Search

Your search keyword '"Whitehead, William E."' showing total 571 results
Start Over Author "Whitehead, William E." Search Limiters Peer Reviewed
571 results on '"Whitehead, William E."'

3. Proton Therapy Mediates Dose Reductions to Brain Structures Associated With Cognition in Children With Medulloblastoma

Author

Sienna, Julianna, Kahalley, Lisa S., Mabbott, Donald, Grosshans, David, Santiago, Anna Theresa, Paulino, Arnold dela Cruz, Merchant, Thomas E., Manzar, Gohar S., Dama, Hitesh, Hodgson, David C., Chintagumpala, Murali, Okcu, Mehmet Fatih, Whitehead, William E., Laperriere, Normand, Ramaswamy, Vijay, Bartels, Ute, Tabori, Uri, Bennett, Julie M., Das, Anirban, Craig, Tim, and Tsang, Derek S.

Published
2024
Full Text
View/download PDF

7. Greater Overlap of Rome IV Disorders of Gut-Brain Interactions Leads to Increased Disease Severity and Poorer Quality of Life

Author

Sperber, Ami D., Freud, Tamar, Aziz, Imran, Palsson, Olafur S., Drossman, Douglas A., Dumitrascu, Dan L., Fang, Xuicai, Fukudo, Shin, Ghoshal, Uday C., Kellow, John, Khatun, Rutaba, Okeke, Edith, Quigley, Eamonn M.M., Schmulson, Max, Simren, Magnus, Tack, Jan, Whitehead, William E., Whorwell, Peter, and Bangdiwala, Shrikant I.

Published
2022
Full Text
View/download PDF

9. Controlling faecal incontinence in women by performing anal exercises with biofeedback or loperamide: a randomised clinical trial

Author

Jelovsek, John Eric, Barber, Mathew D., Paraiso, Marie Fidela R., Walters, Mark D., Ridgeway, Beri, Gurland, Brooke, Zutshi, Massarat, Krishnan, Geetha, Pung, Ly, Graham, Annette, Sung, Vivian W., Myers, Deborah L., Rardin, Charles R., Carberry, Cassandra, Hampton, B. Star, Wohlrab, Kyle, Meers, Ann S., Visco, Anthony, Amundsen, Cindy, Weidner, Alison, Siddiqui, Nazema, Kawasaki, Amie, McLean, Shantae, Longoria, Nicole, Carrington, Jessica, Mehta, Niti, Harm-Ernandes, Ingrid, Maddocks, Jennifer, Pannullo, Amy, Markland, Alayne, Richter, Holly E., Varner, R. Edward, Holley, Robert, Lloyd, L. Keith, Wilson, Tracy S., Ballard, Alicia, McCormick, Jeannine, Willis, Velria, Saxon, Nancy, Carter, Kathy, Meikle, Susan, Nager, Charles, Albo, Michael, Lukacz, Emily, Furey, Cindy, Riley, Patricia, Columbo, JoAnn, Johnson, Sherella, Menefee, Shawn, Luber, Karl, Dyer, Keisha, Diwadkar, Gouri, Tan-Kim, Jasmine, Rogers, Rebecca G., Komesu, Yuko, Dunivan, Gena, Jeppson, Peter, Cichowski, Sara, Miller, Christy, Yane, Erin, Middendorf, Julia, Nava, Risela, Gantz, Marie G., Wallace, Dennis, Shaffer, Amanda, Pande, Poonam, Roney, Kelly, Carper, Benjamin, Whitworth, Ryan E., Warren, Lauren Klein, Wilson, Kevin A., Hair, Brenda, Glass, Kendra, Matthews, Daryl, Pickett, James W., Tang, Yan, Terry, Tamara L., Tatum, Lynda, Bibb, Barbara, Thornberry, Jutta, Zaterka-Baxter, Kristin, Morris, Lindsay, Arya, Lily, Smith, Ariana, Harve, Heidi, Andy, Uduak Umoh, Levin, Pamela, Newman, Diane K., Wang, Mary, Thompson, Donna, Carney, Teresa, Kingslee, Michelle, Flick, Lorraine, Zyczynski, Halina M., Moalli, Pam, Sutkin, Gary, Shepherd, Jonathan, Bonidie, Michael, Abo, Steven, Harrison, Janet, Chermansky, Christopher, Geraci, Lori, Gruss, Judy, Mislanovich, Karen, Eline, Ellen, Klump, Beth, George, Susan E., Whitehead, William E., Dickersin, Kay, Jiang, Luohua, Lavender, Missy, O'Dell, Kate, Ryan, Kate, Tulikangas, Paul, Kong, Lan, McClish, Donna, Rickey, Leslie, Shade, David, Tuteja, Ashok, Yount, Susan, Jelovsek, J Eric, Markland, Alayne D, Whitehead, William E, Barber, Matthew D, Newman, Diane K, Rogers, Rebecca G, Visco, Anthony G, Zyczynski, Halina M, Meikle, Susan F, Sung, Vivian W, and Gantz, Marie G

Published
2019
Full Text
View/download PDF

10. Maternal serum alpha-fetoprotein level and the relationship to ventriculomegaly in fetal neural tube defect: A retrospective cohort study

Author

Corroenne, Romain, Zhu, Katherine, Orman, Gunes, Huisman, Thierry A.G.M., Mehollin-Ray, Amy R., Johnson, Emily, Johnson, Rebecca M., Andrucioli, Aline, Espinoza, Jimmy, Nassr, Ahmed A., Belfort, Michael, Donepudi, Roopali, Shamshirsaz, Alireza A., Aagaard, Kjersti, Whitehead, William E., and Sanz Cortes, Magdalena

Published
2021
Full Text
View/download PDF

13. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study

Author

Sperber, Ami D., Bangdiwala, Shrikant I., Drossman, Douglas A., Ghoshal, Uday C., Simren, Magnus, Tack, Jan, Whitehead, William E., Dumitrascu, Dan L., Fang, Xuicai, Fukudo, Shin, Kellow, John, Okeke, Edith, Quigley, Eamonn M.M., Schmulson, Max, Whorwell, Peter, Archampong, Timothy, Adibi, Payman, Andresen, Viola, Benninga, Marc A., Bonaz, Bruno, Bor, Serhat, Fernandez, Luis Bustos, Choi, Suck Chei, Corazziari, Enrico S., Francisconi, Carlos, Hani, Albis, Lazebnik, Leonid, Lee, Yeong Yeh, Mulak, Agata, Rahman, M. Masudur, Santos, Javier, Setshedi, Mashiko, Syam, Ari Fahrial, Vanner, Stephen, Wong, Reuben K., Lopez-Colombo, Aurelio, Costa, Valeria, Dickman, Ram, Kanazawa, Motoyori, Keshteli, Ammar Hassanzadeh, Khatun, Rutaba, Maleki, Iradj, Poitras, Pierre, Pratap, Nitesh, Stefanyuk, Oksana, Thomson, Sandie, Zeevenhooven, Judith, and Palsson, Olafur S.

Published
2021
Full Text
View/download PDF

15. A re-evaluation of the Endoscopic Third Ventriculostomy Success Score: a Hydrocephalus Clinical Research Network study.

Author

Verhey, Leonard H., Kulkarni, Abhaya V., Reeder, Ron W., Riva-Cambrin, Jay, Jensen, Hailey, Pollack, Ian F., Rocque, Brandon G., Tamber, Mandeep S., McDonald, Patrick J., Krieger, Mark D., Pindrik, Jonathan A., Hauptman, Jason S., Browd, Samuel R., Whitehead, William E., Jackson, Eric M., Wellons III, John C., Hankinson, Todd C., Chu, Jason, Limbrick Jr., David D., and Strahle, Jennifer M.

Published
2024
Full Text
View/download PDF

22. Prenatal diagnosis and postnatal outcome of closed spinal dysraphism.

Author

Bedei, Ivonne, Krispin, Eyal, Sanz Cortes, Magdalena, Lombaard, Hennie, Zemet, Roni, Whitehead, William E., Belfort, Michael A., and Huisman, Thierry A. G. M.

Abstract

Objective: To evaluate the prenatal diagnosis of closed dysraphism (CD) and its correlation with postnatal findings and neonatal adverse outcomes. Methods: A retrospective cohort study including pregnancies diagsnosed with fetal CD by prenatal ultrasound (US) and magnetic resonance imaging (MRI) at a single tertiary center between September 2011 and July 2021. Results: CD was diagnosed prenatally and confirmed postnatally in 12 fetuses. The mean gestational age of prenatal imaging was 24.2 weeks, in 17% the head circumference was ≤fifth percentile and in 25% the cerebellar diameter was ≤fifth percentile. US findings included banana sign in 17%, and lemon sign in 33%. On MRI, posterior fossa anomalies were seen in 33% of cases, with hindbrain herniation below the foramen magnum in two cases. Mean clivus‐supraocciput angle (CSA) was 74°. Additional anomalies outside the CNS were observed in 50%. Abnormal foot position was demonstrated prenatally in 17%. Neurogenic bladder was present in 90% of patients after birth. Conclusion: Arnold Chiari II malformation and impaired motor function can be present on prenatal imaging of fetuses with CD and may be associated with a specific type of CD. Prenatal distinction of CD can be challenging. Associated extra CNS anomalies are frequent and the rate of neurogenic urinary tract dysfunction is high. Key points: What is already known about this topic? Closed dysraphism poses a challenge in prenatal diagnosis.There is limited data on the prenatal findings and postnatal outcome. What does this study add? Cranial findings associated with Arnold Chiari II (AC II) malformation and impairment of motor function can be present on prenatal imaging of fetuses with closed spinal dysraphism and may depend on the specific type of closed dysraphism. MRI adds important information.Ventriculoperitoneal Shunt rate is very low and abnormal corpus callosum seems not to be a typical finding. Anomalies of the urogenital and skeletal systems are frequently associated. Neurogenic bladder is a common finding. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

23. The aging gut: Symptoms compatible with disorders of gut‐brain interaction (DGBI) in older adults in the general population.

Author

Busby‐Whitehead, Jan, Whitehead, William E., Sperber, Ami D., Palsson, Olafur S., and Simrén, Magnus

Subjects
*BRAIN, *GASTROINTESTINAL system, *BRAIN diseases, *ANUS, *PAIN, *DIARRHEA, *AGE distribution, *OPERATIVE surgery, *IRRITABLE colon, *CONSTIPATION, *GASTROINTESTINAL diseases, *SEVERITY of illness index, *MEDICAL care use, *RECTUM, *SURVEYS, *AGING, *RESEARCH funding, *QUESTIONNAIRES, *QUALITY of life, *DRUGS, *DESCRIPTIVE statistics, *STATISTICAL sampling, *SOMATOFORM disorders, *FECAL incontinence, *SYMPTOMS, *EVALUATION, *ADULTS, *OLD age
Abstract

Background: Little is known about changes in gastrointestinal symptoms compatible with disorders of gut‐brain interaction (DGBI) with increasing age at the population level. The objective of this study was to describe the patterns of DGBI in individuals 65 years of age and above and contrasting them with those of younger adults. Methods: A community sample of 6300 individuals ages 18 and older in the US, UK, and Canada completed an online survey. Quota‐based sampling was used to ensure equal proportion of sex and age groups (40% aged 18–39, 40% aged 40–64, 20% aged 65+) across countries, and to control education distributions. The survey included the Rome IV Diagnostic Questionnaire for DGBI, demographic questions, questionnaires measuring overall somatic symptom severity and quality of life, and questions on healthcare utilization, medications, and surgical history. Results: We included 5926 individuals in our analyses; 4700 were 18–64 years of age and 1226 were ages 65+. Symptoms compatible with at least one DGBI were less prevalent in participants ages 65+ vs. ages 18–64 years (34.1% vs. 41.3%, p < 0.0001). For symptoms compatible with upper GI DGBI, lower prevalence for most disorders was noted in the 65+ group. For lower GI DGBI, a different pattern was seen. Prevalence was lower in ages 65+ for irritable bowel syndrome and anorectal pain, but no differences from younger participants for the disorders defined by abnormal bowel habits (constipation and/or diarrhea) were seen. Fecal incontinence was the only DGBI that was more common in ages 65+. Having a DGBI was associated with reduced quality of life, more severe non‐GI somatic symptoms, and increased healthcare seeking, both in younger and older participants. Conclusion: Symptoms compatible with DGBI are common, but most of these decrease in older adults at the population level, with the exception of fecal incontinence which increases. This pattern needs to be taken into account when planning GI health care for the growing population of older adults. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

24. Endoscopic Endonasal Odontoidectomy in Pediatric Patients with Congenital Skeletal Dysplasia: A Case Series.

Author

Jackson, Hudin N., Ramaswamy, Uma, Giannoni, Carla, Whitehead, William E., and Bauer, David F

Subjects
CHILD patients, SKELETAL dysplasia, DYSPLASIA, ARNOLD-Chiari deformity, CRANIOVERTEBRAL junction, BASILAR invagination
Abstract

This article discusses the use of endoscopic endonasal odontoidectomy as a treatment for pediatric patients with ventral brainstem compression caused by congenital skeletal dysplasia. The study involved four pediatric patients who underwent posterior instrumented fusion followed by endoscopic endonasal odontoid resection. The patients experienced symptoms such as dysphagia, dysphonia, gait instability, extraocular movement dysfunction, and tongue numbness. The procedure was successful in achieving brainstem decompression and improving or resolving preoperative symptoms. The article highlights the challenges of performing this procedure in pediatric patients, including narrow nasopharyngeal anatomy and the need for preoperative planning and specialized instruments. [Extracted from the article]

Published
2024
Full Text
View/download PDF

30. Variability in Management of First Cerebrospinal Fluid Shunt Infection: A Prospective Multi-Institutional Observational Cohort Study

Author

Simon, Tamara D., Kronman, Matthew P., Whitlock, Kathryn B., Gove, Nancy, Browd, Samuel R., Holubkov, Richard, Kestle, John R.W., Kulkarni, Abhaya V., Langley, Marcie, Limbrick, David D., Jr, Luerssen, Thomas G., Oakes, Jerry, Riva-Cambrin, Jay, Rozzelle, Curtis, Shannon, Chevis, Tamber, Mandeep, Wellons, John C., III, Whitehead, William E., and Mayer-Hamblett, Nicole

Published
2016
Full Text
View/download PDF

35. Comparison of outcomes in the management of abdominal pseudocyst in children with shunted hydrocephalus: a Hydrocephalus Clinical Research Network study.

Author

Ravindra, Vijay M., Jensen, Hailey, Riva-Cambrin, Jay, Wellons III, John C., Limbrick Jr., David D., Pindrik, Jonathan, Jackson, Eric M., Pollack, Ian F., Hankinson, Todd C., Hauptman, Jason S., Tamber, Mandeep S., Kulkarni, Abhaya V., Rocque, Brandon G., Rozzelle, Curtis, Whitehead, William E., Chu, Jason, Krieger, Mark D., Simon, Tamara D., Reeder, Ron, and McDonald, Patrick J.

Published
2023
Full Text
View/download PDF

36. Imaging Changes in Pediatric Intracranial Ependymoma Patients Treated With Proton Beam Radiation Therapy Compared to Intensity Modulated Radiation Therapy

Author

Gunther, Jillian R., Sato, Mariko, Chintagumpala, Murali, Ketonen, Leena, Jones, Jeremy Y., Allen, Pamela K., Paulino, Arnold C., Okcu, M. Fatih, Su, Jack M., Weinberg, Jeffrey, Boehling, Nicholas S., Khatua, Soumen, Adesina, Adekunle, Dauser, Robert, Whitehead, William E., and Mahajan, Anita

Published
2015
Full Text
View/download PDF

43. Face‐to‐face interviews versus Internet surveys: Comparison of two data collection methods in the Rome foundation global epidemiology study: Implications for population‐based research.

Author

Sperber, Ami D., Bor, Serhat, Fang, Xuicai, Bangdiwala, Shrikant I., Drossman, Douglas A., Ghoshal, Uday C., Simren, Magnus, Tack, Jan, Whitehead, William E., Dumitrascu, Dan L., Fukudo, Shin, Kellow, John, Okeke, Edith, Quigley, Eamonn M. M., Schmulson, Max, Whorwell, Peter, Archampong, Timothy, Adibi, Payman, Andresen, Viola, and Benninga, Marc A.

Subjects
INTERNET surveys, ACQUISITION of data, LOGISTIC regression analysis, EPIDEMIOLOGICAL research, SOCIAL influence
Abstract

Background and Aims: The Rome Foundation Global Epidemiology Study (RFGES) assessed the prevalence, burden, and associated factors of Disorders of Gut–Brain Interaction (DGBI) in 33 countries around the world. Achieving worldwide sampling necessitated use of two different surveying methods: In‐person household interviews (9 countries) and Internet surveys (26 countries). Two countries, China and Turkey, were surveyed with both methods. This paper examines the differences in the survey results with the two methods, as well as likely reasons for those differences. Methods: The two RFGES survey methods are described in detail, and differences in DGBI findings summarized for household versus Internet surveys globally, and in more detail for China and Turkey. Logistic regression analysis was used to elucidate factors contributing to these differences. Results: Overall, DGBI were only half as prevalent when assessed with household vs Internet surveys. Similar patterns of methodology‐related DGBI differences were seen within both China and Turkey, but prevalence differences between the survey methods were dramatically larger in Turkey. No clear reasons for outcome differences by survey method were identified, although greater relative reduction in bowel and anorectal versus upper gastrointestinal disorders when household versus Internet surveying was used suggests an inhibiting influence of social sensitivity. Conclusions: The findings strongly indicate that besides affecting data quality, manpower needs and data collection time and costs, the choice of survey method is a substantial determinant of symptom reporting and DGBI prevalence outcomes. This has important implications for future DGBI research and epidemiological research more broadly. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

44. Prevalence and associated factors of disorders of gut‐brain interaction in the United States: Comparison of two nationwide Internet surveys.

Author

Palsson, Olafur S., Sperber, Ami D., Bangdiwala, Shrikant, and Whitehead, William E.

Subjects
INTERNET surveys, AGE groups, MENTAL depression, WELL-being, QUALITY of life
Abstract

Background: No comprehensive assessment of disorders of gut‐brain interaction (DGBI) in the United States (US) national population has been published in the past three decades. We aimed to provide an updated picture of DGBI in the United States and associated factors, using data from two national Internet surveys. Methods: Data were analyzed from 1949 people surveyed in 2015, and 2023 people surveyed in 2017 as a part of the Rome Foundation Global Epidemiology Study (RFGES). The surveys had nearly identical methodology and included the Rome IV Diagnostic Questionnaire and questions on demographics, quality of life (QoL), emotional symptoms, and healthcare utilization. Key Results: The prevalence of having any DGBI was 36.0% and 39.9% in the two surveys. Prevalence estimates for the 22 DGBI assessed were broadly comparable between the surveys, as their 95% confidence intervals overlapped for every disorder. Females had DGBI more commonly than males in both surveys (odds ratios 1.66 and 1.52), and people of age 65 and older had lower DGBI prevalence than younger age groups. Having DGBI was associated in both surveys with significant QoL impairment, elevated anxiety, depression and somatization symptoms, and increased doctor visits. Conclusions and Inferences: Approximately 4 out of every 10 US adults have a DGBI; more commonly women and people under the age of 65. DGBI adversely affect QoL and emotional well‐being and increase healthcare needs. The similarity of findings between the two surveys supports the reliability of DGBI prevalence estimates obtained with the Internet survey method used globally in the RFGES. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

48. Cognitive Sparing in Proton versus Photon Radiotherapy for Pediatric Brain Tumor Is Associated with White Matter Integrity: An Exploratory Study.

Author

Mash, Lisa E., Kahalley, Lisa S., Raghubar, Kimberly P., Goodrich-Hunsaker, Naomi J., Abildskov, Tracy J., De Leon, Luz A., MacLeod, Marianne, Stancel, Heather, Parsons, Kelley, Biekman, Brian, Desai, Nilesh K., Grosshans, David R., Paulino, Arnold C., Chu, Zili D., Whitehead, William E., Okcu, Mehmet Fatih, Chintagumpala, Murali, and Wilde, Elisabeth A.

Subjects
BRAIN tumor treatment, COGNITION disorders, RESEARCH, MAGNETIC resonance imaging, WHITE matter (Nerve tissue), CANCER patients, NEUROPSYCHOLOGICAL tests, COMPARATIVE studies, PROTON therapy, DESCRIPTIVE statistics, RESEARCH funding, RADIOTHERAPY, CHILDREN
Abstract

Simple Summary: Research has shown that children who undergo radiotherapy for brain tumors are at risk for long-term changes in both their thinking and brain structure. Compared to photon radiotherapy (i.e., X-rays), proton radiotherapy may cause less damage to healthy brain tissue and result in fewer cognitive problems. This study compared cognitive functioning and white matter damage in survivors of pediatric brain tumors who were treated with proton or photon therapy. The results showed that patients who received photon therapy had more cognitive problems and showed more white matter change than those who received proton therapy. Patients who underwent proton therapy, on the other hand, were similar to healthy individuals with no history of brain tumors. This study suggests that proton therapy may protect healthy brain tissue, leading to better long-term cognitive outcomes. Radiotherapy for pediatric brain tumors is associated with reduced white matter structural integrity and neurocognitive decline. Superior cognitive outcomes have been reported following proton radiotherapy (PRT) compared to photon radiotherapy (XRT), presumably due to improved sparing of normal brain tissue. This exploratory study examined the relationship between white matter change and late cognitive effects in pediatric brain tumor survivors treated with XRT versus PRT. Pediatric brain tumor survivors treated with XRT (n = 10) or PRT (n = 12) underwent neuropsychological testing and diffusion weighted imaging >7 years post-radiotherapy. A healthy comparison group (n = 23) was also recruited. Participants completed age-appropriate measures of intellectual functioning, visual-motor integration, and motor coordination. Tractography was conducted using automated fiber quantification (AFQ). Fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) were extracted from 12 tracts of interest. Overall, both white matter integrity (FA) and neuropsychological performance were lower in XRT patients while PRT patients were similar to healthy control participants with respect to both FA and cognitive functioning. These findings support improved long-term outcomes in PRT versus XRT. This exploratory study is the first to directly support for white matter integrity as a mechanism of cognitive sparing in PRT. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results