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A temperature sensor based on photonic crystal fiber filled with liquid and silver nanowires using surface plasmon resonance is demonstrated both theoretically and experimentally in this paper. Numerical simulation shows that a blue shift is obtained when temperature increases, and the resonance wavelength and resonance intensity can be tuned effectively by adjusting the volume ratios of the liquid constituents. A large temperature range from 25°C to 60°C at different ratios is detected to investigate the sensor's performance, and the sensitivity -2.08 nm/°C with the figure of merit of 0.1572 is obtained by experiment. Moreover, with the all-fiber device with strong mechanical stability, it is easy to realize remote sensing by changing the downlead fiber length, which is promising for developing a high-sensitive, real-time, and distributed temperature sensor.

C(sub 60) and C(sub70) molecules are studied in detail. A comparison study indicates that these molecules adsorbed on gold nanoparticles by one of their pentagonal faces gives experimental proof of molecule adsorption on metal surfaces.

The article explains the genetic and physiological characterization of the OsCem mutant in rice, which is used to change the embryo axis pattern to produce multiple plumules and radicles. The three different phenotypes of the mutant are also discussed.

BACKGROUND AND AIM: S100A4 is a well established marker and mediator of metastatic disease, but the exact mechanisms responsible for the metastasis promoting effects are less well defined. We tested a hypothesis that the S100A4 gene plays a role in the proliferation and invasiveness of human renal cancer cells (RCC) and may be associated with its metastatic spread. MATERIALS AND METHODS: The small interference RNA vector pcDNA3.1-S100A4 siRNA was transfected in to the human renal cancer cell lines ACHN, Ketr-3, OS-RC-2, CaKi-2 and HTB-47, then treated with ABT-737 or BB94. Cell apoptosis and cell viability was detected by flow cytometry and MTT assay. Matrigel was used for cell motility and invasion assay. MMP-2, bcl-2 and S100A4 was detected by RT-PCR and western blot assay. NF-ΚB subunit p65 activity was detected by confocal microscopy assay. We then determine the effect S100A4 sliencing on tumor growth, lung metastasis development in vivo. Immunohistochemistry was used to detected the expression of S100A4, bcl-2, MMP-2, p65 and CD31. RESULTS: S100A4 silencing in ACHN cells by RNA interference significantly inhibited NF-ΚB and NF-ΚB-mediated MMP-2 and bcl-2 activation and cellular migration, proliferation, and promoted apoptosis. Furthermore, re-expression of S100A4 in S100A4-siRNA-transfected ACHN cells by transient S100A4 cDNA transfection restored the NF-ΚB and NF-ΚB-mediated MMP-2 and bcl-2 activation and their high migratory and cellular proliferative ability. An inhibitor ABT-737 (the Bcl-2 antagonist targets Bcl-2) against Bcl-2 suppressed cellular proliferation and promoted apoptosis induced by S100A4 re-expression in S100A4-siRNA-transfected ACHN cells. A inhibitor BB94 against MMPs to neutralize MMP-2 protein suppressed cellular invasion and migration induced by S100A4 re-expression in S100A4-siRNA-transfected ACHN cells. In the prevention model, S100A4 silencing inhibited primary tumor growth by (tumor weight) (76 ± 8%) and (tumor volum) (78 ± 4%) respectively and promoted apoptosis and the formation of lung metastases was inhibited by 89% (p < 0.01). Microvascular density was reduced by 70% (p < 0.01). In addition, S100A4 sliencing inhibited the expression of S100A4 in vivo, followed by the NF-ΚB, MMP-2 and bcl-2 suppression. CONCLUSIONS: We conclude that S100A4 plays a crucial role in proliferation and migratory/invasive processes in human RCC by a mechanism involving activation of NF-ΚB-bcl-2 and NF-ΚB-MMP-2 pathway. [ABSTRACT FROM AUTHOR]