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"The mechanism of polyamide (PA)toughened by brominated polyisobutylene-p-methyl styrene (BIMS), mechanism and influencing factors of PA/BIMS dynamic vulcanization and dispersion, formula and composite technology of PA/BIMS dynamic vulcanized alloy (DVA) as well as preparation technology of PA/BIMS DVA were summarized, and the application of PA/BIMS DVA in tire airtight layer was reviewed with 29 references. The application prospect of PA/BIMS DVA was predicted. "

The typical curing system and vulca-nization reaction mechanism of brominated isobutylene-p-methylstyrene rubber (BIMS) were systematically summarized in this paper, and application formulation technology and application performance of BIMS in the field of tread, side wall and innerliner of tire, tire curing bladder and medical plug were introduced in detail with 26 references. The properties of BIMS were compared with those of ordinary butyl rubber and halogenated butyl rubber. Finally, the future development direction of BIMS was prospected.

Cannabidiol (CBD) is a terpenoid naturally found in plants. The purified compound is used in the treatment of mental disorders because of its antidepressive, anxiolytic, and antiepileptic effects. CBD can affect the regulation of several pathophysiologic processes, including autophagy, cytokine secretion, apoptosis, and innate and adaptive immune responses. However, several authors have reported contradictory findings concerning the magnitude and direction of CBD-mediated effects. For example, CBD treatment can increase, decrease, or have no significant effect on autophagy and apoptosis. These variable results can be attributed to the differences in the biological models, cell types, and CBD concentration used in these studies. This review focuses on the mechanism of regulation of autophagy and apoptosis in inflammatory response and cancer by CBD. Further, we broadly elaborated on the prospects of using CBD as an anti-inflammatory agent and in cancer therapy in the future.

Biodegradable stents have advantages for the treatment of benign and malignant biliary stricture, especially eliminating the need for stent removal. In our present work, helical poly-l-lactic acids (PLLA) stent was fabricated and evaluated in vivo and in vitro. For in vivo study, bile duct injury canine models were made by transection of common bile ducts. Duct to duct anastomosis was done with helical PLLA biodegradable stents. Scanning electron microscopy (SEM) and histopathology were performed after three months. For In vitro study, sludge attachment assessment was performed. Polyethylene (PE) and PLLA membranes were immersed in human bile for two months. The samples were taken out and characterized by SEM. Self-expanding property of the helical stent was tested in 37°C water. The results demonstrate that the biodegradable stent had not only good biocompatibility, but also self-clearing effect to clear the attached sludge away. The self-expanding property facilitated stent implantation and also suggested possibility to be implanted endoscopically. [ABSTRACT FROM AUTHOR]