16 results on '"Voronin, Denis V."'
Search Results
2. Case study of freezing-induced loading of silver nanoparticles into vaterite microcrystals
- Author
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Voronin, Denis V., Panchenko, Andrei A., Cherednichenko, Kirill A., Novikov, Andrei A., Vinokurov, Vladimir A., and Kopitsyn, Dmitry S.
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- 2024
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3. Time-Delayed Anticancer Effect of an Extremely Low Frequency Alternating Magnetic Field and Multimodal Protein–Tannin–Mitoxantrone Carriers with Brillouin Microspectroscopy Visualization In Vitro.
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Abalymov, Anatolii A., Anisimov, Roman A., Demina, Polina A., Kildisheva, Veronika A., Kalinova, Alexandra E., Serdobintsev, Alexey A., Novikova, Nadezhda G., Petrenko, Dmitry B., Sadovnikov, Alexandr V., Voronin, Denis V., and Lomova, Maria V.
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MAGNETIC fields ,ANTINEOPLASTIC agents ,BRILLOUIN scattering ,DATA visualization ,DRUG carriers - Abstract
The effect of an extremely low frequency alternating magnetic field (ELF AMF) at frequencies of 17, 48, and 95 Hz at 100 mT on free and internalized 4T1 breast cancer cell submicron magnetic mineral carriers with an anticancer drug, mitoxantrone, was shown. The alternating magnetic field (100 mT; 17, 48, 95 Hz; time of treatment—10.5 min with a 30 s delay) does not lead to the significant destruction of carrier shells and release of mitoxantrone or bovine serum albumin from them according to the data of spectrophotometry, or the heating of carriers in the process of exposure to magnetic fields. The most optimal set of factors that would lead to the suppression of proliferation and survival of cells with anticancer drug carriers on the third day (in comparison with the control and first day) is exposure to an alternating magnetic field of 100 mT in a pulsed mode with a frequency of 95 Hz. The presence of magnetic nanocarriers in cell lines was carried out by a direct label-free method, space-resolved Brillouin light scattering (BLS) spectrometry, which was realized for the first time. The analysis of the series of integrated BLS spectra showed an increase in the magnetic phase in cells with a growth in the number of particles per cell (from 10 to 100) after their internalization. The safety of magnetic carriers in the release of their constituent ions has been evaluated using atomic absorption spectrometry. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Natural Fibrous Materials Based on Fungal Mycelium Hyphae as Porous Supports for Shape-Stable Phase-Change Composites.
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Sayfutdinova, Adeliya R., Cherednichenko, Kirill A., Rakitina, Maria A., Dubinich, Valeria N., Bardina, Kristina A., Rubtsova, Maria I., Petrova, Daria A., Vinokurov, Vladimir A., and Voronin, Denis V.
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MYCELIUM ,PARAFFIN wax ,PHASE change materials ,SOLID-state fermentation ,LATENT heat ,HEAT storage ,MORTAR - Abstract
Adsorption of organic phase-change materials (PCMs) by the porous matrix of microfibrillar cellulose (MFC) is a simple and versatile way to prepare shape-stable phase-change composites, which are promising as sustainable thermoregulating additives to construction materials. However, due to MFC inherent morphology, the resulting composites have relatively low poured density that complicates their introduction in sufficient amounts, for instance, into mortar mixes. Unlike MFC, fungal mycelium has, by an order, less fibrils thickness and, thus, possesses significantly higher poured density. Herein, we studied the feasibility of fungal mycelium-based matrices as alternative biopolymeric porous supports for preparation of sustainable and shape-stable phase-change composites. Two methods were employed to prepare the porous mycelium-based supports. The first one was the solid-state fermentation, which resulted in partial biotransformation of MFCs to mycelium hyphae, while the second one was the liquid-state surface fermentation, used to cultivate the reference matrix of Trametes hirsuta hyphae. The phase-change composites were prepared by adsorption of model organic PCMs on porous biopolymer matrices. The mass ratio of support/PCM was 40/60 wt%. The composites were studied with respect to their structure, composition, poured density, latent heat storage properties, and thermal and shape stability. The employment of the partially transformed to mycelium-hyphae MFC fibers was found to be a suitable way to prepare phase-change composites with improved poured density while preserving a reasonable latent heat capacity and shape stability as compared to the MFC/PCM composites. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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5. Polyurethane/ n -Octadecane Phase-Change Microcapsules via Emulsion Interfacial Polymerization: The Effect of Paraffin Loading on Capsule Shell Formation and Latent Heat Storage Properties.
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Voronin, Denis V., Sitmukhanova, Eliza, Mendgaziev, Rais I., Rubtsova, Maria I., Kopitsyn, Dmitry, Cherednichenko, Kirill A., Semenov, Anton P., Fakhrullin, Rawil, Shchukin, Dmitry G., and Vinokurov, Vladimir
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HEAT storage , *LATENT heat , *HEAT of formation , *EMULSION polymerization , *PHASE change materials , *FOOD emulsions , *POLYURETHANE elastomers - Abstract
Organic phase-change materials (PCMs) hold promise in developing advanced thermoregulation and responsive energy systems owing to their high latent heat capacity and thermal reliability. However, organic PCMs are prone to leakages in the liquid state and, thus, are hardly applicable in their pristine form. Herein, we encapsulated organic PCM n-Octadecane into polyurethane capsules via polymerization of commercially available polymethylene polyphenylene isocyanate and polyethylene glycol at the interface oil-in-water emulsion and studied how various n-Octadecane feeding affected the shell formation, capsule structure, and latent heat storage properties. The successful shell polymerization and encapsulation of n-Octadecane dissolved in the oil core was verified by confocal microscopy and Fourier-transform infrared spectroscopy. The mean capsule size varied from 9.4 to 16.7 µm while the shell was found to reduce in thickness from 460 to 220 nm as the n-Octadecane feeding increased. Conversely, the latent heat storage capacity increased from 50 to 132 J/g corresponding to the growth in actual n-Octadecane content from 25% to 67% as revealed by differential scanning calorimetry. The actual n-Octadecane content increased non-linearly along with the n-Octadecane feeding and reached a plateau at 66–67% corresponded to 3.44–3.69 core-to-monomer ratio. Finally, the capsules with the reasonable combination of structural and thermal properties were evaluated as a thermoregulating additive to a commercially available paint. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Degradation of Hybrid Drug Delivery Carriers with a Mineral Core and a Protein-Tannin Shell under Proteolytic Hydrolases.
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Demina, Polina A., Saveleva, Mariia S., Anisimov, Roman A., Prikhozhdenko, Ekaterina S., Voronin, Denis V., Abalymov, Anatolii A., Cherednichenko, Kirill A., Timaeva, Olesya I., and Lomova, Maria V.
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DRUG delivery systems ,TANNINS ,HYDROLASES ,ANTINEOPLASTIC agents ,CANCER cells - Abstract
Hybrid carriers with the mineral CaCO
3 /Fe3 O4 core and the protein-tannin shell are attractive for drug delivery applications due to reliable coupling of anticancer drugs with protein-tannin complex and the possibility of remote control over drug localization and delivery by the external magnetic field. This study aims to elucidate the mechanisms of drug release via enzymatic degradation of a protein-tannin carrier shell triggered by proteolytic hydrolases trypsin and pepsin under physiological conditions. To do this, the carriers were incubated with the enzyme solutions in special buffers to maintain the enzyme activity. The time-lapse spectrophotometric and electron microscopy measurements were carried out to evaluate the degradation of the carriers. It was established that the protein-tannin complex demonstrates the different degradation behavior depending on the enzyme type and buffer medium. The incubation in trypsin solution mostly resulted in the protein shell degradation. The incubation in pepsin solution did not affect the protein component; however, the citric buffer stimulates the degradation of the mineral core. The presented results allow for predicting the degradation pathways of the carriers including the release profile of the loaded cargo under physiological conditions. The viability of 4T1 breast cancer cells with mineral magnetic carriers with protein-tannin shells was investigated, and their movement in the fields of action of the permanent magnet was shown. [ABSTRACT FROM AUTHOR]- Published
- 2022
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7. Effect of Systemic Polyelectrolyte Microcapsule Administration on the Blood Flow Dynamics of Vital Organs.
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Sindeeva, Olga A., Verkhovskii, Roman A., Abdurashitov, Arkady S., Voronin, Denis V., Gusliakova, Olga I., Kozlova, Anastasiia A., Mayorova, Oksana A., Ermakov, Aleksey V., Lengert, Ekaterina V., Navolokin, Nikita A., Tuchin, Valery V., Gorin, Dmitry A., Sukhorukov, Gleb B., and Bratashov, Daniil N.
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- 2020
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8. Focused ultrasound-mediated fluorescence of composite microcapsules loaded with magnetite nanoparticles: In vitro and in vivo study.
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Novoselova, Marina V., Voronin, Denis V., Abakumova, Tatiana O., Demina, Polina A., Petrov, Arsenii V., Petrov, Vladimir V., Zatsepin, Timofei S., Sukhorukov, Gleb B., and Gorin, Dmitry A.
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MICROBUBBLE diagnosis , *MAGNETITE , *CONTROLLED release drugs , *FLUORESCENCE , *TANNINS , *NANOPARTICLES - Abstract
• Freezing induced loading and Layer by Layer methods were used for capsule preparation. • The release of Cy7 labeled BSA initially quenched by magnetite was shown in vivo. • The decrease of Cy7 fluorescence after HIFU due to reactive oxygen species was observed. • Fast time- and site-specific release of Cy7-BSA in vivo under HIFU was demonstrated. High intensity focused ultrasound (HIFU) is widely used in medical practice, including cancer therapy. Also this approach is promising for remote release of encapsulated drugs in various other biomedical applications where local treatment is needed. Our approach underpins the minimization of HIFU impact on possible degradation of biological tissues and expand the use of HIFU in the controlled release of encapsulated drugs. We demonstrated the efficient ultrasound-induced release of labeled protein (Cy7-BSA) from elaborated nanocomposite microcapsules in vitro an in vivo. The capsule fabrication was done using combination of recently developed freezing-induced loading (FIL) technique and Layer-by-Layer assembly (LbL) used for the preparation of complex multilayer BSA/tannic acid nanocomposite capsules sensitive to HIFU. These capsules contain NIR fluorescent Cy7-labeled BSA in the shell for tracking in vivo and the high concentration of labels inside the capsules resulted in self-quenching provides the real-time detection of the protein once it is released from the capsule. Ultrasound-induced release in vivo of Cy7-labeled BSA initially quenched by magnetite nanoparticles was confirmed by fluorescent tomography. The significant decrease of Cy7 fluorescence under HIFU treatment in vitro was found to be due to a generation of reactive oxygen species and fast dye oxidation. Our results demonstrate that adapted HIFU setup can be used for the directed release of encapsulated substances in vivo under tissue compatible NIR monitoring by fluorescent tomography. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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9. Inorganic/Organic Multilayer Capsule Composition for Improved Functionality and External Triggering.
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Timin, Alexander S., Gao, Hui, Voronin, Denis V., Gorin, Dmitry A., and Sukhorukov, Gleb B.
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CONTROLLED release drugs ,NANOCOMPOSITE materials ,POLYELECTROLYTES ,NANOPARTICLES ,ENCAPSULATION (Catalysis) - Abstract
Polyelectrolyte (PE) and nanocomposite (NC) microcapsules fabricated by layer-by-layer technique have been of great interest in the past decade as novel entities for cargo encapsulation and delivery as well as for diagnostic purposes. The unique physicochemical properties of polymers and inorganic nanoparticles used in layer-by-layer synthesis of PE and NC microcapsules make them promising in various fields, such as storage, catalysis, cells imaging, controlled drug release, and targeted drug delivery. However, the requirement of the cargo encapsulation is that the cargo should have a relatively large molecular weight in order to avoid the leakage from the capsules. In this review, recent progress in the design and functionalization of PE and NC microcapsules using sol-gel method for storage of small cargos have been presented. Moreover, various remote exposures on the permeability of organic/inorganic composite microcapsule shells such as ultrasound, magnetic field gradient, laser, and microwave radiation have been observed. Finally, the description and discussion of the new trends and perspectives for improved functionality of PE microcapsules are the major topic of this progress report. [ABSTRACT FROM AUTHOR]
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- 2017
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10. Effect of Surface Functionalizationof Metal Wireon Electrophysical Properties of Inductive Elements.
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Voronin, Denis V., Borisova, Dimitriya, Belova, Valentina, Gorin, Dmitry A., and Shchukin, Dmitry G.
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SURFACES (Technology) , *PROPERTIES of matter , *MICROELECTRONICS industry , *INTEGRATED circuits , *POROUS materials , *MOLECULAR structure , *MAGNETITE , *NANOPARTICLES - Abstract
The development of the microelectronics industry requiresa newelement basis with reduced size and increased functionality. The mostimportant components in modern microelectronic integrated circuitsare passive elements. One of the key challenges in order to improvethe functionality of integrated circuits is to increase the qualityof passive elements composing them. In this paper we suggest a novelapproach to increase the quality factor Q of inductors by the surfacemodification and functionalization of the metal components. Ultrasoundinduced surface modification of metal wires led to the formation ofa porous surface structure, which further can be functionalized withmagnetite nanoparticles using layer-by-layer assembly technique. Thesurface modification and deposition of magnetite nanoparticles wasinvestigated with SEM, XRD, and contact angle measurements. Additionally,inductance and resistance measurements, as the main parameters determiningthe Q-factor of inductors, were carried out. Samples with high numberof magnetic nanoparticleâpolyelectrolyte bilayers demonstratea significant increase in inductance and a slight decrease in resistancein comparison to uncoated ones. The combination of these factors ledto enhancement the Q-factor of the investigated inductive elements. [ABSTRACT FROM AUTHOR]
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- 2012
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11. Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials.
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Voronin, Denis V., Abalymov, Anatolii A., Svenskaya, Yulia I., and Lomova, Maria V.
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EXPERIMENTAL design , *DRUG delivery systems , *THERAPEUTICS - Abstract
The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accumulation of the therapeutic molecules. However, designing the formulation endowed with the targeting properties in vitro does not guarantee its selective delivery in vivo. The various biological barriers that the carrier encounters upon intravascular administration should be adequately addressed in its overall design to reduce the off-target effects and unwanted toxicity in vivo and thereby enhance the therapeutic efficacy of the payload. Here, we discuss the main parameters of remote-controlled drug delivery systems: (i) key principles of the carrier selection; (ii) the most significant physiological barriers and limitations associated with the drug delivery; (iii) major concepts for its targeting and cargo release stimulation by external stimuli in vivo. The clinical translation for drug delivery systems is also described along with the main challenges, key parameters, and examples of successfully translated drug delivery platforms. The essential steps on the way from drug delivery system design to clinical trials are summarized, arranged, and discussed. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Freezing-induced loading of Au nanoparticles into halloysite nanotubes.
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Voronin, Denis V., Demina, Polina A., Abramova, Anna M., Cherednichenko, Kirill A., and Vinokurov, Vladimir
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GOLD nanoparticles , *HALLOYSITE , *TRANSMISSION electron microscopy , *NANOTUBES , *ELECTRON spectroscopy , *ULTRAVIOLET-visible spectroscopy - Abstract
• Halloysites (HNTs) are suitable containers for freezing-induced loading (FIL). • FIL of AuNPs into HNTs has an efficiency of 85% after 5 loading cycles. • FIL is twice efficient than vacuum impregnation and adsorption from solution. • FIL efficiency may be improved by adjusting the size and concentration of NPs. Au nanoparticles were loaded into halloysite nanotubes by freezing-induced loading method. The loading efficiency and Au nanoparticle distribution were studied by UV–Vis absorption spectroscopy and transmission electron microscopy and compared to those of vacuum impregnation and adsorption from solution loading methods. The freezing-induced loading was found to be the most effective with the loading efficiency up to 85% after 5 loading cycles and the best Au nanoparticle distribution into halloysite nanotubes. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches.
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Voronin, Denis V., Kozlova, Anastasiia A., Verkhovskii, Roman A., Ermakov, Alexey V., Makarkin, Mikhail A., Inozemtseva, Olga A., and Bratashov, Daniil N.
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DEEP learning , *BLOOD parasites , *BLOOD flow , *TUMOR classification , *CELLS , *BIOLOGY - Abstract
Flow cytometry nowadays is among the main working instruments in modern biology paving the way for clinics to provide early, quick, and reliable diagnostics of many blood-related diseases. The major problem for clinical applications is the detection of rare pathogenic objects in patient blood. These objects can be circulating tumor cells, very rare during the early stages of cancer development, various microorganisms and parasites in the blood during acute blood infections. All of these rare diagnostic objects can be detected and identified very rapidly to save a patient's life. This review outlines the main techniques of visualization of rare objects in the blood flow, methods for extraction of such objects from the blood flow for further investigations and new approaches to identify the objects automatically with the modern deep learning methods. [ABSTRACT FROM AUTHOR]
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- 2020
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14. High-efficiency freezing-induced loading of inorganic nanoparticles and proteins into micron- and submicron-sized porous particles.
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German, Sergei V., Novoselova, Marina V., Bratashov, Daniil N., Demina, Polina A., Atkin, Vsevolod S., Voronin, Denis V., Khlebtsov, Boris N., Parakhonskiy, Bogdan V., Sukhorukov, Gleb B., and Gorin, Dmitry A.
- Abstract
We demonstrate a novel approach to the controlled loading of inorganic nanoparticles and proteins into submicron- and micron-sized porous particles. The approach is based on freezing/thawing cycles, which lead to high loading densities. The process was tested for the inclusion of Au, magnetite nanoparticles, and bovine serum albumin in biocompatible vaterite carriers of micron and submicron sizes. The amounts of loaded nanoparticles or substances were adjusted by the number of freezing/thawing cycles. Our method afforded at least a three times higher loading of magnetite nanoparticles and a four times higher loading of protein for micron vaterite particles, in comparison with conventional methods such as adsorption and coprecipitation. The capsules loaded with magnetite nanoparticles by the freezing-induced loading method moved faster in a magnetic field gradient than did the capsules loaded by adsorption or coprecipitation. Our approach allows the preparation of multicomponent nanocomposite materials with designed properties such as remote control (e.g. via the application of an electromagnetic or acoustic field) and cargo unloading. Such materials could be used as multimodal contrast agents, drug delivery systems, and sensors. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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15. Phase-change composites for bimodal solar/electromagnetic energy storage based on magnetite-modified cellulose microfibers.
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Pirtsul, Alexandra E., Rubtsova, Maria I., Mendgaziev, Rais I., Cherednichenko, Kirill A., Kruglov, Vladimir V., Komlev, Aleksei S., Lomova, Maria V., Vinokurov, Vladimir, and Voronin, Denis V.
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MICROFIBERS , *IRON oxide nanoparticles , *ELECTROMAGNETIC waves , *IRON oxides , *ENERGY storage , *CELLULOSE - Abstract
• Cellulose microfibers were modified with Fe 3 O 4 nanoparticles in a tunable way. • Adsorption of lauric acid onto Fe 3 O 4 -modified fibers leads to shape-stable PCM. • Magnetic PCM composites can store thermal energy under alternating magnetic field. • Magnetite nanoparticles improves light-to-thermal conversion of PCM composites. Fe 3 O 4 -modified cellulose microfibers containing 7, 16, and 31 wt% of magnetite were prepared via co-precipitation of Fe2+ and Fe3+ salts. The magnetic phase-change composites were synthesized by adsorption of lauric acid onto the modified fibers with the highest saturation magnetization (23 emu/g) and magnetic-to-thermal conversion. The resulted composites demonstrated the saturation magnetization of 11.2 emu/g and latent heat storage capacity of 90 J/g corresponding to the loading efficiency of lauric acid of 49–51 wt%. The IR-imaging revealed the efficient accumulation of latent heat in the phase-change composite under the simulated sunlight and high frequency alternating magnetic field along with the excellent shape stability of the composites during the melting of lauric acid. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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16. Ag-Modified microfibrillar cellulose as support in composite phase change materials with enhanced thermal transfer properties.
- Author
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Pirtsul, Alexandra E., Krainov, Alexey, Rubtsova, Maria I., Mendgaziev, Rais I., Cherednichenko, Kirill A., Vinokurov, Vladimir, and Voronin, Denis V.
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STEARIC acid , *HEAT transfer , *CELLULOSE fibers , *THERMAL properties , *PHASE change materials , *CELLULOSE , *HEAT storage , *THERMOGRAPHY - Abstract
• MFC was modified with Ag nanoparticles with a mass content of 13% • Adsorption of SA onto AgMFC fibers results in shape stable PCM composites. • Ag nanoparticles do not affect the phase transitions of SA on the fiber surface. • SA/AgMFC composites have improved heating and cooling rate comparing to SA/MFC ones. • The improved heat transfer in SA/AgMFC composites reduces their thermal stability. Composite phase change material was prepared via adsorption of stearic acid onto cellulose microfibrils modified with Ag nanoparticles. The latent heat storage capacity, cycling performance, thermal stability, and heating/cooling rate of the composites were studied with differential scanning calorimetry, thermogravimetric analysis, and thermal imaging and compared to those of the composite prepared by adsorption of stearic acid onto pure microfibrillar cellulose. The modification of cellulose with Ag nanoparticles improves the heating and cooling rate of the composites and promotes latent heat release during the solidification of stearic acid on the fiber surface. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
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