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5. Searches for new physics below twice the electron mass with GERDA

Author

Agostini, M., Alexander, A., Araujo, G., Bakalyarov, A. M., Balata, M., Barabanov, I., Baudis, L., Bauer, C., Belogurov, S., Bettini, A., Bezrukov, L., Biancacci, V., Bossio, E., Bothe, V., Brugnera, R., Caldwell, A., Calgaro, S., Cattadori, C., Chernogorov, A., Chiu, P.-J., Comellato, T., D’Andrea, V., Demidova, E. V., Marco, N. Di, Doroshkevich, E., Fomina, M., Gangapshev, A., Garfagnini, A., Gooch, C., Grabmayr, P., Gurentsov, V., Gusev, K., Hakenmüller, J., Hemmer, S., Hofmann, W., Huang, J., Hult, M., Inzhechik, L. V., Csáthy, J. Janicskó, Jochum, J., Junker, M., Kazalov, V., Kermaïdic, Y., Khushbakht, H., Kihm, T., Kilgus, K., Kirpichnikov, I. V., Klimenko, A., Knöpfle, K. T., Kochetov, O., Kornoukhov, V. N., Krause, P., Kuzminov, V. V., Laubenstein, M., Lindner, M., Lippi, I., Lubashevskiy, A., Lubsandorzhiev, B., Lutter, G., Macolino, C., Majorovits, B., Maneschg, W., Marshall, G., Misiaszek, M., Morella, M., Müller, Y., Nemchenok, I., Neuberger, M., Pandola, L., Pelczar, K., Pertoldi, L., Piseri, P., Pullia, A., Ransom, C., Rauscher, L., Redchuk, M., Riboldi, S., Rumyantseva, N., Sada, C., Sailer, S., Salamida, F., Schönert, S., Schreiner, J., Schütz, A-K., Schulz, O., Schwarz, M., Schwingenheuer, B., Selivanenko, O., Shevchik, E., Shirchenko, M., Shtembari, L., Simgen, H., Smolnikov, A., Stukov, D., Sullivan, S., Vasenko, A. A., Veresnikova, A., Vignoli, C., Sturm, K. von, Wester, T., Wiesinger, C., Wojcik, M., Yanovich, E., Zatschler, B., Zhitnikov, I., Zhukov, S. V., Zinatulina, D., Zschocke, A., Zuber, K., and Zuzel, G.

Published
2024
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6. Searches for new physics below twice the electron mass with GERDA

Author

GERDA Collaboration, M. Agostini, A. Alexander, G. Araujo, A. M. Bakalyarov, M. Balata, I. Barabanov, L. Baudis, C. Bauer, S. Belogurov, A. Bettini, L. Bezrukov, V. Biancacci, E. Bossio, V. Bothe, R. Brugnera, A. Caldwell, S. Calgaro, C. Cattadori, A. Chernogorov, P.-J. Chiu, T. Comellato, V. D’Andrea, E. V. Demidova, N. Di Marco, E. Doroshkevich, M. Fomina, A. Gangapshev, A. Garfagnini, C. Gooch, P. Grabmayr, V. Gurentsov, K. Gusev, J. Hakenmüller, S. Hemmer, W. Hofmann, J. Huang, M. Hult, L. V. Inzhechik, J. Janicskó Csáthy, J. Jochum, M. Junker, V. Kazalov, Y. Kermaïdic, H. Khushbakht, T. Kihm, K. Kilgus, I. V. Kirpichnikov, A. Klimenko, K. T. Knöpfle, O. Kochetov, V. N. Kornoukhov, P. Krause, V. V. Kuzminov, M. Laubenstein, M. Lindner, I. Lippi, A. Lubashevskiy, B. Lubsandorzhiev, G. Lutter, C. Macolino, B. Majorovits, W. Maneschg, G. Marshall, M. Misiaszek, M. Morella, Y. Müller, I. Nemchenok, M. Neuberger, L. Pandola, K. Pelczar, L. Pertoldi, P. Piseri, A. Pullia, C. Ransom, L. Rauscher, M. Redchuk, S. Riboldi, N. Rumyantseva, C. Sada, S. Sailer, F. Salamida, S. Schönert, J. Schreiner, A-K. Schütz, O. Schulz, M. Schwarz, B. Schwingenheuer, O. Selivanenko, E. Shevchik, M. Shirchenko, L. Shtembari, H. Simgen, A. Smolnikov, D. Stukov, S. Sullivan, A. A. Vasenko, A. Veresnikova, C. Vignoli, K. von Sturm, T. Wester, C. Wiesinger, M. Wojcik, E. Yanovich, B. Zatschler, I. Zhitnikov, S. V. Zhukov, D. Zinatulina, A. Zschocke, K. Zuber, and G. Zuzel

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A search for full energy depositions from bosonic keV-scale dark matter candidates of masses between 65 and 1021 keV has been performed with data collected during Phase II of the GERmanium Detector Array (Gerda) experiment. Our analysis includes direct dark matter absorption as well as dark Compton scattering. With a total exposure of 105.5 kg years, no evidence for a signal above the background has been observed. The resulting exclusion limits deduced with either Bayesian or Frequentist statistics are the most stringent direct constraints in the major part of the 140–1021 keV mass range. As an example, at a mass of 150 keV the dimensionless coupling of dark photons and axion-like particles to electrons has been constrained to $$\alpha '/\alpha 1.5 \times 10^{24}$$ τ n > 1.5 × 10 24 years and for a proton $$\tau _\textrm{p} > 1.3 \times 10^{24}$$ τ p > 1.3 × 10 24 years at 90% CI. For the electron decay $$e^\text {-} \rightarrow \nu _\textrm{e} \gamma $$ e - → ν e γ a lower limit of $$\tau _\textrm{e} > 5.4\times 10^{25}$$ τ e > 5.4 × 10 25 years at 90% CI has been determined.

Published
2024
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8. NOSSA COR: O ENCONTRO COM HUMANÆ E ANGÉLICA DASS

Author

Joana Lira, Lucia Vignoli, Milena Quattre, Marcelo Cucco, Juliana Cavassin, and Anna Martha Tuttman Diegues

Subjects
arte, cor, identidade, comunidade, educação com surdos., Special aspects of education, LC8-6691, Vocational rehabilitation. Employment of people with disabilities, HD7255-7256
Abstract

Apresenta-se um relato afetivo e visual sobre projetos artísticos realizados pelo Núcleo de Artes do Instituto Nacional de Educação de Surdos (INES) baseado, sobretudo, na experiência vivenciada com a artista Angélica Dass na instituição. Os resultados materiais foram: um vídeo com imagens do processo, no qual a letra da música Nossa cor, na edição, traz mais uma camada de significado; a pintura de um mural no pátio do INES e a confecção coletiva de um painel de autorretratos dos alunos. Além da materialidade, a experiência possibilitou a vivência de uma pedagogia da autonomia, refletindo e transformando os agentes envolvidos a partir da perspectiva dialógica, coletiva e de empoderamento identitário surdo e discussões acerca do racismo na busca de ações afirmativas para combatê-lo.

Published
2024
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10. What Teachers Tell Us about the Impact of the COVID-19 Pandemic on Public Education in Italy

Author

Decarli, Gisella, Surian, Luca, Vignoli, Michela, and Franchin, Laura

Abstract

The Coronavirus disease (COVID-19) state of emergency has brought about a radical change in the way of teaching. In a questionnaire, we asked 120 teachers from Italian Primary, Middle and High Schools about the advantages and disadvantages of online teaching, the students' conduct during lessons and the methodologies applied to students with special educational needs. Primary School teachers most strongly reported an increase in boredom and distraction, and disagreed that online teaching helps students' learning and that it makes them more active. The main advantage of online teaching was the technical and methodological innovations, while the main disadvantage was the lack of relationship with students. In the case of students with special educational needs, many teachers reported that they used simplified procedures and personalized meetings. Overall, teachers appear to think that online teaching has many drawbacks, though it also has some positive aspects that need to be appreciated and exploited.

Published
2022

11. Expanding the Frontiers of Innovation

Author

Matteo Vignoli and Jonathan Wareham

Subjects
CIJ, CERN IdeaSquare, editorial, Technology (General), T1-995, Technological innovations. Automation, HD45-45.2
Abstract

The papers in this issue offer novel insights and tools to recraft and extend innovation beyond its traditional domains to focus on complex global challenges, driving innovation frontiers toward transformative and impactful outcomes. In an era where economic growth, societal progress and social equity are focal for policy makers, this issue explores the power of structure and experimentation to surface the complexities of university and industry collaboration.

Published
2024
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12. Reiterated male-to-female violence disrupts hippocampal estrogen receptor β expression, prompting anxiety-like behavior

Author

Jacopo Agrimi, Lucia Bernardele, Naeem Sbaiti, Marco Brondi, Donato D’Angelo, Marta Canato, Ivan Marchionni, Christian U. Oeing, Giussy Barbara, Beatrice Vignoli, Marco Canossa, Nina Kaludercic, Gaya Spolverato, Anna Raffaello, Claudia Lodovichi, Marco Dal Maschio, and Nazareno Paolocci

Subjects
Neuroscience, Behavioral neuroscience, Molecular neuroscience, Science
Abstract

Summary: Intimate partner violence (IPV) is a significant public health concern whose neurological/behavioral sequelae remain to be mechanistically explained. Using a mouse model recapitulating an IPV scenario, we evaluated the female brain neuroendocrine alterations produced by a reiterated male-to-female violent interaction (RMFVI). RMFVI prompted anxiety-like behavior in female mice whose hippocampus displayed a marked neuronal loss and hampered neurogenesis, namely reduced BrdU-DCX-positive nuclei and diminished dendritic arborization in the dentate gyrus (DG): effects paralleled by a substantial downregulation of the estrogen receptor β (ERβ). After RMFVI, the DG harbored reduced brain-derived neurotrophic factor (BDNF) pools and tyrosine kinase receptor B (TrkB) phosphorylation. Accordingly, ERβ knockout (KO) mice had heightened anxiety and curtailed BDNF levels at baseline while dying prematurely during the RMFVI procedure. Strikingly, injecting an ERβ antagonist or agonist into the wild-type (WT) female hippocampus enhanced or reduced anxiety, respectively. Thus, reiterated male-to-female violence jeopardizes hippocampal homeostasis, perturbing the ERβ/BDNF axis and ultimately instigating anxiety and chronic stress.

Published
2024
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15. Myoclonus: Differential diagnosis and current management

Author

Antonella Riva, Gianluca D'Onofrio, Edoardo Ferlazzo, Angelo Pascarella, Elena Pasini, Silvana Franceschetti, Ferruccio Panzica, Laura Canafoglia, Aglaia Vignoli, Antonietta Coppola, Valeria Badioni, Francesca Beccaria, Angelo Labate, Antonio Gambardella, Antonino Romeo, Giuseppe Capovilla, Roberto Michelucci, Pasquale Striano, and Vincenzo Belcastro

Subjects
electroclinical features, epilepsy, myoclonus, neurophysiology, nosology, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Myoclonus classically presents as a brief (10–50 ms duration), non‐rhythmic jerk movement. The etiology could vary considerably ranging from self‐limited to chronic or even progressive disorders, the latter falling into encephalopathic pictures that need a prompt diagnosis. Beyond the etiological classification, others evaluate myoclonus' body distribution (i.e., clinical classification) or the location of the generator (i.e., neurophysiological classification); particularly, knowing the anatomical source of myoclonus gives inputs on the observable clinical patterns, such as EMG bursts duration or EEG correlate, and guides the therapeutic choices. Among all the chronic disorders, myoclonus often presents itself as a manifestation of epilepsy. In this context, myoclonus has many facets. Myoclonus occurs as one, or the only, seizure manifestation while it can also present as a peculiar type of movement disorder; moreover, its electroclinical features within specific genetically determined epileptic syndromes have seldom been investigated. In this review, following a meeting of recognized experts, we provide an up‐to‐date overview of the neurophysiology and nosology surrounding myoclonus. Through the dedicated exploration of epileptic syndromes, coupled with pragmatic guidance, we aim to furnish clinicians and researchers alike with practical advice for heightened diagnostic management and refined treatment strategies. Plain Language Summary In this work, we described myoclonus, a movement characterized by brief, shock‐like jerks. Myoclonus could be present in different diseases and its correct diagnosis helps treatment.

Published
2024
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16. Gut microbiota profile in CDKL5 deficiency disorder patients

Author

Elisa Borghi, Ornella Xynomilakis, Emerenziana Ottaviano, Camilla Ceccarani, Ilaria Viganò, Paola Tognini, and Aglaia Vignoli

Subjects
CDKL5 deficiency disorder, Gastrointestinal disturbances, Gut microbiota, Gut-brain-axis, Medicine, Science
Abstract

Abstract CDKL5 deficiency disorder (CDD) is a neurodevelopmental condition characterized by global developmental delay, early-onset seizures, intellectual disability, visual and motor impairments. Unlike Rett Syndrome (RTT), CDD lacks a clear regression period. Patients with CDD frequently encounter gastrointestinal (GI) disturbances and exhibit signs of subclinical immune dysregulation. However, the underlying causes of these conditions remain elusive. Emerging studies indicate a potential connection between neurological disorders and gut microbiota, an area completely unexplored in CDD. We conducted a pioneering study, analyzing fecal microbiota composition in individuals with CDD (n = 17) and their healthy relatives (n = 17). Notably, differences in intestinal bacterial diversity and composition were identified in CDD patients. In particular, at genus level, CDD microbial communities were characterized by an increase in the relative abundance of Clostridium_AQ, Eggerthella, Streptococcus, and Erysipelatoclostridium, and by a decrease in Eubacterium, Dorea, Odoribacter, Intestinomonas, and Gemmiger, pointing toward a dysbiotic profile. We further investigated microbiota changes based on the severity of GI issues, seizure frequency, sleep disorders, food intake type, impairment in neuro-behavioral features and ambulation capacity. Enrichment in Lachnoclostridium and Enterobacteriaceae was observed in the microbiota of patients with more severe GI symptoms, while Clostridiaceae, Peptostreptococcaceae, Coriobacteriaceae, Erysipelotrichaceae, Christensenellaceae, and Ruminococcaceae were enriched in patients experiencing daily epileptic seizures. Our findings suggest a potential connection between CDD, microbiota and symptom severity. This study marks the first exploration of the gut-microbiota-brain axis in subjects with CDD. It adds to the growing body of research emphasizing the role of the gut microbiota in neurodevelopmental disorders and opens doors to potential interventions that target intestinal microbes with the aim of improving the lives of patients with CDD.

Published
2024
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17. Practical Use of Upadacitinib in Patients with Severe Atopic Dermatitis in a Real-World Setting: A Systematic Review

Author

Ibba L, Gargiulo L, Vignoli CA, Fiorillo G, Valenti M, Costanzo A, and Narcisi A

Subjects
jaki, real-life, upadacitinib, atopic dermatitis, systematic review, Dermatology, RL1-803
Abstract

Luciano Ibba,1,2 Luigi Gargiulo,1,2 Carlo Alberto Vignoli,1,2 Giovanni Fiorillo,1,2 Mario Valenti,1,2 Antonio Costanzo,1,2 Alessandra Narcisi1 1Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy; 2Department of Biomedical Sciences, Humanitas University, Milan, ItalyCorrespondence: Luciano Ibba, Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, 20089, Italy, Email luciano.ibba@humanitas.itAbstract: Upadacitinib is a selective Janus kinase inhibitor approved for the treatment of severe atopic dermatitis (AD). This systematic review aims to summarize the most recent data in terms of effectiveness and safety of upadacitinib in the treatment of severe AD in a real-world setting. The review included a comprehensive search of databases, including PubMed, Google Scholar and Web of Science, according to Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. The literature search initially identified 242 studies. Of these, 214 were excluded after reviewing their titles and abstracts. We then conducted a full-text review of 25 studies, of which 17 met our inclusion criteria and were therefore included in our systematic review. The analysis of real-world studies showed high effectiveness of upadacitinib, in terms of both clinical signs and subjective symptoms, in different patient populations, including those resistant to other treatments. No new significant safety concerns have emerged as compared to randomized clinical trials.Keywords: JAKi, real-life, upadacitinib, atopic dermatitis, systematic review

Published
2024

18. Structural brain abnormalities in Pallister-Killian syndrome: a neuroimaging study of 31 children

Author

Anna Fetta, Francesco Toni, Ilaria Pettenuzzo, Emilia Ricci, Alessandro Rocca, Caterina Gambi, Luca Soliani, Veronica Di Pisa, Silvia Martini, Giacomo Sperti, Valeria Cagnazzo, Patrizia Accorsi, Emanuele Bartolini, Domenica Battaglia, Pia Bernardo, Maria Paola Canevini, Anna Rita Ferrari, Lucio Giordano, Chiara Locatelli, Margherita Mancardi, Alessandro Orsini, Tommaso Pippucci, Dario Pruna, Anna Rosati, Agnese Suppiej, Sara Tagliani, Alessandro Vaisfeld, Aglaia Vignoli, Kosuke Izumi, Ian Krantz, and Duccio Maria Cordelli

Subjects
Medicine
Abstract

Abstract Background Pallister-Killian syndrome (PKS) is a rare genetic disorder caused by mosaic tetrasomy of 12p with wide neurological involvement. Intellectual disability, developmental delay, behavioral problems, epilepsy, sleep disturbances, and brain malformations have been described in most individuals, with a broad phenotypic spectrum. This observational study, conducted through brain MRI scan analysis on a cohort of patients with genetically confirmed PKS, aims to systematically investigate the neuroradiological features of this syndrome and identify the possible existence of a typical pattern. Moreover, a literature review differentiating the different types of neuroimaging data was conducted for comparison with our population. Results Thirty-one individuals were enrolled (17 females/14 males; age range 0.1–17.5 years old at first MRI). An experienced pediatric neuroradiologist reviewed brain MRIs, blindly to clinical data. Brain abnormalities were observed in all but one individual (compared to the 34% frequency found in the literature review). Corpus callosum abnormalities were found in 20/30 (67%) patients: 6 had callosal hypoplasia; 8 had global hypoplasia with hypoplastic splenium; 4 had only hypoplastic splenium; and 2 had a thin corpus callosum. Cerebral hypoplasia/atrophy was found in 23/31 (74%) and ventriculomegaly in 20/31 (65%). Other frequent features were the enlargement of the cisterna magna in 15/30 (50%) and polymicrogyria in 14/29 (48%). Conversely, the frequency of the latter was found to be 4% from the literature review. Notably, in our population, polymicrogyria was in the perisylvian area in all 14 cases, and it was bilateral in 10/14. Conclusions Brain abnormalities are very common in PKS and occur much more frequently than previously reported. Bilateral perisylvian polymicrogyria was a main aspect of our population. Our findings provide an additional tool for early diagnosis.Further studies to investigate the possible correlations with both genotype and phenotype may help to define the etiopathogenesis of the neurologic phenotype of this syndrome.

Published
2024
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20. 24-h continuous non-invasive multiparameter home monitoring of vitals in patients with Rett syndrome by an innovative wearable technology: evidence of an overlooked chronic fatigue status

Author

Silvia Leoncini, Lidia Boasiako, Sofia Di Lucia, Amir Beker, Valeria Scandurra, Aglaia Vignoli, Maria Paola Canevini, Giulia Prato, Lino Nobili, Antonio Gennaro Nicotera, Gabriella Di Rosa, Maria Beatrice Testa Chiarini, Renato Cutrera, Salvatore Grosso, Giacomo Lazzeri, Enrico Tongiorgi, Pasquale Morano, Matteo Botteghi, Alessandro Barducci, and Claudio De Felice

Subjects
Rett syndrome, cardiorespiratory monitoring, wearable devices, sleep–wake cycle, exercise fatigue, Neurology. Diseases of the nervous system, RC346-429
Abstract

BackgroundSleep is disturbed in Rett syndrome (RTT), a rare and progressive neurodevelopmental disorder primarily affecting female patients (prevalence 7.1/100,000 female patients) linked to pathogenic variations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene. Autonomic nervous system dysfunction with a predominance of the sympathetic nervous system (SNS) over the parasympathetic nervous system (PSNS) is reported in RTT, along with exercise fatigue and increased sudden death risk. The aim of the present study was to test the feasibility of a continuous 24 h non-invasive home monitoring of the biological vitals (biovitals) by an innovative wearable sensor device in pediatric and adolescent/adult RTT patients.MethodsA total of 10 female patients (mean age 18.3 ± 9.4 years, range 4.7–35.5 years) with typical RTT and MECP2 pathogenic variations were enrolled. Clinical severity was assessed by validated scales. Heart rate (HR), respiratory rate (RR), and skin temperature (SkT) were monitored by the YouCare Wearable Medical Device (Accyourate Group SpA, L’Aquila, Italy). The average percentage of maximum HR (HRmax%) was calculated. Heart rate variability (HRV) was expressed by consolidated time-domain and frequency-domain parameters. The HR/LF (low frequency) ratio, indicating SNS activation under dynamic exercise, was calculated. Simultaneous continuous measurement of indoor air quality variables was performed and the patients’ contributions to the surrounding water vapor partial pressure [PH2O (pt)] and carbon dioxide [PCO2 (pt)] were indirectly estimated.ResultsOf the 6,559.79 h of biovital recordings, 5051.03 h (77%) were valid for data interpretation. Sleep and wake hours were 9.0 ± 1.1 h and 14.9 ± 1.1 h, respectively. HRmax % [median: 71.86% (interquartile range 61.03–82%)] and HR/LF [median: 3.75 (interquartile range 3.19–5.05)] were elevated, independent from the wake–sleep cycle. The majority of HRV time- and frequency-domain parameters were significantly higher in the pediatric patients (p ≤ 0.031). The HRV HR/LF ratio was associated with phenotype severity, disease progression, clinical sleep disorder, subclinical hypoxia, and electroencephalographic observations of multifocal epileptic activity and general background slowing.ConclusionOur findings indicate the feasibility of a continuous 24-h non-invasive home monitoring of biovital parameters in RTT. Moreover, for the first time, HRmax% and the HR/LF ratio were identified as potential objective markers of fatigue, illness severity, and disease progression.

Published
2024
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21. Simulation and background characterisation of the SABRE South experiment

Author

Barberio, E., Baroncelli, T., Bignell, L. J., Bolognino, I., Brooks, G., Dastgiri, F., D'Imperio, G., Di Giacinto, A., Duffy, A. R., Froehlich, M., Fu, G., Gerathy, M. S. M., Hill, G. C., Krishnan, S., Lane, G. J., Lawrence, G., Leaver, K. T., Mahmood, I., Mariani, A., McGee, P., McKie, L. J., McNamara, P. C., Mews, M., Melbourne, W. J. D., Milana, G., Milligan, L. J., Mould, J., Nuti, F., Pettinacci, V., Scutti, F., Slavkovská, Z., Spinks, N. J., Stanley, O., Stuchbery, A. E., Taylor, G. N., Tomei, C., Urquijo, P., Vignoli, C., Williams, A. G., Zhong, Y. Y., and Zurowski, M. J.

Subjects
Physics - Instrumentation and Detectors
Abstract

SABRE (Sodium iodide with Active Background REjection) is a direct detection dark matter experiment based on arrays of radio-pure NaI(Tl) crystals. The experiment aims at achieving an ultra-low background rate and its primary goal is to confirm or refute the results from the DAMA/LIBRA experiment. The SABRE Proof-of-Principle phase was carried out in 2020-2021 at the Gran Sasso National Laboratory (LNGS), in Italy. The next phase consists of two full-scale experiments: SABRE South at the Stawell Underground Physics Laboratory, in Australia, and SABRE North at LNGS. This paper focuses on SABRE South and presents a detailed simulation of the detector, which is used to characterise the background for dark matter searches including DAMA/LIBRA-like modulation. We estimate an overall background of 0.72 cpd/kg/keV$_{ee}$ in the energy range 1$-$6 keV$_{ee}$ primarily due to radioactive contamination in the crystals. Given this level of background and considering that the SABRE South has a target mass of 50 kg, we expect to exclude (confirm) DAMA/LIBRA modulation at $4~(5)\sigma$ within 2.5 years of data taking.

Published
2022
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22. Percurso formativo: uma proposta de formação continuada e colaborativa em culturas disciplinares

Author

Marlene Aparecida Ferrarini-Bigareli, Jacqueline Sanches Vignoli, and Márcia Adriana Dias Kraemer

Subjects
letramentos acadêmico-científicos, percurso formativo, culturas disciplinares, Romanic languages, PC1-5498, Philology. Linguistics, P1-1091
Abstract

Este ensaio apresenta um estudo do Percurso Formativo (PFor) inserido nas ações do Laboratório Integrado de Letramentos Acadêmico-Científicos – LILA e do Grupo de Pesquisa Linguagem e Educação – LED. Objetiva-se apresentar e explicar o construto teórico dos letramentos acadêmico-científicos nas culturas disciplinares de Ciências Biológicas, Ciências Contábeis e Economia, no intuito de compreender como o PFor é delineado no âmbito dessas e de outras áreas afins. O estudo justifica-se por ser uma temática relevante nas atuais investigações acerca de leitura, escrita e produção oral como práticas sociais situadas. Trata-se de uma investigação teórico-prática, com caráter qualitativo-interpretativista e fins explicativos. A geração de dados acontece por meio de revisão bibliográfica e de acervo documental. O método de abordagem é dialético, de cunho histórico, comparativo e monográfico, por se tratar de um estudo de caso. Os resultados alcançados apontam para o PFor como uma formação continuada que margeia a Sequência de Formação (Francescon; Cristovão; Tognato, 2018), expandindo as suas possibilidades, por ser espaço de colaboração ativa dos participantes e flexível para (re)adequar o processo com a inserção de temáticas, ferramentas e conceitos, conforme o surgimento de novas demandas. Espera-se que esta reflexão contribua para melhor compreender a natureza constitutiva do PFor, na perspectiva do LILA, auxiliando futuras ações em prol dos letramentos acadêmico-científicos.

Published
2023
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23. In vitro effectiveness of ceftazidime-avibactam in combination with aztreonam on carbapenemase-producing Enterobacterales

Author

Papa-Ezdra Romina, Araújo Lucía, Caiata Leticia, Ferreira Federica, Ávila Pablo, Seija Verónica, Galiana Antonio, Bado Inés, and Vignoli Rafael

Subjects
Carbapenemase, Aztreonam, Ceftazidime-avibactam, Synergy, Ceftazidime, Microbiology, QR1-502
Abstract

Objective: This work aimed to describe the in vitro performance of the combined activity of ceftazidime-avibactam (CZA) plus aztreonam (ATM) against carbapenemase-producing Enterobacterales (CPE). Methods: We studied 44 CPE clinical isolates: NDM-1 (31), KPC-2 (5), KPC-3 (3), VIM-2 (2), NDM-1+KPC-2 (2), and OXA-48 (1). The efficacy of CZA in combination with were determined by two methods: (i) Kirby-Bauer's double disk synergy test and; (ii) Determination of the minimum inhibitory concentration to CZA by E-test, in either Mueller-Hinton agar alone or, supplemented with ATM 4 mg/L. Additionally, the Fractional inhibitory concentration index (FICI) was determined; values of ≤ 0.5 were interpreted as synergistic, while FICI > 0.5 were considered indifferent. Results: All isolates were carbapenem-resistant, 14 were resistant to CZA and ATM, 15 were only CZA resistant, 12 were only ATM resistant, and three were susceptible to both. 34/44 isolates presented positive double disk synergy tests between CZA and ATM regardless of their susceptibility profile, the isolates with negative synergy tests were susceptible to at least one of the agents. On the other hand, the 21 isolates selected to compare the MIC to CZA alone and CZA plus 4 mg/L ATM of exhibited FICI values between 0.016 and 0.125, indicating a synergistic effect. Conclusions: This method is available to clinical laboratories and would provide valuable information to guide the treatment of infections with CZA and ATM. In this sense, the use of CZA together with ATM is a potentially suitable combination for the treatment of carbapenemase-producing microorganisms.

Published
2023
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24. B-Flow and Contrast-Enhanced Ultrasound (CEUS) Features of Subcutaneous Masses and Nodular Lesions in Dogs

Author

Andrea De Bonis, Francesco Simeoni, Andrea Paolini, Martina Rosto, Francesca Del Signore, Laura Bongiovanni, Amanda Bianchi, Roberto Tamburro, and Massimo Vignoli

Subjects
subcutaneous 1, B-flow 2, CEUS 3, Veterinary medicine, SF600-1100
Abstract

Subcutaneous lesions in dogs are common in clinical practice. This prospective clinical study aims to compare B-flow and CEUS for the characterization of subcutaneous lesions evaluating their usefulness to distinguish benign subcutaneous lesions from malignant ones. Dogs were enrolled and ultrasound cine-loops were achieved in B-mode, Colour Doppler, Power Doppler, B-flow and CEUS. Lesions vascularisation highlighted through B-flow and CEUS were classified into five patterns: P1, absence of contrast uptake; P2, enhancement only in the peripheral area of the lesion; P3, thin (2 mm) and more numerous vessels (>5/field); P5 enhancement with a reticular aspect and both thick and thin bands inside. Patterns highlighted with B-flow and CEUS were compared to a histological diagnosis of subcutaneous lesions. A total of 24 dogs and 30 subcutaneous nodules were included and divided into three groups: 3 non-neoplastic, 16 benign tumours and 11 malignant tumours. There was a statistically significant difference for B-flow and CEUS to differentiate benign tumours from malignant tumours. B-flow and CEUS had an excellent agreement. B-flow and CEUS displayed similar ability to evaluate different patterns and could be helpful in the evaluation of subcutaneous nodules.

Published
2024
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25. Strain Elastography Evaluation of Patellar Tendons in Dogs after TPLO/TTA for Cranial Cruciate Ligament Rupture, Qualitative and Semiquantitative Evaluation Compared with Healthy Subjects

Author

Francesca Del Signore, Stefania De Dominicis, Camilla Smoglica, Martina Rosto, Andrea De Bonis, Andrea Paolini, and Massimo Vignoli

Subjects
patellar tendon, dog, TPLO, TTA, strain elastography, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

Strain elastography (SE) evaluates tissue stiffness, providing qualitative and semiquantitative evaluation, with a strain ratio (SR) > 1 indicating that the target lesion is stiffer than the reference tissue. The patellar tendon has been described as soft in healthy dogs and hard in dogs with cranial cruciate ligament rupture, but SR usefulness has not been assessed. Dogs were divided into healthy (G1) and at least 1 month after surgery (G2) groups. Thickness was recorded, and a B-mode score of 0–3 was determined based on the abnormality’s severity. SE was qualitatively performed with a score of 1–4, and EI was recorded on the whole ligament and in proximal, intermediate and distal areas; SR was collected with the fat pad and cutis/subcutis. G1 was significantly thinner, with a lower score than G2 and a more elastic pattern. EI for G1 was significantly lower than G2 for the whole tendon and the single portions, and EI for the distal portion was significantly lower than the proximal and intermediate one in G2. SR was 1 in G2 for both the fat pad and cutis/subcutis. These data suggest that after surgery, the tendon may become non-uniformly stiffer. The cutis/subcutis appears to be a more reliable reference tissue than the infrapatellar fat pad.

Published
2024
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26. Lookism, a Leak in the Career Pipeline? Career Perspective Consequences of Lookism Climate and Workplace Incivility

Author

Miren Chenevert, Cristian Balducci, and Michela Vignoli

Subjects
lookism climate, workplace incivility, imposter syndrome, perceived employability, leaky pipeline, Psychology, BF1-990
Abstract

Despite strides toward gender equality in the workforce, women continue to face significant challenges, including the “glass ceiling” and the “leaky pipeline”, partially stemming from low occupational self-confidence. This study examined whether a climate of lookism leads to workplace mistreatment, undermining employees’ perceptions of job competence and career potential, with a focus on gender differences. Using a cross-sectional design, data from 699 Italian workers (42.8% male, 56.3% female) were analyzed through multi-group structural equation modeling. The model explored relationships between lookism climate, workplace incivility, imposter syndrome, and perceived employability. The results revealed a full serial mediation for women; lookism climate was positively related to workplace incivility, which in turn was related to imposter syndrome, negatively impacting perceived employability. For men, no serial mediation was found; lookism climate was directly related to both incivility and imposter syndrome, with no significant relationship between the two. Like women, men experienced a negative relationship between imposter syndrome and perceived employability, yet this relationship was stronger for men. This study highlights that identifying and addressing workplace climates that foster subtle mistreatment can prevent larger issues like the leaky pipeline, suggesting targeted organizational-level intervention and prevention strategies can enhance job competence perceptions and career potential for both genders.

Published
2024
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27. Multi-Junction Solar Module and Supercapacitor Self-Powering Miniaturized Environmental Wireless Sensor Nodes

Author

Mara Bruzzi, Giovanni Pampaloni, Irene Cappelli, Ada Fort, Maurizio Laschi, Valerio Vignoli, and Dario Vangi

Subjects
multi-junction photovoltaic module, supercapacitors, wireless sensor nodes, CO2 sensors, self-powered sensors, environmental gas monitoring, Chemical technology, TP1-1185
Abstract

A novel prototype based on the combination of a multi-junction, high-efficiency photovoltaic (PV) module and a supercapacitor (SC) able to self-power a wireless sensor node (WSN) for outdoor air quality monitoring has been developed and tested. A PV module with about an 8 cm2 active area made of eight GaAs-based triple-junction solar cells with a nominal 29% efficiency was assembled and characterized under terrestrial clear-sky conditions. Energy is stored in a 4000 F/4.2 V supercapacitor with high energy capacity and a virtually infinite lifetime (104 cycles). The node power consumption was tailored to the typical power consumption of miniaturized, low-consumption NDIR CO2 sensors relying on an LED as the IR source. The charge/discharge cycles of the supercapacitor connected to the triple-junction PV module were measured under illumination with a Sun Simulator device at selected radiation intensities and different node duty cycles. Tests of the miniaturized prototype in different illumination conditions outdoors were carried out. A model was developed from the test outcomes to predict the maximum number of sensor samplings and data transmissions tolerated by the node, thus optimizing the WSN operating conditions to ensure its self-powering for years of outdoor deployment. The results show the self-powering ability of the WSN node over different insolation periods throughout the year, demonstrating its operation for a virtually unlimited lifetime without the need for battery substitution.

Published
2024
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28. Performance of a Modular Ton-Scale Pixel-Readout Liquid Argon Time Projection Chamber

Author

A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, B. Aimard, F. Akbar, K. Allison, S. Alonso Monsalve, M. Alrashed, A. Alton, R. Alvarez, T. Alves, H. Amar, P. Amedo, J. Anderson, D. A. Andrade, C. Andreopoulos, M. Andreotti, M. P. Andrews, F. Andrianala, S. Andringa, N. Anfimov, A. Ankowski, M. Antoniassi, M. Antonova, A. Antoshkin, A. Aranda-Fernandez, L. Arellano, E. Arrieta Diaz, M. A. Arroyave, J. Asaadi, A. Ashkenazi, D. Asner, L. Asquith, E. Atkin, D. Auguste, A. Aurisano, V. Aushev, D. Autiero, F. Azfar, A. Back, H. Back, J. J. Back, I. Bagaturia, L. Bagby, N. Balashov, S. Balasubramanian, P. Baldi, W. Baldini, J. Baldonedo, B. Baller, B. Bambah, R. Banerjee, F. Barao, G. Barenboim, P. B̃arham Alzás, G. J. Barker, W. Barkhouse, G. Barr, J. Barranco Monarca, A. Barros, N. Barros, D. Barrow, J. L. Barrow, A. Basharina-Freshville, A. Bashyal, V. Basque, C. Batchelor, L. Bathe-Peters, J. B. R. Battat, F. Battisti, F. Bay, M. C. Q. Bazetto, J. L. L. Bazo Alba, J. F. Beacom, E. Bechetoille, B. Behera, E. Belchior, G. Bell, L. Bellantoni, G. Bellettini, V. Bellini, O. Beltramello, N. Benekos, C. Benitez Montiel, D. Benjamin, F. Bento Neves, J. Berger, S. Berkman, J. Bernal, P. Bernardini, A. Bersani, S. Bertolucci, M. Betancourt, A. Betancur Rodríguez, A. Bevan, Y. Bezawada, A. T. Bezerra, T. J. Bezerra, A. Bhat, V. Bhatnagar, J. Bhatt, M. Bhattacharjee, M. Bhattacharya, S. Bhuller, B. Bhuyan, S. Biagi, J. Bian, K. Biery, B. Bilki, M. Bishai, A. Bitadze, A. Blake, F. D. Blaszczyk, G. C. Blazey, E. Blucher, J. Bogenschuetz, J. Boissevain, S. Bolognesi, T. Bolton, L. Bomben, M. Bonesini, C. Bonilla-Diaz, F. Bonini, A. Booth, F. Boran, S. Bordoni, R. Borges Merlo, A. Borkum, N. Bostan, J. Bracinik, D. Braga, B. Brahma, D. Brailsford, F. Bramati, A. Branca, A. Brandt, J. Bremer, C. Brew, S. J. Brice, V. Brio, C. Brizzolari, C. Bromberg, J. Brooke, A. Bross, G. Brunetti, M. Brunetti, N. Buchanan, H. Budd, J. Buergi, D. Burgardt, S. Butchart, G. Caceres V., I. Cagnoli, T. Cai, R. Calabrese, J. Calcutt, M. Calin, L. Calivers, E. Calvo, A. Caminata, A. F. Camino, W. Campanelli, A. Campani, A. Campos Benitez, N. Canci, J. Capó, I. Caracas, D. Caratelli, D. Carber, J. M. Carceller, G. Carini, B. Carlus, M. F. Carneiro, P. Carniti, I. Caro Terrazas, H. Carranza, N. Carrara, L. Carroll, T. Carroll, A. Carter, E. Casarejos, D. Casazza, J. F. Castaño Forero, F. A. Castaño, A. Castillo, C. Castromonte, E. Catano-Mur, C. Cattadori, F. Cavalier, F. Cavanna, S. Centro, G. Cerati, C. Cerna, A. Cervelli, A. Cervera Villanueva, K. Chakraborty, S. Chakraborty, M. Chalifour, A. Chappell, N. Charitonidis, A. Chatterjee, H. Chen, M. Chen, W. C. Chen, Y. Chen, Z. Chen-Wishart, D. Cherdack, C. Chi, R. Chirco, N. Chitirasreemadam, K. Cho, S. Choate, D. Chokheli, P. S. Chong, B. Chowdhury, D. Christian, A. Chukanov, M. Chung, E. Church, M. F. Cicala, M. Cicerchia, V. Cicero, R. Ciolini, P. Clarke, G. Cline, T. E. Coan, A. G. Cocco, J. A. B. Coelho, A. Cohen, J. Collazo, J. Collot, E. Conley, J. M. Conrad, M. Convery, S. Copello, P. Cova, C. Cox, L. Cremaldi, L. Cremonesi, J. I. Crespo-Anadón, M. Crisler, E. Cristaldo, J. Crnkovic, G. Crone, R. Cross, A. Cudd, C. Cuesta, Y. Cui, F. Curciarello, D. Cussans, J. Dai, O. Dalager, R. Dallavalle, W. Dallaway, H. da Motta, Z. A. Dar, R. Darby, L. Da Silva Peres, Q. David, G. S. Davies, S. Davini, J. Dawson, R. De Aguiar, P. De Almeida, P. Debbins, I. De Bonis, M. P. Decowski, A. de Gouvêa, P. C. De Holanda, I. L. De Icaza Astiz, P. De Jong, P. Del Amo Sanchez, A. De la Torre, G. De Lauretis, A. Delbart, D. Delepine, M. Delgado, A. Dell’Acqua, G. Delle Monache, N. Delmonte, P. De Lurgio, R. Demario, G. De Matteis, J. R. T. de Mello Neto, D. M. DeMuth, S. Dennis, C. Densham, P. Denton, G. W. Deptuch, A. De Roeck, V. De Romeri, J. P. Detje, J. Devine, R. Dharmapalan, M. Dias, A. Diaz, J. S. Díaz, F. Díaz, F. Di Capua, A. Di Domenico, S. Di Domizio, S. Di Falco, L. Di Giulio, P. Ding, L. Di Noto, E. Diociaiuti, C. Distefano, R. Diurba, M. Diwan, Z. Djurcic, D. Doering, S. Dolan, F. Dolek, M. J. Dolinski, D. Domenici, L. Domine, S. Donati, Y. Donon, S. Doran, D. Douglas, T. A. Doyle, A. Dragone, F. Drielsma, L. Duarte, D. Duchesneau, K. Duffy, K. Dugas, P. Dunne, B. Dutta, H. Duyang, D. A. Dwyer, A. S. Dyshkant, S. Dytman, M. Eads, A. Earle, S. Edayath, D. Edmunds, J. Eisch, P. Englezos, A. Ereditato, T. Erjavec, C. O. Escobar, J. J. Evans, E. Ewart, A. C. Ezeribe, K. Fahey, L. Fajt, A. Falcone, M. Fani’, C. Farnese, S. Farrell, Y. Farzan, D. Fedoseev, J. Felix, Y. Feng, E. Fernandez-Martinez, G. Ferry, L. Fields, P. Filip, A. Filkins, F. Filthaut, R. Fine, G. Fiorillo, M. Fiorini, S. Fogarty, W. Foreman, J. Fowler, J. Franc, K. Francis, D. Franco, J. Franklin, J. Freeman, J. Fried, A. Friedland, S. Fuess, I. K. Furic, K. Furman, A. P. Furmanski, R. Gaba, A. Gabrielli, A. M. Gago, F. Galizzi, H. Gallagher, A. Gallas, N. Gallice, V. Galymov, E. Gamberini, T. Gamble, F. Ganacim, R. Gandhi, S. Ganguly, F. Gao, S. Gao, D. Garcia-Gamez, M. Á. García-Peris, F. Gardim, S. Gardiner, D. Gastler, A. Gauch, J. Gauvreau, P. Gauzzi, S. Gazzana, G. Ge, N. Geffroy, B. Gelli, S. Gent, L. Gerlach, Z. Ghorbani-Moghaddam, T. Giammaria, D. Gibin, I. Gil-Botella, S. Gilligan, A. Gioiosa, S. Giovannella, C. Girerd, A. K. Giri, C. Giugliano, V. Giusti, D. Gnani, O. Gogota, S. Gollapinni, K. Gollwitzer, R. A. Gomes, L. V. Gomez Bermeo, L. S. Gomez Fajardo, F. Gonnella, D. Gonzalez-Diaz, M. Gonzalez-Lopez, M. C. Goodman, S. Goswami, C. Gotti, J. Goudeau, E. Goudzovski, C. Grace, E. Gramellini, R. Gran, E. Granados, P. Granger, C. Grant, D. R. Gratieri, G. Grauso, P. Green, S. Greenberg, J. Greer, W. C. Griffith, F. T. Groetschla, K. Grzelak, L. Gu, W. Gu, V. Guarino, M. Guarise, R. Guenette, E. Guerard, M. Guerzoni, D. Guffanti, A. Guglielmi, B. Guo, Y. Guo, A. Gupta, V. Gupta, G. Gurung, D. Gutierrez, P. Guzowski, M. M. Guzzo, S. Gwon, A. Habig, H. Hadavand, L. Haegel, R. Haenni, L. Hagaman, A. Hahn, J. Haiston, J. Hakenmueller, T. Hamernik, P. Hamilton, J. Hancock, F. Happacher, D. A. Harris, J. Hartnell, T. Hartnett, J. Harton, T. Hasegawa, C. Hasnip, R. Hatcher, K. Hayrapetyan, J. Hays, E. Hazen, M. He, A. Heavey, K. M. Heeger, J. Heise, S. Henry, M. A. Hernandez Morquecho, K. Herner, V. Hewes, A. Higuera, C. Hilgenberg, S. J. Hillier, A. Himmel, E. Hinkle, L. R. Hirsch, J. Ho, J. Hoff, A. Holin, T. Holvey, E. Hoppe, S. Horiuchi, G. A. Horton-Smith, M. Hostert, T. Houdy, B. Howard, R. Howell, I. Hristova, M. S. Hronek, J. Huang, R. G. Huang, Z. Hulcher, M. Ibrahim, G. Iles, N. Ilic, A. M. Iliescu, R. Illingworth, G. Ingratta, A. Ioannisian, B. Irwin, L. Isenhower, M. Ismerio Oliveira, R. Itay, C. M. Jackson, V. Jain, E. James, W. Jang, B. Jargowsky, D. Jena, I. Jentz, X. Ji, C. Jiang, J. Jiang, L. Jiang, A. Jipa, F. R. Joaquim, W. Johnson, C. Jollet, B. Jones, R. Jones, D. José Fernández, N. Jovancevic, M. Judah, C. K. Jung, T. Junk, Y. Jwa, M. Kabirnezhad, A. C. Kaboth, I. Kadenko, I. Kakorin, A. Kalitkina, D. Kalra, M. Kandemir, D. M. Kaplan, G. Karagiorgi, G. Karaman, A. Karcher, Y. Karyotakis, S. Kasai, S. P. Kasetti, L. Kashur, I. Katsioulas, A. Kauther, N. Kazaryan, L. Ke, E. Kearns, P. T. Keener, K. J. Kelly, E. Kemp, O. Kemularia, Y. Kermaidic, W. Ketchum, S. H. Kettell, M. Khabibullin, N. Khan, A. Khvedelidze, D. Kim, J. Kim, M. Kim, B. King, B. Kirby, M. Kirby, A. Kish, J. Klein, J. Kleykamp, A. Klustova, T. Kobilarcik, L. Koch, K. Koehler, L. W. Koerner, D. H. Koh, L. Kolupaeva, D. Korablev, M. Kordosky, T. Kosc, U. Kose, V. A. Kostelecký, K. Kothekar, I. Kotler, M. Kovalcuk, V. Kozhukalov, W. Krah, R. Kralik, M. Kramer, L. Kreczko, F. Krennrich, I. Kreslo, T. Kroupova, S. Kubota, M. Kubu, Y. Kudenko, V. A. Kudryavtsev, G. Kufatty, S. Kuhlmann, J. Kumar, P. Kumar, S. Kumaran, P. Kunze, J. Kunzmann, R. Kuravi, N. Kurita, C. Kuruppu, V. Kus, T. Kutter, J. Kvasnicka, T. Labree, T. Lackey, A. Lambert, B. J. Land, C. E. Lane, N. Lane, K. Lang, T. Langford, M. Langstaff, F. Lanni, O. Lantwin, J. Larkin, P. Lasorak, D. Last, A. Laudrain, A. Laundrie, G. Laurenti, E. Lavaut, A. Lawrence, P. Laycock, I. Lazanu, M. Lazzaroni, T. Le, S. Leardini, J. Learned, T. LeCompte, C. Lee, V. Legin, G. Lehmann Miotto, R. Lehnert, M. A. Leigui de Oliveira, M. Leitner, D. Leon Silverio, L. M. Lepin, J.-Y. Li, S. W. Li, Y. Li, H. Liao, C. S. Lin, D. Lindebaum, S. Linden, R. A. Lineros, J. Ling, A. Lister, B. R. Littlejohn, H. Liu, J. Liu, Y. Liu, S. Lockwitz, M. Lokajicek, I. Lomidze, K. Long, T. V. Lopes, J. Lopez, I. López de Rego, N. López-March, T. Lord, J. M. LoSecco, W. C. Louis, A. Lozano Sanchez, X.-G. Lu, K. B. Luk, B. Lunday, X. Luo, E. Luppi, J. Maalmi, D. MacFarlane, A. A. Machado, P. Machado, C. T. Macias, J. R. Macier, M. MacMahon, A. Maddalena, A. Madera, P. Madigan, S. Magill, C. Magueur, K. Mahn, A. Maio, A. Major, K. Majumdar, M. Man, R. C. Mandujano, J. Maneira, S. Manly, A. Mann, K. Manolopoulos, M. Manrique Plata, S. Manthey Corchado, V. N. Manyam, M. Marchan, A. Marchionni, W. Marciano, D. Marfatia, C. Mariani, J. Maricic, F. Marinho, A. D. Marino, T. Markiewicz, F. Das Chagas Marques, C. Marquet, D. Marsden, M. Marshak, C. M. Marshall, J. Marshall, L. Martina, J. Martín-Albo, N. Martinez, D. A. Martinez Caicedo, F. Martínez López, P. Martínez Miravé, S. Martynenko, V. Mascagna, C. Massari, A. Mastbaum, F. Matichard, S. Matsuno, G. Matteucci, J. Matthews, C. Mauger, N. Mauri, K. Mavrokoridis, I. Mawby, R. Mazza, A. Mazzacane, T. McAskill, N. McConkey, K. S. McFarland, C. McGrew, A. McNab, L. Meazza, V. C. N. Meddage, B. Mehta, P. Mehta, P. Melas, O. Mena, H. Mendez, P. Mendez, D. P. Méndez, A. Menegolli, G. Meng, A. C. E. A. Mercuri, A. Meregaglia, M. D. Messier, S. Metallo, J. Metcalf, W. Metcalf, M. Mewes, H. Meyer, T. Miao, A. Miccoli, G. Michna, V. Mikola, R. Milincic, F. Miller, G. Miller, W. Miller, O. Mineev, A. Minotti, L. Miralles, O. G. Miranda, C. Mironov, S. Miryala, S. Miscetti, C. S. Mishra, S. R. Mishra, A. Mislivec, M. Mitchell, D. Mladenov, I. Mocioiu, A. Mogan, N. Moggi, R. Mohanta, T. A. Mohayai, N. Mokhov, J. Molina, L. Molina Bueno, E. Montagna, A. Montanari, C. Montanari, D. Montanari, D. Montanino, L. M. Montaño Zetina, M. Mooney, A. F. Moor, Z. Moore, D. Moreno, O. Moreno-Palacios, L. Morescalchi, D. Moretti, R. Moretti, C. Morris, C. Mossey, M. Mote, C. A. Moura, G. Mouster, W. Mu, L. Mualem, J. Mueller, M. Muether, F. Muheim, A. Muir, M. Mulhearn, D. Munford, L. J. Munteanu, H. Muramatsu, J. Muraz, M. Murphy, T. Murphy, J. Muse, A. Mytilinaki, J. Nachtman, Y. Nagai, S. Nagu, R. Nandakumar, D. Naples, S. Narita, A. Nath, A. Navrer-Agasson, N. Nayak, M. Nebot-Guinot, A. Nehm, J. K. Nelson, O. Neogi, J. Nesbit, M. Nessi, D. Newbold, M. Newcomer, R. Nichol, F. Nicolas-Arnaldos, A. Nikolica, J. Nikolov, E. Niner, K. Nishimura, A. Norman, A. Norrick, P. Novella, J. A. Nowak, M. Oberling, J. P. Ochoa-Ricoux, S. Oh, S. B. Oh, A. Olivier, A. Olshevskiy, T. Olson, Y. Onel, Y. Onishchuk, A. Oranday, M. Osbiston, J. A. Osorio Vélez, L. Otiniano Ormachea, J. Ott, L. Pagani, G. Palacio, O. Palamara, S. Palestini, J. M. Paley, M. Pallavicini, C. Palomares, S. Pan, P. Panda, W. Panduro Vazquez, E. Pantic, V. Paolone, V. Papadimitriou, R. Papaleo, A. Papanestis, D. Papoulias, S. Paramesvaran, A. Paris, S. Parke, E. Parozzi, S. Parsa, Z. Parsa, S. Parveen, M. Parvu, D. Pasciuto, S. Pascoli, L. Pasqualini, J. Pasternak, C. Patrick, L. Patrizii, R. B. Patterson, T. Patzak, A. Paudel, L. Paulucci, Z. Pavlovic, G. Pawloski, D. Payne, V. Pec, E. Pedreschi, S. J. M. Peeters, W. Pellico, A. Pena Perez, E. Pennacchio, A. Penzo, O. L. G. Peres, Y. F. Perez Gonzalez, L. Pérez-Molina, C. Pernas, J. Perry, D. Pershey, G. Pessina, G. Petrillo, C. Petta, R. Petti, M. Pfaff, V. Pia, L. Pickering, F. Pietropaolo, V. L. Pimentel, G. Pinaroli, J. Pinchault, K. Pitts, K. Plows, R. Plunkett, C. Pollack, T. Pollman, D. Polo-Toledo, F. Pompa, X. Pons, N. Poonthottathil, V. Popov, F. Poppi, J. Porter, M. Potekhin, R. Potenza, J. Pozimski, M. Pozzato, T. Prakash, C. Pratt, M. Prest, F. Psihas, D. Pugnere, X. Qian, J. L. Raaf, V. Radeka, J. Rademacker, B. Radics, A. Rafique, E. Raguzin, M. Rai, S. Rajagopalan, M. Rajaoalisoa, I. Rakhno, L. Rakotondravohitra, L. Ralte, M. A. Ramirez Delgado, B. Ramson, A. Rappoldi, G. Raselli, P. Ratoff, R. Ray, H. Razafinime, E. M. Rea, J. S. Real, B. Rebel, R. Rechenmacher, M. Reggiani-Guzzo, J. Reichenbacher, S. D. Reitzner, H. Rejeb Sfar, E. Renner, A. Renshaw, S. Rescia, F. Resnati, D. Restrepo, C. Reynolds, M. Ribas, S. Riboldi, C. Riccio, G. Riccobene, J. S. Ricol, M. Rigan, E. V. Rincón, A. Ritchie-Yates, S. Ritter, D. Rivera, R. Rivera, A. Robert, J. L. Rocabado Rocha, L. Rochester, M. Roda, P. Rodrigues, M. J. Rodriguez Alonso, J. Rodriguez Rondon, S. Rosauro-Alcaraz, P. Rosier, D. Ross, M. Rossella, M. Rossi, M. Ross-Lonergan, N. Roy, P. Roy, C. Rubbia, A. Ruggeri, G. Ruiz Ferreira, B. Russell, D. Ruterbories, A. Rybnikov, A. Saa-Hernandez, R. Saakyan, S. Sacerdoti, S. K. Sahoo, N. Sahu, P. Sala, N. Samios, O. Samoylov, M. C. Sanchez, A. Sánchez Bravo, P. Sanchez-Lucas, V. Sandberg, D. A. Sanders, S. Sanfilippo, D. Sankey, D. Santoro, N. Saoulidou, P. Sapienza, C. Sarasty, I. Sarcevic, I. Sarra, G. Savage, V. Savinov, G. Scanavini, A. Scaramelli, A. Scarff, T. Schefke, H. Schellman, S. Schifano, P. Schlabach, D. Schmitz, A. W. Schneider, K. Scholberg, A. Schukraft, B. Schuld, A. Segade, E. Segreto, A. Selyunin, C. R. Senise, J. Sensenig, M. H. Shaevitz, P. Shanahan, P. Sharma, R. Kumar, K. Shaw, T. Shaw, K. Shchablo, J. Shen, C. Shepherd-Themistocleous, A. Sheshukov, W. Shi, S. Shin, S. Shivakoti, I. Shoemaker, D. Shooltz, R. Shrock, B. Siddi, M. Siden, J. Silber, L. Simard, J. Sinclair, G. Sinev, Jaydip Singh, J. Singh, L. Singh, P. Singh, V. Singh, S. Singh Chauhan, R. Sipos, C. Sironneau, G. Sirri, K. Siyeon, K. Skarpaas, J. Smedley, E. Smith, J. Smith, P. Smith, J. Smolik, M. Smy, M. Snape, E. L. Snider, P. Snopok, D. Snowden-Ifft, M. Soares Nunes, H. Sobel, M. Soderberg, S. Sokolov, C. J. Solano Salinas, S. Söldner-Rembold, S. R. Soleti, N. Solomey, V. Solovov, W. E. Sondheim, M. Sorel, A. Sotnikov, J. Soto-Oton, A. Sousa, K. Soustruznik, F. Spinella, J. Spitz, N. J. C. Spooner, K. Spurgeon, D. Stalder, M. Stancari, L. Stanco, J. Steenis, R. Stein, H. M. Steiner, A. F. Steklain Lisbôa, A. Stepanova, J. Stewart, B. Stillwell, J. Stock, F. Stocker, T. Stokes, M. Strait, T. Strauss, L. Strigari, A. Stuart, J. G. Suarez, J. Subash, A. Surdo, L. Suter, C. M. Sutera, K. Sutton, Y. Suvorov, R. Svoboda, S. K. Swain, B. Szczerbinska, A. M. Szelc, A. Sztuc, A. Taffara, N. Talukdar, J. Tamara, H. A. Tanaka, S. Tang, N. Taniuchi, A. M. Tapia Casanova, B. Tapia Oregui, A. Tapper, S. Tariq, E. Tarpara, E. Tatar, R. Tayloe, D. Tedeschi, A. M. Teklu, J. Tena Vidal, P. Tennessen, M. Tenti, K. Terao, F. Terranova, G. Testera, T. Thakore, A. Thea, A. Thiebault, S. Thomas, A. Thompson, C. Thorn, S. C. Timm, E. Tiras, V. Tishchenko, N. Todorović, L. Tomassetti, A. Tonazzo, D. Torbunov, M. Torti, M. Tortola, F. Tortorici, N. Tosi, D. Totani, M. Toups, C. Touramanis, D. Tran, R. Travaglini, J. Trevor, E. Triller, S. Trilov, J. Truchon, D. Truncali, W. H. Trzaska, Y. Tsai, Y.-T. Tsai, Z. Tsamalaidze, K. V. Tsang, N. Tsverava, S. Z. Tu, S. Tufanli, C. Tunnell, J. Turner, M. Tuzi, J. Tyler, E. Tyley, M. Tzanov, M. A. Uchida, J. Ureña González, J. Urheim, T. Usher, H. Utaegbulam, S. Uzunyan, M. R. Vagins, P. Vahle, S. Valder, G. A. Valdiviesso, E. Valencia, R. Valentim, Z. Vallari, E. Vallazza, J. W. F. Valle, R. Van Berg, R. G. Van de Water, D. V. Forero, A. Vannozzi, M. Van Nuland-Troost, F. Varanini, D. Vargas Oliva, S. Vasina, N. Vaughan, K. Vaziri, A. Vázquez-Ramos, J. Vega, S. Ventura, A. Verdugo, S. Vergani, M. Verzocchi, K. Vetter, M. Vicenzi, H. Vieira de Souza, C. Vignoli, C. Vilela, E. Villa, S. Viola, B. Viren, A. Vizcaya-Hernandez, T. Vrba, Q. Vuong, A. V. Waldron, M. Wallbank, J. Walsh, T. Walton, H. Wang, J. Wang, L. Wang, M. H. L. S. Wang, X. Wang, Y. Wang, K. Warburton, D. Warner, L. Warsame, M. O. Wascko, D. Waters, A. Watson, K. Wawrowska, A. Weber, C. M. Weber, M. Weber, H. Wei, A. Weinstein, H. Wenzel, S. Westerdale, M. Wetstein, K. Whalen, J. Whilhelmi, A. White, L. H. Whitehead, D. Whittington, M. J. Wilking, A. Wilkinson, C. Wilkinson, F. Wilson, R. J. Wilson, P. Winter, W. Wisniewski, J. Wolcott, J. Wolfs, T. Wongjirad, A. Wood, K. Wood, E. Worcester, M. Worcester, M. Wospakrik, K. Wresilo, C. Wret, S. Wu, W. Wu, M. Wurm, J. Wyenberg, Y. Xiao, I. Xiotidis, B. Yaeggy, N. Yahlali, E. Yandel, K. Yang, T. Yang, A. Yankelevich, N. Yershov, K. Yonehara, T. Young, B. Yu, H. Yu, J. Yu, Y. Yu, W. Yuan, R. Zaki, J. Zalesak, L. Zambelli, B. Zamorano, A. Zani, O. Zapata, L. Zazueta, G. P. Zeller, J. Zennamo, K. Zeug, C. Zhang, S. Zhang, M. Zhao, E. Zhivun, E. D. Zimmerman, S. Zucchelli, J. Zuklin, V. Zutshi, R. Zwaska, and on behalf of the DUNE Collaboration

Subjects
neutrino, near detector, Deep Underground Neutrino Experiment, DUNE, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

The Module-0 Demonstrator is a single-phase 600 kg liquid argon time projection chamber operated as a prototype for the DUNE liquid argon near detector. Based on the ArgonCube design concept, Module-0 features a novel 80k-channel pixelated charge readout and advanced high-coverage photon detection system. In this paper, we present an analysis of an eight-day data set consisting of 25 million cosmic ray events collected in the spring of 2021. We use this sample to demonstrate the imaging performance of the charge and light readout systems as well as the signal correlations between the two. We also report argon purity and detector uniformity measurements and provide comparisons to detector simulations.

Published
2024
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29. Design Thinking Mindset: Scale Development and Validation

Author

Vignoli, Matteo, Dosi, Clio, and Balboni, Bernardo

Abstract

Expectations from Higher Education institutions are increasing towards the education of professionals able to face complex societal issues. In this context, traditional thinking is losing ground, and scholars agree on the importance of promoting a Design Thinking (DT) Mindset in educational settings to address wicked problems. However, an explanation of and measurement for the DT mindset still needs to be adequately developed. We developed and validated a scale to measure DT mindset to fill this gap. After a comprehensive literature review, quantitative research was performed on two samples of professionals (N = 151) and students (N = 201). We employed confirmatory factor analysis, which yielded a 31-item scale based on ten dimensions. Overall, this study supports the conceptualization and operationalization of the DT mindset as a second-order factor that reflects uncertainty and risk, empathy, holistic thinking, collaboration and diversity, learning orientation, experimentation, critical questioning, abduction, creative confidence, and impact. Our findings advance knowledge that facilitates new research paths and has practical implications for educational and management fields.

Published
2023
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33. Research in action to push the boundaries of scientific research and technological development

Author

Matteo Vignoli and Jonathan Wareham

Subjects
CERN IdeaSquare, innovation, CERN, CIJ, Technology (General), T1-995, Technological innovations. Automation, HD45-45.2
Abstract

Lying in the space of human curiosity, this issue of CIJ experiments with the boundaries of scientific exploration to foster technological development. To cultivate experimental innovation, it is imperative to translate research into tangible action, explore multifaceted problems, offer support for implementation, and effectuate meaningful changes.

Published
2024
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34. Probabilistic Petrophysical Reconstruction of Danta's Alpine Peatland via Electromagnetic Induction Data

Author

N. Zaru, S. Silvestri, M. Assiri, P. Bai, T. M. Hansen, and G. Vignoli

Subjects
probabilistic inversion, frequency‐domain electromagnetics, peatland, petrophysical inversion, Astronomy, QB1-991, Geology, QE1-996.5
Abstract

Abstract Peatlands are fundamental deposits of organic carbon. Thus, their protection is of crucial importance to avoid emissions from their degradation. Peat is a mixture of organic soil that originates from the accumulation of wetland plants under continuous or cyclical anaerobic conditions for long periods. Hence, a precise quantification of peat deposits is extremely important; for that, remote‐ and proximal‐sensing techniques are excellent candidates. Unfortunately, remote‐sensing can provide information only on the few shallowest centimeters, whereas peatlands often extend to several meters in depth. In addition, peatlands are usually characterized by difficult (flooded) terrains. So, frequency‐domain electromagnetic instruments, as they are compact and contactless, seem to be the ideal solution for the quantitative assessment of the extension and geometry of peatlands. Generally, electromagnetic methods are used to infer the electrical resistivity of the subsurface. In turn, the resistivity distribution can, in principle, be interpreted to infer the morphology of the peatland. Here, to some extent, we show how to shortcut the process and include the expectation and uncertainty regarding the peat resistivity directly into a probabilistic inversion workflow. The present approach allows for retrieving what really matters: the spatial distribution of the probability of peat occurrence, rather than the mere electrical resistivity. To evaluate the efficiency and effectiveness of the proposed probabilistic approach, we compare the outcomes against the more traditional deterministic fully nonlinear (Occam's) inversion and against some boreholes available in the investigated area.

Published
2024
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35. Fine-scale spatial genetic structure and dispersal among Italian smooth newt populations in a rural landscape

Author

Vincenzo Buono, Alessandra Maria Bissattini, Francesca Davoli, Chiara Mengoni, Nadia Mucci, and Leonardo Vignoli

Subjects
Medicine, Science
Abstract

Abstract Amphibians are particularly sensitive to habitat loss and fragmentation caused by the intensification and modernization of farming occurring in the second half of the twentieth century in the Mediterranean basin. However, artificial water bodies, associated with traditional husbandry, proved to be important surrogate for amphibian feeding and reproduction. Here, multilocus genotypes were used to investigate the spatial population structure of Lissotriton vulgaris meridionalis and the role of drinking troughs in supporting viable breeding populations within a rural landscape interested by traditional husbandry and agriculture. Our genetic analysis highlighted the conservation value and the potential stepping-stone function of artificial aquatic sites in the dispersal of the species and for the gene flow maintenance. Indeed, populations of drinking troughs show allelic richness and heterozygosity levels comparable to those from natural ponds and there is no great evidence of genetic bottlenecks. A complex system of artificial aquatic sites and few natural wetlands was identified sustaining a well-structured network of demes highly interconnected with themselves and natural aquatic sites. The conservation of the identified genetic clusters may be useful to prevent further population declines and future loss of genetic diversity within the study area characterized by scarce natural wetlands that frequently dried because of agricultural practices and strong seasonality. Site-specific protection measures are needed to contrast the progressive disappearance of drinking troughs observed in the last years in Italy because of the abandonment of traditional farming practices in favour of modern agriculture and intensive farming.

Published
2023
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36. Ependymal cyst in the caudal cranial fossa of a young Belgian Malinois dog with abnormal cerebrospinal fluid findings

Author

Rosto Martina, Canal Sara, Salda Leonardo Della, Cantile Carlo, Cauduro Alberto, Terragni Rossella, Bonis Andrea De, Signore Francesca Del, and Vignoli Massimo

Subjects
aseptic meningitis, brain anomaly, congenital anomaly, ependymal cyst, intracranial cyst, working dog, Veterinary medicine, SF600-1100
Abstract

Fluid-filled cavities within the brain are well-recognized in human and veterinary medicine. Congenital or acquired brain cystic lesions could be isolated or associated with other diseases. Clinical signs related to cysts depend on their size and the mass effect they exert on surrounding neuroanatomical structures. We present a case of a 5-month-old Belgian Malinois dog with cervical pain and right head tilt. The dog had a normal haematochemical profile and negative infectious disease tests. A contrast enhancement Computed Tomography scan revealed the presence of a thin-walled cystic lesion in the caudal cranial fossa at the level of the right pontine-cerebellar junction. A cerebrospinal fluid tap was performed by lumbar puncture, revealing a monocytic pleocytosis. After initial improvement following corticosteroid and antibiotic therapy, clinical signs worsened, and the dog underwent a second clinical evaluation and magnetic resonance imaging examination. After euthanasia a complete postmortem examination was performed. Histological and immunohistochemical findings were suggestive of an ependymal cyst.

Published
2023
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37. Simulation and background characterisation of the SABRE South experiment

Author

E. Barberio, T. Baroncelli, L. J. Bignell, I. Bolognino, G. Brooks, F. Dastgiri, G. D’Imperio, A. Di Giacinto, A. R. Duffy, M. Froehlich, G. Fu, M. S. M. Gerathy, G. C. Hill, S. Krishnan, G. J. Lane, G. Lawrence, K. T. Leaver, I. Mahmood, A. Mariani, P. McGee, L. J. McKie, P. C. McNamara, M. Mews, W. J. D. Melbourne, G. Milana, L. J. Milligan, J. Mould, F. Nuti, V. Pettinacci, F. Scutti, Z. Slavkovská, N. J. Spinks, O. Stanley, A. E. Stuchbery, G. N. Taylor, C. Tomei, P. Urquijo, C. Vignoli, A. G. Williams, Y. Y. Zhong, and M. J. Zurowski

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract SABRE (Sodium iodide with Active Background REjection) is a direct detection dark matter experiment based on arrays of radio-pure NaI(Tl) crystals. The experiment aims at achieving an ultra-low background rate and its primary goal is to confirm or refute the results from the DAMA/LIBRA experiment. The SABRE Proof-of-Principle phase was carried out in 2020–2021 at the Gran Sasso National Laboratory (LNGS), in Italy. The next phase consists of two full-scale experiments: SABRE South at the Stawell Underground Physics Laboratory, in Australia, and SABRE North at LNGS. This paper focuses on SABRE South and presents a detailed simulation of the detector, which is used to characterise the background for dark matter searches including DAMA/LIBRA-like modulation. We estimate an overall background of 0.72 cpd/kg/ $$\hbox {keV}_{\hbox {{ee}}}$$ keV ee in the energy range 1–6 $$\hbox {keV}_{\hbox {{ee}}}$$ keV ee primarily due to radioactive contamination in the crystals. Given this level of background and considering that the SABRE South has a target mass of 50 kg, we expect to exclude (confirm) DAMA/LIBRA modulation at $$4~(5)\sigma $$ 4 ( 5 ) σ within 2.5 years of data taking.

Published
2023
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38. Search for tri-nucleon decays of $$^{76}$$ 76 Ge in GERDA

Author

M. Agostini, A. Alexander, G. Araujo, A. M. Bakalyarov, M. Balata, I. Barabanov, L. Baudis, C. Bauer, S. Belogurov, A. Bettini, L. Bezrukov, V. Biancacci, E. Bossio, V. Bothe, R. Brugnera, A. Caldwell, S. Calgaro, C. Cattadori, A. Chernogorov, P.-J. Chiu, T. Comellato, V. D’Andrea, E. V. Demidova, A. Di Giacinto, N. Di Marco, E. Doroshkevich, F. Fischer, M. Fomina, A. Gangapshev, A. Garfagnini, C. Gooch, P. Grabmayr, V. Gurentsov, K. Gusev, J. Hakenmüller, S. Hemmer, W. Hofmann, M. Hult, L. V. Inzhechik, J. Janicskó Csáthy, J. Jochum, M. Junker, V. Kazalov, Y. Kermaïdic, H. Khushbakht, T. Kihm, K. Kilgus, I. V. Kirpichnikov, A. Klimenko, K. T. Knöpfle, O. Kochetov, V. N. Kornoukhov, P. Krause, V. V. Kuzminov, M. Laubenstein, M. Lindner, I. Lippi, A. Lubashevskiy, B. Lubsandorzhiev, G. Lutter, C. Macolino, B. Majorovits, W. Maneschg, L. Manzanillas, G. Marshall, M. Misiaszek, M. Morella, Y. Müller, I. Nemchenok, M. Neuberger, L. Pandola, K. Pelczar, L. Pertoldi, P. Piseri, A. Pullia, L. Rauscher, M. Redchuk, S. Riboldi, N. Rumyantseva, C. Sada, S. Sailer, F. Salamida, S. Schönert, J. Schreiner, M. Schütt, A.-K. Schütz, O. Schulz, M. Schwarz, B. Schwingenheuer, O. Selivanenko, E. Shevchik, M. Shirchenko, L. Shtembari, H. Simgen, A. Smolnikov, D. Stukov, S. Sullivan, A. A. Vasenko, A. Veresnikova, C. Vignoli, K. von Sturm, T. Wester, C. Wiesinger, M. Wojcik, E. Yanovich, B. Zatschler, I. Zhitnikov, S. V. Zhukov, D. Zinatulina, A. Zschocke, A. J. Zsigmond, K. Zuber, G. Zuzel, and GERDA collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We search for tri-nucleon decays of $$^{76}$$ 76 Ge in the dataset from the GERmanium Detector Array (GERDA) experiment. Decays that populate excited levels of the daughter nucleus above the threshold for particle emission lead to disintegration and are not considered. The ppp-, ppn-, and pnn-decays lead to $$^{73}$$ 73 Cu, $$^{73}$$ 73 Zn, and $$^{73}$$ 73 Ga nuclei, respectively. These nuclei are unstable and eventually proceed by the beta decay of $$^{73}$$ 73 Ga to $$^{73}$$ 73 Ge (stable). We search for the $$^{73}$$ 73 Ga decay exploiting the fact that it dominantly populates the 66.7 keV $$^{73m}$$ 73 m Ga state with half-life of 0.5 s. The nnn-decays of $$^{76}$$ 76 Ge that proceed via $$^{73m}$$ 73 m Ge are also included in our analysis. We find no signal candidate and place a limit on the sum of the decay widths of the inclusive tri-nucleon decays that corresponds to a lower lifetime limit of 1.2 $$\times $$ × 10 $$^{26}$$ 26 yr (90% credible interval). This result improves previous limits for tri-nucleon decays by one to three orders of magnitude.

Published
2023
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40. Classical and variational Poisson cohomology

Author

Bakalov, Bojko, De Sole, Alberto, Heluani, Reimundo, Kac, Victor G., and Vignoli, Veronica

Subjects
Mathematics - Representation Theory, Mathematics - Quantum Algebra, Primary 17B69. Secondary 17B63, 17B65, 17B80, 18D50
Abstract

We prove that, for a Poisson vertex algebra V, the canonical injective homomorphism of the variational cohomology of V to its classical cohomology is an isomorphism, provided that V, viewed as a differential algebra, is an algebra of differential polynomials in finitely many differential variables. This theorem is one of the key ingredients in the computation of vertex algebra cohomology. For its proof, we introduce the sesquilinear Hochschild and Harrison cohomology complexes and prove a vanishing theorem for the symmetric sesquilinear Harrison cohomology of the algebra of differential polynomials in finitely many differential variables., Comment: 33 pages

Published
2021
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41. Resolvin D5 Protects Female Hairless Mouse Skin from Pathological Alterations Caused by UVB Irradiation

Author

Priscila Saito, Ingrid C. Pinto, Camilla C. A. Rodrigues, Ricardo L. N. de Matos, David L. Vale, Cristina P. B. Melo, Victor Fattori, Telma Saraiva-Santos, Soraia Mendes-Pierotti, Mariana M. Bertozzi, Ana P. F. R. L. Bracarense, Josiane A. Vignoli, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, and Rubia Casagrande

Subjects
collagen, cytokine, inflammation, lipid, oxidative stress, reactive oxygen species, Therapeutics. Pharmacology, RM1-950
Abstract

Resolvin D5 (RvD5) is a lipid mediator that has been reported to present anti-inflammatory and pro-resolution properties. Evidence also supports its capability to enhance reactive oxygen species (ROS) production during bacterial infections, which would be detrimental in diseases driven by ROS. The biological activity of RvD5 and mechanisms against UVB irradiation skin pathology have not been investigated so far. Female hairless mice were treated intraperitoneally with RvD5 before UVB stimulus. RvD5 reduced skin edema in a dose-dependent manner as well as oxidative stress by increasing antioxidants (endogenous tissue antioxidant scavenging of cationic radical, iron reduction, catalase activity and reduced glutathione levels) and decreasing pro-oxidants (superoxide anion and lipid peroxidation). RvD5 antioxidant activity was accompanied by enhancement of Nrf2, HO-1 and NQO1 mRNA expression. RvD5 reduced the production of IL-1β, TNF-α, TGF-β, and IL-10. RvD5 also reduced the inflammatory cell counts, including mast cells and neutrophils/macrophages. The reduction of oxidative stress and inflammation resulted in diminished matrix metalloproteinase 9 activity, collagen degradation, epidermal thickening and sunburn cell development. Therefore, this study demonstrates, to our knowledge, the first body of evidence that RvD5 can be used to treat UVB skin pathology and unveils, at least in part, its mechanisms of action.

Published
2024
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42. Seasonal Phenotypic Variation in the Aeolian Wall Lizard, Podarcis raffonei, of the Capo Grosso (Vulcano) Population

Author

Benedetta Gambioli, Daniele Macale, and Leonardo Vignoli

Subjects
coloration, seasonal variation, captive breeding, Podarcis, reptiles, Biology (General), QH301-705.5
Abstract

In recent decades, studies on animal coloration have expanded significantly, from understanding color production and perception mechanisms to exploring the selective pressures driving these patterns. Conservation biology has begun leveraging these studies to develop effective strategies, gauge public support for conservation projects, select flagship species, and determine reproductive pairs and optimal rearing and release conditions for captive breeding. Critically endangered Aeolian wall lizards (Podarcis raffonei) were housed at the Fondazione Bioparco di Roma for a pilot captive breeding project following alarming hypotheses of rising numbers of “green” hybrids (P. raffonei × P. siculus) in one of the four surviving populations. Through a quantitative analysis of visible dorsal color in captive and natural populations, we aim to determine whether P. raffonei is characterized by seasonal variation in its dorsal coloration and if color is influenced by sex and ontogenesis. Our findings show that P. raffonei’s dorsal pigmentation varies between seasons. In spring, the size and age of the animals does not seem to affect any color component, while the sexes always differ in their hue, with males having consistently more yellow-green dorsa. Between-year analyses, including measurements from the wild population, indicate that yearly variation is not limited to the captive population but also occurs in nature. We caution against identifying potential hybrids based solely on phenotypic traits.

Published
2024
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43. Phenotypic Characterization of the Martina Franca Donkey: An Endangered Italian Donkey Breed

Author

Alberto De Berardinis, Roberta Bucci, Ippolito De Amicis, Francesca Del Signore, Salvatore Parrillo, Ivano Massirio, Massimo Vignoli, and Augusto Carluccio

Subjects
Martina Franca donkey morphology, endangered breed, phenotype, body measurements, Montanaro study, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

The Martina Franca (MF) donkey breed (Equus asinus) primarily inhabits the rural areas surrounding the homonymous municipality, as well as neighboring municipalities in the provinces of Bari and Brindisi, all located in the Apulia region of Italy. The objective of this study was to assess the current phenotype through the evaluation of 27 morphologic measurements. The study was conducted on 73 female and 18 male breeding animals from eight different herds located in central and southern Italy. Statistical analysis was performed in order to demonstrate statistical differences between males and females, as well as sexual dimorphism and uniformity of all measurements in both genders. The results demonstrated that the mean of three parameters used for the evaluation of an MF donkey (height at withers, circumference of thorax, and shin circumference) are highly representative of the population, with minimal dispersion Cv^ = 0.05–0.06 up to a maximum of 10%, as evidenced by relatively low standard deviations across observed measurements in both genders. Regarding sexual dimorphism, a statistically significant difference was found between males and females. This dimorphism is linked to reproductive activity and is useful during gestation. Overall, our findings suggest that the MF donkey phenotype has been largely preserved over time with high uniformity in males, slight inhomogeneity in the female population, and less variability in both genders.

Published
2024
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44. Use of Caudal Quadratus Lumborum Block with Ropivacaine as Part of an Opioid-Free Analgesic Protocol in Dogs Undergoing Orchiectomy: A Randomized Trial

Author

Andrea Paolini, Roberta Bucci, Amanda Bianchi, Francesca Del Signore, Salvatore Parrillo, Alessandro Di Giosia, Claudia Ristori, Roberto Tamburro, Domenico Robbe, Augusto Carluccio, Valeria Rosa, and Massimo Vignoli

Subjects
loco-regional anesthesia technique, interfascial plane block, Quadratus Lumborum block, ropivacaine, orchiectomy, dogs, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

In veterinary medicine, the use of loco-regional anesthesia techniques is increasing. The Quadratus Lumborum block (QL) is an interfascial loco-regional technique that involves the release of local anesthetic (LA) between the Quadratus Lumborum and the Small Psoas (Pm) muscle. The study aims to evaluate the effect of the QL block on reducing the total amount of opioids in dogs undergoing pre-scrotal orchiectomy. A group of 36 dogs was enrolled in a randomized blinded study. The animals were divided into two groups: 18 in the experimental group (QL) and 18 in the control group (C). The QL group received 0.4 mL kg−1 of ropivacaine 0.5% for each hemiabdomen (total amount of 3 mg kg−1 of ropivacaine, 1.5 mg kg−1 per side). The C group was brought into the operating room (OR) after receiving the same clipping as the QL group. In the intraoperative period, opioid consumption in the QL group was significantly lower than in the C group. No differences were found in the post-operative phase. No side effects were reported when performing the QL technique. The QL block performed at the level of L6 appears to be a valid approach to reducing opioid use in dogs undergoing orchidectomy with a pre-scrotal surgical approach.

Published
2024
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45. Advancing Thrombosis Research: A Novel Device for Measuring Clot Permeability

Author

Elia Landi, Marco Mugnaini, Tunahan Vatansever, Ada Fort, Valerio Vignoli, Elvira Giurranna, Flavia Rita Argento, Eleonora Fini, Giacomo Emmi, Claudia Fiorillo, and Matteo Becatti

Subjects
blood clot, permeability measurement, low-cost, portable measurement system, Chemical technology, TP1-1185
Abstract

Thromboembolism, a global leading cause of mortality, needs accurate risk assessment for effective prophylaxis and treatment. Current stratification methods fall short in predicting thrombotic events, emphasizing the need for a deeper understanding of clot properties. Fibrin clot permeability, a crucial parameter in hypercoagulable states, impacts clot structure and resistance to lysis. Current clot permeability measurement limitations propel the need for standardized methods. Prior findings underscore the importance of clot permeability in various thrombotic conditions but call for improvements and more precise, repeatable, and standardized methods. Addressing these challenges, our study presents an upgraded, portable, and cost-effective system for measuring blood clot permeability, which utilizes a pressure-based approach that adheres to Darcy’s law. By enhancing precision and sensitivity in discerning clot characteristics, this innovation provides a valuable tool for assessing thrombotic risk and associated pathological conditions. In this paper, the authors present a device that is able to automatically perform the permeability measurements on plasma or fibrinogen in vitro-induced clots on specific holders (filters). The proposed device has been tailored to distinguish clot permeability, with high precision and sensitivity, between healthy subjects and high cardiovascular-risk patients. The precise measure of clot permeability represents an excellent indicator of thrombotic risk, thus allowing the clinician, also on the basis of other anamnestic and laboratory data, to attribute a risk score to the subject. The proposed instrument was characterized by performing permeability measurements in plasma and purified fibrinogen clots derived from 17 Behcet patients and 15 sex- and age-matched controls. As expected, our results clearly indicate a significant difference in plasma clot permeability in Behcet patients with respect to controls (0.0533 ± 0.0199 d vs. 0.0976 ± 0.0160 d, p < 0.001). This difference was confirmed in the patient’s vs. control fibrin clots (0.0487 ± 0.0170 d vs. 0.1167 ± 0.0487 d, p < 0.001). In conclusion, our study demonstrates the feasibility, efficacy, portability, and cost-effectiveness of a novel device for measuring clot permeability, allowing healthcare providers to better stratify thrombotic risk and tailor interventions, thereby improving patient outcomes and reducing healthcare costs, which could significantly improve the management of thromboembolic diseases.

Published
2024
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46. Reconstruction of interactions in the ProtoDUNE-SP detector with Pandora

Author

A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, C. Adriano, A. Aduszkiewicz, J. Aguilar, Z. Ahmad, J. Ahmed, B. Aimard, F. Akbar, B. Ali-Mohammadzadeh, K. Allison, S. Alonso Monsalve, M. AlRashed, C. Alt, A. Alton, R. Alvarez, P. Amedo, J. Anderson, C. Andreopoulos, M. Andreotti, M. Andrews, F. Andrianala, S. Andringa, N. Anfimov, A. Ankowski, M. Antoniassi, M. Antonova, A. Antoshkin, S. Antusch, A. Aranda-Fernandez, L. Arellano, L. O. Arnold, M. A. Arroyave, J. Asaadi, L. Asquith, A. Aurisano, V. Aushev, D. Autiero, V. Ayala Lara, M. Ayala-Torres, F. Azfar, A. Back, H. Back, J. J. Back, C. Backhouse, I. Bagaturia, L. Bagby, N. Balashov, S. Balasubramanian, P. Baldi, B. Baller, B. Bambah, F. Barao, G. Barenboim, G. Barker, W. Barkhouse, C. Barnes, G. Barr, J. Barranco Monarca, A. Barros, N. Barros, J. L. Barrow, A. Basharina-Freshville, A. Bashyal, V. Basque, C. Batchelor, J. Battat, F. Battisti, F. Bay, M. C. Q. Bazetto, J. L. Bazo Alba, J. F. Beacom, E. Bechetoille, B. Behera, E. Belchior Batista das Chagas, L. Bellantoni, G. Bellettini, V. Bellini, O. Beltramello, N. Benekos, C. Benitez Montiel, F. Bento Neves, J. Berger, S. Berkman, P. Bernardini, R. M. Berner, A. Bersani, S. Bertolucci, M. Betancourt, A. Betancur Rodríguez, A. Bevan, Y. Bezawada, A. T. Bezerra, T. J. Bezerra, A. Bhardwaj, V. Bhatnagar, M. Bhattacharjee, D. Bhattarai, S. Bhuller, B. Bhuyan, S. Biagi, J. Bian, M. Biassoni, K. Biery, B. Bilki, M. Bishai, A. Bitadze, A. Blake, F. D. M. Blaszczyk, G. C. Blazey, E. Blucher, J. Boissevain, S. Bolognesi, T. Bolton, L. Bomben, M. Bonesini, C. Bonilla-Diaz, F. Bonini, A. Booth, F. Boran, S. Bordoni, A. Borkum, N. Bostan, P. Bour, D. Boyden, J. Bracinik, D. Braga, D. Brailsford, A. Branca, A. Brandt, J. Bremer, C. Brew, S. J. Brice, C. Brizzolari, C. Bromberg, J. Brooke, A. Bross, G. Brunetti, M. Brunetti, N. Buchanan, H. Budd, I. Butorov, I. Cagnoli, T. Cai, D. Caiulo, R. Calabrese, P. Calafiura, J. Calcutt, M. Calin, S. Calvez, E. Calvo, A. Caminata, A. Campos Benitez, D. Caratelli, D. Carber, J. M. Carceller, G. Carini, B. Carlus, M. F. Carneiro, P. Carniti, I. Caro Terrazas, H. Carranza, T. Carroll, J. F. Castaño Forero, A. Castillo, C. Castromonte, E. Catano-Mur, C. Cattadori, F. Cavalier, G. Cavallaro, F. Cavanna, S. Centro, G. Cerati, A. Cervelli, A. Cervera Villanueva, M. Chalifour, A. Chappell, E. Chardonnet, N. Charitonidis, A. Chatterjee, S. Chattopadhyay, M. S. Chavarry Neyra, H. Chen, M. Chen, Y. Chen, Z. Chen, Z. Chen-Wishart, Y. Cheon, D. Cherdack, C. Chi, S. Childress, R. Chirco, A. Chiriacescu, K. Cho, S. Choate, D. Chokheli, P. S. Chong, A. Christensen, D. Christian, G. Christodoulou, A. Chukanov, M. Chung, E. Church, V. Cicero, P. Clarke, G. Cline, T. E. Coan, A. G. Cocco, J. Coelho, J. Collot, N. Colton, E. Conley, R. Conley, J. Conrad, M. Convery, S. Copello, P. Cova, L. Cremaldi, L. Cremonesi, J. I. Crespo-Anadón, M. Crisler, E. Cristaldo, J. Crnkovic, R. Cross, A. Cudd, C. Cuesta, Y. Cui, D. Cussans, J. Dai, O. Dalager, H. Da Motta, L. Da Silva Peres, C. David, Q. David, G. S. Davies, S. Davini, J. Dawson, K. De, S. De, P. Debbins, I. De Bonis, M. Decowski, A. De Gouvea, P. C. De Holanda, I. L. De Icaza Astiz, A. Deisting, P. De Jong, A. Delbart, V. De Leo, D. Delepine, M. Delgado, A. Dell’Acqua, N. Delmonte, P. De Lurgio, J. R. De Mello Neto, D. M. DeMuth, S. Dennis, C. Densham, G. W. Deptuch, A. De Roeck, V. De Romeri, G. De Souza, R. Devi, R. Dharmapalan, M. Dias, J. Diaz, F. Díaz, F. Di Capua, A. Di Domenico, S. Di Domizio, L. Di Giulio, P. Ding, L. Di Noto, G. Dirkx, C. Distefano, R. Diurba, M. Diwan, Z. Djurcic, D. Doering, S. Dolan, F. Dolek, M. Dolinski, L. Domine, Y. Donon, D. Douglas, A. Dragone, G. Drake, F. Drielsma, L. Duarte, D. Duchesneau, K. Duffy, P. Dunne, B. Dutta, H. Duyang, O. Dvornikov, D. Dwyer, A. Dyshkant, M. Eads, A. Earle, D. Edmunds, J. Eisch, L. Emberger, S. Emery, P. Englezos, A. Ereditato, T. Erjavec, C. Escobar, L. Escudero Sanchez, G. Eurin, J. J. Evans, E. Ewart, A. C. Ezeribe, K. Fahey, A. Falcone, M. Fani’, C. Farnese, Y. Farzan, D. Fedoseev, J. Felix, Y. Feng, E. Fernandez-Martinez, P. Fernandez Menendez, F. Ferraro, L. Fields, P. Filip, F. Filthaut, R. Fine, G. Fiorillo, M. Fiorini, V. Fischer, R. S. Fitzpatrick, W. Flanagan, B. Fleming, R. Flight, S. Fogarty, W. Foreman, J. Fowler, W. Fox, J. Franc, K. Francis, D. Franco, J. Freeman, J. Freestone, J. Fried, A. Friedland, S. Fuess, I. K. Furic, K. Furman, A. P. Furmanski, A. Gabrielli, A. Gago, H. Gallagher, A. Gallas, A. Gallego-Ros, N. Gallice, V. Galymov, E. Gamberini, T. Gamble, F. Ganacim, R. Gandhi, S. Ganguly, F. Gao, S. Gao, D. Garcia-Gamez, M. Á. García-Peris, S. Gardiner, D. Gastler, J. Gauvreau, P. Gauzzi, G. Ge, N. Geffroy, B. Gelli, A. Gendotti, S. Gent, Z. Ghorbani-Moghaddam, P. Giammaria, T. Giammaria, N. Giangiacomi, D. Gibin, I. Gil-Botella, S. Gilligan, C. Girerd, A. Giri, D. Gnani, O. Gogota, M. Gold, S. Gollapinni, K. Gollwitzer, R. A. Gomes, L. Gomez Bermeo, L. S. Gomez Fajardo, F. Gonnella, D. González Caamaño, D. Gonzalez-Diaz, M. Gonzalez-Lopez, M. C. Goodman, O. Goodwin, S. Goswami, C. Gotti, E. Goudzovski, C. Grace, R. Gran, E. Granados, P. Granger, C. Grant, D. Gratieri, P. Green, S. Green, S. Greenberg, L. Greenler, J. Greer, J. Grenard, C. Griffith, M. Groh, J. Grudzinski, K. Grzelak, W. Gu, E. Guardincerri, V. Guarino, M. Guarise, R. Guenette, E. Guerard, M. Guerzoni, D. Guffanti, A. Guglielmi, B. Guo, A. Gupta, V. Gupta, K. Guthikonda, P. Guzowski, M. M. Guzzo, S. Gwon, C. Ha, K. Haaf, A. Habig, H. Hadavand, R. Haenni, A. Hahn, J. Haiston, P. Hamacher-Baumann, T. Hamernik, P. Hamilton, J. Han, D. A. Harris, J. Hartnell, T. Hartnett, J. Harton, T. Hasegawa, C. Hasnip, R. Hatcher, K. W. Hatfield, A. Hatzikoutelis, C. Hayes, K. Hayrapetyan, J. Hays, E. Hazen, M. He, A. Heavey, K. M. Heeger, J. Heise, S. Henry, M. Hernandez Morquecho, K. Herner, J. Hewes, C. Hilgenberg, T. Hill, S. J. Hillier, A. Himmel, E. Hinkle, L. R. Hirsch, J. Ho, J. Hoff, A. Holin, E. Hoppe, G. A. Horton-Smith, M. Hostert, A. Hourlier, B. Howard, R. Howell, I. Hristova, M. S. Hronek, J. Huang, Z. Hulcher, G. Iles, N. Ilic, A. M. Iliescu, R. Illingworth, G. Ingratta, A. Ioannisian, B. Irwin, L. Isenhower, R. Itay, C. M. Jackson, V. Jain, E. James, W. Jang, B. Jargowsky, F. Jediny, D. Jena, Y. Jeong, C. Jesús-Valls, X. Ji, J. Jiang, L. Jiang, S. Jiménez, A. Jipa, F. Joaquim, W. Johnson, N. Johnston, B. Jones, M. Judah, C. Jung, T. Junk, Y. Jwa, M. Kabirnezhad, A. Kaboth, I. Kadenko, I. Kakorin, A. Kalitkina, D. Kalra, F. Kamiya, D. M. Kaplan, G. Karagiorgi, G. Karaman, A. Karcher, M. Karolak, Y. Karyotakis, S. Kasai, S. P. Kasetti, L. Kashur, N. Kazaryan, E. Kearns, P. Keener, K. J. Kelly, E. Kemp, O. Kemularia, W. Ketchum, S. H. Kettell, M. Khabibullin, A. Khotjantsev, A. Khvedelidze, D. Kim, B. King, B. Kirby, M. Kirby, J. Klein, A. Klustova, T. Kobilarcik, K. Koehler, L. W. Koerner, D. H. Koh, S. Kohn, P. P. Koller, L. Kolupaeva, D. Korablev, M. Kordosky, T. Kosc, U. Kose, V. Kostelecky, K. Kothekar, R. Kralik, L. Kreczko, F. Krennrich, I. Kreslo, W. Kropp, T. Kroupova, S. Kubota, Y. Kudenko, V. A. Kudryavtsev, S. Kuhlmann, S. Kulagin, J. Kumar, P. Kumar, P. Kunze, R. Kuravi, N. Kurita, C. Kuruppu, V. Kus, T. Kutter, J. Kvasnicka, D. Kwak, A. Lambert, B. Land, C. E. Lane, K. Lang, T. Langford, M. Langstaff, J. Larkin, P. Lasorak, D. Last, A. Laundrie, G. Laurenti, A. Lawrence, I. Lazanu, R. LaZur, M. Lazzaroni, T. Le, S. Leardini, J. Learned, P. LeBrun, T. LeCompte, C. Lee, S. Lee, G. Lehmann Miotto, R. Lehnert, M. Leigui de Oliveira, M. Leitner, L. M. Lepin, S. Li, Y. Li, H. Liao, C. Lin, Q. Lin, S. Lin, R. A. Lineros, J. Ling, A. Lister, B. R. Littlejohn, J. Liu, Y. Liu, S. Lockwitz, T. Loew, M. Lokajicek, I. Lomidze, K. Long, T. Lord, J. LoSecco, W. C. Louis, X. Lu, K. Luk, B. Lunday, X. Luo, E. Luppi, T. Lux, V. P. Luzio, J. Maalmi, D. MacFarlane, A. Machado, P. Machado, C. Macias, J. Macier, A. Maddalena, A. Madera, P. Madigan, S. Magill, K. Mahn, A. Maio, A. Major, J. A. Maloney, G. Mandrioli, R. C. Mandujano, J. C. Maneira, L. Manenti, S. Manly, A. Mann, K. Manolopoulos, M. Manrique Plata, V. N. Manyam, M. Marchan, A. Marchionni, W. Marciano, D. Marfatia, C. Mariani, J. Maricic, R. Marie, F. Marinho, A. D. Marino, T. Markiewicz, D. Marsden, M. Marshak, C. Marshall, J. Marshall, J. Marteau, J. Martín-Albo, N. Martinez, D. A. Martinez Caicedo, P. Martínez Miravé, S. Martynenko, V. Mascagna, K. Mason, A. Mastbaum, F. Matichard, S. Matsuno, J. Matthews, C. Mauger, N. Mauri, K. Mavrokoridis, I. Mawby, R. Mazza, A. Mazzacane, E. Mazzucato, T. McAskill, E. McCluskey, N. McConkey, K. S. McFarland, C. McGrew, A. McNab, A. Mefodiev, P. Mehta, P. Melas, O. Mena, H. Mendez, P. Mendez, D. P. Méndez, A. Menegolli, G. Meng, M. Messier, W. Metcalf, M. Mewes, H. Meyer, T. Miao, G. Michna, V. Mikola, R. Milincic, G. Miller, W. Miller, J. Mills, O. Mineev, A. Minotti, O. G. Miranda, S. Miryala, C. Mishra, S. Mishra, A. Mislivec, M. Mitchell, D. Mladenov, I. Mocioiu, K. Moffat, N. Moggi, R. Mohanta, T. A. Mohayai, N. Mokhov, J. A. Molina, L. Molina Bueno, E. Montagna, A. Montanari, C. Montanari, D. Montanari, D. Montanino, L. M. Montaño Zetina, S. Moon, M. Mooney, A. F. Moor, D. Moreno, D. Moretti, C. Morris, C. Mossey, M. Mote, E. Motuk, C. A. Moura, J. Mousseau, G. Mouster, W. Mu, L. Mualem, J. Mueller, M. Muether, S. Mufson, F. Muheim, A. Muir, M. Mulhearn, D. Munford, H. Muramatsu, M. Murphy, S. Murphy, J. Musser, J. Nachtman, Y. Nagai, S. Nagu, M. Nalbandyan, R. Nandakumar, D. Naples, S. Narita, A. Nath, A. Navrer-Agasson, N. Nayak, M. Nebot-Guinot, K. Negishi, J. K. Nelson, J. Nesbit, M. Nessi, D. Newbold, M. Newcomer, H. Newton, R. Nichol, F. Nicolas-Arnaldos, A. Nikolica, E. Niner, K. Nishimura, A. Norman, A. Norrick, R. Northrop, P. Novella, J. A. Nowak, M. Oberling, J. Ochoa-Ricoux, A. Olivier, A. Olshevskiy, Y. Onel, Y. Onishchuk, J. Ott, L. Pagani, G. Palacio, O. Palamara, S. Palestini, J. M. Paley, M. Pallavicini, C. Palomares, W. Panduro Vazquez, E. Pantic, V. Paolone, V. Papadimitriou, R. Papaleo, A. Papanestis, S. Paramesvaran, S. Parke, E. Parozzi, Z. Parsa, M. Parvu, S. Pascoli, L. Pasqualini, J. Pasternak, J. Pater, C. Patrick, L. Patrizii, R. B. Patterson, S. Patton, T. Patzak, A. Paudel, B. Paulos, L. Paulucci, Z. Pavlovic, G. Pawloski, D. Payne, V. Pec, S. J. Peeters, A. Pena Perez, E. Pennacchio, A. Penzo, O. L. Peres, J. Perry, D. Pershey, G. Pessina, G. Petrillo, C. Petta, R. Petti, V. Pia, F. Piastra, L. Pickering, F. Pietropaolo, V. L. Pimentel, G. Pinaroli, K. Plows, R. Plunkett, F. Pompa, X. Pons, N. Poonthottathil, F. Poppi, S. Pordes, J. Porter, S. Porzio, M. Potekhin, R. Potenza, B. V. Potukuchi, J. Pozimski, M. Pozzato, S. Prakash, T. Prakash, M. Prest, S. Prince, F. Psihas, D. Pugnere, X. Qian, J. Raaf, V. Radeka, J. Rademacker, B. Radics, A. Rafique, E. Raguzin, M. Rai, M. Rajaoalisoa, I. Rakhno, A. Rakotonandrasana, L. Rakotondravohitra, R. Rameika, M. Ramirez Delgado, B. Ramson, A. Rappoldi, G. Raselli, P. Ratoff, S. Raut, H. Razafinime, R. Razakamiandra, E. M. Rea, J. S. Real, B. Rebel, R. Rechenmacher, M. Reggiani-Guzzo, J. Reichenbacher, S. D. Reitzner, H. Rejeb Sfar, A. Renshaw, S. Rescia, F. Resnati, M. Ribas, S. Riboldi, C. Riccio, G. Riccobene, L. C. Rice, J. S. Ricol, A. Rigamonti, Y. Rigaut, E. V. Rincón, H. Ritchie-Yates, D. Rivera, A. Robert, J. Rocabado Rocha, L. Rochester, M. Roda, P. Rodrigues, J. V. Rodrigues da Silva Leite, M. J. Rodriguez Alonso, J. Rodriguez Rondon, S. Rosauro-Alcaraz, P. Rosier, B. Roskovec, M. Rossella, M. Rossi, J. Rout, P. Roy, A. Rubbia, C. Rubbia, B. Russell, D. Ruterbories, A. Rybnikov, A. Saa-Hernandez, R. Saakyan, S. Sacerdoti, N. Sahu, P. Sala, N. Samios, O. Samoylov, M. Sanchez, V. Sandberg, D. A. Sanders, D. Sankey, N. Saoulidou, P. Sapienza, C. Sarasty, I. Sarcevic, G. Savage, V. Savinov, A. Scaramelli, A. Scarff, A. Scarpelli, T. Schefke, H. Schellman, S. Schifano, P. Schlabach, D. Schmitz, A. W. Schneider, K. Scholberg, A. Schukraft, E. Segreto, A. Selyunin, C. R. Senise, J. Sensenig, D. Sgalaberna, M. Shaevitz, S. Shafaq, F. Shaker, M. Shamma, R. Sharankova, H. R. Sharma, R. Sharma, R. K. Sharma, K. Shaw, T. Shaw, K. Shchablo, C. Shepherd-Themistocleous, A. Sheshukov, S. Shin, I. Shoemaker, D. Shooltz, R. Shrock, H. Siegel, L. Simard, J. Sinclair, G. Sinev, J. Singh, L. Singh, P. Singh, V. Singh, R. Sipos, F. Sippach, G. Sirri, A. Sitraka, K. Siyeon, K. Skarpaas, E. Smith, P. Smith, J. Smolik, M. Smy, E. Snider, P. Snopok, D. Snowden-Ifft, M. Soares Nunes, H. Sobel, M. Soderberg, S. Sokolov, C. J. Solano Salinas, S. Söldner-Rembold, S. Soleti, N. Solomey, V. Solovov, W. E. Sondheim, M. Sorel, A. Sotnikov, J. Soto-Oton, F. Soto Ugaldi, A. Sousa, K. Soustruznik, F. Spagliardi, M. Spanu, J. Spitz, N. J. C. Spooner, K. Spurgeon, M. Stancari, L. Stanco, C. Stanford, R. Stein, H. Steiner, A. F. Steklain Lisbôa, J. Stewart, B. Stillwell, J. Stock, F. Stocker, T. Stokes, M. Strait, T. Strauss, L. Strigari, A. Stuart, J. G. Suarez, J. Suárez Sunción, H. Sullivan, A. Surdo, V. Susic, L. Suter, C. Sutera, Y. Suvorov, R. Svoboda, B. Szczerbinska, A. M. Szelc, N. Talukdar, H. Tanaka, S. Tang, B. Tapia Oregui, A. Tapper, S. Tariq, E. Tarpara, N. Tata, E. Tatar, R. Tayloe, A. Teklu, P. Tennessen, M. Tenti, K. Terao, C. A. Ternes, F. Terranova, G. Testera, T. Thakore, A. Thea, C. Thorn, S. Timm, V. Tishchenko, L. Tomassetti, A. Tonazzo, D. Torbunov, M. Torti, M. Tortola, F. Tortorici, N. Tosi, D. Totani, M. Toups, C. Touramanis, R. Travaglini, J. Trevor, S. Trilov, W. H. Trzaska, Y. Tsai, Z. Tsamalaidze, K. Tsang, N. Tsverava, S. Z. Tu, S. Tufanli, C. Tull, J. Tyler, E. Tyley, M. Tzanov, L. Uboldi, M. A. Uchida, J. Urheim, T. Usher, S. Uzunyan, M. R. Vagins, P. Vahle, S. Valder, G. D. Valdiviesso, E. Valencia, R. Valentim, Z. Vallari, E. Vallazza, J. W. Valle, S. Vallecorsa, R. Van Berg, R. G. Van de Water, D. Vanegas Forero, D. Vannerom, F. Varanini, D. Vargas Oliva, G. Varner, J. Vasel, S. Vasina, G. Vasseur, N. Vaughan, K. Vaziri, S. Ventura, A. Verdugo, S. Vergani, M. A. Vermeulen, M. Verzocchi, M. Vicenzi, H. Vieira de Souza, C. Vignoli, C. Vilela, B. Viren, T. Vrba, T. Wachala, A. V. Waldron, M. Wallbank, C. Wallis, T. Walton, H. Wang, J. Wang, L. Wang, M. H. Wang, X. Wang, Y. Wang, K. Warburton, D. Warner, M. Wascko, D. Waters, A. Watson, K. Wawrowska, P. Weatherly, A. Weber, M. Weber, H. Wei, A. Weinstein, D. Wenman, M. Wetstein, A. White, L. H. Whitehead, D. Whittington, M. J. Wilking, A. Wilkinson, C. Wilkinson, Z. Williams, F. Wilson, R. J. Wilson, W. Wisniewski, J. Wolcott, T. Wongjirad, A. Wood, K. Wood, E. Worcester, M. Worcester, K. Wresilo, C. Wret, W. Wu, Y. Xiao, B. Yaeggy, E. Yandel, G. Yang, K. Yang, T. Yang, A. Yankelevich, N. Yershov, K. Yonehara, Y. Yoon, T. Young, B. Yu, H. Yu, J. Yu, Y. Yu, W. Yuan, R. Zaki, J. Zalesak, L. Zambelli, B. Zamorano, A. Zani, L. Zazueta, G. Zeller, J. Zennamo, K. Zeug, C. Zhang, S. Zhang, Y. Zhang, M. Zhao, E. Zhivun, G. Zhu, E. D. Zimmerman, S. Zucchelli, J. Zuklin, V. Zutshi, R. Zwaska, and DUNE Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The Pandora Software Development Kit and algorithm libraries provide pattern-recognition logic essential to the reconstruction of particle interactions in liquid argon time projection chamber detectors. Pandora is the primary event reconstruction software used at ProtoDUNE-SP, a prototype for the Deep Underground Neutrino Experiment far detector. ProtoDUNE-SP, located at CERN, is exposed to a charged-particle test beam. This paper gives an overview of the Pandora reconstruction algorithms and how they have been tailored for use at ProtoDUNE-SP. In complex events with numerous cosmic-ray and beam background particles, the simulated reconstruction and identification efficiency for triggered test-beam particles is above 80% for the majority of particle type and beam momentum combinations. Specifically, simulated 1 GeV/c charged pions and protons are correctly reconstructed and identified with efficiencies of 86.1 $$\pm 0.6$$ ± 0.6 % and 84.1 $$\pm 0.6$$ ± 0.6 %, respectively. The efficiencies measured for test-beam data are shown to be within 5% of those predicted by the simulation.

Published
2023
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47. Decent Work and Representations of Work among Unskilled and Low-Skilled Emerging Adults in France

Author

Soazig Disquay-Perot, Laurence Cocandeau-Bellanger, Angel Egido-Portela, Nadia Baatouche, Nathalie Prudhomme, and Emmanuelle Vignoli

Subjects
decent work, meaning of work, young adults, Psychology, BF1-990
Abstract

The current labor market context is characterized by a diversification of forms of employment, a transformation of work organizations and a singularization of career paths. This article aims to analyze and describe how young adults conceive their professional future and how they define a decent job. Data were obtained through semistructured interviews with ten young adults. The corpus of interviews was subjected to content analysis. The results show that work is a necessity for young people, without being a priori an end in itself. Some criteria of decent work (ILO) are more widespread than others, however, the links with the desire to maintain an activity and the social and fulfillment dimensions tend to show that models of a job integrating the dimension of personal development remain prevalent. This study leads to a reflection on the value of the diploma, which had been meaningless in school and is now presented as a passport to renew professional life. It is true that the emerging adult finds work, but to aspire to more, he or she will have to undergo training, which is now essential for personal and professional development.

Published
2023

48. ICARUS at the Fermilab Short-Baseline Neutrino program: initial operation

Author

P. Abratenko, A. Aduszkiewicz, F. Akbar, M. Artero Pons, J. Asaadi, M. Aslin, M. Babicz, W. F. Badgett, L. F. Bagby, B. Baibussinov, B. Behera, V. Bellini, O. Beltramello, R. Benocci, J. Berger, S. Berkman, S. Bertolucci, R. Bertoni, M. Betancourt, M. Bettini, S. Biagi, K. Biery, O. Bitter, M. Bonesini, T. Boone, B. Bottino, A. Braggiotti, D. Brailsford, J. Bremer, S. J. Brice, V. Brio, C. Brizzolari, J. Brown, H. S. Budd, F. Calaon, A. Campani, D. Carber, M. Carneiro, I. Caro Terrazas, H. Carranza, D. Casazza, L. Castellani, A. Castro, S. Centro, G. Cerati, M. Chalifour, P. Chambouvet, A. Chatterjee, D. Cherdack, S. Cherubini, N. Chithirasreemadam, M. Cicerchia, V. Cicero, T. Coan, A. G. Cocco, M. R. Convery, S. Copello, E. Cristaldo, A. A. Dange, I. de Icaza Astiz, A. De Roeck, S. Di Domizio, L. Di Noto, C. Di Stefano, D. Di Ferdinando, M. Diwan, S. Dolan, L. Domine, S. Donati, R. Doubnik, F. Drielsma, J. Dyer, S. Dytman, C. Fabre, F. Fabris, A. Falcone, C. Farnese, A. Fava, H. Ferguson, A. Ferrari, F. Ferraro, N. Gallice, F. G. Garcia, M. Geynisman, M. Giarin, D. Gibin, S. G. Gigli, A. Gioiosa, W. Gu, M. Guerzoni, A. Guglielmi, G. Gurung, S. Hahn, K. Hardin, H. Hausner, A. Heggestuen, C. Hilgenberg, M. Hogan, B. Howard, R. Howell, J. Hrivnak, M. Iliescu, G. Ingratta, C. James, W. Jang, M. Jung, Y.-J. Jwa, L. Kashur, W. Ketchum, J. S. Kim, D.-H. Koh, U. Kose, J. Larkin, G. Laurenti, G. Lukhanin, S. Marchini, C. M. Marshall, S. Martynenko, N. Mauri, A. Mazzacane, K. S. McFarland, D. P. Méndez, A. Menegolli, G. Meng, O. G. Miranda, D. Mladenov, A. Mogan, N. Moggi, E. Montagna, C. Montanari, A. Montanari, M. Mooney, G. Moreno-Granados, J. Mueller, D. Naples, M. Nebot-Guinot, M. Nessi, T. Nichols, M. Nicoletto, B. Norris, S. Palestini, M. Pallavicini, V. Paolone, R. Papaleo, L. Pasqualini, L. Patrizii, R. Peghin, G. Petrillo, C. Petta, V. Pia, F. Pietropaolo, J. Poirot, F. Poppi, M. Pozzato, M. C. Prata, A. Prosser, G. Putnam, X. Qian, G. Rampazzo, A. Rappoldi, G. L. Raselli, R. Rechenmacher, F. Resnati, A. M. Ricci, G. Riccobene, L. Rice, E. Richards, A. Rigamonti, M. Rosenberg, M. Rossella, C. Rubbia, P. Sala, P. Sapienza, G. Savage, A. Scaramelli, A. Scarpelli, D. Schmitz, A. Schukraft, F. Sergiampietri, G. Sirri, J. S. Smedley, A. K. Soha, M. Spanu, L. Stanco, J. Stewart, N. B. Suarez, C. Sutera, H. A. Tanaka, M. Tenti, K. Terao, F. Terranova, V. Togo, D. Torretta, M. Torti, F. Tortorici, N. Tosi, Y.-T. Tsai, S. Tufanli, M. Turcato, T. Usher, F. Varanini, S. Ventura, F. Vercellati, M. Vicenzi, C. Vignoli, B. Viren, D. Warner, Z. Williams, R. J. Wilson, P. Wilson, J. Wolfs, T. Wongjirad, A. Wood, E. Worcester, M. Worcester, M. Wospakrik, H. Yu, J. Yu, A. Zani, P. G. Zatti, J. Zennamo, J. C. Zettlemoyer, C. Zhang, S. Zucchelli, and M. Zuckerbrot

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The ICARUS collaboration employed the 760-ton T600 detector in a successful 3-year physics run at the underground LNGS laboratory, performing a sensitive search for LSND-like anomalous $$\nu _e$$ ν e appearance in the CERN Neutrino to Gran Sasso beam, which contributed to the constraints on the allowed neutrino oscillation parameters to a narrow region around 1 eV $$^2$$ 2 . After a significant overhaul at CERN, the T600 detector has been installed at Fermilab. In 2020 the cryogenic commissioning began with detector cool down, liquid argon filling and recirculation. ICARUS then started its operations collecting the first neutrino events from the booster neutrino beam (BNB) and the Neutrinos at the Main Injector (NuMI) beam off-axis, which were used to test the ICARUS event selection, reconstruction and analysis algorithms. ICARUS successfully completed its commissioning phase in June 2022. The first goal of the ICARUS data taking will be a study to either confirm or refute the claim by Neutrino-4 short-baseline reactor experiment. ICARUS will also perform measurement of neutrino cross sections with the NuMI beam and several Beyond Standard Model searches. After the first year of operations, ICARUS will search for evidence of sterile neutrinos jointly with the Short-Baseline Near Detector, within the Short-Baseline Neutrino program. In this paper, the main activities carried out during the overhauling and installation phases are highlighted. Preliminary technical results from the ICARUS commissioning data with the BNB and NuMI beams are presented both in terms of performance of all ICARUS subsystems and of capability to select and reconstruct neutrino events.

Published
2023
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49. Design Thinking and Career Development: A Comparative Study

Author

Clio Dosi, Eric Guerci, Jacek Jakieła, Joanna Świętoniowska, Eleni Vordou, Maria José Varadinov, Matteo Vignoli, Gastão de Jesus Marques, and Joanna Wójcik

Subjects
Mechanical drawing. Engineering graphics, T351-385
Abstract

This study conceives career development as a design process and not as a planning activity. An uncertain and fast-changing professional environment requires adaptation and training in a proper mindset. Since there is no such thing as “expertise” in life, Design methodologies and principles may be helpful for students to develop self-awareness and guidance. This study presents a comparative approach based on Beckman and Barry’s (2007) learning framework of the two main career development methodologies for students based on Design Thinking: “Designing Your Life and BE(A)ST” (BE Aware STudent). Designing Your Life explores design thinking principles and techniques to help individuals create fulfilling and meaningful careers. BE(A)ST is an approach, process, and set of tools that assist students in designing their careers while still at university.

Published
2024
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50. Simulation and background characterisation of the SABRE South experiment: SABRE South Collaboration

Author

Barberio, E., Baroncelli, T., Bignell, L. J., Bolognino, I., Brooks, G., Dastgiri, F., D’Imperio, G., Di Giacinto, A., Duffy, A. R., Froehlich, M., Fu, G., Gerathy, M. S. M., Hill, G. C., Krishnan, S., Lane, G. J., Lawrence, G., Leaver, K. T., Mahmood, I., Mariani, A., McGee, P., McKie, L. J., McNamara, P. C., Mews, M., Melbourne, W. J. D., Milana, G., Milligan, L. J., Mould, J., Nuti, F., Pettinacci, V., Scutti, F., Slavkovská, Z., Spinks, N. J., Stanley, O., Stuchbery, A. E., Taylor, G. N., Tomei, C., Urquijo, P., Vignoli, C., Williams, A. G., Zhong, Y. Y., and Zurowski, M. J.

Published
2023
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