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2. In vitro and in vivo biological evaluation of newly synthesized multi-target 20(R)-panaxadiol derivatives for treating Alzheimer's disease

Author

Lei Pang, Jin Li, Zheng Liu, Yin-Sheng Quan, He Huan Sui, Yi Jia, Fener Chen, Jung Joon Lee, Peng Liu, Zhe-Shan Quan, Qing-Kun Shen, and Hong-Yan Guo

Subjects
Pharmacology, Mice, Amyloid beta-Peptides, Neuroprotective Agents, Alzheimer Disease, Drug Design, Organic Chemistry, Drug Discovery, Acetylcholinesterase, Animals, Donepezil, General Medicine, Cholinesterase Inhibitors
Abstract

An extensive study was performed to discover a series of novel 20(R)-panaxadiol derivatives with various substituents at the 3-OH position as nontoxic, brain-permeable, multi-target leads for treating Alzheimer's disease. In vitro analysis revealed that a compound bearing benzyl-substituted carbamate, which we denoted compound 14a, exhibited the most potent neuroprotective activity, with an EC

Published
2022

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