1. Levels of hypocretin-1 (orexin A) in the cerebrospinal fluid of two young hypersomniacs suspected of being narcoleptic
- Author
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Takahito Urakami, Hiroshi Yoneda, Takashi Kanbayashi, Masaharu Mandai, Narutsugu Emura, Kenji Kuroda, Yasushi Yoshida, Seiji Nishino, and Hitoshi Matsumura
- Subjects
medicine.medical_specialty ,Neurology ,Cataplexy ,Physiology ,business.industry ,media_common.quotation_subject ,Excessive daytime sleepiness ,Appetite ,HYPOCRETIN 1 ,medicine.disease ,Orexin-A ,Neuropsychology and Physiological Psychology ,Cerebrospinal fluid ,Endocrinology ,nervous system ,Physiology (medical) ,Internal medicine ,mental disorders ,medicine ,medicine.symptom ,business ,psychological phenomena and processes ,Narcolepsy ,media_common - Abstract
The level of hypocretin-1 (orexin A) is reported to be low in the cerebrospinal fluid (CSF) of subjects with narcolepsy. We measured the CSF level of hypocretin-1 of two young hypersomniacs. The first subject was a 9-year-old boy who exhibited cataplexy, and was demonstrated to be human leukocyte antigen-DR2 (HLA-DR2) positive. The second subject was a 16-year-old boy who exhibited no cataplexy and was HLA-DR2 negative. When excessive daytime sleepiness ensued, appetite and bodyweight were increased in case 1 but not in case 2. The level of CSF hypocretin-1 was undetectably low and within normal limits in case 1 and case 2, respectively. It appears to be important to measure the CSF level of hypocretin-1 in the diagnosis and treatment of narcolepsy.
- Published
- 2003
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