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Over the past few years, academics have undertaken initiatives to bridge the gap between theory and practice in the ever-growing field of business analytics, including implementing real-life student projects in all shapes and forms. Every year since 2015, Manhattan College has invited student teams from across North America and elsewhere in the world to its campus in order to participate in an intercollegiate business analytics competition (BAC@MC). This well-received event and the objectives behind it are described in this article. The program is shown to serve as an effective experiential learning adventure for the undergraduate students as it hones their data analytic skills in the context of an engaging real-world business problem. The roles various stakeholders play in this high-impact practice are highlighted. Furthermore, an example of a recent competition question is presented (along with a summary of the analytical approaches attempted) by the student teams. Descriptive visualizations, regression, and cluster algorithms implemented using python, R, Excel, or Tableau are among the typical analyses utilized by participating students. As witnessed by the students, faculty advisors, and the industry practitioners who attended the event, competitions such as BAC@MC can be rewarding, community-building, and transformative experiences for undergraduate students who will soon become tomorrow's business analysts.

A generic template for clinical trials simulations that are typically required by statisticians is developed. Realistic clinical trials data sets are created using a unifying model that allows general correlation structures for endpoint*timepoint data and nonnormal distributions (including time-to-event), and computationally efficient algorithms are presented. The model allows for patient dropout and noncompliance. A grid-enabled SAS-based system has been developed to implement this model; details are presented summarizing the system development. An example illustrating use of the system is given. [ABSTRACT FROM AUTHOR]

Identifying the pathways that are significantly impacted in a given condition is a crucial step in understanding the underlying biological phenomena. All approaches currently available for this purpose calculate a P-value that aims to quantify the significance of the involvement of each pathway in the given phenotype. These P-values were previously thought to be independent. Here we show that this is not the case, and that many pathways can considerably affect each other's P-values through a "crosstalk" phenomenon. Although it is intuitive that various pathways could influence each other, the presence and extent of this phenomenon have not been rigorously studied and, most importantly, there is no currently available technique able to quantify the amount of such crosstalk. Here, we show that all three major categories of pathway analysis methods (enrichment analysis, functional class scoring, and topology-based methods) are severely influenced by crosstalk phenomena. Using real pathways and data, we show that in some cases pathways with significant P-values are not biologically meaningful, and that some biologically meaningful pathways with nonsignificant P-values become statistically significant when the crosstalk effects of other pathways are removed. We describe a technique able to detect, quantify, and correct crosstalk effects, as well as identify independent functional modules. We assessed this novel approach on data from four experiments involving three phenotypes and two species. This method is expected to allow a better understanding of individual experiment results, as well as a more refined definition of the existing signaling pathways for specific phenotypes. [ABSTRACT FROM AUTHOR]