38 results on '"Sulzgruber P"'
Search Results
2. The Impact of Chronic Oral Beta-Blocker Intake on Intravenous Bolus Landiolol Response in Hospitalized Intensive Care Patients with Sudden-Onset Supraventricular Tachycardia—A Post Hoc Analysis of a Cross-Sectional Trial
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Felix Eibensteiner, Emmilie Mosor, Daniel Tihanyi, Sonja Anders, Andrea Kornfehl, Marco Neymayer, Julia Oppenauer, Christoph Veigl, Valentin Al Jalali, Hans Domanovits, Patrick Sulzgruber, and Sebastian Schnaubelt
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intensive care medicine ,critical care ,cardioselective β-blockers ,landiolol ,arrhythmia ,dysrhythmia ,Pharmacy and materia medica ,RS1-441 - Abstract
Background: Landiolol, a highly cardioselective agent with a short half-life (2.4–4 min), is commonly used as a perfusor or bolus application to treat tachycardic arrhythmia. Some small studies suggest that prior oral β-blocker use results in a less effective response to intravenous β-blockers. Methods: This study investigated whether prior chronic oral β-blocker (Lβ) or no prior chronic oral β-blocker (L–) intake influences the response to intravenous push-dose Landiolol in intensive care patients with acute tachycardic arrhythmia. Results: The effects in 30 patients (67 [55–72] years) were analyzed, 10 (33.3%) with and 20 (66.7%) without prior oral β-blocker therapy. Arrhythmias were diagnosed as tachycardic atrial fibrillation in 14 patients and regular, non-fluid-dependent, supraventricular tachycardia in 16 cases. Successful heart rate control (Lβ 4 vs. L– 7, p = 1.00) and rhythm control (Lβ 3 vs. L– 6, p = 1.00) did not significantly differ between the two groups. Both groups showed a significant decrease in heart rate when comparing before and after the bolus administration, without significant differences between the two groups (Lβ −26/min vs. L– −33/min, p = 0.528). Oral β-blocker therapy also did not influence the change in mean arterial blood pressure after Landiolol bolus administration (Lβ −5 mmHg vs. L– −4 mmHg, p = 0.761). Conclusions: A prior chronic intake of β-blockers neither affected the effectiveness of push-dose Landiolol in heart rate or rhythm control nor impacted the difference in heart rate or mean arterial blood pressure before and after the Landiolol boli.
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- 2024
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3. A combinatorial expansion of vertical-strip LLT polynomials in the basis of elementary symmetric functions
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Alexandersson, Per and Sulzgruber, Robin
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Mathematics - Combinatorics ,Mathematics - Representation Theory ,05E05, 05A19, 05E10 - Abstract
We give a new characterization of the vertical-strip LLT polynomials $\mathrm{LLT}_P(x;q)$ as the unique family of symmetric functions that satisfy certain combinatorial relations. This characterization is then used to prove an explicit combinatorial expansion of vertical-strip LLT polynomials in terms of elementary symmetric functions. Such formulas were conjectured independently by A. Garsia et al. and the first named author, and are governed by the combinatorics of orientations of unit-interval graphs. The obtained expansion is manifestly positive if $q$ is replaced by $q+1$, thus recovering a recent result of M. D'Adderio. Our results are based on linear relations among LLT polynomials that arise in the work of D'Adderio, and of E. Carlsson and A. Mellit. To some extent these relations are given new bijective proofs using colorings of unit-interval graphs. As a bonus we obtain a new characterization of chromatic quasisymmetric functions of unit-interval graphs., Comment: 49 pages. This version has updated .bib, and some improvements in section 6
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- 2020
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4. Editorial: Advances in the prevention and treatment of sudden cardiac death
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Sebastian Schnaubelt, Enrico Baldi, and Patrick Sulzgruber
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sudden cardiac arrest ,sudden cardiac death ,emergency medicine ,critical care ,cardiopulmonary resuscitation ,extracorporeal membrane oxygenation (ECMO) ,Medicine (General) ,R5-920 - Published
- 2023
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5. The Prognostic Impact of Anti-thrombotic Treatment Strategies After Biological Aortic Valve Replacement
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Hammer, Andreas, Hofer, Felix, Kazem, Niema, Koller, Lorenz, Schnaubelt, Sebastian, Laufer, Günther, Steinlechner, Barbara, Wojta, Johann, Hengstenberg, Christian, Niessner, Alexander, and Sulzgruber, Patrick
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- 2022
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6. Out of sight – Out of mind? The need for a professional and standardized peri-mission first responder support model
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Sebastian Schnaubelt, Simon Orlob, Christoph Veigl, Patrick Sulzgruber, Mario Krammel, Kasper G. Lauridsen, and Robert Greif
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Cardiopulmonary resuscitation ,First responders ,Automated-external defibrillator ,Debriefing ,System to save lives ,Chainmail of survival ,Specialties of internal medicine ,RC581-951 - Abstract
First responders are an essential part of the chain (-mail) of survival as they bridge and reduce the time to first chest compressions and defibrillation substantially. However, in the peri-mission phase before and after being sent to a cardiac arrest, these first responders are in danger of being forgotten and taken for granted, and the potential psychological impact has to be remembered. We propose a standardized first responder support system (FRSS) that needs to ensure that first responders are valued and cared for in terms of psychological safety and continuing motivation. This multi-tiered program should involve tailored education and standardized debriefing, as well as actively seeking contact with the first responders after their missions to facilitate potentially needed professional psychological support.
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- 2023
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7. Relationship of diabetes, heart failure, and N‐terminal pro‐B‐type natriuretic peptide with cardiovascular outcomes in patients with atrial fibrillation
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Felix Hofer, Ulrike Pailer, Patrick Sulzgruber, Christian Gerges, Max‐Paul Winter, Robert P. Giugliano, Michael Gottsauner‐Wolf, Martin Hülsmann, Niema Kazem, Lorenz Koller, Robert Schönbauer, Alexander Niessner, Christian Hengstenberg, and Thomas A. Zelniker
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Heart failure ,Diabetes mellitus ,NT‐proBNP ,Atrial fibrillation ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims We aim to explore the relationship of heart failure (HF) and diabetes with cardiovascular (CV) death or hospitalization for HF (HHF) and to study the clinical utility of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) in an unselected patient population with atrial fibrillation (AF). Methods and results Patients with AF admitted to a tertiary academic center between January 2005 and July 2019 were identified through a search of electronic health records. We used Cox regression models adjusted for age, sex, estimated glomerular filtration rate, diabetes, HF, body mass index, prior myocardial infarction, coronary artery disease, hypertension, smoking, C‐reactive protein, and low‐density lipoprotein cholesterol. To select the most informative variables, we performed a least absolute shrinkage and selection operator Cox regression with 10‐fold cross‐validation. In total, 7412 patients (median age 70 years, 39.7% female) were included in this analysis and followed over a median of 4.5 years. Both diabetes [adjusted (Adj.) HR 1.87, 95% CI 1.55–2.25] and HF (Adj. HR 2.57, 95% CI 2.22–2.98) were significantly associated with CV death/HHF after multivariable adjustment. Compared with patients with diabetes, HF patients had a higher risk of HHF but a similar risk of CV and all‐cause death. NT‐proBNP showed good discriminatory performance (area under the curve 0.78, 95% CI 0.77–0.80) and the addition of NT‐proBNP to the covariates used for adjustment resulted in a significant area under the curve improvement (Δ = 0.04, P
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- 2022
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8. Patterns in Shi Tableaux and Dyck Paths
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Kallipoliti, Myrto, Sulzgruber, Robin, and Tzanaki, Eleni
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- 2022
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9. Prescription Patterns of Sodium-Glucose Cotransporter 2 Inhibitors and Cardiovascular Outcomes in Patients with Diabetes Mellitus and Heart Failure
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Hofer, Felix, Kazem, Niema, Richter, Bernhard, Sulzgruber, Patrick, Schweitzer, Ronny, Pailer, Ulrike, Hammer, Andreas, Koller, Lorenz, Hengstenberg, Christian, and Niessner, Alexander
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- 2022
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10. Relationship of Fibroblast Growth Factor 23 With Hospitalization for Heart Failure and Cardiovascular Outcomes in Patients Undergoing Cardiac Surgery
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Felix Hofer, Andreas Hammer, Ulrike Pailer, Lorenz Koller, Niema Kazem, Eva Steinacher, Barbara Steinlechner, Martin Andreas, Günther Laufer, Johann Wojta, Thomas A. Zelniker, Christian Hengstenberg, Alexander Niessner, and Patrick Sulzgruber
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cardiac surgery ,cardiovascular death ,fibroblast growth factor 23 ,hospitalization for heart failure ,postoperative atrial fibrillation ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Fibroblast growth factor 23 (FGF‐23) is crucial in regulating phosphate and vitamin D metabolism and is moreover associated with an increased cardiovascular risk. The specific objective of this study was to investigate the influence of FGF‐23 on cardiovascular outcomes, including hospitalization for heart failure (HHF), postoperative atrial fibrillation, and cardiovascular death, in an unselected patient population after cardiac surgery. Methods and Results Patients undergoing elective coronary artery bypass graft and/or cardiac valve surgery were prospectively enrolled. FGF‐23 blood plasma concentrations were assessed before surgery. A composite of cardiovascular death/HHF was chosen as primary end point. A total of 451 patients (median age 70 years; 28.8% female) were included in the present analysis and followed over a median of 3.9 years. Individuals with higher FGF‐23 quartiles showed elevated incidence rates of the composite of cardiovascular death/HHF (quartile 1, 7.1%; quartile 2, 8.6%; quartile 3, 15.1%; and quartile 4, 34.3%). After multivariable adjustment, FGF‐23 modeled as a continuous variable (adjusted hazard ratio for a 1‐unit increase in standardized log‐transformed biomarker, 1.82 [95% CI, 1.34–2.46]) as well as using predefined risk groups and quartiles remained independently associated with the risk of cardiovascular death/HHF and the secondary outcomes, including postoperative atrial fibrillation. Reclassification analysis indicated that the addition of FGF‐23 to N‐terminal pro‐B‐type natriuretic peptide provides a significant improvement in risk discrimination (net reclassification improvement at the event rate, 0.58 [95% CI, 0.34–0.81]; P
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- 2023
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11. Prescription Patterns of Sodium-Glucose Cotransporter 2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists in Patients with Coronary Artery Disease
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Hofer, Felix, Kazem, Niema, Schweitzer, Ronny, Hammer, Andreas, Jakse, Friedrich, Koller, Lorenz, Hengstenberg, Christian, Sulzgruber, Patrick, and Niessner, Alexander
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- 2021
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12. Design for a Heat Pump with Sink Temperatures of 200 °C Using a Radial Compressor
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Julian Unterluggauer, Verena Sulzgruber, Clemens Kroiss, Johannes Riedl, Reinhard Jentsch, and Reinhard Willinger
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high-temperature heat pump ,radial compressor ,simulation ,Technology - Abstract
To reduce CO2 emissions in the industrial sector, high-temperature heat pumps are a key technology. This work presents an approach to design such an industrial heat pump system capable of supplying 200 °C sink temperature and a capacity of approximately 1 MW. Today’s market-available heat pumps using displacement compressors are not suitable for reaching that high sink temperatures as they need lubricating oil, which is not temperature resistant enough. As a consequence, in this study a transcritical heat pump cycle using a two-stage oil-free radial compressor is investigated. Based on preliminary studies, R1233zd(E) is chosen as a refrigerant. The procedure couples 1D thermodynamic cycle simulations with a radial compressor mean-line design model. A preliminary geometry for a compressor with and without inlet guide vanes is presented, and compressor maps including the compressors behaviour in off-design are calculated. The compressor design is then imported into a 1D simulation to analysis the performance of the heat pump in the whole operating range. In the analysis, the application of a fixed inlet is evaluated, and an improvement of approximately 21% and 16% of the isentropic efficiency is achieved. The thermodynamic simulations showed a maximum COP of approximately 2.8 and a possible operating range of 0.5 to 1.3 MW thermal power. Furthermore, a techno-economical analysis by means of a deep-fryer use case showed reasonable payback times of between 2 and 10 years, depending on the electricity to gas price ratio.
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- 2023
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13. Differences in Automated External Defibrillator Types in Out-of-Hospital Cardiac Arrest Treated by Police First Responders
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Mario Krammel, Jakob Eichelter, Constantin Gatterer, Elisabeth Lobmeyr, Marco Neymayer, Daniel Grassmann, Michael Holzer, Patrick Sulzgruber, and Sebastian Schnaubelt
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automated external defibrillator ,out-of-hospital cardiac arrest ,basic life support ,police ,first responder ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Police first responder systems also including automated external defibrillation (AED) has in the past shown considerable impact on favourable outcomes after out-of-hospital cardiac arrest (OHCA). While short hands-off times in chest compressions are known to be beneficial, various AED models use different algorithms, inducing longer or shorter durations of crucial timeframes along basic life support (BLS). Yet, data on details of these differences, and also of their potential impact on clinical outcomes are scarce. Methods: For this retrospective observational study, patients with OHCA of presumed cardiac origin and initially shockable rhythm treated by police first responders in Vienna, Austria, between 01/2013 and 12/2021 were included. Data from the Viennese Cardiac Arrest Registry and AED files were extracted, and exact timeframes were analyzed. Results: There were no significant differences in the 350 eligible cases in demographics, return of spontaneous circulation, 30-day survival, or favourable neurological outcome between the used AED types. However, the Philips HS1 and -FrX AEDs showed immediate rhythm analysis after electrode placement (0 [0–1] s) and almost no shock loading time (0 [0–1] s), as opposed to the LP CR Plus (3 [0–4] and 6 [6–6] s, respectively) and LP 1000 (3 [2–10] and 6 [5–7] s, respectively). On the other hand, the HS1 and -FrX had longer analysis times of 12 [12–16] and 12 [11–18] s than the LP CR Plus (5 [5–6] s) and LP 1000 (6 [5–8] s). The duration from when the AED was turned on until the first defibrillation were 45 [28–61] s (Philips FrX), 59 [28–81] s (LP 1000), 59 [50–97] s (HS1), and 69 [55–85] s (LP CR Plus). Conclusion: In a retrospective analysis of OHCA-cases treated by police first responders, we could not find significant differences in clinical patient outcomes concerning the respective used AED model. However, various differences in time durations (e.g., electrode placement to rhythm analysis, analysis duration, or AED turned on until first defibrillation) along the BLS algorithm were seen. This opens up the question of AED-adaptations and tailored training methods for professional first responders.
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- 2023
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14. Incidence and Survival of Out-of-Hospital Cardiac Arrest in Public Housing Areas in 3 European Capitals.
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Grabmayr, Anne Juul, Folke, Fredrik, Kjoelbye, Julie Samsoee, Andelius, Linn, Krammel, Mario, Ettl, Florian, Sulzgruber, Patrick, Krychtiuk, Konstantin A., Sasson, Comilla, Stieglis, Remy, van Schuppen, Hans, Tan, Hanno L., van der Werf, Christian, Torp-Pedersen, Christian, Ersbøll, Annette Kjær, and Hansen, Carolina Malta
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BACKGROUND: Strategies to reach out-of-hospital cardiac arrests (called cardiac arrest) in residential areas and reduce disparities in care and outcomes are warranted. This study investigated incidences of cardiac arrests in public housing areas. METHODS: This register-based cohort study included cardiac arrest patients from Amsterdam (the Netherlands) from 2016 to 2021, Copenhagen (Denmark) from 2016 to 2021, and Vienna (Austria) from 2018 to 2021. Using Poisson regression adjusted for spatial correlation and city, we compared cardiac arrest incidence rates (number per square kilometer per year and number per 100 000 inhabitants per year) in public housing and other residential areas and examined the proportion of cardiac arrests within public housing and adjacent areas (100-m radius). RESULTS: Overall, 9152 patients were included of which 3038 (33.2%) cardiac arrests occurred in public housing areas and 2685 (29.3%) in adjacent areas. In Amsterdam, 635/1801 (35.3%) cardiac arrests occurred in public housing areas; in Copenhagen, 1036/3077 (33.7%); and in Vienna, 1367/4274 (32.0%). Public housing areas covered 42.4 (12.6%) of 336.7 km2 and 1 024 470 (24.6%) of 4 164 700 inhabitants. Across the capitals, we observed a lower probability of 30-day survival in public housing versus other residential areas (244/2803 [8.7%] versus 783/5532 [14.2%]). The incidence rates and rate ratio of cardiac arrest in public housing versus other residential areas were incidence rate, 16.5 versus 4.1 n/km2 per year; rate ratio, 3.46 (95% CI, 3.31--3.62) and incidence rate, 56.1 versus 36.8 n/100 000 inhabitants per year; rate ratio, 1.48 (95% CI, 1.42--1.55). The incidence rates and rate ratios in public housing versus other residential areas were consistent across the 3 capitals. CONCLUSIONS: Across 3 European capitals, one-third of cardiac arrests occurred in public housing areas, with an additional third in adjacent areas. Public housing areas exhibited consistently higher cardiac arrest incidences per square kilometer and 100 000 inhabitants and lower survival than other residential areas. Public housing areas could be a key target to improve cardiac arrest survival in countries with a public housing sector. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Hemodynamic and Rhythmologic Effects of Push-Dose Landiolol in Critical Care—A Retrospective Cross-Sectional Study
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Sebastian Schnaubelt, Felix Eibensteiner, Julia Oppenauer, Daniel Tihanyi, Marco Neymayer, Roman Brock, Andrea Kornfehl, Christoph Veigl, Valentin Al Jalali, Sonja Anders, Barbara Steinlechner, Hans Domanovits, and Patrick Sulzgruber
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Landiolol ,beta-blockers ,critical care ,intensive care ,hemodynamic stability ,dysrhythmia ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Background: The highly β1-selective beta-blocker Landiolol is known to facilitate efficient and safe rate control in non-compensatory tachycardia or dysrhythmia when administered continuously. However, efficacy and safety data of the also-available bolus formulation in critically ill patients are scarce. Methods: We conducted a retrospective cross-sectional study on a real-life cohort of critical care patients, who had been treated with push-dose Landiolol due to sudden-onset non-compensatory supraventricular tachycardia. Continuous hemodynamic data had been acquired via invasive blood pressure monitoring. Results: Thirty patients and 49 bolus applications were analyzed. Successful heart rate control was accomplished in 20 (41%) cases, rhythm control was achieved in 13 (27%) episodes, and 16 (33%) applications showed no effect. Overall, the heart rate was significantly lower (145 (130–150) vs. 105 (100–125) bpm, p < 0.001) in a 90 min post-application observational period in all subgroups. The median changes in blood pressure after the bolus application did not reach clinical significance. Compared with the ventilation settings before the bolus application, the respiratory settings including the required FiO2 after the bolus application did not differ significantly. No serious adverse events were seen. Conclusions: Push-dose Landiolol was safe and effective in critically ill ICU patients. No clinically relevant impact on blood pressure was noted.
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- 2023
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16. Meditation and Cardiovascular Health: What is the Link?
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Sebastian Schnaubelt, Andreas Hammer, Lorenz Koller, Jan Niederdoeckl, Niema Kazem, Alexander Spiel, Alexander Niessner, and Patrick Sulzgruber
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Meditation as a form of body–mind interaction for primary and secondary prevention in cardiovascular disease has been discussed critically in the past. However, data that aimed to link this intervention to a reduction of various aspects of cardiovascular disease, rendering it a potential part of a cost-effective treatment approach in patients at risk, remain scarce and inconclusive. This article aims to provide an overview of currently available evidence in the literature and the potential impact of meditation on cardiovascular health. However, the data highlighted in this article cannot render with certainty directly reproducible effects of meditation on patients’ cardiovascular disease profiles. Meditation may be suggested only as an additional link in the chain of primary and secondary prevention until future research provides sufficient data on this topic.
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- 2019
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17. Time of out-of-hospital cardiac arrest is not associated with outcome in a metropolitan area: A multicenter cohort study
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Schriefl, C., Mayr, F.B., Poppe, M., Zajicek, A., Nürnberger, A., Clodi, C., Herkner, H., Sulzgruber, P., Lobmeyr, E., Schober, A., Holzer, M., Sterz, F., and Uray, T.
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- 2019
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18. Regional cerebral oxygen saturation during cardiopulmonary resuscitation as a predictor of return of spontaneous circulation and favourable neurological outcome – A review of the current literature
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Schnaubelt, S., Sulzgruber, P., Menger, J., Skhirtladze-Dworschak, K., Sterz, F., and Dworschak, M.
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- 2018
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19. Rational Shi tableaux and the skew length statistic
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Robin Sulzgruber
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combinatorics ,[math.math-co]mathematics [math]/combinatorics [math.co] ,Mathematics ,QA1-939 - Abstract
We define two refinements of the skew length statistic on simultaneous core partitions. The first one relies on hook lengths and is used to prove a refined version of the theorem stating that the skew length is invariant under conjugation of the core. The second one is equivalent to a generalisation of Shi tableaux to the rational level of Catalan combinatorics. We prove that the rational Shi tableau is injective. Moreover we present a uniform definition of the rational Shi tableau for Weyl groups and conjecture injectivity in the general case.
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- 2020
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20. The impact of a high-quality basic life support police-based first responder system on outcome after out-of-hospital cardiac arrest.
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Mario Krammel, Elisabeth Lobmeyr, Patrick Sulzgruber, Markus Winnisch, David Weidenauer, Michael Poppe, Philip Datler, Sebastian Zeiner, Markus Keferboeck, Jakob Eichelter, Thomas Hamp, Thomas Uray, Sebastian Schnaubelt, and Alexander Nuernberger
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Medicine ,Science - Abstract
BACKGROUND:Laypersons' efforts to initiate basic life support (BLS) in witnessed Out-of-Hospital Cardiac Arrest (OHCA) remain comparably low within western society. Therefore, in order to shorten no-flow times in cardiac arrest, several police-based first responder systems equipped with automated external defibrillators (Pol-AED) were established in urban areas, which subsequently allow early BLS and AED administration by police officers. However, data on the quality of BLS and AED use in such a system and its impact on patient outcome remain scarce and inconclusive. METHODS:A total of 85 Pol-AED cases were randomly assigned to a gender, age and first rhythm matched non-Pol-AED control group (n = 170) in a 1:2 ratio. Data on quality of BLS were extracted via trans-thoracic impedance tracings of used AED devices. RESULTS:Comparing Pol-AED cases and the control group, we observed a similar compression rate per minute (p = 0.677) and compression ratio (p = 0.651), mirroring an overall high quality of BLS administered by police officers. Time to the first shock was significantly shorter in Pol-AED cases (6 minutes [IQR: 2-10] vs. 12 minutes [IQR: 8-17]; p
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- 2020
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21. The Prognostic Impact of Circulating Regulatory T Lymphocytes on Mortality in Patients with Ischemic Heart Failure with Reduced Ejection Fraction
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Andreas Hammer, Patrick Sulzgruber, Lorenz Koller, Niema Kazem, Felix Hofer, Bernhard Richter, Steffen Blum, Martin Hülsmann, Johann Wojta, and Alexander Niessner
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Pathology ,RB1-214 - Abstract
Background. Heart failure with reduced ejection fraction (HFrEF) constitutes a global health issue. While proinflammatory cytokines proved to have a pivotal role in the development and progression of HFrEF, less attention has been paid to the cellular immunity. Regulatory T lymphocytes (Tregs) seem to have an important role in the induction and maintenance of immune homeostasis. Therefore, we aimed to investigate the impact of Tregs on the outcome in HFrEF. Methods. We prospectively enrolled 112 patients with HFrEF and performed flow cytometry for cell phenotyping. Individuals were stratified in ischemic (iHFrEF, n=57) and nonischemic etiology (niHFrEF, n=55). Cox regression hazard analysis was used to assess the influence of Tregs on survival. Results. Comparing patients with iHFrEF to niHFrEF, we found a significantly lower fraction of Tregs within lymphocytes in the ischemic subgroup (0.42% vs. 0.56%; p=0.009). After a mean follow-up time of 4.5 years, 32 (28.6%) patients died due to cardiovascular causes. We found that Tregs were significantly associated with cardiovascular survival in the entire study cohort with an adjusted HR per one standard deviation (1-SD) of 0.60 (95% CI: 0.39-0.92; p=0.017). A significant inverse association of Tregs and cardiovascular mortality in patients with iHFrEF with an adj. HR per 1-SD of 0.59 (95% CI: 0.36-0.96; p=0.034) has been observed, while this association was not evident in the nonischemic subgroup (adj. HR per 1-SD of 0.62 (95% CI: 0.17-2.31); p=0.486). Conclusion. Our results indicate a potential influence of Tregs in the pathogenesis and progression of iHFrEF, fostering the implication of cellular immunity in iHFrEF pathophysiology and proving Tregs as a predictor for long-term survival among iHFrEF patients. A preview of this study has been presented at a meeting of the European Society of Cardiology earlier this year.
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- 2020
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22. An increase in acute heart failure offsets the reduction in acute coronary syndrome during coronavirus disease 2019 (COVID‐19) outbreak
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Patrick Sulzgruber, Mario Krammel, Patrick Aigner, Georg Pfenneberger, Albert Espino, Johannes Stommel, Klaus Herbich, Felix Hofer, Niema Kazem, Lorenz Koller, Christian Hengstenberg, and Alexander Niessner
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2021
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23. An Extended Duration of the Pre-Operative Hospitalization is Associated with an Increased Risk of Healthcare-Associated Infections after Cardiac Surgery
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Sulzgruber, Patrick, Schnaubelt, Sebastian, Koller, Lorenz, Laufer, Günther, Pilz, Arnold, Kazem, Niema, Winter, Max-Paul, Steinlechner, Barbara, Andreas, Martin, Fleck, Tatjana, Distelmaier, Klaus, Goliasch, Georg, Toma, Aurel, Hengstenberg, Christian, and Niessner, Alexander
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- 2020
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24. Hemodynamic effects of Vernakalant in cardio-surgical ICU-patients treated for recent-onset postoperative atrial fibrillation
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Schnaubelt, S., Niederdöckl, J., Simon, A., Schütz, N., Holaubek, C., Edlinger-Stanger, M., Niessner, A., Steinlechner, B., Sulzgruber, P., Spiel, A. O., and Domanovits, H.
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- 2020
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25. FP-TES: Fluidization Based Particle Thermal Energy Storage, Part II: Experimental Investigations
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Verena Sulzgruber, David Wünsch, Heimo Walter, and Markus Haider
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thermal energy storage (TES) ,fluidized bed technology ,fluidized bed heat exchanger ,particle transport ,experimental investigations ,Technology - Abstract
In recent years, the fight against global warming and therefore CO2 reduction have become the most important issue for humanity. As a result, volatile sources of energy—like wind and solar power—are penetrating the electrical grid and therefore an increased demand on storage capacities is required. At the TU Wien Institute for Energy Systems and Thermodynamics, a Fluidization Based Particle Thermal Energy Storage (FP-TES) working with bulk material as a sensible storage material is developed. In this paper, the concept and an experimental study of the cold test rig is presented. By means of various pressure measurements, a novel concept of particle transport based on advanced fluidization technology without any mechanical transport devices is investigated. Moreover, a mathematical correlation between the pressure gradients and the particle mass flow is found. Overall, the experimental study provides a full proof of concept and functionality of the novel energy storage system.
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- 2020
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26. FP-TES: A Fluidisation-Based Particle Thermal Energy Storage, Part I: Numerical Investigations and Bulk Heat Conductivity
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David Wünsch, Verena Sulzgruber, Markus Haider, and Heimo Walter
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thermal energy storage (TES) ,fluidised bed technology ,fluidised bed heat exchanger ,particle transport ,numerical investigation ,Technology - Abstract
Renewables should become more continuously available, reliable and cost-efficient to manage the challenges caused by the energy transition. Thus, analytic and numerical investigations for the layout of a pilot plant of a concept called Fluidisation-Based Particle Thermal Energy Storage (FP-TES)—a highly flexible, short- to long-term fluidised bed regenerative heat storage utilising a pressure gradient for hot powder transport, and thus enabling minimal losses, high energy densities, compact construction and countercurrent heat exchange—are presented in this article. Such devices in decentralised set-up—being included in energy- and especially heat-intensive industries, storing latent or sensible heat or power-to-heat to minimise losses and compensate fluctuations—can help to achieve the above-stated goals. Part I of this article is focused on geometrical and fluidic design via numerical investigations utilising Computational Particle Fluid Dynamics (CPFD). In the process a controlled transient simulation method called co-simulation of FP-TES is developed forming the basis for test bench design and execution of further co-simulation. Within this process an advanced design of rotational symmetric hoppers with additional baffles in the heat exchanger (HEX) and internal pipes to stabilise the particle mass flow is developed. Moreover, a contribution bulk heat conductivity is presented to demonstrate low thermal losses and limited needs for thermal insulation by taking into account the thermal insulation of the outer layer of the hopper.
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- 2020
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27. Gender and age-specific aspects of awareness and knowledge in basic life support.
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Mario Krammel, Sebastian Schnaubelt, David Weidenauer, Markus Winnisch, Matthias Steininger, Jakob Eichelter, Thomas Hamp, Raphael van Tulder, and Patrick Sulzgruber
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Medicine ,Science - Abstract
BACKGROUND:The 'chain of survival'-including early call for help, early cardiopulmonary resuscitation (CPR) and early defibrillation-represents the most beneficial approach for favourable patient outcome after out-of-hospital cardiac arrest (OHCA). Despite increasing numbers of publicly accessible automated external defibrillators (AED) and interventions to increase public awareness for basic life support (BLS), the number of their use in real-life emergency situations remains low. METHODS:In this prospective population-based cross-sectional study, a total of 501 registered inhabitants of Vienna (Austria) were randomly approached via telephone calls between 08/2014 and 09/2014 and invited to answer a standardized questionnaire in order to identify public knowledge and awareness of BLS and AED-use. RESULTS:We found that more than 52 percent of participants would presume OHCA correctly and would properly initiate BLS attempts. Of alarming importance, only 33 percent reported that they would be willing to perform CPR and 50 percent would use an AED device. There was a significantly lower willingness to initiate BLS attempts (male: 40% vs. female: 25%; OR: 2.03 [95%CI: 1.39-2.98]; p
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- 2018
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28. CD4+CD28null T Lymphocytes are Associated with the Development of Atrial Fibrillation after Elective Cardiac Surgery
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Sulzgruber, Patrick, Thaler, Barbara, Koller, Lorenz, Baumgartner, Johanna, Pilz, Arnold, Steininger, Matthias, Schnaubelt, Sebastian, Fleck, Tatjana, Laufer, Günther, Steinlechner, Barbara, Winter, Max-Paul, Goliasch, Georg, Wojta, Johann, and Niessner, Alexander
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- 2018
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29. Impaired High‐Density Lipoprotein Anti‐Oxidative Function Is Associated With Outcome in Patients With Chronic Heart Failure
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Lore Schrutka, Klaus Distelmaier, Philipp Hohensinner, Patrick Sulzgruber, Irene M. Lang, Gerald Maurer, Johann Wojta, Martin Hülsmann, Alexander Niessner, and Lorenz Koller
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heart failure ,high‐density lipoprotein cholesterol ,oxidative stress ,prognosis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundOxidative stress is mechanistically linked to the pathogenesis of chronic heart failure (CHF). Antioxidative functions of high‐density lipoprotein (HDL) particles have been found impaired in patients with ischemic cardiomyopathy; however, the impact of antioxidative HDL capacities on clinical outcome in CHF patients is unknown. We therefore investigated the predictive value of antioxidative HDL function on mortality in a representative cohort of patients with CHF. Methods and ResultsWe prospectively enrolled 320 consecutive patients admitted to our outpatient department for heart failure and determined antioxidative HDL function using the HDL oxidative index (HOI). During a median follow‐up time of 2.8 (IQR: 1.8‐4.9) years, 88 (27.5%) patients reached the combined cardiovascular endpoint defined as the combination of death due to cardiovascular events and heart transplantation. An HOI ≥1 was significantly associated with survival free of cardiovascular events in Cox regression analysis with a hazard ratio (HR) of 2.28 (95% CI 1.48‐3.51, P
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- 2016
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30. Type C parking functions and a zeta map
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Robin Sulzgruber and Marko Thiel
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parking functions ,shi arrangement ,zeta map ,dinv statistic ,[info.info-dm] computer science [cs]/discrete mathematics [cs.dm] ,Mathematics ,QA1-939 - Abstract
We introduce type $C$ parking functions, encoded as vertically labelled lattice paths and endowed with a statistic dinv'. We define a bijection from type $C$ parking functions to regions of the Shi arrangement of type $C$, encoded as diagonally labelled ballot paths and endowed with a natural statistic area'. This bijection is a natural analogue of the zeta map of Haglund and Loehr and maps dinv' to area'. We give three different descriptions of it.
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- 2015
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31. Butyrylcholinesterase predicts cardiac mortality in young patients with acute coronary syndrome.
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Patrick Sulzgruber, Lorenz Koller, Thomas Reiberger, Feras El-Hamid, Stefan Forster, David-Jonas Rothgerber, Georg Goliasch, Johann Wojta, and Alexander Niessner
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Medicine ,Science - Abstract
The incidence of acute coronary syndrome (ACS) in young people (≤65 years) is continuously rising. While prognostic factors in ACS are well-investigated less attention has been paid to their age-dependent prognostic value and their particular relevance in younger patients. The aim of our study was to assess the age-dependent prognostic impact of butyrylcholinesterase (BChE).Retrospective cohort study including 624 patients with ACS. Patients were stratified by age into equal groups (n = 208) corresponding to "young patients" (45-64 years), "middle-aged patients" (65-84 years) and "old patients" (85-100 years). Cox regression hazard analysis was used to assess the influence of BChE on survival.After a mean follow-up time of 4.0 (interquartile range [IQR] 2.0-6.4) years, 154 patients (24.7%) died due to a cardiac cause. In the overall cohort, BChE was indirectly associated with cardiac mortality-free survival (adjusted hazard ratio (HR): 0.70 (95% confidence interval [CI] 0.53-0.93, p = 0.01). The primary-analysis of BChE by age strata showed the strongest effect in the age group 45-64 years with an adjusted HR per 1-SD of 0.28 (95% CI 0.12-0.64, p = 0.003), a weaker association with mortality in middle aged (65-84 years: adjusted HR per 1-SD 0.66 [95% CI: 0.41-1.06], p = 0.087), and no association in older patients (85-100 years: adjusted HR per 1-SD 0.89 [95% CI: 0.58-1.38], p = 0.613).BChE is a strong predictor for cardiac mortality specifically in younger patients with ACS aged between 45 and 64 years. No significant association of BChE with cardiac-mortality was detected in other age classes.
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- 2015
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32. Galectin-3 is an independent predictor of postoperative atrial fibrillation and survival after elective cardiac surgery.
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Richter, Bernhard, Koller, Lorenz, Hofer, Felix, Kazem, Niema, Hammer, Andreas, Silbert, Benjamin I., Laufer, Guenther, Steinlechner, Barbara, Wojta, Johann, Hengstenberg, Christian, Niessner, Alexander, and Sulzgruber, Patrick
- Abstract
Background: Postoperative atrial fibrillation (POAF) is a frequent complication after heart surgery and is associated with thromboembolic events, prolonged hospital stay, and adverse outcomes. Inflammation and fibrosis are involved in the pathogenesis of atrial fibrillation.Objective: The purpose of this study was to assess whether galectin-3, which reflects preexisting atrial fibrosis, has the potential to predict POAF and mortality after cardiac surgery.Methods: Four hundred seventy-five consecutive patients (mean age 67.4 ± 11.8 years; 336 (70.7%) male) undergoing elective heart surgery at the Medical University of Vienna were included in this prospective single-center cohort study. Galectin-3 plasma levels were assessed on the day before surgery.Results: The 200 patients (42.1%) who developed POAF had significantly higher galectin-3 levels (9.60 ± 6.83 ng/mL vs 7.10 ± 3.54 ng/mL; P < .001). Galectin-3 significantly predicted POAF in multivariable logistic regression analysis (adjusted odds ratio per 1-SD increase 1.44; 95% confidence interval 1.15-1.81; P = .002). During a median follow-up of 4.3 years (interquartile range 3.4-5.4 years), 72 patients (15.2%) died. Galectin-3 predicted all-cause mortality in multivariable Cox regression analysis (adjusted hazard ratio per 1-SD increase 1.56; 95% confidence interval 1.16-2.09; P = .003). Patients with the highest-risk galectin-3 levels according to classification and regression tree analysis (>11.70 ng/mL) had a 3.3-fold higher risk of developing POAF and a 4.4-fold higher risk of dying than did patients with the lowest-risk levels (≤5.82 ng/mL).Conclusion: The profibrotic biomarker galectin-3 is an independent predictor of POAF and mortality after cardiac surgery. This finding highlights the role of the underlying arrhythmogenic substrate in the genesis of POAF. Galectin-3 may help to identify patients at risk of POAF and adverse outcome after cardiac surgery. [ABSTRACT FROM AUTHOR]- Published
- 2022
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33. Symmetry properties of the Novelli-Pak-Stoyanovskii algorithm
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Robin Sulzgruber
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complexity ,hook-length formula ,young tableaux ,[info.info-dm] computer science [cs]/discrete mathematics [cs.dm] ,[math.math-co] mathematics [math]/combinatorics [math.co] ,Mathematics ,QA1-939 - Abstract
The number of standard Young tableaux of a fixed shape is famously given by the hook-length formula due to Frame, Robinson and Thrall. A bijective proof of Novelli, Pak and Stoyanovskii relies on a sorting algorithm akin to jeu-de-taquin which transforms an arbitrary filling of a partition into a standard Young tableau by exchanging adjacent entries. Recently, Krattenthaler and Müller defined the complexity of this algorithm as the average number of performed exchanges, and Neumann and the author proved it fulfils some nice symmetry properties. In this paper we recall and extend the previous results and provide new bijective proofs.
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- 2014
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34. C-reactive protein predicts mortality in patients referred for coronary angiography and symptoms of heart failure with preserved ejection fraction
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Koller, L., Kleber, M., Goliasch, G., Sulzgruber, P., Scharnagl, H., Silbernagel, G., Grammer, T., Delgado, G., Tomaschitz, A., Pilz, S., März, W., and Niessner, A.
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- 2014
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35. Clusterin/apolipoprotein J is independently associated with survival in patients with chronic heart failure.
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Koller, Lorenz, Richter, Bernhard, Winter, Max-Paul, Sulzgruber, Patrick, Potolidis, Christos, Liebhart, Florian, Mörtl, Deddo, Berger, Rudolf, Goliasch, Georg, Lang, Irene, Wojta, Johann, Hülsmann, Martin, and Niessner, Alexander
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CARDIOVASCULAR disease related mortality ,HEART failure risk factors ,APOLIPOPROTEINS ,BIOMARKERS ,CARDIOVASCULAR diseases risk factors ,CONFIDENCE intervals ,GLYCOPROTEINS ,HEART failure ,LONGITUDINAL method ,RESEARCH methodology ,SURVIVAL ,MATHEMATICAL variables ,DESCRIPTIVE statistics ,ODDS ratio ,PROGNOSIS - Abstract
Background Clusterin/apolipoprotein J (CLU) is a ubiquitous expressed glycoprotein with cytoprotective properties capable to prevent myocardial injury in experimental studies. We hypothesized that decreasing levels of CLU might be involved in progression of chronic heart failure (HF) and therefore represent a potential biomarker for prognosis in this vulnerable group of patient. Objective We aimed to determine the prognostic value of plasma CLU in patients with HF. Methods Plasma CLU levels were determined in a prospectively recruited cohort comprising 318 patients with chronic HF and validated in a second cohort comprising 346 patients with advanced HF. Results During a median follow-up time of 3.2 years (interquartile range 2.0–4.9), 119 patients (37.3%) deceased including 83 patients (26.1%), who died from cardiovascular events. CLU was an inverse predictor of mortality with a crude hazard ratio (HR) per increase of 1 standard deviation (1 SD) of 0.75 (95% confidence interval [CI]: 0.62 to 0.9, P = .002) and specifically cardiovascular mortality with an HR per 1 SD of 0.67 (95% CI: 0.53–0.84, P < .001). CLU remained significantly associated with cardiovascular mortality after comprehensive adjustment for established HF-related risk factors and potential confounders with an adjusted HR per 1 SD of 0.79 (95% CI: 0.63–0.99, P = .042). Validation in the second cohort yielded similar results and confirmed CLU as independent prognosticator in patients with chronic HF. Conclusion Our results point toward an ongoing consumption of CLU involved in the complex pathophysiology of HF and suggest CLU as novel and promising biomarker for prognosis in patients with chronic HF. [ABSTRACT FROM AUTHOR]
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- 2017
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36. Fibroblast Growth Factor 23 Is an Independent and Specific Predictor of Mortality in Patients With Heart Failure and Reduced Ejection Fraction.
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Koller, Lorenz, Kleber, Marcus E., Brandenburg, Vincent M., Goliasch, Georg, Richter, Bernhard, Sulzgruber, Patrick, Scharnagl, Hubert, Silbernagel, Günther, Grammer, Tanja B., Delgado, Graciela, Tomaschitz, Andreas, Pilz, Stefan, Berger, Rudolf, Mörtl, Deddo, Hülsmann, Martin, Pacher, Richard, März, Winfried, and Niessner, Alexander
- Abstract
Background--Strategies to improve risk prediction are of major importance in patients with heart failure (HF). Fibroblast growth factor 23 (FGF-23) is an endocrine regulator of phosphate and vitamin D homeostasis associated with an increased cardiovascular risk. We aimed to assess the prognostic effect of FGF-23 on mortality in HF patients with a particular focus on differences between patients with HF with preserved ejection fraction and patients with HF with reduced ejection fraction (HFrEF). Methods and Results--FGF-23 levels were measured in 980 patients with HF enrolled in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study including 511 patients with HFrEF and 469 patients with HF with preserved ejection fraction and a median follow-up time of 8.6 years. FGF-23 was additionally measured in a second cohort comprising 320 patients with advanced HFrEF. FGF-23 was independently associated with mortality with an adjusted hazard ratio per 1-SD increase of 1.30 (95% confidence interval, 1.14-1.48; P<0.001) in patients with HFrEF, whereas no such association was found in patients with HF with preserved ejection fraction (for interaction, P=0.043). External validation confirmed the significant association with mortality with an adjusted hazard ratio per 1 SD of 1.23 (95% confidence interval, 1.02-1.60; P=0.027). FGF-23 demonstrated an increased discriminatory power for mortality in addition to N-terminal pro-B-type natriuretic peptide (C-statistic: 0.59 versus 0.63) and an improvement in net reclassification index (39.6%; P<0.001). Conclusions--FGF-23 is independently associated with an increased risk of mortality in patients with HFrEF but not in those with HF with preserved ejection fraction, suggesting a different pathophysiologic role for both entities. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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37. Von Willebrand Factor Improves Risk Prediction in Addition to N-Terminal Pro-B-type Natriuretic Peptide in Patients Referred to Coronary Angiography and Signs and Symptoms of Heart Failure and Preserved Ejection Fraction.
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Kleber, Marcus E., Koller, Lorenz, Goliasch, Georg, Sulzgruber, Patrick, Scharnagl, Hubert, Silbernagel, Günther, Grammer, Tanja B., Delgado, Graciela, Tomaschitz, Andreas, Pilz, Stefan, März, Winfried, and Niessner, Alexander
- Published
- 2015
- Full Text
- View/download PDF
38. Butyrylcholinesterase Predicts Cardiac Mortality in Young Patients with Acute Coronary Syndrome
- Author
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Sulzgruber, Patrick, Koller, Lorenz, Reiberger, Thomas, El-Hamid, Feras, Forster, Stefan, Rothgerber, David-Jonas, Goliasch, Georg, Wojta, Johann, and Niessner, Alexander
- Abstract
Background: The incidence of acute coronary syndrome (ACS) in young people (≤65 years) is continuously rising. While prognostic factors in ACS are well-investigated less attention has been paid to their age-dependent prognostic value and their particular relevance in younger patients. The aim of our study was to assess the age-dependent prognostic impact of butyrylcholinesterase (BChE). Methods: Retrospective cohort study including 624 patients with ACS. Patients were stratified by age into equal groups (n = 208) corresponding to “young patients” (45–64 years), "middle-aged patients” (65–84 years) and “old patients” (85–100 years). Cox regression hazard analysis was used to assess the influence of BChE on survival. Results: After a mean follow-up time of 4.0 (interquartile range [IQR] 2.0–6.4) years, 154 patients (24.7%) died due to a cardiac cause. In the overall cohort, BChE was indirectly associated with cardiac mortality-free survival (adjusted hazard ratio (HR): 0.70 (95% confidence interval [CI] 0.53–0.93, p = 0.01). The primary-analysis of BChE by age strata showed the strongest effect in the age group 45–64 years with an adjusted HR per 1-SD of 0.28 (95% CI 0.12–0.64, p = 0.003), a weaker association with mortality in middle aged (65–84 years: adjusted HR per 1-SD 0.66 [95% CI: 0.41–1.06], p = 0.087), and no association in older patients (85–100 years: adjusted HR per 1-SD 0.89 [95% CI: 0.58–1.38], p = 0.613). Conclusion: BChE is a strong predictor for cardiac mortality specifically in younger patients with ACS aged between 45 and 64 years. No significant association of BChE with cardiac-mortality was detected in other age classes.
- Published
- 2015
- Full Text
- View/download PDF
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