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Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and Objectives: The goal of this study was to investigate the effect of selective serotonin reuptake inhibitor treatment on the ovarian reserves of women of reproductive age with major depressive disorder. Materials and Methods: The current study is a prospective controlled trial including 48 women with major depressive disorder and 48 age-matched healthy controls. Ovarian reserve tests are performed prior to treatment and after six cycles of selective serotonin reuptake inhibitor treatment in the major depressive disorder group. Serum follicle-stimulating hormone, luteinizing hormone, estradiol, and anti-Müllerian hormone levels were evaluated from blood samples, and endometrial thickness, total antral follicle count, and volume of both ovaries were assessed using transvaginal ultrasonography. Results: When the first measurements were compared, menstrual duration and menstrual bleeding increased (p = 0.007 and 0.005, respectively) and luteinizing hormone decreased (p = 0.045) in the major depressive disorder group, while follicle-stimulating hormone, estradiol, anti-Müllerian hormone, endometrial thickness, total antral follicle count, and mean ovarian volume did not differ significantly between groups (p > 0.05). When the major depressive disorder group's first and final measurements were compared, follicle-stimulating hormone, estradiol, and endometrial thickness increased (p = 0.05, 0.0001, and 0.005, respectively), luteinizing hormone remained constant (p = 0.541), and anti-Müllerian hormone and total antral follicle count decreased (p = 0.024 and 0.042, respectively). Conclusions: In this study, we observed that the ovarian reserve test results of patients diagnosed with major depression for the first time after 6 months of SSRI treatment were significantly different from the results of the pretreatment and control groups. [ABSTRACT FROM AUTHOR]

Background/aim: Major depressive disorder (MDD) is a significant cause of workforce loss, and is associated with cognitive impairments which can continue even after the elimination of mood and behavioural symptoms. The aim of this study was to investigate the benefit of transcranial magnetic stimulation (TMS) on cognitive functions in treatment resistant depression. Materials and methods: This randomised controlled clinical trial was conducted at a university hospital, department of psychiatry (tertiary centre) between October 2019 and July 2020. The study included 30 patients with depressive disorder, aged 18-50 years, who did not respond to at least two antidepressant medications for at least 8 weeks (one drug used was serotonin norepinephrine reuptake inhibitor [SNRI]; and 15 healthy control subjects. The patients were separated into two equal groups in a double-blind, random manner, and 20 sessions of repeated TMS was applied to one group, and 20 sessions of sham TMS to the other. The Montgomery Asberg Depression Scale (MADRS), Hamilton Depression Rating Scale (HAM-D), Stroop test, Wisconsin Card Sorting Test (WCST), Digit Span Test (DST), Trail Making Test A-B, and Verbal Memory Processes Test (VMPT) were applied to the patients before and after the TMS procedure. Results: The decrease in the HAM-D score was greater in the active magnetic stimulation (25 trains, 10 Hz, 110% motor threshold intensity) group, and with the exception of verbal memory processes, better performance was obtained by the active magnetic stimulation group than the sham group in the cognitive function tests. Conclusion: TMS was seen to improve the cognitive defects present in the active phase of treatment-resistant depression, and therefore TMS could provide early improvement in cognitive functions in clinical use. [ABSTRACT FROM AUTHOR]

Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of Neuropsychiatry / Nöropsikiyatri Arşivi is the property of Turkish Association of Neuropsychiatry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turk Psikiyatri Dergisi is the property of Turk Psikiyatri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turk Psikiyatri Dergisi is the property of Turk Psikiyatri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: In this study, we aimed to adapt the Structured Clinical Interview for DSM-5-ClinicianVersion into Turkish and to demonstrate its reliability. Method: A total of 185 patients, both inpatient and outpatient, from two different university hospitals were included. Training sessions on the features and use of SCID-5/CV were held before the data collection. During the study, in order to test the diagnostic agreement and accuracy, two psychiatrists remained present at the evaluation of each participant; alternatively being interviewer and the observer. Cohen's kappa coefficient for inter-rater reliability was calculated for every diagnostic category. Results: The patient group had a mean age of 37.2 (±13.5) years and 55.7% were female. The education status was as follows: 2.7% were illiterate, 1.7% literate with no primary education, 33% had primary education, 23.8% had secondary education and 38.9% had higher education. The calculated kappa value showed excellent agreement for schizophrenia (κ=0.93), bipolar disorder (κ=0.96), major depressive disorder (κ=0.89), dysthymic disorder (κ=0.82), alcohol use disorder (κ=0.96), panic disorder (κ=0.84), agoraphobia (κ=0.85), social anxiety disorder (κ=0.95), generalized anxiety disorder (κ=0.89), obsessive compulsive disorder (κ=0.87), posttraumatic stress disorder (κ=0.89), adult attention deficit and hyperactivity disorder (κ=1.00), specific phobias (κ=0.82) and very good agreement with adjustment disorder (κ=0.78) and somatic symptom disorder (κ=0.65). Conclusion: Similar to the past SCID versions, kappa values were found to be quite high and all were statistically significant. The Turkish version of SCID-5/ CV can be reliably used in both clinical practice and clinical studies. [ABSTRACT FROM AUTHOR]

Objective: Previous studies suggest that the level of clinical insight in schizophrenia patients is related to working memory functions. However, these studies were not specifically concerned with the components of working memory and had not focused in detail on working memory functions. For this reason, the current study investigated the relationship between clinical insight and working memory components in patients with schizophrenia and schizoaffective disorder. Method: The patient group was evaluated by using the Scale for Assessment of Negative Symptoms, the Scale for Assessment of Positive Symptoms, and the Scale to Assess Unawareness of Mental Disorder to measure clinical insight. Moreover, all participants underwent a "Situation Awareness" test in order to measure working memory functions. Based on published data, the first stage of this test was accepted to measure the "visual spatial sketchpad" component of working memory, and the second stage was accepted to measure the "episodic buffer" (bound information storage) component. The functions of these components were measured separately as top-down and bottom-up cognitive processes. Results: The episodic buffer function (managed by the bottom-up cognitive process) was related with clinical insight. This relationship also continued after correcting for the effect of positive symptoms on insight. The patients performed worse than the controls in terms of visual spatial sketchpad function, which was managed by both top-down and bottom-up cognitive processes. The patients performed worse than the controls in terms of both top-down and bottom-up cognitive processes and visual spatial sketchpad function. Furthermore, the patients were also worse than the controls in terms of episodic buffer function (managed by top-down cognitive processes). Conclusion: Clinical insight may be associated with binding function (associated with episodic buffer function) managed by bottom-up cognitive processes in patients with schizophrenia and schizoaffective disorder. Further studies are necessary to confirm this novel finding. [ABSTRACT FROM AUTHOR]

Amaç: Bu araştırmanın amacı, Tıp fakültesi birinci sınıf öğrencileri ile altıncı sınıf öğrencilerini tükenmişlik riski açısından karşılaştırmak, uzun ve zorlu bir süreç olan tıp eğitiminin ve ilk kez hasta-hekim ilişkisinin yaşandığı son sınıf yıllarının tükenmişlik gelişimine olan etkisinive bunun kişilik özellikleriyle bağlantısı olup olmadığını ortaya koymaktır. Yöntem: Tıp Fakültesi Dönem 1 öğrencilerinden 30 ve Dönem 6 öğrencilerinden 30 olmak üzere onam veren toplam 60 öğrenci çalışmaya dâhil edildi.Tüm katılımcıların sosyodemografik bilgileri alınarak, her birine Maslach Tükenmişlik Envanteriile A Tipi Davranış Testi uygulandı. Bulgular: Dönem 6 öğrencilerinin Maslach Tükenmişlik Envanteri duygusal tükenmişlik alt ölçeği ortalaması Dönem 1 öğrencilerinden yüksekti. Kişilik davranışı açısından iki grup karşılaştırıldığında; A ve B tipi kişilik davranışı dağılımının iki g r u p t a da benzer olduğu belirlendi. Sonuç: Bu çalışmada, yapılan diğer çalışmalarla benzer olarak son sınıf öğrencilerinde tükenmişlik düzeyi artmaktadır. Bizim çalışmamızda, son sınıf intörn öğrencilerinde A tipi kişilik sayıca fazla bulunsa da bu fazlalık istatiksel olarak anlamlı düzeye ulaşmamıştır. Ayrıca kişilik tipi ile tükenmişlik düzeyi ve kişisel başarı duygusu arasında herhangi biristatistiksel ilişki d e izlenmemiştir. Objectives: The aim of this study was to investigate the differences of the risk of burnout in medical students between the first year and last year which students first experience both physician-patient relationship and so long, so challenging medical course process. Method: A cross-sectional study was carried out in a sample of 60 medical students which were randomly selected and gave informed consent. Thirty students (50%) were in the first year and 30 were (50%) in the sixth year of training using sociodemographic data form, Maslach Burn out Inventory and A type personality test. Results: Maslach Burnout Ýnventory emotional exhaustion subscale was higher at last year medical students than the first year students. About personality behaviour; when two groups compared, no significant differenceswere found in each groups. Conclusion:In this study, burnout levels was higher at the last year medical students as previous studies had done before. In our study, although type A characteristics were numerously higher, it was not significant statically. Further more we did not find any relationship between personality characteristics in terms of type A and type B and burnout levels or sense of personel accomplishment. [ABSTRACT FROM AUTHOR]

Objective: In this study it is aimed to compare the theory of mind skills and executive functions in bipolar disorder patients and their first degree relatives with controls, and to demonstrate the relationship between executive functions and theory of mind. Method: 30 patients with euthymic bipolar I disorder, their first degree relatives, and 30 healthy controls were included in the study. Sociodemographic data form, Hamilton Depression Rating Scale, Young Mania Rating Scale, Wechsler Adults Intelligence Test were applied to all participants; Wisconsin Card Sorting Test, Stroop Test, Trail Making Test A and B, and Digit Span Test were applied to evaluate the executive functions; Reading the Mind in the Eyes Test, Hinting Task and Faux Pas Test were applied to evaluate the theory of mind skills. Results: There was not any significant difference between the groups in terms of theory of mind, although total scores were seen from bad to good in bipolar patients, first degree relatives and controls respectively. Patient group had significantly lower performance in Trail Making Test A, and DigitSpan Test inverse number scores. As the severity of disease increased, cognitive functions and the theory of mind were seen to be worsened. The theory of mind was related to executive functions. Discussion: In conclusion, we did not find significant losses in terms of theory of mind in bipolar patients and their first degree relatives. But bipolar patients had a deficiency in attention, psychomotor speed and verbal working memory; and theory of mind was related to executive functions. [ABSTRACT FROM AUTHOR]