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This letter, written by Drs Berezin and Zolotov, discusses the concept of Lacertus syndrome and its potential pathologies. They argue that there is a lack of experimental evidence to support the idea that compression of the median nerve in the proximal forearm is a source of symptoms. They suggest that further research is needed to establish reproducible pathophysiology or conduct controlled trials to determine the specific effects of addressing the proposed pathophysiology. The authors caution against overdiagnosis and overtreatment, emphasizing the importance of critical thinking and evidence-based medicine. In response, Drs Teunis and Ring express gratitude for the article and discuss the confusion surrounding the terminology of median nerve pathology. They suggest that the authors' ideas can be considered a null hypothesis and call for further experimental and clinical confirmation. They also express hope for future advancements in studying the pathology of the median nerve. [Extracted from the article]

Objectives: The aim of this study was to investigate whether serum anti-Müllerian hormone (AMH) predicts symptom burden after risk-reducing salpingo-oophorectomy (RRSO) in order to individualize counseling.Methods: Patient-reported menopausal symptoms, sexual functioning, and psychological distress (depression and anxiety) were assessed 1 day before (T0) and 6 weeks (T1) and 7 months (T2) after RRSO. AMH was assessed before RRSO. Multivariable regression analysis was used to investigate the association between AMH and short-term and long-term change in symptom burden following RRSO.Results: Ninety-one premenopausal women at high risk of ovarian cancer were included. Presurgical AMH was not related significantly to change in symptoms post RRSO. As a secondary outcome we found that regular menses before RRSO was associated specifically with long-term increase in hot flushes (sr = 0.40, p = 0.001; total R2 = 0.171) and depression (sr = 0.29, p = 0.012; total R2 = 0.132). Earlier receipt of chemotherapy was associated with long-term improvement in sexual functioning (sr = 0.24, p = 0.041; total R2 = 0.348).Conclusion: In this cohort, AMH was not a significant predictor of change in symptoms following RRSO. Regular menses prior to RRSO and earlier receipt of chemotherapy were significantly, but relatively weakly, associated with changes in outcomes 6 weeks and/or 7 months after RRSO. [ABSTRACT FROM AUTHOR]

Treatment with a variable angle locking plate can, in theory, maintain near anatomic reduction of intra-articular distal radius fractures, but it is unknown to what extent reduction is maintained as measured by computed tomography. We assessed changes in radiographic fracture position 1 year post-operatively. We included 73 patients of whom 66 patients (90%) had radiographs available for review at 1 year post-operatively. We found a small (less than 2 mm or 2°) but statistically significant change in several measures. Accounting for inter-observer variability, this is probably within measurement error. We found no difference in change in fracture position or range of motion, grip strength or patient-reported outcome between the use of one or two distal rows of screws. Our results show that minimal changes in reduction can be expected after volar plate fixation in most patients. We recommend using only one screw row routinely, limiting costs, surgical time and the risk of misplacement of screws.Level of evidence: IV [ABSTRACT FROM AUTHOR]