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The article describes the potent microbidical activities of S-nitrosogluthione and S-nitroso-N-acetylcysteine against trophozoites of Acanthamoeba castellanii. It notes the important role played by nitric oxide (NO) in a myriad of physiological systems. It also cites that S-nitrosothiols (RSNOs) are NO donor molecules that could be involved in NO-dependent biological signalling processes. A high and time-dependent amoebicidal action was shown by GNSO at the 500µM concentration, with a killing rate of 86%-99% after 3 to four hours (h).