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Tumors in the middle ear rarely have an adenomatous nature. Adenomatous tumors can manifest as neuroendocrine adenoma, endocrine adenoma and middle ear adenoma (or temporal bone adenoma). They may represent the same tumors at different stages of glandular and neuroendocrine differentiation. Middle ear adenoma refers to rare tumors. The tumor can clinically manifest itself with nonspecific symptoms, which makes timely diagnosis difficult. According to computed tomography and magnetic resonance imaging, a soft-tissue tumor with clear boundaries usually is detected in the middle ear, without destructive changes and spreading beyond the middle ear. Usually no difference between adenoma and other middle ear tumors, which makes differential diagnosis difficult. The final diagnosis is usually made according to the histological examination. Surgery is the main method of treatment of middle ear adenoma, the purpose of which is radical resection of tumor.