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1. Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI))

Author

Reinhart, K., Brunkhorst, F. M., Bone, H.-G., Bardutzky, J., Dempfle, C.-E., Forst, H., Gastmeier, P., Gerlach, H., Gründling, M., John, S., Kern, W., Kreymann, G., Krüger, W., Kujath, P., Marggraf, G., Martin, J., Mayer, K., Meier-Hellmann, A., Oppert, M., Putensen, C., Quintel, M., Ragaller, M., Rossaint, R., Seifert, H., Spies, C., Stüber, F., Weiler, N., Weimann, A., Werdan, K., and Welte, T.

Subjects
guideline, German Sepsis Society, German Sepsis Aid, severe sepsis, septic shock, prevention, diagnosis, treatment, follow-up care, Medicine
Abstract

Practice guidelines are systematically developed statements and recommendations that assist the physicians and patients in making decisions about appropriate health care measures for specific clinical circumstances taking into account specific national health care structures. The 1st revision of the S-2k guideline of the German Sepsis Society in collaboration with 17 German medical scientific societies and one self-help group provides state-of-the-art information (results of controlled clinical trials and expert knowledge) on the effective and appropriate medical care (prevention, diagnosis, therapy and follow-up care) of critically ill patients with severe sepsis or septic shock. The guideline had been developed according to the “German Instrument for Methodological Guideline Appraisal” of the Association of the Scientific Medical Societies (AWMF). In view of the inevitable advancements in scientific knowledge and technical expertise, revisions, updates and amendments must be periodically initiated. The guideline recommendations may not be applied under all circumstances. It rests with the clinician to decide whether a certain recommendation should be adopted or not, taking into consideration the unique set of clinical facts presented in connection with each individual patient as well as the available resources.

Published
2010

5. Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the ENABLE Trials

Author

Packer, Milton, Caspi, Avi, Kiowski, Wolfgang, Krum, Henry, Pratt, Craig, Swedberg, Karl, Massie, Barry, McMurray, John, Connally, Eugene, Petrie, Mark, DeMets, David, Anderson, Susan, Barnet, Jody, Cody, Robert, Dargie, Henry, Francis, Gary, Greenberg, Barry, Reichen, Juerg, Karrasch, J., Krum, H., Horowitz, J., Amerena, J., Sindone, A., MacDonald, P., Jeffrey, I., Button, I., DeAngelis, E., Pacher, R., Davies, R., McAlister, F., Tanser, P., Sussex, B., Baumann, G., Fleck, E., Olbrich, H.-G., Werdan, K., Klein, H., Staffeld, F., Zeiher, A.M., Roediger, C., Caspi, A., Marmor, A., Reisin, L., Vered, Z., Klainman, E., Roguin, N., Tzivoni, D., David, D., Lewis, B., Abinader, E., Omary, M., Rosenman, Y., Kaluski, E., Breedveld, R.W., van der Burgh, P.H., Dunselman, P.H.J.M., Schaafsma, H.J., Hertzberger, D.P., Holwerda, N.J., Kragten, J.A., van Wijngaarden, J., Posma, J.L., Said, S.A.M., Slegers, L.C., Tjon Joe Gin, R.M., Wempe, F.N., Wesdorp, J.C.L., Willems, A.R., Withagen, A.J.A.M., Cornel, J.M., van Kempen, L.H.J., Kiowski, W., Bertel, O., Moccetti, T., McMurray, J.J.V., Greenbaum, R.A., Bennett, P., Swan, J., Davies, G., Findlay, I., Gould, B., Ball, S., Hubner, P., Lahiri, A., McLay, J., Northcote, R., Saltissi, S., Squire, I., Stephens, J., Stewart, M., Bridgen, G., Walsh, J., Webb, D.J., Ansari, Z., Baron, S., Bellinger, R., Bennet, W., Benvenuti, D., Dawley, D., Egbujiobi, L.C., Eisenstein, I., Little, T., Hertsberg, A., Greenspan, M., Grossman, R.J., Hanley, P., Jesrani, M., Kashou, H., Levites, R., Malik, R., Marmorstein, B., Schwartz, M., Nisar, A., Perelman, R., Schwarz, M.L., Sedlis, S., Srebro, J., Taveras, M., Weiss, R., Weitzman, P., Wetherley, G.K., El Shahawy, M., Kereiakes, D., Campos, L., Peterson, G., Small, R.S., Davis, W.R., Olivari, M.-T., Meengs, W., Koren, M., Slagona, P., Jennison, S., Hershberger, R., Browne, K.F., Farnham, D.J., Zelenkofske, S., Lawless, C., Nathan, M., Meyer, T., Kukin, M., Parekh, H., Berkowitz, R., Boehmer, J., Brozena, S., Dandona, P., Dec, G.W., DeQuattro, V., Fenster, P., Fowler, M., Ellaham, S., Geller, M., Gheorgiade, M., Ghali, J., Murali, S., Katz, S., Bott-Silverman, C., Singh, B., Thadani, U., Torre, G., Teerlink, J., Chandraratna, T., Kesselbrenner, M., Mukherjee, A., Che-Pin Tsai, C., Abbo, K., Goldberg, M., Smith, T., Martin, R.T., McMurray, John J.V., Massie, Barry M., Pratt, Craig M., Petrie, Mark C., Kobrin, Isaac, and Roux, Sebastien

Published
2017
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12. Comparison of outcome in 1809 patients treated with drug-eluting stents or bare-metal stents in a real-world setting

Author

Vogt A, Schoelmerich A, Pollner F, Schlitt M, Raaz U, Maegdefessel L, Reindl I, Buerke M, Werdan K, and Schlitt

Subjects
coronary stent, outcome, renal insufficiency, myocardial infarction, STEMI, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Alexander Vogt1, Anke Schoelmerich1, Franziska Pollner1, Manuela Schlitt1, Uwe Raaz1, Lars Maegdefessel2, Iris Reindl1, Michael Buerke1, Karl Werdan1, Axel Schlitt11Department of Medicine III, Martin Luther-University, Halle, Germany; 2Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USAPurpose: The aim of this study was to determine the long-term safety of drug-eluting stent (DES) versus bare metal stent (BMS) implantation in a “real-world” setting.Patients and methods: A total of 1809 patients who were treated with implantation of either BMS or DES were assessed. Kaplan-Meier and multivariate Cox regression analyses concerning primary endpoint of cardiac mortality were performed.Results: A total of 609 patients received DES. Mean age was 66.2 ± 11.3 years, 69.4% were male, and 1517 (83.8%) were treated for acute coronary syndrome (unstable angina 510 [28.2%], non-ST-elevation myocardial infarction [NSTEMI] 506 [28.0%], and ST-elevation myocardial infarction [STEMI] 501 [27.7%]). Mean follow-up was 34 ± 15 months. During follow-up, 268 patients died of cardiac causes (DES 42 [7.3%]; BMS 226 [19.6%]; P < 0.001). Univariate Kaplan-Meier analysis showed an advantage of DES over BMS concerning the primary endpoint (P < 0.001). When adjusting for classic risk factors and additional factors that affect the progression of coronary heart disease (CHD), DES was not found to be superior to BMS (hazard ratio 0.996, 95% confidence interval 0.455–2.182, P = 0.993). Severely impaired renal function was an independent predictor for cardiac mortality after stent implantation.Conclusion: Treatment with DES is safe in the long term, also in patients presenting with STEMI. However, in multivariate analyses it is not superior to BMS treatment.Keywords: coronary stent, outcome, renal insufficiency, myocardial infarction, STEMI

Published
2011

14. Curriculum Kardiologie

Author

Werdan, K., Flachskampf, F.A., Griebenow, R., Hamm, C., Heinemann-Meerz, S., Hoffmeister, H.M., Irmer, M., Katus, H.A., Krämer, L.I., Mudra, H., Schunkert, H., Smetak, N., and Weber, M.A.

Published
2013
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38. Prävention, Diagnose, Therapie und Nachsorge der Sepsis: Erste Revision der S2k-Leitlinien der Deutschen Sepsis-Gesellschaft e.V. (DSG) und der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI)

Author

Reinhart, K., Brunkhorst, F.M., Bone, H.-G., Bardutzky, J., Dempfle, C.-E., Forst, H., Gastmeier, P., Gerlach, H., Gründling, M., John, S., Kern, W., Kreymann, G., Krüger, W., Kujath, P., Marggraf, G., Martin, J., Mayer, K., Meier-Hellmann, A., Oppert, M., Putensen, C., Quintel, M., Ragaller, M., Rossaint, R., Seifert, H., Spies, C., Stüber, F., Weiler, N., Weimann, A., Werdan, K., and Welte, T.

Published
2010
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48. Septische Kardiomyopathie

Author

Müller-Werdan, U., Buerke, M., Christoph, A., Flieger, R. R., Heinroth, K., Herklotz, A., Ruß, M., Schlitt, A., Schmidt, H., Söffker, G., and Werdan, K.

Published
2006
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49. Diagnose und Therapie der Sepsis: S-2 Leitlinien der Deutschen Sepsis-Gesellschaft e. V. (DSG) und der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI) *: Teil 2

Author

Reinhart, K., Brunkhorst, F. M., Bone, H.-G., Gerlach, H., Gründling, M., Kreymann, G., Kujath, P., Marggraf, G., Mayer, K., Meier-Hellmann, A., Peckelsen, C., Putensen, C., Stüber, F., Quintel, M., Ragaller, M., Rossaint, R., Weiler, N., Welte, T., and Werdan, K.

Published
2006
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50. Diagnose und Therapie der Sepsis: S-2 Leitlinien der Deutschen Sepsis-Gesellschaft e.V. (DSG) und der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI)*

Author

Reinhart, K., Brunkhorst, F. M., Bone, H.-G., Gerlach, H., Gründling, M., Kreymann, G., Kujath, P., Marggraf, G., Mayer, K., Meier-Hellmann, A., Peckelsen, C., Putensen, C., Stüber, F., Quintel, M., Ragaller, M., Rossaint, R., Weiler, N., Welte, T., and Werdan, K.

Published
2006
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