371 results on '"Vijg, Jan"'
Search Results
2. Concurrent analysis of genome and transcriptome in one single cell
3. Polygenic prediction of human longevity on the supposition of pervasive pleiotropy
4. Measuring cell-to-cell expression variability in single-cell RNA-sequencing data: a comparative analysis and applications to B cell aging
5. Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation
6. Mitigating age-related somatic mutation burden
7. Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking
8. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
9. Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation
10. From DNA damage to mutations: All roads lead to aging
11. A workflow for simultaneous DNA copy number and methylome analysis of inner cell mass and trophectoderm cells from human blastocysts
12. Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span
13. Rare genetic coding variants associated with human longevity and protection against age-related diseases
14. Somatic mutations in aging and disease.
15. Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging
16. Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
17. Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways
18. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species
19. Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities
20. Aging and Genome Maintenance: Lessons from the Mouse?
21. Genome instability and aging: Cause or effect?
22. Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation
23. Clonally Expanded mtDNA Point Mutations are Abundant in Individual Cells of Human Tissues
24. Analyzing somatic mutations by single-cell whole-genome sequencing.
25. Distinct Spectra of Somatic Mutations Accumulated with Age in Mouse Heart and Small Intestine
26. Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain
27. Do DNA Double-Strand Breaks Drive Aging?
28. A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses
29. Chromosome instability and aneuploidy in the mammalian brain.
30. High-throughput sequencing in mutation detection: A new generation of genotoxicity tests?
31. Single-cell transcriptogenomics reveals transcriptional exclusion of ENU-mutated alleles
32. Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo
33. Somatic mutations, genome mosaicism, cancer and aging
34. INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform
35. Bleomycin-induced genome structural variations in normal, non-tumor cells
36. Accurate identification of single-nucleotide variants in whole-genome-amplified single cells
37. Direct mutation analysis by high-throughput sequencing: From germline to low-abundant, somatic variants
38. Chromosomal aneuploidy in the aging brain
39. Genetic evidence for common pathways in human age-related diseases
40. Single-cell, locus-specific bisulfite sequencing (SLBS) for direct detection of epimutations in DNA methylation patterns
41. Interventions to Slow Aging in Humans: Are We Ready?
42. Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human
43. Genome instability, cancer and aging
44. Mitochondrial DNA mutations and aging: devils in the details?
45. Editorial: Somatic mutations, genome mosaicism and aging.
46. Two-Dimensional DNA Fingerprinting of Human Individuals
47. Efficient Rescue of Integrated Shuttle Vectors from Transgenic Mice: A Model for Studying Mutations in vivo
48. Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues
49. The role of DNA damage and repair in aging: New approaches to an old problem
50. Whole genome sequencing of glioblastoma multiforme identifies multiple structural variations involved in EGFR activation
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