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3. Overexpression of EPAC2 reduces the invasion of glioma cells via MMP-2

Author

Ming Jiang, Lei Jiao, Shiming Zhang, Wang‑Cun Zu, Seidu A. Richard, and Yan Zhuang

Subjects
0301 basic medicine, Cancer Research, Cell, cyclic adenosine 3′,5′-monophosphate, 03 medical and health sciences, 0302 clinical medicine, Glioma, glioma, medicine, Oncogene, Chemistry, exchange protein directly activated by cAMP 1, Transfection, Articles, Cell cycle, medicine.disease, Blot, 030104 developmental biology, medicine.anatomical_structure, Oncology, matrix metalloproteinase 2, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Signal transduction, overexpression
Abstract

Exchange proteins directly activated by cAMP (EPACs) are crucial cyclic adenosine 3',5'-monophosphate- determined signaling pathway intercessors, which are associated with the pathogenesis of neurological disorders and numerous human diseases. To the best of our knowledge, the role of EPAC2 signaling via matrix metalloproteinase 2 (MMP-2) in the pathogenesis of glioma has not been studied. Therefore, the present study focused on the role of EPAC2 in glioma, and assessed the invasiveness of human glioma cell lines following EPAC2 overexpression. Expression levels of EPAC2 in normal brain tissues and clinical glioma specimens were detected by western blotting. An EPAC2 overexpression vector was transfected into U251 and U87 cell lines to increase the expression levels of EPAC2. Expression levels of MMP-2 were detected by western blotting, and the invasive abilities of glioma cells were detected by a Transwell assay. EPAC2 was relatively highly expressed in normal brain tissue, while EPAC2 expression was significantly decreased in clinical glioma specimens (P

Published
2019

4. Analysis of risk factors for transformation of traumatic subdural effusion into chronic subdural hematoma.

Author

YI Pan, WANG Cun-zu, CHEN Pin, WANG Dong-dong, WANG Hui, HE Shi-wei, and ZENG Wei

Subjects
CHRONIC disease risk factors, BRAIN injuries, COMPUTED tomography, CONFIDENCE intervals, MAGNETIC resonance imaging, MENINGITIS, RISK assessment, STATISTICS, SUBDURAL hematoma, LOGISTIC regression analysis, DESCRIPTIVE statistics, ODDS ratio, DISEASE complications
Abstract

Objective To analyze the risk factors of traumatic subdural effusion (TSE) transforming into chronic subdural hematoma (CSDH). Methods A total of 75 patients with TSE after traumatic brain injury (TBI) were included from December 2017 to July 2019. CT or MRI reexamination during treatment and follow-up were performed to observe whether CSDH was transformed and relevant influencing factors were analyzed. Univariate and multivariate Logistic regression analyses were performed to screen the risk factors for the transformation of TSE into CSDH. Results Logistic regression analysis showed that the higher effusion density (OR = 6.021, 95% CI: 1.047-34.631; P = 0.044), subdural effusion increases for a long time (OR = 1.253, 95% CI: 1.002-1.568; P = 0.048), the thicker effusion (OR = 2.080, 95% CI: 1.267-3.414; P = 0.004) and brain atrophy (OR = 35.392, 95% CI: 1.397-896.474; P = 0.031) were risk factors for the transformation of TSE into CSDH. Conclusions The subdural effusion increases for a long time, higher effusion density, thicker effusion and brain atrophy are the risk factors associated with the transformation of TSE into CSDH. [ABSTRACT FROM AUTHOR]

Published
2020
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