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370 results on '"Vidal, L."'

1. Combination of Indomethacin with Nanostructured Lipid Carriers for Effective Anticancer Therapy

Author

Thiruchenthooran V, Espina M, Świtalska M, Bonilla-Vidal L, Wietrzyk J, Garcia ML, Souto EB, Sánchez-López E, and Gliszczyńska A

Subjects
lipid nanoparticles, indomethacin, antitumoral activity, tumor-targeting, Medicine (General), R5-920
Abstract

Vaikunthavasan Thiruchenthooran,1 Marta Espina,2,3 Marta Świtalska,4 Lorena Bonilla-Vidal,2,3 Joanna Wietrzyk,4 Maria Luisa Garcia,2,3 Eliana B Souto,5 Elena Sánchez-López,2,3,6,* Anna Gliszczyńska1,* 1Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Wrocław, Poland; 2Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, University of Barcelona, Barcelona, Spain; 3Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain; 4Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland; 5Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; 6Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Barcelona, Spain*These authors contributed equally to this workCorrespondence: Anna Gliszczyńska; Elena Sánchez-López, Email anna.gliszczynska@upwr.edu.pl; esanchezlopez@ub.eduPurpose: The anticancer potential of indomethacin and other nonsteroidal anti-inflammatory drugs (NSAIDs) in vitro, in vivo, and in clinical trials is well known and widely reported in the literature, along with their side effects, which are mainly observed in the gastrointestinal tract. Here, we present a strategy for the application of the old drug indomethacin as an anticancer agent by encapsulating it in nanostructured lipid carriers (NLC). We describe the production method of IND-NLC, their physicochemical parameters, and the results of their antiproliferative activity against selected cancer cell lines, which were found to be higher compared to the activity of free indomethacin.Methods: IND-NLC were fabricated using the hot high-pressure homogenization method. The nanocarriers were physicochemically characterized, and their biopharmaceutical behaviour and therapeutic efficacy were evaluated in vitro.Results: Lipid nanoparticles IND-NLC exhibited a particle size of 168.1 nm, a negative surface charge (– 30.1 mV), low polydispersity index (PDI of 0.139), and high encapsulation efficiency (over 99%). IND-NLC were stable for over 60 days and retained integrity during storage at 4 °C and 25 °C. The potential therapeutic benefits of IND-NLC were screened using in vitro cancer models, where nanocarriers with encapsulated drug effectively inhibited the growth of breast cancer cell line MDA-MB-468 at dosage 15.7 μM.Conclusion: We successfully developed IND-NLC for delivery of indomethacin to cancer cells and confirmed their antitumoral efficacy in in vitro studies. The results suggest that indomethacin encapsulated in lipid nanoparticles possesses high anticancer potential. Moreover, the presented strategy is highly promising and may offer a new alternative for future therapeutic drug innovations. Keywords: lipid nanoparticles, indomethacin, antitumoral activity, tumor-targeting

Published
2024

5. Dually Active Apigenin-Loaded Nanostructured Lipid Carriers for Cancer Treatment

Author

Bonilla-Vidal L, Świtalska M, Espina M, Wietrzyk J, García ML, Souto EB, Gliszczyńska A, and Sánchez López E

Subjects
antitumoral, lipid nanoparticles, apigenin, rosehip oil., Medicine (General), R5-920
Abstract

Lorena Bonilla-Vidal,1,2 Marta Świtalska,3 Marta Espina,1,2 Joanna Wietrzyk,3 Maria Luisa García,1,2 Eliana B Souto,4,5 Anna Gliszczyńska,6,* Elena Sánchez López1,2,7,* 1Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, University of Barcelona, Barcelona, Spain; 2Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain; 3Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland; 4Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal; 5Associate Laboratory i4HB—Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal; 6Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Wrocław, Poland; 7Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Barcelona, Spain*These authors contributed equally to this workCorrespondence: Elena Sánchez López; Anna Gliszczyńska, Email esanchezlopez@ub.edu; anna.gliszczynska@upwr.edu.plPurpose: Cancer is one of the major causes of death worldwide affecting more than 19 million people. Traditional cancer therapies have many adverse effects and often result in unsatisfactory outcomes. Natural flavones, such as apigenin (APG), have demonstrated excellent antitumoral properties. However, they have a low aqueous solubility. To overcome this drawback, APG can be encapsulated in nanostructured lipid carriers (NLC). Therefore, we developed dual NLC encapsulating APG (APG-NLC) with a lipid matrix containing rosehip oil, which is known for its anti-inflammatory and antioxidant properties.Methods: Optimisation, physicochemical characterisation, biopharmaceutical behaviour, and therapeutic efficacy of this novel nanostructured system were assessed.Results: APG-NLC were optimized obtaining an average particle size below 200 nm, a surface charge of − 20 mV, and an encapsulation efficiency over 99%. The APG-NLC released APG in a sustained manner, and the results showed that the formulation was stable for more than 10 months. In vitro studies showed that APG-NLC possess significant antiangiogenic activity in ovo and selective antiproliferative activity in several cancer cell lines without exhibiting toxicity in healthy cells.Conclusion: APG-NLC containing rosehip oil were optimised. They exhibit suitable physicochemical parameters, storage stability for more than 10 months, and prolonged APG release. Moreover, APG-NLC were internalised inside tumour cells, showing the capacity to cause cytotoxicity in cancer cells without damaging healthy cells.Keywords: antitumoral, lipid nanoparticles, apigenin, rosehip oil

Published
2023

9. Post-acute phase and sequelae management of epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus

Author

Ingen-Housz-Oro, S., Schmidt, V., Ameri, M. M., Abe, R., Brassard, A., Mostaghimi, A., Paller, A. S., Romano, A., Didona, B., Kaffenberger, B. H., Ben Said, B., Thong, B. Y. H., Ramsay, B., Brezinova, E., Milpied, B., Mortz, C. G., Chu, C. Y., Sotozono, C., Gueudry, J., Fortune, D. G., Dridi, S. M., Tartar, D., Do-Pham, G., Gabison, E., Phillips, E. J., Lewis, F., Salavastru, C., Horvath, B., Dart, J., Setterfield, J., Newman, J., Schulz, J. T., Delcampe, A., Brockow, K., Seminario-Vidal, L., Jörg, L., Watson, M. P., Gonçalo, M., Lucas, M., Torres, M., Noe, M. H., Hama, N., Shear, N. H., O’Reilly, P., Wolkenstein, P., Romanelli, P., Dodiuk-Gad, R. P., Micheletti, R. G., Tiplica, G. S., Sheridan, R., Rauz, S., Ahmad, S., Chua, S. L., Flynn, T. H., Pichler, W., Le, S. T., Maverakis, E., Walsh, S., French, L. E., and Brüggen, M. C.

Published
2023
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41. Clinical Practice Guideline (CPG). Recommendations on strategy for reducing risk of heart failure patients requiring noncardiac surgery: Reducing risk of heart failure patients in noncardiac surgery

Author

Alvarez Escudero, J., Calvo Vecino, J.M., Baluja, A., Cabadas, R., Cariñena, A., Garcia, R., González, A., González-Juanatey, J.R., Gilsanz, F., Muñoz Aguilera, R., Muñoz, P., Solera, J., Martín Trapero, C., Ortega Urbaneja, M., Veiras, S., Abad Gurumeta, A., Acosta, F., Alvarez, J., Baños, G., Calderón, E., Castaño, B., Casans Francés, R., De Paz, D., Emad-Assi, A., Espinosa, A.V., García, G., García, J., García Sánchez, J.I., Guillén, A., Longás Valién, J., Matute, P., Moguel, J.A., López Pais, P., Olmos, M.A., Pensado, A., Pereira, M.A., Ripollés Melchor, J., Rodríguez Fernández, V., Segovia, J., Torres, L.M., Valía, J.C., Veiga Almeida, C., Veintemilla, F., Vidal, M., Vidal, L., and García, R.

Published
2015
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