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32 results on '"Venneman, Niels G."'

1. Long-Term Outcome of Immediate Versus Postponed Intervention in Patients With Infected Necrotizing Pancreatitis (POINTER): Multicenter Randomized Trial

Author

Van Veldhuisen, Charlotte L., Sissingh, Noor J., Boxhoorn, Lotte, van Dijk, Sven M., van Grinsven, Janneke, Verdonk, Robert C., Boermeester, Marja A., Bouwense, Stefan A.W., Bruno, Marco J., Cappendijk, Vincent C., van Duijvendijk, Peter, van Eijck, Casper H J., Fockens, Paul, van Goor, Harry, Hadithi, Muhammed, Haveman, Jan Willem, Jacobs, Maarten A.J.M., Jansen, Jeroen M., Kop, Marnix P.M., Manusama, Eric R., Mieog, J. Sven D., Molenaar, I. Quintus, Nieuwenhuijs, Vincent B., Poen, Alexander C., Poley, Jan-Werner, Quispel, Rutger, Römkens, Tessa E.H., Schwartz, Matthijs P., Seerden, Tom C., Dijkgraaf, Marcel G.W., Stommel, Martijn W.J., Straathof, Jan Willem A., Venneman, Niels G., Voermans, Rogier P., van Hooft, Jeanin E., van Santvoort, Hjalmar C., and Besselink, Marc G.

Published
2024
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2. Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO): study protocol for a randomized controlled trial

Author

Kastelijn, Janine B., van de Pavert, Yorick L., Besselink, Marc G., Fockens, Paul, Voermans, Rogier P., van Wanrooij, Roy L. J., de Wijkerslooth, Thomas R., Curvers, Wouter L., de Hingh, Ignace H. J. T., Bruno, Marco J., Koerkamp, Bas Groot, Patijn, Gijs A., Poen, Alexander C., van Hooft, Jeanin E., Inderson, Akin, Mieog, J. Sven D., Poley, Jan-Werner, Bijlsma, Alderina, Lips, Daan J., Venneman, Niels G., Verdonk, Robert C., van Dullemen, Hendrik M., Hoogwater, Frederik J. H., Frederix, Geert W. J., Molenaar, I. Quintus, Welsing, Paco M. J., Moons, Leon M. G., van Santvoort, Hjalmar C., and Vleggaar, Frank P.

Published
2023
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4. A mixed-methods study to define Textbook Outcome for the treatment of patients with uncomplicated symptomatic gallstone disease with hospital variation analyses in Dutch trial data

Author

Eijsbouts, Quirijn A.J., Heisterkamp, Joos, Boerma, Djamila, Jennifer, M.J., van Duivendijk, Peter, Wiering, Bastiaan, Boermeester, Marja A., Diepenhorst, Gwen, van der Bilt, Jarmila, Buyne, Otmar, Venneman, Niels G., Keszthelyi, Daniel, Ahmed, Ifran, Hugh, Thomas J., Wigmore, Stephen J., Strasberg, Steven M., Harrison, Ewen M., Lammert, Frank, Gurusamy, Kurinchi, Moris, Dimitros, Soreide, Kjetil, Pappas, Theodore N., Kapoor, Vinay K., Speelman, Antonia, van den Brink, Chris, Thunnissen, Floris M., Comes, Daan J., Latenstein, Carmen S.S., Stommel, Martijn W.J., van Laarhoven, Cornelis J.H.M., Drenth, Joost P.H., Lantinga, Marten A., Atsma, Femke, and de Reuver, Philip R.

Published
2023
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5. Overuse and Misuse of Antibiotics and the Clinical Consequence in Necrotizing Pancreatitis: An Observational Multicenter Study

Author

Timmerhuis, Hester C., van den Berg, Fons F., Noorda, Paula C., van Dijk, Sven M., van Grinsven, Janneke, Sperna Weiland, Christina J., Umans, Devica S., Mohamed, Yasmin A., Curvers, Wouter L., Bouwense, Stefan A.W., Hadithi, Muhammed, Inderson, Akin, Issa, Yama, Jansen, Jeroen M., de Jonge, Pieter Jan F., Quispel, Rutger, Schwartz, Matthijs P., Stommel, Martijn W.J., Tan, Adriaan C.I.T.L., Venneman, Niels G., Besselink, Marc G., Bruno, Marco J., Bollen, Thomas L., Sieswerda, Elske, Verdonk, Robert C., Voermans, Rogier P., and van Santvoort, Hjalmar C.

Published
2023
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6. Diagnostic accuracy of endoscopic ultrasonography-guided tissue acquisition prior to resection of pancreatic carcinoma: a nationwide analysis

Author

Quispel, Rutger, Schutz, Hannah M., Keultjes, Augustinus W.P., Erler, Nicole S., Janssen, Quisette P., van Hooft, Jeanin E., Venneman, Niels G., Honkoop, Pieter, Hol, Lieke, Scheffer, Robert C., Bisseling, Tanya M., Voermans, Rogier P., Vleggaar, Frank P., Schwartz, Matthijs P., Verdonk, Robert C., Hoge, Chantal V., Kuiken, Sjoerd D., Curvers, Wouter L., van Vilsteren, Frederike G.I., Poen, Alexander C., Spanier, Marcel B., Bruggink, Annette H., Smedts, Frank M., van Velthuysen, Marie-Louise F., van Eijck, Casper H., Besselink, Marc G., Veldt, Bart J., Koerkamp, Bas G., van Driel, Lydi M.J.W., and Bruno, Marco J.

Published
2023
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7. Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT): a multicentre, open-label, randomised, controlled trial

Author

Sperna Weiland, Christina J, Smeets, Xavier J N M, Kievit, Wietske, Verdonk, Robert C, Poen, Alexander C, Bhalla, Abha, Venneman, Niels G, Witteman, Ben J M, da Costa, David W, van Eijck, Brechje C, Schwartz, Matthijs P, Römkens, Tessa E H, Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M C J, Baak, Lubbertus C, Thijs, Willem J, van Wanrooij, Roy L, Tan, Adriaan C I T L, Seerden, Tom C J, Keulemans, Yolande C A, de Wijkerslooth, Thomas R, van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M, Hallensleben, Nora D L, Sperna Weiland, Ruud L, Timmerhuis, Hester C, Umans, Devica S, van Hooft, Jeanin E, van Goor, Harry, van Santvoort, Hjalmar C, Besselink, Marc G, Bruno, Marco J, Fockens, Paul, Drenth, Joost P H, and van Geenen, Erwin J M

Published
2021
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8. Nationwide practice and outcomes of endoscopic biliary drainage in resectable pancreatic head and periampullary cancer

Author

Latenstein, Anouk E.J., Mackay, Tara M., van Huijgevoort, Nadine C.M., Bonsing, Bert A., Bosscha, Koop, Hol, Lieke, Bruno, Marco J., van Coolsen, Marielle M.E., Festen, Sebastiaan, van Geenen, Erwin, Groot Koerkamp, Bas, Hemmink, Gerrit J.M., de Hingh, Ignace H.J.T., Kazemier, Geert, Lubbinge, Hans, de Meijer, Vincent E., Molenaar, I. Quintus, Quispel, Rutger, van Santvoort, Hjalmar C., Seerden, Tom C.J., Stommel, Martijn W.J., Venneman, Niels G., Verdonk, Robert C., Besselink, Marc G., and van Hooft, Jeanin E.

Published
2021
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9. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial

Author

Manusama, Eric R, Hadithi, Mohammed, Rosman, Camiel, Schaapherder, Alexander F, Schoon, Erik J, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C, Bakker, Olaf J, Besselink, Marc G, Boermeester, Marja A, Bollen, Thomas L, Bosscha, Koop, Bouwense, Stefan A, Bruno, Marco J, Cappendijk, Vincent C, Consten, Esther C, Dejong, Cornelis H, van Eijck, Casper H, Erkelens, Willemien G, van Goor, Harry, van Grevenstein, Wilhelmina M U, Haveman, Jan-Willem, Hofker, Sijbrand H, Jansen, Jeroen M, Laméris, Johan S, van Lienden, Krijn P, Meijssen, Maarten A, Mulder, Chris J, Nieuwenhuijs, Vincent B, Poley, Jan-Werner, Quispel, Rutger, de Ridder, Rogier J, Römkens, Tessa E, Scheepers, Joris J, Schepers, Nicolien J, Schwartz, Matthijs P, Seerden, Tom, Spanier, B W Marcel, Straathof, Jan Willem A, Strijker, Marin, Timmer, Robin, Venneman, Niels G, Vleggaar, Frank P, Voermans, Rogier P, Witteman, Ben J, Gooszen, Hein G, Dijkgraaf, Marcel G, and Fockens, Paul

Published
2018
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10. Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial

Author

Smeets, Xavier J. N. M., da Costa, David W., Fockens, Paul, Mulder, Chris J. J., Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J., Besselink, Marc G. H., Vleggaar, Frank P., van der Hulst, Rene W. M., Poen, Alexander C., Heine, Gerbrand D. N., Venneman, Niels G., Kolkman, Jeroen J., Baak, Lubbertus C., Römkens, Tessa E. H., van Dijk, Sven M., Hallensleben, Nora D. L., van de Vrie, Wim, Seerden, Tom C. J., Tan, Adriaan C. I. T. L., Voorburg, Annet M. C. J., Poley, Jan-Werner, Witteman, Ben J., Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J., Schwartz, Matthijs P., Vrolijk, Jan Maarten, Verdonk, Robert C., van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P. H., van Geenen, Erwin J. M., and for the Dutch Pancreatitis Study Group

Published
2018
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11. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients.

Author

Timmerhuis, Hester C., van Dijk, Sven M., Hollemans, Robbert A., Weiland, Christina J. Sperna, Umans, Devica S., Boxhoorn, Lotte, Hallensleben, Nora H., van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa E. H., Quispel, Rutger, Schwartz, Matthijs P., Tan, Adriaan C. I. T. L., Venneman, Niels G., and Vleggaar, Frank P.

Published
2023
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14. Performance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction.

Author

Sperna Weiland, Christina J., Busch, Celine B. E., Bhalla, Abha, Bruno, Marco J., Fockens, Paul, van Hooft, Jeanin E., Poen, Alexander C., Timmerhuis, Hester C., Umans, Devica S., Venneman, Niels G., Verdonk, Robert C., Drenth, Joost P. H., de Wijkerslooth, Thomas R., and van Geenen, Erwin J. M.

Abstract

Background: Acute cholangitis is an infection requiring endoscopic retrograde cholangiopancreatography (ERCP) and antibiotics. Several diagnostic tools help to diagnose cholangitis. Because diagnostic performance of these tools has not been studied and might therefore impose unnecessary ERCPs, we aimed to evaluate this. Methods: We established a nationwide prospective cohort of patients with suspected biliary obstruction who underwent an ERCP. We assessed the diagnostic performance of Tokyo Guidelines (TG18), Dutch Pancreatitis Study Group (DPSG) criteria, and Charcot triad relative to real‐world cholangitis as the reference standard. Results: 127 (16%) of 794 patients were diagnosed with real‐world cholangitis. Using the TG18, DPSG, and Charcot triad, 345 (44%), 55 (7%), and 66 (8%) patients were defined as having cholangitis, respectively. Sensitivity for TG18 was 82% (95% CI 74‐88) and specificity 60% (95% CI 56‐63). The sensitivity for DPSG and Charcot was 42% (95% CI 33‐51) and 46% (95% CI 38‐56), specificity was 99.7% (95% CI 99‐100) and 99% (95% CI 98‐100), respectively. Conclusions: TG18 criteria incorrectly diagnoses four out of ten patients with real‐world cholangitis, while DPSG and Charcot criteria failed to diagnose more than half of patients. As the cholangitis diagnosis has many consequences for treatment, there is a need for more accurate diagnostic tools or work‐up towards ERCP. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Increased Use of Prophylactic Measures in Preventing Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis.

Author

Sperna Weiland, Christina J., Engels, Megan M. L., Poen, Alexander C., Bhalla, Abha, Venneman, Niels G., van Hooft, Jeanin E., Bruno, Marco J., Verdonk, Robert C., Fockens, Paul, Drenth, Joost P. H., and van Geenen, Erwin J. M.

Subjects
PANCREATIC duct, CHRONIC pancreatitis, PANCREATITIS, ANTI-inflammatory agents, NONSTEROIDAL anti-inflammatory agents, INJECTIONS
Abstract

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs), pancreatic duct stenting, and intensive intravenous hydration have been proven to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Trial participation and guideline changes demanded an assessment of the clinical practice of post-ERCP pancreatitis prophylaxis. Aims: The surveys aim to identify points of improvement to inform and educate ERCPists about current evidence-based practice. Methods: Two anonymous surveys were conducted among Dutch gastroenterologists in 2013 (n = 408) and 2020 (n = 575) for longitudinal views and attitudes pertaining to post-ERCP pancreatitis prophylaxis and recognition of post-ERCP pancreatitis risk factors. Results: In 2013 and 2020, respectively, 121 and 109 ERCPists responded. In the 2013 survey, 98% of them utilized NSAID prophylaxis and 62% pancreatic duct stent prophylaxis in specific cases. In the 2020 survey, the use of NSAIDs (100%), pancreatic duct stents (78%), and intensive intravenous hydration (33%) increased among ERCPists. NSAID prophylaxis was the preferred prophylactic measure for all risk factors in the 2020 survey, except for ampullectomy, pancreatic duct contrast injection, and pancreatic duct cannulation, for which NSAID prophylaxis and pancreatic duct stent combined was equally favored or preferred. Conclusion: Rectal NSAIDs are the most applied post-ERCP pancreatitis prophylaxis in the Netherlands, followed by pancreatic duct stents and intensive intravenous hydration. Additionally, there is reason to believe that recent guideline updates and active research participation have led to increased prophylaxis implementation. [ABSTRACT FROM AUTHOR]

Published
2021
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21. Higher quality of life after metal stent placement compared with plastic stent placement for malignant extrahepatic bile duct obstruction: a randomized controlled trial.

Author

Walter, Daisy, van Boeckel, Petra G.A., Groenen, Marcel J.M., Weusten, Bas L.A.M., Witteman, Ben J., Tang, Gi, Brink, Menno A., Nicolai, Jan, Tan, Adriaan C., Alderliesten, Joyce, Venneman, Niels G., Laleman, Wim, Jansen, Jeroen M., Bodelier, Alexander, Wolters, Frank L., van der Waaij, Laurens A., Breumelhof, Ronald, Peters, Frans T.M., Scheffer, Robbert C.H., and Steyerberg, Ewout W.

Published
2017
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23. Cost Efficacy of Metal Stents for Palliation of Extrahepatic Bile Duct Obstruction in a Randomized Controlled Trial.

Author

Walter, Daisy, van Boeckel, Petra G.A., Groenen, Marcel J., Weusten, Bas L.A.M., Witteman, Ben J., Tan, Gi, Brink, Menno A., Nicolai, Jan, Tan, Adriaan C., Alderliesten, Joyce, Venneman, Niels G., Laleman, Wim, Jansen, Jeroen M., Bodelier, Alexander, Wolters, Frank L., van der Waaij, Laurens A., Breumelhof, Ronald, Peters, Frank T.M., Scheffer, Robbert C.H., and Leenders, Max

Abstract

Background & Aims Endoscopic stents are placed for palliation of extrahepatic bile duct obstruction. Although self-expandable metal stents (SEMS) remain patent longer than plastic stents, they are more expensive. We aimed to evaluate which type of stent (plastic, uncovered SEMS [uSEMS], or partially covered SEMS [pcSEMS]) is the most effective and we assessed costs. Methods We performed a multicenter randomized trial in 219 patients at 18 hospitals in The Netherlands from February 2008 through February 2013. Patients were assigned randomly for placement of a plastic stent (n = 73), uSEMS (n = 75), or pcSEMS (n = 71) during endoscopic retrograde cholangiopancreatography. Patients were followed up for up to 1 year. Researchers were not blinded to groups. The main study end points included functional stent time and costs. Results The mean functional stent times were 172 days for plastic stents, 288 days for uSEMS, and 299 days for pcSEMS ( P < .005 for uSEMS and pcSEMS vs plastic). The initial placement of plastic stents (€1042 or $1106) cost significantly less than placement of SEMS (€1973 or $2094) ( P = .001). However, the total cost per patient at the end of the follow-up period did not differ significantly between plastic stents (€7320 or $7770) and SEMS (€6932 or $7356) ( P = .61). Furthermore, in patients with short survival times (≤3 mo) or metastatic disease, the total cost per patient did not differ between plastic stents and SEMS. No differences in costs were found between pcSEMS and uSEMS. Conclusions Although placement of SEMS (uncovered or partially covered) for palliation of extrahepatic bile duct obstruction initially is more expensive than placement of plastic stents, SEMS have longer functional time. The total costs after 1 year do not differ significantly with stent type. Dutch Clinical Trial Registration no: NTR1361. [ABSTRACT FROM AUTHOR]

Published
2015
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24. Reassessment of the predictive value of the Forrest classification for peptic ulcer rebleeding and mortality: can classification be simplified?

Author

de Groot, Nicolette L., van Oijen, Martijn G. H., Kessels, Koen, Hemmink, Maarten, Weusten, Bas L. A. M., Timmer, Robin, Hazen, Wouter L., van Lelyveld, Niels, Vermeijden, Reinoud R., Curvers, Wouter L., Baak, Bert C., Verburg, Robert, Bosman, Joukje H., de Wijkerslooth, Laetitia R. H, de Rooij, Janne, Venneman, Niels G., Pennings, Marieke, van Hee, Koen, Scheffer, Bob C. H., and van Eijk, Rachel L.

Subjects
PEPTIC ulcer, STOMACH ulcers, GASTROINTESTINAL hemorrhage, MORTALITY, GASTROENTEROLOGY
Abstract

Background and study aims: This study aimed to reassess whether the Forrest classification is still useful for the prediction of rebleeding and mortality in peptic ulcer bleedings and, based on this, whether the classification could be simplified. Patients and methods: Prospective registry data on peptic ulcer bleedingswere collected and categorized according to the Forrest classification. The primary outcomes were 30-day rebleeding and all-cause mortality rates. Receiver operating characteristic curves were used to test whether simplification of the Forrest classification into high risk (Forrest Ia), increased risk (Forrest Ib -IIc), and low risk (Forrest III) classes could be an alternative to the original classification. Results: In total, 397 patients were included, with 18 bleedings (4.5 %) being classified as Forrest Ia, 73 (18.4 %) as Forrest Ib, 86 (21.7 %) as Forrest IIa, 32 (8.1 %) as Forrest IIb, 59 (14.9 %) as Forrest IIc, and 129 (32.5 %) as Forrest III. Rebleeding occurred in 74 patients (18.6 %). Rebleeding rates were highest in Forrest Ia peptic ulcers (59 %). The odds ratios for rebleeding among Forrest Ib -IIc ulcers were similar. In subgroup analysis, predicting rebleeding using the Forrest classificationwas more reliable for gastric ulcers than for duodenal ulcers. The simplified Forrest classification had similar test characteristics to the original Forrest classification. Conclusion: The Forrest classification still has predictive value for rebleeding of peptic ulcers, especially for gastric ulcers; however, it does not predict mortality. Based on these results, a simplified Forrest classification is proposed. However, further studies are needed to validate these findings. [ABSTRACT FROM AUTHOR]

Published
2014
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25. ID: 3520219 A RANDOMIZED TRIAL OF AGGRESSIVE FLUID HYDRATION TO PREVENT POST-ERCP PANCREATITIS (FLUYT).

Author

Sperna Weiland, Christa J., Smeets, Xavier, Kievit, Wietske, Verdonk, Robert C., Poen, A.C., Bhalla, Abha, Venneman, Niels G., Witteman, Ben, da Costa, David W., van Eijck, Brechje, Schwartz, Matthijs P., Romkens, Tessa, Vrolijk, Jan, Hadithi, Muhammed, Voorburg, Annet, Baak, Lubbertus C., Thijs, Willem, Wanrooij, Roy V., Tan, Adriaan C., and Seerden, Tom

Published
2021
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28. Effects of hydrophobic and hydrophilic bile salts on gallstone growth and dissolution in model biles

Author

Venneman, Niels G., van Kammen, Marieke, Renooij, Willem, vanBerge-Henegouwen, Gerard P., and van Erpecum, Karel J.

Subjects
*GALLSTONES, *BILE duct diseases, *BILE salts, *CHOLESTEROL, *STEROLS, *ISOPENTENOIDS
Abstract

Abstract: Cholesterol crystallization is a prerequisite for gallstone formation and growth, whereas dissolution of crystallized cholesterol forms the basis of nonsurgical therapy. Crystallization has been studied in detail, but dissolution mechanisms and effects of gallstones are largely unknown. Methods: We evaluated gallstone growth or dissolution, cholesterol crystallization and lipid distribution into various phases, in model biles with low or intermediate phospholipid contents (crystal-containing left two-phase or central three-phase zones), and with high phospholipid or low cholesterol contents (crystal-free right two-phase or bottom one-phase zones). Results: In model biles with added gallstones plotting in left two-phase and central three-phase zones, gallstone masses increased, whereas crystallization in the aqueous phase was less than without gallstones (P<0.001). In biles plotting in the right two-phase zone, gallstone masses decreased, depending on bile salt hydrophobicity (TUDC>TC>TCDC: P<0.001). In biles plotting in the bottom one-phase zone containing TC or TCDC, gallstone masses increased. In contrast, gallstone masses decreased in case of TUDC with preferential distribution of cholesterol into emerging vesicles. Conclusions: Our findings suggest competition between gallstone surface and surrounding aqueous phase for precipitation of cholesterol in crystal-containing zones. Different gallstone dissolution mechanisms may exist for TUDC and TCDC. [Copyright &y& Elsevier]

Published
2005
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29. Effects of hydrophobic and hydrophilic bile salt mixtures on cholesterol crystallization in model biles

Author

Venneman, Niels G., Huisman, Sebastiaan J., Moschetta, Antonio, vanBerge-Henegouwen, Gerard P., and van Erpecum, Karel J.

Subjects
*BILE salts, *GALLSTONES, *LECITHIN
Abstract

The hydrophilic bile salt ursodeoxycholate is frequently used to dissolve cholesterol gallstones. We have now quantitated crystallization as a function of bile salt hydrophobicity, phospholipid content, cholesterol saturation and total lipid concentration (TLCo). Methods: Crystallization in supersaturated model biles with low phospholipid contents (left two-phase-micelles and crystal-containing-zone) was assessed during 21 days by microscopy and chemical measurement of crystal mass. For model biles with higher phospholipid contents (central three-phase-micelles, vesicles and crystal-containing-zone), lipid distribution into various phases was determined by combined ultracentrifugation–filtration–dialysis methodology (Biochim. Biophys. Acta 1532 (2001) 15–27). Results: In the left two-phase zone, crystal numbers and masses were highest in case of more hydrophilic bile salt composition (TUDC 100%>TC/TUDC 70%/30%>TC 100%>TC/TDC 70%/30%>TDC 100%) and decreased with increasing phospholipid contents, lower TLCo and lower cholesterol saturation index (CSI). In contrast, in the presence of vesicles (three-phase zone), crystallization decreased at increasing bile salt hydrophilicity, with concomitant increased vesicular cholesterol solubilization. Conclusions: Presence of vesicular phases is a prerequisite for inhibition of cholesterol crystallization by tauroursodeoxycholate. [Copyright &y& Elsevier]

Published
2002
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