25 results on '"Tonini, C"'
Search Results
2. Frequency of headaches in patients over 80. A preliminary report
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Piamarta, F., Condemi-Meyer, E., Sansone, E., Coppola, C., Perri, G., Grassi, F., Mantica, D., Tonini, C., and Coppola, A.
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- 2005
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3. Predictors of epilepsy surgery outcome: a meta-analysis
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Tonini, C., Beghi, E., Berg, A.T., Bogliun, G., Giordano, L., Newton, R.W., Tetto, A., Vitelli, E., Vitezic, D., and Wiebe, S.
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- 2004
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4. Chronic alcohol use and first symptomatic epileptic seizures
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Leone, M, Tonini, C, Bogliun, G, Monaco, F, Mutani, R, Bottacchi, E, Gambaro, P, Rocci, E, Tassinari, T, Cavestro, C, and Beghi, E
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- 2002
5. Airway management in an infant with congenital centrofacial dysgenesia
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Carenzi, B., Corso, R. M., Stellino, V., Carlino, G. D., Tonini, C., Rossini, L., and Gentili, G.
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- 2002
6. Serological biomarkers of zearalenone exposure in beef heifers receiving anti-mycotoxin additive.
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Tonini, C., Oliveira, M.S., Parmeggiani, E.B., Sturza, D.A.F., Mallmann, A.O., Rubin, M.I.B., and Mallmann, C.A.
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- 2021
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7. Psychiatric events in epilepsy
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Cornaggia, Cesare Maria, Beghi, Massimiliano, Beghi, Ettore, Cornaggia, C. M., Airoldi, L., Beghi, M., Bogliun, G., Brambilla, E., Fiordelli, E., Mascarini, A., Moltrasio, L., Primati, C., Hauser, W. A., Loeber, J. N., De Boer, H., Thorbecke, R., Steuernagel, E., Wolf, P., Sonnen, A. E. H., Severi, S., Zolo, P., Specchio, L. M., Specchio, N., Pasolini, M. P., Antonini, L., Aguglia, U., Russo, C., Gambardella, A., Giubergia, S., Zagnoni, P. G., Cosottini, Mirco, Zaccara, G., Trio, R., Pisani, F., Russo, M., Oteri, G., Cavestro, C. E., Tonini, C., Avanzini, G., Arienti, F., Defanti, C. A., Tartara, A., Manni, R., Castelnuovo, G., Murelli, R., Galimberti, C. A., Zanotta, N., Di Viesti, P., Zarrelli, M., Apollo, F., Runge, U., de Krom, M. C. T. F. M., van Heijden, C., Griet, J., Brown, S. W., Coyle, H., Lopez Lima, J. M., Beleza, P., Ferreira, E., Talvik, T., Beilmann, A., Belousova, E., Levart, T., Zupancic, N., Gromov, S., Lipatova, L. V., Mikhailov, V., Cornaggia, C, Beghi, M, Beghi, E, and Rest, 1
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Adult ,Male ,medicine.medical_specialty ,Neurology ,Adolescent ,Referral ,Population ,Clinical Neurology ,Comorbidity ,Anxiety ,Epilepsy ,medicine ,Humans ,epilepsy, psychiatry ,Occupations ,Psychiatry ,Prospective cohort study ,education ,Depression (differential diagnoses) ,education.field_of_study ,Depression ,business.industry ,Mental Disorders ,Case-control study ,General Medicine ,Case-control ,medicine.disease ,Psychiatric ,Case-Control Studies ,Female ,Follow-Up Studies ,Hospitalization ,Socioeconomic Factors ,Neurology (clinical) ,MED/25 - PSICHIATRIA ,Case–control ,business - Abstract
Psychiatric events are thought to be more frequent in people with epileptic seizures than in the general population. However, inter-ictal psychiatric events attributable to epilepsy remain controversial. The aim of the present study was to evaluate the occurrence of psychiatric events in a population of fairly unselected patients with epilepsy and in the general population, and the correlation between psychiatric complaints and selected demographic and disease characteristics. The survey was part of a multicentre prospective cohort study of everyday life risks conducted in eight European countries and comparing referral children and adults with epilepsy referred to secondary/tertiary centers to age- and sex-matched non-epileptic controls. Nine hundred and fifty-one patients with epilepsy and 909 controls were studied. Each patient and his/her control received a diary to record any accident or illness, with severity, circumstances, causes, consequences, and (for the cases) the possible relation to a seizure. The follow-up period ranged between 1 and 2 years. Fifty-eight psychiatric events occurred in 25 patients (2.6%) and 88 in 19 controls (2.1%). Housewives (9.3%) and unemployed persons (4.1%) were mostly affected. No correlation was found between psychiatric events, demographic and disease characteristics. Our results suggest that people with epilepsy if unselected are not at higher risk for psychiatric disorders than the general population. © 2007 British Epilepsy Association.
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- 2007
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8. Accidents in Patients with Epilepsy: Types, Circumstances, and Complications: A European Cohort Study
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van den Broek, Mariska, Beghi, Ettore, Cornaggia, C. M., Beghi, M., Bogliun, G., Fiordelli, E., Airoldi, L., Frigeni, B., Mascarini, A., Mapelli, L., Moltrasio, L., Biagi, E., Hauser, W. A., Loeber, J. N., Thorbecke, R., Di Viesti, P., Zarrelli, M., Apollo, F., Giovanni Rotondo, S., Steuernagel, E., Wolf, P., Sonnen, A. E. H., Specchio, L. M., Specchio, N., Boati, E., Defanti, C. A., Pinto, P., Breviario, E., Pasolini, M. P., Antonini, L., Aguglia, U., Russo, C., Gambardella, A., Giubergia, S., Zagnoni, P., Cosottini, Mirco, Zaccara, G., Pisani, F., Oteri, G., Cavestro, C. E., David, A., Tonini, C., Avanzini, G., Arienti, F., Tartara, A., Manni, R., Castelnovo, G., Murelli, R., Galimberti, C. A., Zanotta, N., Runge, U., Dekrom, M. C. T. F. M., Vanheijden, C., Griet, J., van denBroek, M. W. C., Brown, S. W., Coyle, H., Edge, Nr Alderley, Lopes Lima, J. M., Beleza, P., Ferreira, E., Talvik, T., Beilmann, A., Belousova, E., Nikanorowa, M., Ravnik, I. M., Levart, T., Zupancic, N., Gromov, S., Lipatova, L. V., Mikhailov, V., Van den Broek, M, Beghi, E, and Cornaggia, C
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Poison control ,Cohort Studies ,Epilepsy ,Risk Factors ,Injury prevention ,Accidents, Occupational ,Humans ,Medicine ,Prospective Studies ,Preschool ,Child ,Prospective cohort study ,Injuries ,business.industry ,epilepsy, complications, types, circumstances ,Accidents ,Accidents, Home ,Child, Preschool ,Europe ,Female ,Follow-Up Studies ,Hospitalization ,Patient Acceptance of Health Care ,Wounds and Injuries ,Neurology ,Neurology (clinical) ,medicine.disease ,Occupational ,Relative risk ,Cohort ,Home ,business ,Risk assessment ,Cohort study - Abstract
Purpose: To investigate the risk of accidents in a cohort of patients with epilepsy and in matched nonepilepsy controls. by type, circumstances, and complications. Methods: A total of 95 1 children and adults with idiopathic, cryptogenic, or remote symptomatic epilepsy and 904 matched controls seen in secondary and tertiary centers in eight European Countries (England. Estonia, Germany, Italy, the Netherlands, Portugal. Russia. and Slovenia) were followed Lip prospectively for 17,484 and 17.206 person-months and asked to report any accident requiring medical attention. its site, and complications. Risk assessment was done by using actuarial methods, relative risks (RRs). and 95% confidence intervals (CIs). Results: During the study period, 199 (21%) patients and 123 (14%) controls reported all accident (p < 0.0001); 24% were seizure related. The Cumulative probability of accidents at 12 and 24 months was 17 and 27% in the cases and 12 and 17% in the controls. The risk was highest for concussions (RR, 2.6; 95% Cl, 1.2-5.8), abrasions (RR, 2.1; 95% Cl, 1.1-4.0), and Wounds (RR, 1.9; Cl, 1.2-3.1). Domestic accidents prevailed in both groups, followed by street and work accidents, and were more common among cases. Compared with controls, patients with epilepsy reported more hospitalization, complications, and medical action. Disease characteristics associated with an increased risk of accidents included generalized epilepsy (conclusions), active epilepsy, and at least monthly seizures (abrasions). Most risks decreased, becoming nonsignificant after excluding, seizure-related events. Conclusions: Patients with epilepsy are at higher risk of accidents and their complications. However, the risk was substantially lower after exclusion of seizure-related events
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- 2004
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9. Morbidity and Accidents in Patients with Epilepsy: Results of a European Cohort Study
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Beghi, E, Cornaggia, C, Specchio, Lm, Specchio, N, Boati, E, Defanti, Ca, Pinto, P, Breviario, E, Pasolini, Mp, Antonini, L, Tiberti, A, Valseriati, D, Aguglia, U, Russo, C, Gambardella, A, Giubergia, S, Zagnoni, P, Cosottini, Mirco, Zaccara, G, Pisani, F, Oteri, G, Cavestro, Ce, David, A, Tonini, C, Avanzini, G, Arienti, F, Beghi, M, Bogliun, G, Fiordelli, E, Airoldi, L, Mascarini, A, Mapelli, L, Moltrasio, L, Tartara, A, Manni, R, Castelnovo, G, Murelli, R, Galimberti, Ca, Zanotta, N, Di Viesti, P, Zarrelli, M, Apollo, F, Steuernagel, E, Wolf, P, Runge, U, De Krom MCTFM, Van Heijden, C, Griet, J, Van Den Broek MWC, Brown, Sw, Coyle, H, Lopes Lima JM, Beleza, P, Ferreira, E, Talvik, T, Beilmann, A, Belousova, E, Nikanorowa, M, Gromov, S, Lipatova, Lv, Mikhailov, V, Ravnik, Im, Levart, T, Zupancic, N, Hauser, Wa, Loeber, Jn, Thorbecke, R, Sonnen, Aeh, Beghi, E, and Cornaggia, C
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Adult ,Cross-Cultural Comparison ,Male ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Referral ,Health Status ,Population ,morbidity ,Disease ,Medical Records ,Cohort Studies ,Epilepsy ,Risk Factors ,Epidemiology ,medicine ,Humans ,Prospective Studies ,illnesses ,Prospective cohort study ,education ,Probability ,education.field_of_study ,business.industry ,Case-control study ,accident ,medicine.disease ,Europe ,Neurology ,Accidents ,Case-Control Studies ,injurie ,epilepsy ,Female ,Neurology (clinical) ,business ,Follow-Up Studies ,Cohort study - Abstract
Summary: Purpose: To assess the risk of illnesses and accidents in patients with epilepsy and to evaluate the proportion of those risks attributable to epilepsy. Methods: Nine hundred fifty-one referral patients with idiopathic, cryptogenic, or remote symptomatic epilepsy and 909 matched controls (relatives or friends) were followed up prospectively for 1–2 years in eight European countries (Italy, Germany, Holland, England, Portugal, Russia, Estonia, and Slovenia). Each patient and control received a diary to keep notes regarding any illness or accident. Patients with epilepsy specifically recorded relations with seizures. Results: Six hundred forty-four patients recorded 2,491 illnesses compared with 1,665 illnesses in 508 controls. The cumulative probability of illness in patients was 49% by 12 months and 86% by 24 months (controls, 39 and 75%; p < 0.0001). One hundred ninety-nine patients and 124 controls had 270 and 140 accidents, respectively. The cumulative probability of accident in the cases was 17 and 27% by 12 and 24 months (controls, 12 and 17%; p < 0.0001). The chance of two or more illnesses or accidents was modestly but significantly greater in the patients. Illnesses and accidents were mostly trivial. Thirty percent of illnesses and 24% of accidents were seizure related. When illnesses and accidents related to seizures were excluded, the chance of illnesses and accidents was fairly similar in the two groups. Conclusions: Patients with idiopathic, cryptogenic, or remote symptomatic epilepsy have a moderately higher risk of illnesses and accidents than do the general population. With few exceptions, the events are trivial. When seizure-related events are excluded, patients with epilepsy are not at any significantly higher risk of illnesses and accidents.
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- 2002
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10. Sex pheromone components of the European goat moth,Cossus cossus
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Capizzi, A., Tonini, C., Arsura, E., Guglielmetti, G., Massardo, P., and Piccardi, P.
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- 1983
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11. Study of female sex pheromone of leopard moth,Zeuzera pyrina L. Isolation and identification of three components
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Tonini, C., Cassani, G., Massardo, P., Guglielmetti, G., and Castellari, P. L.
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- 1986
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12. The SAMI Galaxy Survey: gas content and interaction as the drivers of kinematic asymmetry.
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Bloom, J. V., Croom, S. M., Bryant, J. J., Schaefer, A. L., Bland-Hawthorn, J., Brough, S., Callingham, J., Cortese, L., Federrath, C., Scott, N., van de Sande, J., D'Eugenio, F., Sweet, S., Tonini, C., Allen, J. T., Goodwin, M., Green, A. W., Konstantopoulos, I. S., Lawrence, J., and Lorente, N.
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DWARF galaxies ,INTEGRAL field spectroscopy ,ASYMMETRY (Chemistry) ,KINEMATICS ,STELLAR mass ,FLOW velocity - Abstract
In order to determine the causes of kinematic asymmetry in the Hα gas in the SAMI (Sydney- AAO Multi-object IFS) Galaxy Survey sample, we investigate the comparative influences of environment and intrinsic properties of galaxies on perturbation. We use spatially resolved Hα velocity fields from the SAMI Galaxy Survey to quantify kinematic asymmetry (...) in nearby galaxies and environmental and stellar mass data from the Galaxy And Mass Assembly survey. We find that local environment, measured as distance to nearest neighbour, is inversely correlated with kinematic asymmetry for galaxies with log (M
* /M⊙ ) > 10.0, but there is no significant correlation for galaxies with log (M* /M⊙ ) < 10.0. Moreover, lowmass galaxies [log (M* /M⊙ ) < 9.0] have greater kinematic asymmetry at all separations, suggesting a different physical source of asymmetry is important in low-mass galaxies. We propose that secular effects derived from gas fraction and gas mass may be the primary causes of asymmetry in low-mass galaxies. High gas fraction is linked to high σm /V (where σm is Hα velocity dispersion and V the rotation velocity), which is strongly correlated with ..., and galaxies with log (M* /M⊙ ) < 9.0 have offset ... from the rest of the sample. Further, asymmetry as a fraction of dispersion decreases for galaxies with log (M* /M⊙ ) < 9.0. Gas mass and asymmetry are also inversely correlated in our sample. We propose that low gas masses in dwarf galaxies may lead to asymmetric distribution of gas clouds, leading to increased relative turbulence. [ABSTRACT FROM AUTHOR]- Published
- 2018
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13. The SAMI Galaxy Survey: the low-redshift stellar mass Tully-Fisher relation.
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Bloom, J. V., Croom, S. M., Bryant, J. J., Callingham, J. R., Schaefer, A. L., Cortese, L., Hopkins, A. M., D'Eugenio, F., Scott, N., Glazebrook, K., Tonini, C., McElroy, R. E., Clark, H. A., Catinella, B., Allen, J. T., Bland-Hawthorn, J., Goodwin, M., Green, A. W., Konstantopoulos, I. S., and Lawrence, J.
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GALACTIC evolution ,GALACTIC redshift ,STELLAR mass ,SPECTRAL imaging ,INTEGRAL field spectroscopy - Abstract
We investigate the Tully-Fisher relation (TFR) for a morphologically and kinematically diverse sample of galaxies from the Sydney-AAO Multi-object Integral field spectrograph (SAMI) Galaxy Survey using two-dimensional spatially resolved Hα velocity maps and find a welldefined relation across the stellar mass range of 8.0 < log (M
* /M☉ ) < 11.5. We use an adaptation of kinemetry to parametrize the kinematic Hα asymmetry of all galaxies in the sample, and find a correlation between scatter (i.e. residuals off the TFR) and asymmetry. This effect is pronounced at low stellar mass, corresponding to the inverse relationship between stellar mass and kinematic asymmetry found in previous work. For galaxies with log (M* /M☉ ) < 9.5, 25 ± 3 per cent are scattered below the root mean square (RMS) of the TFR, whereas for galaxies with log (M* /M☉ ) > 9.5 the fraction is 10 ± 1 per cent. We use 'simulated slits' to directly compare our results with those from long slit spectroscopy and find that aligning slits with the photometric, rather than the kinematic, position angle, increases global scatter below the TFR. Further, kinematic asymmetry is correlated with misalignment between the photometric and kinematic position angles. This work demonstrates the value of 2D spatially resolved kinematics for accurate TFR studies; integral field spectroscopy reduces the underestimation of rotation velocity that can occur from slit positioning off the kinematic axis. [ABSTRACT FROM AUTHOR]- Published
- 2017
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14. The SAMI Galaxy Survey: the intrinsic shape of kinematically selected galaxies.
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Foster, C., van de Sande, J., D'Eugenio, F., Cortese, L., McDermid, R. M., Bland-Hawthorn, J., Brough, S., Bryant, J., Croom, S. M., Goodwin, M., Konstantopoulos, I. S., Lawrence, J., López-Sánchez, Á. R., Medling, A. M., Owers, M. S., Richards, S. N., Scott, N., Taranu, D. S., Tonini, C., and Zafar, T.
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KINEMATICS ,INTEGRAL field spectroscopy ,AXIAL flow ,GALACTIC dynamics ,GRAVITATIONAL potential - Abstract
Using the stellar kinematic maps and ancillary imaging data from the Sydney AAO Multi Integral field (SAMI) Galaxy Survey, the intrinsic shape of kinematically selected samples of galaxies is inferred. We implement an efficient and optimized algorithm to fit the intrinsic shape of galaxies using an established method to simultaneously invert the distributions of apparent ellipticities and kinematic misalignments. The algorithm output compares favourably with previous studies of the intrinsic shape of galaxies based on imaging alone and our reanalysis of the ATLAS
3D data. Our results indicate that most galaxies are oblate axisymmetric. We show empirically that the intrinsic shape of galaxies varies as a function of their rotational support as measured by the 'spin' parameter proxy λRe . In particular, low-spin systems have a higher occurrence of triaxiality, while high-spin systems are more intrinsically flattened and axisymmetric. The intrinsic shape of galaxies is linked to their formation and merger histories. Galaxies with high-spin values have intrinsic shapes consistent with dissipational minor mergers, while the intrinsic shape of low-spin systems is consistent with dissipationless multimerger assembly histories. This range in assembly histories inferred from intrinsic shapes is broadly consistent with expectations from cosmological simulations. [ABSTRACT FROM AUTHOR]- Published
- 2017
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15. The growth of discs and bulges during hierarchical galaxy formation -- II. Metallicity, stellar populations and dynamical evolution.
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Tonini, C., Mutch, S. J., Wyithe, J. S. B., and Croton, D. J.
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DISK galaxies , *GALACTIC bulges , *GALAXY formation , *STELLAR populations , *STELLAR evolution - Abstract
We investigate the properties of the stellar populations of model galaxies as a function of galaxy evolutionary history and angular momentum content. We use the new semi-analytic model presented in Tonini et al. This new model follows the angular momentum evolution of gas and stars, providing the base for a new star formation recipe, and treatment of the effects of mergers that depends on the central galaxy dynamical structure. We find that the new recipes have the effect of boosting the efficiency of the baryonic cycle in producing and recycling metals, as well as preventing minor mergers from diluting the metallicity of bulges and ellipticals. The model reproduces the stellar mass-stellar metallicity relation for galaxies above 1010 solar masses, including Brightest Cluster Galaxies. Model discs, galaxies dominated by instability-driven components, and merger-driven objects each stem from different evolutionary channels. These model galaxies therefore occupy different loci in the galaxy mass-size relation, which we find to be in accord with the ATLAS 3D classification of disc galaxies, fast rotators and slow rotators. We find that the stellar populations' properties depend on the galaxy evolutionary type, with more evolved stellar populations being part of systems that have lost or dissipated more angular momentum during their assembly history. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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16. The growth of discs and bulges during hierarchical galaxy formation - I. Fast evolution versus secular processes.
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Tonini, C., Mutch, S. J., Croton, D. J., and Wyithe, J. S. B.
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GALAXY formation , *GALACTIC bulges , *GALACTIC evolution , *DISKS (Astrophysics) , *STELLAR populations - Abstract
We present a theoretical model for the evolution of mass, angular momentum and size of galaxy discs and bulges, and we implement it into the semi-analytic galaxy formation code, Semi-Analytic Galaxy Evolution. The model follows both secular and violent evolutionary channels, including smooth accretion, disc instabilities, minor and major mergers. We find that the combination of our recipe with hierarchical clustering produces two distinct populations of bulges: merger-driven bulges, akin to classical bulges and ellipticals, and instability-driven bulges, akin to secular (or pseudo-)bulges. The model mostly reproduces the mass-size relation of gaseous and stellar discs, the evolution of the mass-size relation of ellipticals, the Faber- Jackson relation, and the magnitude-colour diagram of classical and secular bulges. The model predicts only a small overlap of merger-driven and instability-driven components in the same galaxy, and predicts different bulge types as a function of galaxy mass and disc fraction. Bulge type also affects the star formation rate and colour at a given luminosity. The model predicts a population of merger-driven red ellipticals that dominate both the low-mass and high-mass ends of the galaxy population, and span all dynamical ages; merger-driven bulges in disc galaxies are dynamically old and do not interfere with subsequent evolution of the star-forming component. Instability-driven bulges dominate the population at intermediate galaxy masses, especially thriving in massive discs. The model green valley is exclusively populated by instability-driven bulge hosts. Through the present implementation, the mass accretion history is perceivable in the galaxy structure, morphology and colours. [ABSTRACT FROM AUTHOR]
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- 2016
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17. Intensity mapping cross-correlations: connecting the largest scales to galaxy evolution.
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Wolz, L., Tonini, C., Blake, C., and Wyithe, J. S. B.
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CROSS correlation , *GALACTIC evolution , *ASTRONOMICAL surveys , *STAR formation , *METAPHYSICAL cosmology - Abstract
Intensity mapping of the neutral hydrogen (HI) is a new observational tool to efficiently map the large-scale structure over wide redshift ranges. The cross-correlation of intensity maps with galaxy surveys is a robust measure of the cosmological power spectrum and the HI content of galaxies which diminishes systematics caused by instrumental effects and foreground removal. We examine the cross-correlation signature at redshift 0.9 using a semianalytical galaxy formation model in order to model the HI gas of galaxies as well as their optical magnitudes. We determine the scale-dependent clustering of the cross-correlation power for different types of galaxies determined by their colours, which act as a proxy for their star formation activity. We find that the cross-correlation coefficient with HI density for red quiescent galaxies falls off more quickly on smaller scales k > 0.2 h Mpc-1 than for blue star-forming galaxies. Additionally, we create a mock catalogue of highly star-forming galaxies to mimic the WiggleZ Dark Energy Survey, and use this to predict existing and future measurements using data from the Green Bank telescope and Parkes telescope. We find that the cross-power of highly star-forming galaxies shows a higher clustering on small scales than any other galaxy type and that this significantly alters the power spectrum shape on scales k > 0.2 h Mpc-1. We show that the cross-correlation coefficient is not negligible when interpreting the cosmological cross-power spectrum and additionally contains information about the HI content of the optically selected galaxies. [ABSTRACT FROM AUTHOR]
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- 2016
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18. The universal rotation curve of spiral galaxies – II. The dark matter distribution out to the virial radius.
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Salucci, P., Lapi, A., Tonini, C., Gentile, G., Yegorova, I., and Klein, U.
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SPIRAL galaxies ,DARK matter ,GALAXY formation ,METAPHYSICAL cosmology ,KINEMATICS ,ASTRONOMY - Abstract
In the current ΛCDM cosmological scenario, N-body simulations provide us with a universal mass profile, and consequently a universal equilibrium circular velocity of the virialized objects, as galaxies. In this paper we obtain, by combining kinematical data of their inner regions with global observational properties, the universal rotation curve of disc galaxies and the corresponding mass distribution out to their virial radius. This curve extends the results of Paper I, concerning the inner luminous regions of Sb–Im spirals, out to the edge of the galaxy haloes. [ABSTRACT FROM AUTHOR]
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- 2007
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19. Characterization of protein kinase system in human skeletal muscle
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Frattola, L., Pellegrini, G., Tonini, C., and Scarlato, G.
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- 1980
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20. Sex pheromone components of the leafroller moth Pandemis cerasana
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Tonini, C., Cassani, G., Piccardi, P., Maini, S., Castellari, P.L., and Pasqualini, E.
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- 1982
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21. Serotonin-induced Muscular Damage in Hypercalcemic Rats: A Morphologic and Biochemical Study.
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Canal, N., Frattola, L., Nemni, R., Tiby, V., Piolti, R., Tonini, C., and Iannaccone, S.
- Published
- 1984
22. A Short-Term Western Diet Impairs Cholesterol Homeostasis and Key Players of Beta Amyloid Metabolism in Brain of Middle Aged Rats
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Arianna Mazzoli, Luisa Cigliano, Susanna Iossa, Lucia Iannotta, Barbara Morone, Maria Stefania Spagnuolo, Maria Strazzullo, Valentina Pallottini, Claudia Tonini, Raffaella Crescenzo, Marcus Ståhlman, Stefania Spagnuolo, Maria, Pallottini, Valentina, Mazzoli, Arianna, Iannotta, Lucia, Tonini, Claudia, Morone, Barbara, Ståhlman, Marcu, Crescenzo, Raffaella, Strazzullo, Maria, Iossa, Susanna, Cigliano, Luisa, Spagnuolo, M. S., Pallottini, V., Mazzoli, A., Iannotta, L., Tonini, C., Morone, B., Stahlman, M., Crescenzo, R., Strazzullo, M., Iossa, S., and Cigliano, L.
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0301 basic medicine ,Apolipoprotein E ,medicine.medical_specialty ,high fat–high fructose diet ,Apolipoprotein E, cholesterol, high fat-high fructose diet, hippocampus, middle age ,Nicastrin ,Fructose ,Biology ,Reductase ,Presenilin ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,Apolipoproteins E ,Internal medicine ,medicine ,Amyloid precursor protein ,Insulin-degrading enzyme ,Cholesterol 24-Hydroxylase ,Animals ,Homeostasis ,middle age ,apolipoprotein E ,cholesterol ,high fat-high fructose diet ,hippocampus ,Liver X Receptors ,030109 nutrition & dietetics ,Amyloid beta-Peptides ,Membrane Glycoproteins ,hippocampu ,Cholesterol ,Age Factors ,Brain ,030104 developmental biology ,Endocrinology ,chemistry ,Receptors, LDL ,Blood-Brain Barrier ,Diet, Western ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Hydroxymethylglutaryl CoA Reductases ,Amyloid Precursor Protein Secretases ,Low Density Lipoprotein Receptor-Related Protein-1 ,Food Science ,Biotechnology ,Sterol Regulatory Element Binding Protein 2 - Abstract
Scope Cholesterol homeostasis is crucial for brain functioning. Unhealthy nutrition can influence cerebral physiology, but the effect of western diets on brain cholesterol homeostasis, particularly at middle age, is unknown. Given the link between brain cholesterol alteration and beta amyloid production, the aim is to evaluate whether a diet rich in fat and fructose affects the protein network implicated in cholesterol synthesis and shuttling between glial cells and neurons, as well as crucial markers of beta amyloid metabolism. Methods and results Middle aged rats are fed a high fat-high fructose (HFF) or a control diet for 4 weeks. Inflammatory markers and cholesterol levels significantly increase in hippocampus of HFF rats. A higher activation of 3-hydroxy 3-methylglutaryl coenzyme-A reductase, coupled with lower levels of apolipoprotein E, LXR-beta, and lipoproteins receptors is measured in hippocampus from HFF rats. The alteration of critical players of cholesterol homeostasis is associated with increased level of amyloid precursor protein, presenilin 1, and nicastrin, and decreased level of insulin degrading enzyme. Conclusions Overall these data show that a western diet is associated with perturbation of cholesterol homeostasis in middle aged rats, mostly in hippocampus. This might trigger molecular events involved in the onset of neurodegenerative diseases.
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- 2020
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23. Loss of Mevalonate/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome
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Marco Segatto, Claudia Tonini, Frank W. Pfrieger, Valentina Pallottini, Viviana Trezza, Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano [Milano] (UNIMI), Department of Sciences [Roma, Italy], Università degli Studi Roma Tre, Segatto, M., Tonini, C., Pfrieger, F. W., Trezza, V., and Pallottini, V.
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Autism spectrum disorder ,Brain ,Cholesterol ,Mevalonate pathway ,Rett syndrome ,[SDV]Life Sciences [q-bio] ,brain ,Central nervous system ,Mevalonic Acid ,autism spectrum disorder ,Review ,Bioinformatics ,complex mixtures ,Catalysis ,Inorganic Chemistry ,lcsh:Chemistry ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Animals ,Homeostasis ,Humans ,Medicine ,Cholesterol metabolism ,Physical and Theoretical Chemistry ,Molecular Biology ,lcsh:QH301-705.5 ,Spectroscopy ,030304 developmental biology ,0303 health sciences ,business.industry ,Organic Chemistry ,mevalonate pathway ,cholesterol ,General Medicine ,medicine.disease ,Computer Science Applications ,Metabolic pathway ,medicine.anatomical_structure ,chemistry ,lcsh:Biology (General) ,lcsh:QD1-999 ,business ,030217 neurology & neurosurgery - Abstract
International audience; The mevalonate (MVA)/cholesterol pathway is crucial for central nervous system (CNS) development and function and consequently, any dysfunction of this fundamental metabolic pathway is likely to provoke pathologic changes in the brain. Mutations in genes directly involved in MVA/cholesterol metabolism cause a range of diseases, many of which present neurologic and psychiatric symptoms. This raises the question whether other diseases presenting similar symptoms are related albeit indirectly to the MVA/cholesterol pathway. Here, we summarized the current literature suggesting links between MVA/cholesterol dysregulation and specific diseases, namely autism spectrum disorder and Rett syndrome.
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- 2019
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24. Impact of Sex and Age on the Mevalonate Pathway in the Brain: A Focus on Effects Induced by Maternal Exposure to Exogenous Compounds
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Valentina Pallottini, Marco Segatto, Claudia Tonini, Tonini, C., Segatto, M., and Pallottini, V.
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0301 basic medicine ,medicine.medical_specialty ,Mevalonate pathway ,brain ,Endocrinology, Diabetes and Metabolism ,lcsh:QR1-502 ,Review ,Biology ,Age and sex ,Biochemistry ,lcsh:Microbiology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,ageing ,cholesterol ,mevalonate pathway ,sex ,medicine ,Molecular Biology ,Cholesterol homeostasis ,Cholesterol ,Brain ,Ageing ,030104 developmental biology ,Endocrinology ,chemistry ,Sex ,030217 neurology & neurosurgery - Abstract
The mevalonate pathway produces cholesterol and other compounds crucial for numerous cellular processes. It is well known that age and sex modulate this pathway in the liver. Recently, similar effects were also noted in different brain areas, suggesting that alterations of the mevalonate pathway are at the root of marked sex-specific disparities in some neurodevelopmental disorders related to disturbed cholesterol homeostasis. Here, we show how the mevalonate pathway is modulated in a sex-, age- and region-specific manner, and how maternal exposure to exogenous compounds can disturb the regulation of this pathway in the brain, possibly inducing functional alterations.
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- 2020
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25. Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins by JQ1 Unravels a Novel Epigenetic Modulation to Control Lipid Homeostasis
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Valentina Pallottini, Francesco Berardinelli, Giuseppina Caretti, Marco Segatto, Sabrina Di Bartolomeo, Claudia Tonini, Mayra Colardo, Barbara Colella, Tonini, C., Colardo, M., Colella, B., Di Bartolomeo, S., Berardinelli, F., Caretti, G., Pallottini, V., and Segatto, M.
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BET protein ,Epigenesis, Genetic ,lcsh:Chemistry ,LDLr ,lipid metabolism ,BET proteins ,Phosphorylation ,lcsh:QH301-705.5 ,Cell proliferation ,Spectroscopy ,Sterol Regulatory Element Binding Proteins ,Chemistry ,Epigenetic ,Azepines ,Hep G2 Cells ,General Medicine ,Computer Science Applications ,Cell biology ,Cholesterol ,Intracellular ,Epigenetics ,HMGCR ,JQ1 ,Lipid metabolism ,SREBP ,TMEM97 ,Article ,Catalysis ,Inorganic Chemistry ,BET inhibitor ,Lipid biosynthesis ,Humans ,Physical and Theoretical Chemistry ,Molecular Biology ,epigenetics ,Organic Chemistry ,Membrane Proteins ,Proteins ,cholesterol ,Triazoles ,Sterol regulatory element-binding protein ,Bromodomain ,cell proliferation ,Receptors, LDL ,lcsh:Biology (General) ,lcsh:QD1-999 ,Hydroxymethylglutaryl CoA Reductases ,Homeostasis - Abstract
The homeostatic control of lipid metabolism is essential for many fundamental physiological processes. A deep understanding of its regulatory mechanisms is pivotal to unravel prospective physiopathological factors and to identify novel molecular targets that could be employed to design promising therapies in the management of lipid disorders. Here, we investigated the role of bromodomain and extraterminal domain (BET) proteins in the regulation of lipid metabolism. To reach this aim, we used a loss-of-function approach by treating HepG2 cells with JQ1, a powerful and selective BET inhibitor. The main results demonstrated that BET inhibition by JQ1 efficiently decreases intracellular lipid content, determining a significant modulation of proteins involved in lipid biosynthesis, uptake and intracellular trafficking. Importantly, the capability of BET inhibition to slow down cell proliferation is dependent on the modulation of cholesterol metabolism. Taken together, these data highlight a novel epigenetic mechanism involved in the regulation of lipid homeostasis.
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- 2020
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