Search

The objective of this experiment was to assess the influence of some phytobiotics on growth performance of stellate sturgeon (A. stellatus). There were two experimental variants: V1–thyme and V2–seabuckthorn. The fish used in this experiment were one year and four months old, with an initial mean weight of 122.78±31.60 g/fish (V1), respectively 121.21±32.54 g/fish (V2). The phytobiotics used, thyme (Thymus vulgaris) and seabuckthorn (Hippophae rhamnoides), have been embedded in fodder, by using gelatin, having a concentration of 2%/ kg fodder. Alterna Storioni feed-48% crude protein was used. The water quality parameters during the experiment were within normal limits for an optimum growth of experimental fish. At the end of the experiment significant differences (p0.05). Highest individual growth rate value (105.90 g) was recorded in V2 case and the lowest value (98.45 g) in case of V1. As a conclusion, it can be said that the two types of phytobiotics (thyme, seabuckthorn), administered in a concentration of 2%/kg fodder, have influenced the growth performance of stellate sturgeons.

Addition of natural additives (prebiotics, probiotics, phytobiotics) in fish feed is a benefic method because it leads to improved growth performance of fish reared in intensive production systems. Sea buckthorn is one of the most commonly phytobiotics used in aquaculture because of its antioxidant, antimicrobial, immunostimulant, anti-stress, cytoprotective, liver and tissue regeneration properties. Sea buckthorn berries are rich in vitamins (B, C, E and K), flavonoids, carotenoids, tocopherols and many volatile compounds. In this context the aim of this study was to evaluate the effects of dietary vitamin E (500 mg/kg diet) and sea buckthorn on growth performance and survival of the A. stellatus juveniles reared in a recirculating aquaculture system. The experiment took place in the recirculating pilot system of “Dunărea de Jos” University of Galaţi. In order to emphasize the influence of the above mentioned immunostimulants on sevruga fingerlings with different genetic background, four experimental groups from different genitors (V1: ♀2 Danube x ♂1 Aquaculture, V2: ♀1 Danube x ♂1 Danube, V3: ♀1 Danube x ♂2 Aquaculture and V4: ♀2 Danube x ♂2 Danube) have been used. At the end of the experiment no significant differences (p>0.05) were observed in terms of final mean weight, individual growth rate, SGR, FCR, PER, between the sevruga fingerlings obtained from wild genitors, comparing with those obtained from aquaculture genitors.

Public health issues related to chronic pain management and the risks of opioid misuse and abuse remain a challenge for practitioners. Data on the prevalence of disorders related to the use of prescribed opioids in patients suffering from chronic pain remains rather patchy, in particular because of the absence of a gold standard for their clinical assessment. We estimated the prevalence of prescription opioid misuse (POM), using a specific and validated opioid misuse scale (POMI-5F scale), in adults with chronic non-cancer pain. Nine-hundred-fifty-one (951) patients with opioids prescription and followed-up in pain clinics and addictology centers for chronic non-cancer pain (CNCP) completed the survey interview. The results suggest that 44.4% of participants have POM, accompanied by overuse (42.5%), use of opioids for effects other than analgesia (30.9%), withdrawal syndrome (65.7%), and craving (6.9%). The motivations cited for POM, apart from pain relief, were to calm down, relax and improve mood. POM was shown to be related to male sex (OR 1.52), young age (OR 2.21) and the presence of nociplastic pain (OR 1.62) of severe intensity (OR 2.31), codeine use (OR 1.72) and co-prescription of benzodiazepines (OR 1.59). Finally, despite the presence of three subgroups of misusers, no factor was associated with the intensity of misuse, reinforcing the view that distinguishing between strong and weak opioids is not appropriate in the context of use disorder. Almost half of patients with CNCP misuse their prescribed opioid. Practitioners should be attentive of profiles of patients at risk of POM, such as young, male patients suffering from severe nociplastic pain, receiving prescription for codeine and a co-prescription for benzodiazepine. We encourage French-speaking practitioners to use the POMI-5F scale to assess the presence of POM in their patients receiving opioid-based therapy.Clinical Trial Registrationclinicaltrials.gov, identifier NCT03195374

З метою розробки маловідходної технології отримання олієрозчинної фенолформальдегідної смоли для захисних лакофарбових покрить досліджений процес конденсації пара-трет-бутилфенолу з параформом у лужному і кислому середовищах з використанням каталізаторів – аміаку, третинних амінів та щавлевої кислоти. У якості реакційного середовища використовували смольну воду попередніх синтезів з урахуванням в ній залишкової кількості вихідних реагентів. Показана можливість багаторазового використання смольної води у замкненому технологічному циклі. З'ясована необхідність попередньої деполімеризації параформу у разі конденсації у кислому середовищі. На підставі даних ЯМР 1Н та ІЧ-спектральних досліджень зроблені висновки щодо відмінностей ланцюгової будови синтезованих олігомерів: кінцеві складові ланки олігомерних молекул зразків, отриманих у кислому середовищі, є переважно 1, 2, 4-заміщенними фенольними структурами, а значну долю зв'язувальних містків між фенольними циклами у ланцюзі складають метиленетерні фрагменти; кінцевими складовими ланками в молекулах олігомерів, отриманих у лужному середовищі, є гідроксиметиленові групи, а фенольні ланки зв'язані переважно метиленовими містками.

The society we live in today has been profundly shaped by the clash of cultures and civilizations and more recently, by ideological conflicts. It is also the case of the United States of America, whose history and evolution was marked by the continuous reglementations of the structure and relations between the white americans and the afro-americans: the Civil Rights Movement and the Black Power movement The following paper aims to explore this issue through the lenses of two important race theories,both sharing a very important concept when discussig racial conflict -double consciousness, each of them being linked to a main afro-american movement in the USA. I shall try to understand how the concept of race and the attempts to fight racism within the american society in the 20th century, have influenced the political discourse and also, the social and cultural context, throughout the last decades. In doing so, i will draw inspiration from the socio-historical constructivist race theory in explaining the evolution and impact of the Civil Rights Movement, and from Fanon’s critical theory in exploring the evolution and the outcome of the Black Power Movement. The main thesis of this paper is that, starting with the end of the 19th century, all the eliberation and empowerment efforts of the black community in the american society, coagulated in the mentioned ideological movements, had a powerfull impact on the social, cultural and political evolution of the United States, materialised in the introduction of Black Studies in universities, political representation and electoral winnings – culminating with the election of Barack Obama as the President of the USA.

Aim. To study the efficacy of ivabradine in the prevention of cardiotoxic effects due to chemotherapeutic drugs in patients with breast cancer. Material and methods. The open randomized uncontrolled study included 55 patients with breast cancer who had to undergo chemotherapy by anthracyclines. The inclusion criterion was a heart rate >70 beats/min. Collection of complaints and anamnesis, ECG, echocardiography, routine laboratory tests were performed in all patients initially and after 1, 3, 6 and 12 months. All patients were treated with polychemotherapy with anthracyclines in combination with cyclophosphamide and fluorouracil. The patients included into the study were randomized into two groups. Patients of the main group (n=23) were additionally prescribed ivabradine in a daily dose of 10 mg followed by a dose titration. Patients of the control group (n=32) received only polychemotherapy. Results. In the main group a decrease in heart rate was observed already by the first month (from 83.6±9.5 to 67.1±7.5 beats/min, p0.05). A significant change in the LV ejection fraction was not found in both groups. Significant differences in LV global longitudinal strain were found between groups in 1, 3 and 6 months of observation (p70 beats/min was safe and did not cause bradycardia. Ivabradine use was accompanied by a significant reduction in a number of patients with complaints of palpitation, contributed to the preservation of normalLV global longitudinal deformation in chemotherapy, while the control group had negative changes with a maximum by the 6th month of follow-up.

A method for the synthesis of polymeric film based on a copolymer of styrene and maleic anhydride (stiromal) and oligodiol was suggested. Block copolymer of ethylene glycol and propylene glycol was used as oligodiol. It was shown that synthesized materials have moderate water swelling capacity in and ion-exchange properties. Static exchange capacity in 0.1 mol/L NaOH aqueous solution is within the interval of 1.44–1.76 mmol/g. At air-dry state films have a tensile strength of 4–6.6 MPa and an elongation at break tensile 38–61 %. The effect of stiromal molecular weight and oligodiol type, and conditions of film formation on ion-exchange and physical-mechanical properties of the films was studied. The synthesized material appeared to be able to sorb Cu2+-ions from neutral and acidic solutions. The distribution coefficient in case of sorption from slightly acidic solution with Cu2+ concentration of 50 mg/L was 48–50. Composite material with a metal submicroparticles uniformly distributed in the polymeric matrix was obtained by chemical reduction of copper ions sorbed. It was found that the film acquires electric conductivity, as a result of filling of metal particles, which allows copper electrodeposition on the film surface.

The film materials with ion-exchanged properties on the basis of the polymer, obtained by condensation of oligoepichlorohydrined epoxide and piperazine with the subsequent chemical modification have been synthesized. Compounds which have different thermodynamic affinity with the polymer and each other have been used as modifiers. It has been shown that the possibility of overcoming the lack of compatibility of the components by selection of the order of their combination. The result of the combination can be predicted by the Hildebrand parameter values of the ingredients, intermediate products and prepolymers based on them. The properties of synthesized materials can be adjusted by selection of combinations of chemical modifiers: toluilenediisocyanate, epoxyed soybean oil and tetraethoxysilane.

The possibility of acquiring film material from a mixture of oligoepichlorhydrin diglycidylether and piperazyne discussed. The process involves elongation of the chain by means of reaction of the oligomer terminal oxyran cycles with piperazine aminogrups, and the subsequent formation of crosslinked by tertiary amine alongthe chainsalkylation whis chlorometyl dand groups of macromolecules. With this purpose, the model system investigated: epichlorohydrin−piperidine, epichlorohydrin−piperazine, oligoetylenglikol glicidyl ether−piperazine. The possibility of regulating the contributions of reactions of epoxy group and alkylation on crosslinking primary stage is disclosed, as well as material properties. Taking into account the found regularities receive elastic film structured materials with quaternary nitrogen atoms in the nodes. The ratio of tertiary and quaternary structure of nitrogen depends on the process conditions. Films swell in polar solvents and has ion-exchange properties.

Recent years have seen significant progress in the treatment of many oncologicaldiseases associated with the development of new chemotherapeutic agents. Typically, they are used in combination with classical chemotherapy regimens that in-clude doxorubicin. In the background of this combined treatment significant prolongation of life of the patients was noted, but at the same time the risk of cardiotoxicity was considerably increased. The survey provides information about the cardiomyocytesmetabolic disorders during therapy with anthracyclines, discussing the possibility of pathogenetic treatment and prevention.

The interactions of 3-carboxyphenoxathiin with Bovine Serum Albumin (BSA) and Human Serum Albumin (HSA) have been studied by fluorescence and circular dichroism spectroscopy. The binding of 3-carboxyphenoxathiin quenches the BSA and HSA fluorescence, revealing a 1:1 interaction with a binding constant of about 105 M-1. In addition, according to the synchronous fluorescence spectra of BSA and HSA in presence of 3-carboxyphenoxathiin, the tryptophan residues of the proteins are most perturbed by the binding process. Finally, the distance between the acceptor, 3-carboxyphenoxathiin, and the donor, BSA or HSA, was estimated on the basis of the Förster resonance energy transfer (FRET). The fluorescence results are correlated with those obtained from the circular dichroism spectra, which reveal the change of the albumin conformation during the interaction process.

Показана возможность применения метода ИК-спектроскопии для определения доли кросс-агента в сополимерах стирола с дивинилбензолом по характеристическим полосами м- и п-ди-винилбензола.

We should admit that pro-active deeds may need time, they may be expensive and this problem will cause problems to authorities. Although these problems are expensive we should realise that the traffic with human beings and is extremely serious and the expensive matter and the resources that are being used are right and we should not waive. The traffic with human beings may be and must be considered a part of terorrism and drug traffic must be considered a part of terorrism, too and these two ilicit traffics should be tackled with the same method. The dealers consider human beings consumming goods and these consummers must be recruited, delivered, exploited for a profit, we know that this type of deliquency is based on money. The investigation on the traffic with human beings is a complex activity and needs a serious investigation not only on the number of victims but also on dealers.

Инфекции являются одной из наиболее частых причин заболеваемости и смертности онкологических больных, особенно получающих паллиативную терапию. Сдерживанию инфекций способствуют различные гигиенические мероприятия, использование антисептиков, вакцинация, а также рациональное применение антибиотиков. Учет патофизиологии ЖКТ и данных о микробной экосистеме кишечника способствует разработке правильной лечебной тактики в отношении конкретного больного, стратегии рационального применения антибиотиков, а также пре - и пробиотиков у больных с инфекциями ЖКТ.

The numbers and types of cells in an area of cortex define its function. Therefore it is essential to characterize the numbers and distributions of total cells in areas of the cortex, as well as to identify numbers of subclasses of neurons and glial cells. To date, the large size of the primate brain and the lack of innovation in cell counting methods have been a roadblock to obtaining high-resolution maps of cell and neuron density across the cortex in humans and non-human primates. Stereological counting methods and the isotropic fractionator are valuable tools for estimating cell numbers, but are better suited to smaller, well-defined brain structures or to cortex as a whole. In the present study, we have extended our flow-cytometry based counting method, the flow fractionator (Collins et al., 2010a), to include high-throughput total cell population estimates in homogenized cortical samples. We demonstrate that our method produces consistent, accurate and repeatable cell estimates quickly. The estimates we report are in excellent agreement with estimates for the same samples obtained using a Neubauer chamber and a fluorescence microscope. We show that our flow cytometry-based method for total cell estimation in homogenized brain tissue is more efficient and more precise than manual counting methods. The addition of automated nuclei counting to our flow fractionator method allows for a fully automated, rapid characterization of total cells and neuronal and non-neuronal populations in human and non-human primate brains, providing valuable data to further our understanding of the functional organization of normal, aging and diseased brains.

Среди всех нозокомиальных (госпитальных) инфекций 71 % составляют инфекции, развившиеся у больных после той или иной операции. Среди этих инфекций раневые инфекции (РИ) составляют примерно 40%.Наличие злокачественной опухоли у больного само по себе яв­ляется независимым фактором риска РИ. Причем играет роль не только наличие опухоли и связанное с этим угнетение иммуни­тета, но и проводимое противоопухолевое лечение (химио - и лучевая терапия) , которое усугубляет иммуносупрессию, нередко осложняется лейкопенией ( нейтропенией), а в случае лучевой рапии - и радиодерматитами. В связи с этим инфекционные ос ложнения у онкологических больных не только возникают чаще, но и протекают тяжелее, чем у больных с другой патологией. Мы полагаем, что понимание причин возникновения РИ и знание основных подходов к АБП позволит уменьшить количество РИ и улучшить качество жизни больных.

The article focuses on Napoleon's new and last reign can only date from the moment he reappeared in the capital; since his disembarkation he had only had one army during March 20-June 22, 1815 and constitution of the latter is not without difficulties.

During the past five years, a team of Agrogeological Division of the Hungarian Geological and Geophysical Institute has studied the nutrient elements potential of the East-Hungarian sandy soils. Among these elements, the natural potassium sources are insufficient, i.e. neither the soil forming sediments, nor the groundwater cannot satisfy the consumption of the plants. Therefore, the unique K-source seems to be the meteoric water. The authors consulting more than three hundred geochemical, ecological, meteorological, astrophysical and radiological articles, identified the origin of atmospheric K-bearing aerosols. Thus, in this paper, the K-salts, as the main aerosol particles in ice and rain nucleation, with stratospheric origin were discussed, mainly based on references. In the stratosphere, the solid particles show a well expressed stratification: aerosols from desertic, volcanic and anthropogenic origin are concentrated mainly at 20 km altitude, the cosmogenic particles are observable at 50-60 km, while the measurements prove a relatively uniform distribution of K bearing particles, decreasing abruptly in the troposphere, under cloud formation level. K-bearing aerosols form micron sized, soft flakes built up by very thin acicular crystals. They represent ideal nuclei for ice split and rain drop formation. Therefore, we suppose, that the stratospheric potassium is formed by cosmic radiation induced Ar/K reaction, the reverse of K/Ar decay. The increased K+ content in rainwater (or snow) samples above of highly populated centers is explained by the same Ar/K reaction, which is induced by low energy electromagnetic waves (UHF smog) due to (experimented) their Tunnel effect. [ABSTRACT FROM AUTHOR]

Animal models have historically informed veterinary and human pathophysiology. Next-generation genomic sequencing and molecular analyses using analytes derived from tissue require integrative approaches to determine macroanalyte integrity as well as morphology for imaging algorithms that can extend translational applications. The field of biospecimen science and biobanking will play critical roles in tissue sample collection and processing to ensure the integrity of macromolecules, aid experimental design, and provide more accurate and reproducible downstream genomic data. Herein, we employ animal experiments to combine protein expression analysis by microscopy with RNA integrity number and quantitative measures of morphologic changes of autolysis. These analyses can be used to predict the effect of preanalytic variables and provide the basis for standardized methods in tissue sample collection and processing. We also discuss the application of digital imaging with quantitative RNA and tissue-based protein measurements to show that genomic methods augment traditional in vivo imaging to support biospecimen science. To make these observations, we have established a time course experiment of murine kidney tissues that predicts conventional measures of RNA integrity by RIN analysis and provides reliable and accurate measures of biospecimen integrity and fitness, in particular for time points less than 3 hours post–tissue resection. [ABSTRACT FROM AUTHOR]

Introduction: As the incidence of cancer, the bladder neoplasia ranks 9, being on 7 place in man and 17 in woman. Bladder cancer has been associated with many exogenous risk factors as smoking and occupational exposure.(1) The glutathione S-transferase (GST) represent a class of enzymes which conjugate the glutathione, resulted from detoxification of carcinogens and facilitates their removal from the body. Polymorphism of genes encoding GSTP1, GSTM1, GSTT1 was correlated with the risk of bladder cancer but the results of the studies have often been inconclusive.( 2,3) Materials and methods: There have been included in the study 71 patients with superficial bladder cancer who were diagnosed and operated in Oradea Urology Clinic, to which the following parameters were followed: sex, age, living environment, cellular differentiation. Results: The subjects were grouped by age, sex, living environment, and the degree of cell differentiation. Depending on the presence or absence of T1 and M1 allele have resulted 4 variants: T+M+, T+M-, T-M+, T-M-. Conclusions: T+M- genetic variant is most common in patients with superficial bladder cancer. [ABSTRACT FROM AUTHOR]