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2. Quinidine-Digoxin Interaction

Author

Wandell M, Hager Wd, Powell, Conrad K, Graves P, and Paul E. Fenster

Subjects
Quinidine, Digoxin, Dose-Response Relationship, Drug, Serum digoxin, Maintenance dose, business.industry, digestive, oral, and skin physiology, Liter, General Medicine, DIGITALIS INTOXICATION, Pharmacology, Digoxin levels, Digoxin Dose, carbohydrates (lipids), polycyclic compounds, medicine, Humans, Drug Interactions, cardiovascular diseases, business, medicine.drug
Abstract

Administration of quinidine with digoxin increased serum digoxin concentrations in 79 patients and five volunteers. In 38 patients on a constant glycoside maintenance dose, the addition of quinidine to digoxin therapy resulted in a mean 2.5-fold increase (from 0.98±0.37 to 2.47±0.71 ng per milliliter, mean ±1 S.D.) (P

Published
1980
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