1. Maternal health and pregnancy outcomes in autosomal dominant tubulointerstitial kidney disease.
- Author
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Bleyer, Anthony J, Kidd, Kendrah O, Williams, Adrienne H, Johnson, Emily, Robins, Victoria, Martin, Lauren, Taylor, Abbigail, Kim, Alice, Bowline, Isai, Connaughton, Dervla M, Langefeld, Carl D, Zivna, Martina, and Kmoch, Stanislav
- Subjects
COMPETENCY assessment (Law) ,POLYCYSTIC kidney disease ,HYPERTENSION ,CHRONIC kidney failure ,INTERSTITIAL nephritis ,CROSS-sectional method ,HOSPITAL care of newborn infants ,PREGNANCY outcomes ,COMPARATIVE studies ,PREGNANCY complications ,RESEARCH funding ,CESAREAN section ,DISEASE complications ,PREGNANCY - Abstract
Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of chronic kidney disease. ADTKD pregnancy outcomes have not previously been described. Methods: A cross-sectional survey was sent to women from ADTKD families. Results: Information was obtained from 85 afffected women (164 term pregnancies) and 23 controls (50 pregnancies). Only 16.5% of genetically affected women knew they had ADTKD during pregnancy. Eighteen percent of ADTKD mothers had hypertension during pregnancy versus 12% in controls (p = 0.54) and >40% in comparative studies of chronic kidney disease in pregnancy. Eleven percent of births of ADTKD mothers were <37 weeks versus 0 in controls (p < 0.0001). Cesarean section occurred in 19% of pregnancies in affected women versus 38% of unaffected individuals (p = 0.06). Only 12% of babies required a neonatal intensive care unit stay. Conclusions: ADTKD pregnancies had lower rates of hypertension during pregnancy versus other forms of chronic kidney disease, which may have contributed to good maternal and fetal outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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