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Background micro RNAs (mi RNAs) are single-stranded, noncoding RNA molecules. Given the vast regulatory potential of mi RNAs and their often tissue-specific and disease-specific expression patterns, mi RNAs are being assessed as possible biomarkers to aid diagnosis and prediction of different types and stages of cancers, including skin cancer. Basal cell carcinoma ( BCC) and squamous cell carcinoma ( SCC) are the most common forms of nonmelanoma skin cancer ( NMSC). BCC originates from the basal layer of the epidermis, while SCC arises from epidermal keratinocytes or from the dermal appendages. Although NMSCs are currently the most common types of malignancies, both BCC and SCC have a better than 95% cure rate if detected early. Aim To identify plasma mi RNAs suitable for early detection of NMSC. Methods Expression profiles of 741 mi RNAs were evaluated using high-throughput real-time quantitative PCR from plasma samples in 42 patients with NMSC and 282 healthy controls ( HCs). Results Our results demonstrated that in patients with NMSC, compared with HCs, expression levels of miR-30e-3p, miR-145-5p, miR-186-5p and miR-875-5p were significantly ( P < 0.05) upregulated, while those of miR-19a-3p, miR-25-3p, miR-30a-5p, miR-451 and miR-576-3p were significantly downregulated. Conclusion Our study suggests that the mi RNAs with significant changes in expression (miR-19a-3p, miR-25-3p, miR-30a-5p, miR-145-5p and miR-186-5p) could serve as novel noninvasive biomarkers for detection of NMSC. [ABSTRACT FROM AUTHOR]

Background: Behçet's disease is predominantly an inflammatory disease with oral and genital ulcus, uveitis and erythema nodosum. It is a chronic disease with unprecetended remission and activation periods. Behçet's disease may also affect extremities in the form of arthritis, myositis, enthesis, tenosynovitis and dactylitis. The most affected joints are knee, wrist -hand, ankle and elbow. A history of sytemic inflammatory disease in a patient with a hand disease or a one who is a candidate for hand surgery may affect the surgical procedure and post-operative rehabilitation. Thus recognition of this condition is essential for the hand surgeon, physiotherapist, and the patient. Objective: To evaluate the impact of Behçet's disease on grip and key pinch strength. Subjects: Fifty (31 male, 19 female) patients with Behçet's disease and 50 (32 male, 18 female) controls. Results: Hand grip and key pinch strength of Behçet's patients did not differ from that of normal subjects. Conclusions: Behçet's disease does not seem to affect grip and pinch strength. [ABSTRACT FROM AUTHOR]

Recurrent aphthous stomatitis (RAS) is recognized as one of the most common oral mucosal diseases worldwide. The aim of this study was to determine the oxidant/antioxidant status in erythrocyte and plasma samples from patients with RAS in comparison with healthy controls. Twenty-two patients with RAS and 23 healthy controls were recruited. Superoxide dismutase, glutathione peroxidase (GSHPx) and catalase (CAT) activities, and malondialdehyde (MDA) and antioxidant potential (AOP) levels were measured in plasma and erythrocytes from patient with RAS and controls. We found decreased CAT and GSHPx activities and AOP levels in the erythrocytes, and decreased AOP and increased MDA plasma levels in patients with RAS in comparison with control subjects. In summary, this study demonstrated that enzymatic and nonenzymatic antioxidant defence systems are impaired in patients with RAS. [ABSTRACT FROM AUTHOR]

A patient with severe erythema nodosum due to Behçet's disease is reported on here. Erythema nodosum lesions did not respond to classical treatments; however, they cleared after erythromycin treatment, which was prescribed for the treatment of coincidental erythrasma. Erythromycin treatment appears to be an effective treatment option in erythema nodosum. The hypothetical antiinflammatory effects of erythromycin, besides its antibiotic properties, are reviewed and discussed to explain such a clinical improvement. [ABSTRACT FROM AUTHOR]

Pyogenic granuloma is a common benign skin tumour. However, giant recurrent pyogenic granuloma with satellitosis is relatively rare. We present a 52-year-old man who had recurrent gigantic pyogenic granuloma with satellitosis responsive to systemic steroids. Our case of recurrent pyogenic granuloma is interesting because of its clinical presentation, recurrence following surgical excision and its steroid responsiveness. Systemic steroids may be effective in treating recurrent giant pyogenic granulomas during their high-proliferation phase. [ABSTRACT FROM AUTHOR]

Tiaprofenic acid is a propionic acid derivative with analgesic, anti-inflammatory and antipyretic properties. Fixed drug eruption is a common cutaneous reaction by various drugs. Fixed drug eruption induced by tiaprofenic acid has not been reported previously. Described in this paper is a 57-year-old female patient with tiaprofenic acid-associated fixed drug eruption, which occurred shortly after starting tiaprofenic acid therapy for her osteoarthritis. Upon establishment of the diagnosis, tiaprofenic acid therapy was stopped and topical corticosteroids and systemic antihistamines were administered. The eruption resolved, leaving post-inflammatory hyperpigmentation within 5 days. The rash returned following tiaprofenic acid rechallenge. It is proposed that fixed drug eruption is a new side effect of tiaprofenic acid. [ABSTRACT FROM AUTHOR]