism monitoring, and 13C‐metabolic flux analysis targeted SG activity on PDK2, thus regulating PDK‐PDC‐mediated glycolytic metabolism to TCA cycle during mitochondrial OXPHOS damage. The knockdown of PDK2 in the SK‐N‐SH cells validated that SG could rescue mitochondrial damage via the PDK‐PDC axis, promote the MMP level and reduce the mitochondria‐dependent apoptosis. Collectively, this study explored the novel therapeutic approach: the PDK‐PDC axis for neurological injury and cognitive impairment and uncovered the effect of SG on mitochondrial protection via the PDK‐PDC axis and mitochondrial glucose oxidation. The findings indicate that active components ameliorating mitochondrial bioenergetic deficits could be of significant value for neurological disease therapy. [ABSTRACT FROM AUTHOR]

Dried blood spot (DBS) sampling is a promising method for microliter blood sample collection with the advantages of convenient transportation, storage and clinical operations. However, it is challenging to develop an analytical protocol to determine endogenous metabolites, such as bile acids (BAs) in DBSs, due to the low-blood-volume character of DBSs and the complex features of filter paper. Herein, we developed a method of fast ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) to profile and quantify BAs in DBSs. The pretreatment methods were optimized and a two-step solvent addition method, where a small amount of water was firstly added to moisten the DBS and then methanol was added, showed high extraction efficiency for multiple BAs in DBSs. The UHPLC-MS/MS conditions were optimized and 35BAs in different types could be profiled with good resolution and quantified with acceptable precision and accuracy. Preparation of a DBS surrogate matrix without endogenous BAs has been well developed using rat erythrocytes in BSA solution and showed good performance on both the signal suppression/enhancement percentage and parallelism assessment evaluation of three different stable-isotope-labeled (SIL) BAs. The established protocol was successfully applied to profile BAs in DBSs of intrahepatic cholestasis model and healthy control rats with good repeatability. To our knowledge, it is the first time that 35 BAs in DBSs could be well profiled and an appropriate DBS surrogate matrix has been developed. This protocol presents future-oriented applications of DBSs for relevant preclinical studies to profile BAs and probe biomarkers. [ABSTRACT FROM AUTHOR]