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Bulent YaziciDepartment of Ophthalmology, Uludag University, Bursa, TurkeyThe article entitled "Comparison of the effect of W-shaped and linear skin incisions on scar visibility in bilateral external dacryocystorhinostomy" by Ekinci et al1 was published in Clinical Ophthalmology; I reviewed this paper for another journal (Journal of Ophthalmology) several months ago before it appeared in your journal.It seems that the authors submitted their rejected paper to your journal, after making some unethical, methodological changes. View the original paper by Ekinci et al

OBJECTIVE: The incidence of contrast-induced nephropathy (CIN) is higher than 20% in patients with chronic kidney disease. In this study, we sought to define the predictors of CIN and develop a risk prediction tool in patients with chronic kidney disease. PATIENTS AND METHODS: Patients aged 18 years and older who underwent invasive coronary angiography with an iodine-based contrast media between March 2014 and June 2017 were retrospectively analyzed. Independent predictors for CIN development were identified and a new risk prediction tool was created that included these predictors. RESULTS: In total, 283 patients included in the study were divided into those who developed CIN (n=39, 13.8%) and those who did not (n=244, 86.2%). Male gender (OR: 4.874, 95% CI: 2.044-11.621), LVEF (OR: 0.965, 95% CI: 0.936-0.995), diabetes mellitus (OR: 1.711, 95% CI: 1.094-2.677), and e-GFR (OR: 0.880, 95% CI: 0.845-0.917), were identified as independent predictors for the development of CIN in the multivariate analysis. A new scoring system has been designed that can score a minimum of 0 and a maximum of 8 points. Patients with a new scoring system score of ≥4 were at approximately 40 times higher risk of developing CIN than others (OR: 39.9, 95% CI: 5.4-295.3). The area under the curve value of CIN's new scoring system was 0.873 (95% CI, 0.821-0.925). CONCLUSIONS: We found that four easily accessible and routinely collected variables, including sex, diabetes status, e-GFR, and LVEF, were independently associated with the development of CIN. We believe that using this risk prediction tool in routine clinical practice may guide physicians to use preventive medications and techniques in high-risk patients for CIN. [ABSTRACT FROM AUTHOR]

Aim: To evaluate whether an achromatic interferometer, the Lotmar visometer, is useful in predicting postoperative visual outcome in patients with primary rhegmatogenous retinal detachment (RD) involving the macula. Methods: This [...]

Nuestro propósito es establecer el valor pronóstico de los parámetros metabólicos del tumor primario en pacientes diagnosticadas de carcinoma vulvar de células escamosas (VSCC) en las que se realizó un 18F-FDG PET/TC pretratamiento. Estudio retrospectivo que incluyó 47 pacientes con un diagnóstico histopatológico confirmado de VSCC en las que se realizó un 18F-FDG PET/TC antes del tratamiento. Se registraron la fase de la enfermedad, la edad de diagnóstico y el valor estandarizado de captación máximo (SUVmax), los valore de SUVmean, del volumen de tumor metabólico (MTV) y de la glucólisis total de la lesión (TLG) del tumor primario, según una PET basal. Se evaluó la relación entre estos factores, la supervivencia libre de progresión (PFS) y la supervivencia global (OS). La edad media de las 47 pacientes del estudio era de 69,6 ± 1,9 años. Entre las pacientes, 18 estaban en la fase inicial de la enfermedad y 29 estaban en fase avanzada. La edad y los valores de SUVmax, SUVmean, MTV y TLG estaban asociados de forma estadísticamente significativa con la OS y PFS. Además, se observó que OS y PFS era significativamente mayor en las pacientes en fases iniciales que en las pacientes en fase avanzada; en pacientes con un tamaño del tumor < 4 cm que en aquellas con un tamaño del tumor de ≥ 4 cm y en pacientes con metástasis de ganglios linfáticos negativa respecto a aquellas con metástasis ganglionar positiva. Nuestros resultados sugieren que los parámetros de la PET son factores pronósticos del VSCC. Hasta donde sabemos, este estudio es el primero en investigar el valor pronóstico de los parámetros PET de los tumores primarios en pacientes con VSCC, y por esta razón, creemos que contribuye a la literatura especializada. We aim to establish the prognostic value of metabolic parameters of the primary tumor in patients diagnosed with vulvar squamous cell carcinoma (VSCC) who underwent a pretreatment 18F FDG PET/CT scan. This retrospective study included 47 patients with a histopathologically confirmed diagnosis of VSCC, and who underwent a 18F FDG PET/CT scan prior to treatment. The disease stage and age at diagnosis, the maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values of the primary tumor, based on a baseline PET scan, were recorded. The relationship between these factors, and progression-free survival (PFS) and overall survival (OS) was evaluated. The mean age of the 47 study patients was 69.6 ± 1.9 years. Among the patients, 18 were in early stage of the disease and 29 were in the advanced stage. The age, and SUVmax, SUVmean, MTV and TLG values were statistically significantly associated with OS and PFS. Furthermore, it was noted that OS and PFS were significantly longer in the early stage patients than in the advanced stage patients, in patients with a tumor size < 4 cm than those with a tumor size ≥ 4 cm, and in patients with a negative lymph node metastasis than those with a positive lymph node metastasis. Our findings suggest that PET parameters are prognostic factors for VSCC. To the best of our knowledge, this study is the first to investigate the prognostic value of the PET parameters of primary tumors in patients with VSCC, and as such, we believe it contributes to literature. [ABSTRACT FROM AUTHOR]

El presente estudio evalúa el valor pronóstico de los parámetros metabólicos relacionados con el tumor primario en el 18F-FDG PET/TC pretratamiento en pacientes con adenocarcinoma pulmonar en fase avanzada. Este estudio retrospectivo incluyó 258 pacientes con adenocarcinoma pulmonar en fase avanzada a los que se les realizó un escáner PET/TC del pretratamiento y para quienes estaba disponible el receptor del factor de crecimiento epidérmico (EGFR)/cinasa de linfoma anaplásico (ALK). Se registraron el valor máximo de captación estándar (SUVmáx), SUVmean, el volumen tumoral metabólico (MTV) y la glucólisis total de la lesión (TLG) relacionados con el tumor primario en la PET basal y diversos factores clínicos. Se evaluó la relación entre estos factores y la supervivencia global (OS) y la supervivencia libre de progresión (PFS). El estudio incluyó a 258 pacientes con adenocarcinoma pulmonar en fases IIIB-IV (72 mujeres, 186 hombres, de edad media 60,4 ± 10,4 años), 210 de los cuales murieron y 243 progresaron en el momento del análisis. La OS y PFS media de los pacientes fue de 16 ± 1,9 y 5 ± 0,5 meses respectivamente. El presente estudio no reveló una relación significativa entre la OS o PFS y el sexo, el estatus de fumador, la presencia de metástasis a distancia, la edad y el tamaño del tumor. No hubo una diferencia significativa en la OS y PFS de los pacientes que dieron resultados negativos en mutaciones EGFR/reorganizaciones ALK y los que dieron resultados positivos para ambos o para las mutaciones EGFR o las reorganizaciones ALK. La OS fue significativamente más larga en pacientes con MTV bajo (p = 0,011) y en aquellos con TLG bajo (p = 0,012) que en los que los tenían altos. No obstante, no se encontró una relación significativa entre los valores SUVmáx y SUVmean y la OS, ni entre todos los parámetros del PET y la PFS. Los MTV y TLG que reflejen la carga tumoral metabólica pueden predecir la OS en pacientes con adenocarcinoma pulmonar avanzado. The present study evaluates the prognostic value of metabolic parameters related to the primary tumor on pretreatment 18F FDG PET/CT in patients with advanced stage lung adenocarcinoma. This retrospective study included 258 patients with advanced stage lung adenocarcinoma who underwent pretreatment PET/CT scan, and for whom epidermal growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) status was available. The maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) related to the primary tumor at the baseline PET and various clinical factors were recorded. The relation between these factors and overall survival (OS) and progression-free survival (PFS) was evaluated. The study included 258 patients with stage IIIB-IV lung adenocarcinoma (72 female, 186 male, mean age 60.4 ± 10.4 years), 210 of which died and 243 of which progressed at the time of analysis. The median OS and PFS of the patients were 16 ± 1.9 and 5 ± 0.5 months, respectively. The present study revealed no significant relation between OS or PFS and gender, smoking status, presence of distant metastasis, age and tumor size. There was no significant difference in the OS and PFS of patients testing negative for EGFR mutations/ALK rearrangements and those testing positive for both or either of the EGFR mutations and ALK rearrangements. OS was significantly longer in patients with low MTV(p = 0.011) and those with low TLG(p = 0.012) than high ones. However, no significant relation was found between SUVmax and SUVmean values and OS, and between all PET parameters and PFS. MTV and TLG reflecting the metabolic tumor burden can predict OS in patients with advanced lung adenocarcinoma. [ABSTRACT FROM AUTHOR]