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1. In-flight testing of the injection of the LISA Pathfinder test mass into a geodesic

Author

Bortoluzzi, D., Vignotto, D., Zambotti, A., Armano, M., Audley, H., Baird, J., Binetruy, P., Born, M., Castelli, E., Cavalleri, A., Cesarini, A., Cruise, A.M., Danzmann, K., de Deus Silva, M., Diepholz, I., Dixon, G., Dolesi, R., Ferraioli, L., Ferroni, V., Fitzsimons, E.D., Freschi, M., Gesa, L., Gibert, F., Giardini, D., Giusteri, R., Grimani, C., Grzymisch, J., Harrison, I., Hartig, M.-S., Heinzel, G., Hewitson, M., Hollington, D., Hoyland, D., Hueller, M., Inchauspé, H., Jennrich, O., Jetzer, P., Karnesis, N., Kaune, B., Korsakova, N., Killow, C.J., Lobo, J.A., Liu, L., López-Zaragoza, J.P., Maarschalkerweerd, R., Mance, D., Meshksar, N., Martín, V., Martin-Polo, L., Martino, J., Martin-Porqueras, F., McNamara, P.W., Mendes, J., Mendes, L., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pivato, P., Plagnol, E., Ramos-Castro, J., Reiche, J., Robertson, D.I., Rivas, F., Russano, G., Slutsky, J., Sopuerta, C.F., Sumner, T., Texier, D., Thorpe, J.I., Vetrugno, D., Vitale, S., Wanner, G., Ward, H., Wass, P.J., Weber, W.J., Wissel, L., Wittchen, A., Zweifel, P., and Zanoni, Carlo

Published
2021
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2. Measuring the Galactic Cosmic Ray flux with the LISA Pathfinder radiation monitor

Author

Armano, M., Audley, H., Baird, J., Binetruy, P., Born, M., Bortoluzzi, D., Castelli, E., Cavalleri, A., Cesarini, A., Cruise, A.M., Danzmann, K., de Deus Silva, M., Diepholz, I., Dixon, G., Dolesi, R., Ferraioli, L., Ferroni, V., Finetti, N., Fitzsimons, E.D., Freschi, M., Gesa, L., Gibert, F., Giardini, D., Giusteri, R., Grimani, C., Grzymisch, J., Harrison, I., Heinzel, G., Hewitson, M., Hollington, D., Hoyland, D., Hueller, M., Inchauspé, H., Jennrich, O., Jetzer, P., Karnesis, N., Kaune, B., Korsakova, N., Killow, C.J., Lobo, J.A., Lloro, I., Liu, L., Lopez-Zaragoza, J.P., Maarschalkerweerd, R., Mance, D., Meshskar, N., Martín, V., Martin-Polo, L., Martino, J., Martin-Porqueras, F., Mateos, I., McNamara, P.W., Mendes, J., Mendes, L., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pivato, P., Plagnol, E., Ramos-Castro, J., Reiche, J., Robertson, D.I., Rivas, F., Russano, G., Slutsky, J., Sopuerta, C.F., Sumner, T., Texier, D., Thorpe, J.I., Vetrugno, D., Vitale, S., Wanner, G., Ward, H., Wass, P., Weber, W.J., Wissel, L., Wittchen, A., and Zweifel, P.

Published
2018
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20. Mixed agonistic-antagonistic cytokine response in whole blood from patients undergoing abdominal aortic aneurysm repair

Author

Ziegenfuss, T., Wanner, G. A., Grass, C., Bauer, I., Schuder, G., Kleinschmidt, S., Menger, M. D., and Bauer, M.

Subjects
Abdominal aneurysm -- Care and treatment, Abdominal aneurysm -- Genetic aspects, Cytokines -- Health aspects, Gene expression -- Health aspects, Health care industry
Abstract

Byline: T. Ziegenfuss (1), G. A. Wanner (2), C. Grass (1), I. Bauer (1), G. Schuder (3), S. Kleinschmidt (1), M. D. Menger (2), M. Bauer (1) Keywords: Key words Abdominal aortic aneurysm; Cytokines; Systemic inflammatory response syndrome; Ischemia-reperfusion Abstract: Objective: To characterize the impact of abdominal aortic aneurysm repair (AAAR) on spontaneous as well as lipopolysaccharide (LPS)-induced gene expression of pro- and anti-inflammatory cytokines. Design: Prospective, controlled in vivo / ex vivo study. Setting: University hospital. Patients and interventions: Whole blood from 14 consecutive patients undergoing AAAR withdrawn prior to surgery (T1), at the end of ischemia (T2), 90 min after declamping (T3) and on the first postoperative day (T4) was cultured in the absence or presence of LPS. Five patients undergoing elective inguinal hernia repair served as controls. Measurements and results: While tumor necrosis factor (TNF), Interleukin (IL)-1 and IL-10 plasma concentrations did not increase significantly, IL-6 was elevated at each time point, as compared with T1. Despite the spontaneous release of trace amounts of IL-6, the ability of cultured whole blood to mount a cytokine response in vitro to LPS was impaired for all cytokines studied at T2 (TNF --62 %, IL-1 --51 %, IL-6 --20 %, IL-10 --51 %). The stimulated IL-6 response was restored early after declamping (T3: + 56 %) and enhanced 1 day after operation (T4: + 144 %). In contrast, stimulated TNF and IL-1 responses remained depressed at T3 (TNF --48 %, IL-1 --64 %) and T4 (TNF --40 %, IL-1 --24 %). A biphasic pattern was observed for IL-10 with initial depression at T3 (-51 %) and restoration at T4 ( + 40 %). Among the different cytokines monitored, only impaired TNF responsiveness at early reperfusion (T3) correlated with the postoperative course, as reflected by APACHE II. Cytokine response to LPS was maintained or even increased during and after surgery in the whole blood from patients undergoing hernia repair. Conclusions: Despite consistent development of clinical signs of systemic inflammatory response syndrome (SIRS) and spontaneous release of IL-6 abdominal aortic aneurysm repair produces a state of impaired pro-inflammatory cytokine response upon a subsequent in vitro Gram-negative stimulus. This early impairment of TNF responsiveness seems to correlate with an unfavorable postoperative course. Author Affiliation: (1) Klinik fur Anaesthesiologie und Intensivmedizin, Universitat des Saarlandes, D-66 424 Homburg/Saar, Germany e-mail aimbau@med-rz.uni-sb.de Tel. + 49 6841 162728 Fax + 49 6841 162401, DE (2) Institut fur klinisch-experimentelle Chirurgie, Universitat des Saarlandes, D-66 424 Homburg/Saar, Germany, DE (3) Klinik fur Allgemein-, Abdominal- und Gefasschirurgie, Universitat des Saarlandes, D-66 424 Homburg/Saar, Germany, DE Article note: Received: 17 April 1998 Final revision received: 22 July 1998 Accepted: 17 August 1998

Published
1999

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