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Pseudotrimezia juncifolia (Klatt) Lovo & A. Gil (Iridaceae) is a popularly known species with primarily ornamental economic interest. It has traditional uses as purgative, in conditions related to the menstrual cycle, for blood purification, as wound healing, and as anti-inflammatory. The anti-inflammatory and antinociceptive activities of the decoction from its aerial stems, corms, and stamens are described here with dereplication studies on LC-MS/MS supported by the GNPS platform, where phenolic compounds were annotated and correlated with its biological activity. The decoction was evaluated in chemical (formalin and capsaicin) and thermal (hot plate) induced nociception or carrageenan-induced inflammation in mice. Decoction (at 10, 30, or 100 mg/kg doses) significantly reduced formalin- or capsaicin-induced nociception. All doses also demonstrated an antinociceptive effect in the hot plate model increasing the time the animal spent in responding to thermal signal. Naloxone partially reversed the antinociceptive effect. An anti-inflammatory effect was observed since a reduction in cell migration, protein extravasation interleukin-1, and tumor necrosis factor production induced by carrageenan in the subcutaneous air pouch was quantified. Metabolomic analyses showed a predominance of phenolic substances, mainly flavonoids and chlorogenic acids. The literature showed that these two groups have significant anti-inflammatory and analgesic activity, and chemical data corroborate the pharmacological results observed. [ABSTRACT FROM AUTHOR]

The yield and chemical composition of the essential oils from the leaves of seven accessions of sour orange from a germplasm bank, harvested in two different seasons, were analyzed by GC-FID and GC-MS. The oil yields ranged from 0.2 to 0.6% in the dry season and from traces to 1.1% in the wet season. Major compounds found were linalool (6.6 to 48.9%), linalyl acetate (0.4 to 33.8%) and a-terpineol (0.3 to 10.8%) for most of the samples. For one accession, β-pinene (31.3 to 46.0%) was the major constituent, while for another, methyl N-methyl-anthranilate reached up to 30.9% of the oil in the wet season. Within the seasons, each access presented similar profiles, as verified by Principal Component Analysis of the essential oil constituents. [ABSTRACT FROM AUTHOR]

Thepurpose of this study was to evaluate the essential oil composition and yield fromleaves of two Brazilian species (Myracrodruon urundeuva and Blepharocalyx salicifolius) harvested during daytime. Essential oils were obtained by steam distillation and had their yield determined. Blepharocalyx salicifolius presented yields of 0.049% (9 a.m.), 0.045% (1 p.m.), and 0.069% (5 p.m.). For Myracrodruon urundeuva, we found 0.13% (9 a.m.), 0.11% (1 p.m.), and 0.08% (5 p.m.). Finally, compound identification and quantification were carried out by GC-MS and GC-FID techniques, respectively. Thirteen major compounds were identified for Blepharocalyx salicifolius, representing 91.6% of the EOs, of which p-cymene (25.9%) was detected as amajor component. Nine major compounds were identified for Myracrodruon urundeuva, representing 90.3% of the EOs, whereas β-myrcene showed the greatest concentration (66.4%). [ABSTRACT FROM AUTHOR]

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