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Smart biocompatible materials that respond to a variety of external stimuli have a lot of potential in the creation of low-cost diagnostic biosensors. The present work describes the creation of core–shell nanoparticles as a biosensor for smart enzyme detection of salivary alpha-amylase (sAA). A chitosan-tripolyphosphate core was generated via ionic gelation and was coated with a starch–iodine shell to create biocompatible core–shell nanoparticles. The starch–iodine shell was ruptured in the presence of certain amounts of amylase, exposing the core. This application explains a noticeable color change from blue to white that can be used to identify sAA at the point of care. Synthesized nanoparticles were examined for scanning electron microscopy analysis and energy-dispersive X-ray (EDX). An EDX report reveals that the nanoparticles have higher carbon content at 55% followed by an oxygen atom of 35%. Fourier-transform infrared spectroscopic analysis revealed that the core–shell nanoparticles have carbonyl (C═O) functional groups present. A confirmatory test of amylase reaction on nanoparticle-impregnated paper turns blue to white indicating that the nanoparticle reacts with amylase as an indicator. This paper-based method can be used in future applications in forensic and medical applications.

The aim of the present study was the synthesis of hydrogel incorporated with chitosan blend with polyvinyl alcohol (PVA) from red cabbage Brassica oleracea and its application in wound healing and antibacterial activity. The chitosan/PVA hydrogel was synthesized by the combination of chitosan and PVA treated with acetic acid. The silver nanoparticles (AgNPs) were synthesized from the B. oleracea extract and its antibacterial efficacy was examined. The synthesized nanoparticles (NPs) were characterized using UV-spectroscopy and X-ray diffraction methods. The synthesized NPs were purified and combined with the hydrogel. This combined hydrogel and AgNP mixture was then subjected to Fourier transform infrared analysis, and the results were observed to conclude the effectiveness of the hydrogel. This hydrogel would differ in the part of dressing the wound, that is it can last on the wound for a longer period, thus reducing the pain and frequency of dressing and in turn naturally healing the wound in less time.

Abstract The widespread use of plastic goods creates huge disposal issues and environmental concerns. Increasing emphasis has been paid to the notion of a circular economy, which might have a significant impact on the demand for plastic raw materials. Post-consumer plastics recycling is a major focus of the nation’s circular economy. This study focuses on energy recovery from waste plastics as an alternative fuel source to meet the circular economy demand. Waste plastic fuel produced through pyrolysis has been claimed to be utilized as a substituted fuel. This work focuses to determine the performance and emission standards of Waste Plastic Fuel (WPF) generated from the pyrolysis of High-Density Polyethylene (HDPE) in a single-cylinder Direct Injection Diesel Engine (DIDE). Three different ratios of WPF were combined with 10% ethanol and 10% ethoxy ethyl acetate as an oxygenated additive to create quaternary fuel blends. The ethanol has a low viscosity, a high oxygen content, a high hydrogen-to-carbon ratio as favourable properties, the quaternary fuel results the improved brake thermal efficiency, fuel consumption and reduced emissions. The blend WEE20 exhibits 4.7% higher brake thermal efficiency, and 7.8% reduced fuel consumption compared to the diesel. The quaternary fuel blends demonstrated decreased carbon monoxide of 3.7 to 13.4% and reduced hydrocarbons of 2 to 16% under different load conditions.

Oreochromis niloticus a Nile tilapia fish is widely used for fish culture practice in many countries for its easy acclimatization and high yield at a short pace of time. Selenium‐chitosan (SeCh) nanoparticles are efficiently used in agriculture, medicine, and aquaculture practices in several studies. The significant approach of Selenium‐Chitosan incorporated fish feed will be evaluated in the present study to achieve the better aquaculture practice in future. In the present study, SeCh nanoparticle was chemically synthesized and incorporated with formulated fish feed. Selenium formulated fish feed contains 31.49 g of carbohydrates and 41.52 g of proteins. SeCh‐fed O. niloticus fingerlings exhibited significantly increased specific growth rates in terms of weight gain, and feed conversion ratio. Chemical characterization of SeChNPs through FTIR spectroscopy indicates the presence of an adjuvant combination of selenium and chitosan presence through functional groups of COO stretch, CH, CC, and CN stretch representing at 3226, 2878, and 1734 cm−1, respectively. Scanning electron microscopy (SEM) and EDX analysis revealed the structural properties of SeChNPs as a fibrous pattern that contains Carbon, Oxygen, and Selenium elements as predominant peak values. SeChNPs incorporated fish feed has higher protein content which is a standard hallmark for a fish feed and an essential prerequisite for fish growth. The formulated SeCh fish feed in the present study is an innovative approach which can be taken further for higher level testing and processing for developing as a better fish feed in terms of feasible and efficient fish growth enhancer. [ABSTRACT FROM AUTHOR]

This work reports the development of novel curcuminoid-based electrochemical sensors for the detection of environmental pollutants from water. In this study, the first set of electrochemical experiments was carried out using curcumin-conjugated multi-walled carbon nanotubes (MWCNT–CM) for 1,4-dioxane detection. The MWCNT–CM/GCE showed good sensitivity (103.25 nA nM−1 cm−2 in the linear range 1 nM to 1 µM), with LOD of 35.71 pM and LOQ of 108.21 pM. The second set of electrochemical experiments was carried out with bisdemethoxy curcumin analog quantum dots (BDMCAQD) for hydrazine detection. The BDMCAQD/GCE exhibited good sensitivity (74.96 nA nM−1 cm−2 in the linear range 100 nM to 1 µM), with LOD of 10 nM and LOQ of 44.93 nM. Thus, this work will serve as a reference for the fabrication of metal-free electrochemical sensors using curcuminoids as the redox mediator for the enhanced detection of environmental pollutants. [ABSTRACT FROM AUTHOR]

Biowaste originating from aquaculture sector represents a potential feedstock to produce value-added substances and materials like chitin and chitosan. They are the long chain polymers of N-acetylglucosamine polymers with huge industrial and biomedical significance. Chitin has long been recognized as a useful biomaterial for drug delivery and neurological therapy. Similarly, chitosan oligosaccharide, a short chain polymer derived from chitin/chitosan, has been identified for its potential biomedical applications, including antibacterial, anti-inflammatory, and anti-Alzheimer action. Chitosan nanoparticles are also used extensively in biomedical applications. Here we have critically summarized various methods for the extraction of chitin, chitosan, and chitooligossacharides and chitosan nanoparticle preparation and their diverse biomedical applications.

We used cell-free culture filtrate of Pseudomonas aeruginosa as a reducing mediator of AgNO3 to silvernanoparticles (AgNPs) and possibly used as a potential anticancer agent against thyroid cancer cells (TPC1). The bio-generation of AgNPs was firmly established by taking a UV spectrum at 380–500 nm wavelength. The Fourier transform spectrum analysis reveals the association of alcohol, phenol and aromatic functional groups with P. aeruginosa synthesized AgNPs (Ps-AgNPs). By observing under transmission electron microscopy (TEM), the size and structure of the Ps-AgNPs were characterized as the size was 30–70 nm and spherical in shape. The concentration-dependent cytotoxicity of Ps-AgNPs on TPC1 cells was observed and IC50 value was calculated. The alteration of oxidative and antioxidant biomarkers in Ps-AgNPs treated cells were observed. The induced apoptosis was determined by staining the Ps-AgNPs treated cells with DCFH-DA, Rh-123 dye, Acridine Orange (AO) and ethidium bromide (EtBr). Increased level of intracellular reactive oxygen species (ROS) generation and decreased level of mitochondrial membrane potential was observed in Ps-AgNPs treated TPC1 cells. Moreover, the apoptotic morphological changes were explored, which indicates increased apoptosis by inducing cell membrane damage in Ps-AgNPs treated cells. This biogenic approach will enable an effective and significant improvement in nano-oncotherapy.

Introduction: Fungus-derived secondary metabolites are fascinating with biomedical potential and chemical diversity. Mining endophytic fungi for drug candidates is an ongoing process in the field of drug discovery and medicinal chemistry. Endophytic fungal symbionts from terrestrial plants, marine flora, and fauna tend to produce interesting types of secondary metabolites with biomedical importance of anticancer, antiviral, and anti-tuberculosis properties. Methods: An organic ethyl acetate extract of Penicillium verruculosum sponge-derived endophytic fungi from Spongia officinalis yielded seven different secondary metabolites which are purified through HPLC. The isolated compounds are of averufin (1), aspergilol-A (2), sulochrin (3), monomethyl sulochrin (4), methyl emodin (5), citreorosein (6), and diorcinol (7). All the seven isolated compounds were characterized by high-resolution NMR spectral studies. All isolated compounds', such as anticancer, antimicrobial, anti-tuberculosis, and antiviral, were subjected to bioactivity screening. Results: Out of seven tested compounds, compound (1) exhibits strong anticancer activity toward myeloid leukemia. HL60 cell lines have an IC50 concentration of 1.00μm, which is nearly significant to that of the standard anticancer drug taxol. A virtual computational molecular docking approach of averufin with HL60 antigens revealed that averufin binds strongly with the protein target alpha, beta-tubulin (1JFF), with a −10.98 binding score. Consecutive OSIRIS and Lipinski ADME pharmacokinetic validation of averufin with HL60 antigens revealed that averufin has good pharmacokinetic properties such as drug score, solubility, and mutagenic nature. Furthermore, aspergilol-A (2) is the first report on the Penicillium verruculosum fungal strain. Discussion: We concluded that averufin (1) isolated from Penicillium verruculosum can be taken for further preliminary clinical trials like animal model in-vivo studies and pharmacodynamic studies. A future prospect of in-vivo anticancer screening of averufin can be validated through the present experimental findings. [ABSTRACT FROM AUTHOR]

Simple Summary: Cancer therapy today has benefited from multifaceted approaches in early detection and diagnosis, but weak prognosis still hinders progress, as it is a barricade for guaranteed successful treatment. The present study checks the anticancer properties of AMPs, or antimicrobial peptides, isolated from Sphaeranthus amaranthoides, a traditional medicinal plant in a fibroblast cell line. A technique named 'de novo' sequencing was used for identifying the biological potential of the isolated molecule. That molecule was administered in zebrafish embryos. The zebrafish was used as a model organism, as it has close proximity with humans. One specific peptide biomolecule out of 86 peptides showed promising anticancer properties. Therefore, from the results, that specific biomolecule, upon detailed analyses of other parameters, can be taken for upscaling purposes in the pharmaceutical sector for early cancer therapy. Though there are several advancements and developments in cancer therapy, the treatment remains challenging. In recent years, the antimicrobial peptides (AMPs) from traditional herbs are focused for identifying and developing potential anticancer molecules. In this study, AMPs are identified from Sphaeranthus amaranthoides, a natural medicinal herb widely used as a crucial immune stimulant in Indian medicine. A total of 86 peptide traces were identified using liquid-chromatography–electrospray-ionisation mass spectrometry (LC-ESI-MS). Among them, three peptides were sequenced using the manual de novo sequencing technique. The in-silico prediction revealed that SA923 is a cyclic peptide with C-N terminal interaction of the carbon atom of ASP7 with the nitrogen atom of GLU1 (1ELVFYRD7). Thus, SA923 is presented under the orbitides class of peptides, which lack the disulfide bonds for cyclization. In addition, SA923, steered with the physicochemical properties and support vector machine (SVM) algorithm mentioned for the segment, has the highest in silico anticancer potential. Further, the in vitro cytotoxicity assay revealed the peptide has anti-proliferative activity, and toxicity studies were demonstrated in Danio rerio (zebrafish) embryos. [ABSTRACT FROM AUTHOR]

Biopolymers and nanomaterials are an excellent choice for removing heavy metals and keeping the environment clean. The hexavalent chromium (Cr6+) (or) chromium-6 is usually produced by various industrial processes, which can be a toxic liquid pollutant. In this study, a nanopolymeric compound supplemented with Fe nanoparticle was used in the extraction (removal) process of Cr6+ present in the aqueous solutions. Two biopolymers were blended and connected (using a microemulsion process) to produce nanoparticles (Cht/Alg NPs), and the nanoparticles have an average size of 311.2 nm with a negative charge of 23 and 2 mV. During synthesis, the red cabbage extract was also used to make iron nanoparticles (Fe-NPs), and these Fe-NPs had semispherical species with a diameter of 21.4 nm. The nanopolymeric compound was loaded and equally distributed with chitosan and alginate (Cht/Alg) NPs and synthesized Fe-NPs. The assessment using batch adsorption assays showed that both nanocomposites exhibited more ability than the Cr6+ adsorbents under various conditions (e.g., pH, initial ion concentration, adsorbent volume, and contact time (CT)). At the start, the initial Cr6+ concentration was 75 ppm, and the most effective adsorption condition was found at 5.0 pH, the adsorbent capacity was 4 g/L, and the CT was 210 min. These documented results show that Cr6+ may be completely removed from bulk testing. Therefore, the use of these composite nanopolymers (Cht/Alg NPs) combined with the synthesized Fe-NPs can be extrapolated for use in the aquatic milieu for the removal of Cr6+. [ABSTRACT FROM AUTHOR]

Right from the olden days, many products have been made according to foundry practices in order to generate prosperity in the societies in which they operate while reaping these types of benefits through the operation of foundries. It is alarming that the emissions released by foundries affect human health. Therefore, foundries installed Pollution Control devices (PCDs), in accordance with this development; researchers examined the effectiveness of these PCDs in controlling emissions from foundries in different parts of the world. The emission control obtained by installing these PCDs is explained in this article based on the data gathered from the survey. The cartridge filter equipped with an induction furnace reduced the concentration of SPM to less than 20 mg/Nm3. This result of the investigation indicates that the cartridge filter built into the induction furnace achieves the best efficiency in controlling contaminants from iron foundries. Interestingly, the operation of the cartridge filter has yet to be documented. Therefore, the construction operation, the performance of the cartridge filter, and its efficiency in achieving contaminations control in foundries are described. This will provide useful information on the use of cartridge filters in an induction furnace to reduce Iron foundry emissions. [ABSTRACT FROM AUTHOR]

Streptomyces is amongst the most amenable genera for biotechnological applications, and it is extensively used as a scaffold for drug development. One of the most effective therapeutic applications in the treatment of cancer is targeted therapy. Small molecule therapy is one of them, and it has gotten a lot of attention recently. Streptomyces derived compounds namely streptenols A, C, and F–I and streptazolin were subjected for ADMET property assessment. Our computational studies based on molecular docking effectively displayed the synergistic effect of streptomyces-derived compounds on the gynecological cancer target PIK3CA. These compounds were observed with the highest docking scores as well as promising intermolecular interaction stability throughout the molecular dynamic simulation. Molecular docking and molecular dynamic modeling techniques were utilized to investigate the binding mode stability of drugs using a pharmacophore scaffold, as well as physicochemical and pharmacokinetic aspects linked to alpelisib. With a root mean square fluctuation of the protein backbone of less than 0.7 nm, they demonstrated a steady binding mode in the target binding pocket. They have also prompted hydrogen bonding throughout the simulations, implying that the chemicals have firmly occupied the active site. A comprehensive study showed that streptenol D, streptenol E, streptenol C, streptenol G, streptenol F, and streptenol B can be considered as lead compounds for PIK3CA-based inhibitor design. To warrant the treatment efficacy against cancer, comprehensive computational research based on proposed chemicals must be assessed through in vitro studies. [ABSTRACT FROM AUTHOR]

Mosquitoes are the most critical group of insects in the context of public health, since they transmit key parasites and pathogens, causing millions of deaths annually. Aedes albopictus is an important invasive mosquito vector of dengue fever across urban and semiurban areas of India. In this study, we biofabricated silver nanoparticles (AgNPs) using the Fimbristylis miliacea aqueous leaf extract (Fm-ALE) as reducing and stabilizing agent. The synthesis of Fm-AgNPs was confirmed by the excitation of surface plasmon resonance and orange-brown color using ultraviolet-visible (UV-vis) spectrophotometry. High-resolution scanning electron microscopic (HR-SEM) and transmission electron microscopic (TEM) showed the clustered (size 0.5 μm) and quasi-spherical structures of Fm-AgNPs. The formation of AgNPs has been characterized by X-ray diffraction (XRD) spectroscopy. Fourier transform infrared (FTIR) spectroscopy investigated the identity of secondary metabolites, which may act as Fm-AgNP capping agents. These results propose that AgNPs synthesized provided from those Fm-ALE have the high sources to be improved into the most suitable materials useful for protecting and killing the invasive mosquito vector, Ae. albopictus populations. The acute toxicity of Fm-ALE synthesized Ag NPs, and a combined treatment testing blends of mosquito vector was evaluated against I, II, III, and IV instar larva's (ILs) of Ae. albopictus. The LC50 values of Fm-ALE (174.39 ppm I-ILs, 214.40 ppm II-ILs, 232.38 ppm III-ILs, and 251.62 ppm IV-ILs) and Fm-AgNPs synthesized were 23.78 ppm I-ILs; 27.88 ppm II-ILs; 31.47 ppm III-ILs; 36.68 ppm IV-ILs, respectively. Likewise, Fm-AgNP synthesis was more toxic than ALE in the invasive mosquito vector and recorded from UV-vis spectrum, FTIR, TEM, and XRD analysis. These results propose that AgNPs synthesized provided from those Fm-ALE have the high sources to be improved into the most suitable materials useful for protecting and killing the invasive mosquito vector, Ae. albopictus populations. [ABSTRACT FROM AUTHOR]

Hydrogel refers to a three-dimensional cross-linked polymeric network made of synthetic or natural polymers that can hold water in its porous structure. The inclusion of hydrophilic groups in the polymer chains, such as amino, carboxyl, and hydroxyl groups, contributes to the hydrogel's water-holding ability. At physiological temperature and pH, these polymeric materials do not dissolve in water, but they do swell significantly in aqueous media. Hydrogel can be manufactured out of almost any water-soluble polymer, and it comes in a variety of chemical compositions and bulk physical properties. Hydrogel can also be made in a variety of ways. Hydrogel comes in a variety of physical shapes, including slabs, microparticles, nanoparticles, coatings, and films. Due to its ease of manufacture and self-application in clinical and fundamental applications, hydrogel has been widely exploited as a drug carrier. Contact lenses, artificial corneas, wound dressing, suture coating, catheters, and electrode sensors are some of the biomedical applications of hydrogels. The pigment color changes were observed from colorless to pale pink followed by dark reddish-pink. Anthocyanin was produced in large quantities and tested using a UV-visible spectrophotometer. At 450–550 nm, the largest peak (absorbance) was detected, indicating the presence of anthocyanin. The FTIR analysis of this study shows the different stretches of bonds at different peaks: 2918.309 (-C-H alkane stretch), 2812.12 (-C-H aldehyde weak intensity), 192320.37/cm (C-O bend), 21915.50, 2029.08/cm (-C=C arene group), 1906.94/cm (=C-H aromatics), 1797.78/cm (=C-H), 1707.94 (-C=O ketene), 1579.70, 1382.96 (C-H alkane strong bend), 889.18/cm (C-H aromatics plane bend), and 412.77/cm (-C-CI strong bond). The spectra of the PVA/chitosan film depict the peak's formation: 1571.88, 1529.55, 1500.62/cm (C-H alkene strong bend), 1492.90, 1483.26, 1467.83/cm (C-H alkene strong bond), 670.48, 443.63, 412.77/cm (-O-H carboxylic acids with great intensity), 1708.93 (-C=O ketone), and 1656.0/cm (alkenyl C=C stretch strong bond). [ABSTRACT FROM AUTHOR]

Background. Biodegradable biopolymers have been developed in response to the growing environmental concern over plastic packaging disposal. The emergence of active and intelligent packaging systems to monitor the quality of packed food is further necessitated by consumer demand and health concerns. Chemical dyes, on the other hand, are not ideal for use as an indicator in smart packaging for food due to their high toxicity and negative impacts on human health and the environment. As a result, the researchers are concentrating on natural pigments produced from plants and food waste as a signaling component in biodegradable packaging as well as the valorization of food waste. This review is focused on the advancement of active packaging from plant pigments. [ABSTRACT FROM AUTHOR]

Infectious disease-causing pathogenic microorganisms grow rapidly within quorum sensing mediated biofilms. Attempts are made to restrict quorum sensing in pathogens, and the formation of biofilms has paved the way for the identification of bioactive phytochemicals. Anti-QS compounds have been proven to reduce bacterial pathogenicity in the past. Medicinal plants provide an enticing repertoire of phytochemicals with distinct microbial disease-controlling potential due to the vast spectrum of secondary metabolites included in extracts such as phenolics, quinones, flavonoids, alkaloids, terpenoids, and polyacetylenes. This review makes a specialty of the bioactive molecules produced using vegetation which have a target closer to quorum sensing accompanied via biofilm formation in pathogenic microbes. [ABSTRACT FROM AUTHOR]

Background. The direct or indirect effect of chemicals on the nervous system of humans or animals is referred to as neurotoxicity. Trimethyltin chloride (TMT) intoxication causes behavioral and cognitive deficiencies in humans and experimental animals. TMT has long been used as a model toxicant in the study of central nervous system (CNS) toxicity. Momordica charantia, which is used in traditional herbal medicine, has a variety of pharmacological functions. Mesoporous silica nanoparticles have a higher loading capacity, are less dense, and have a larger specific area. Objectives. To investigate a possible nanotherapy for Alzheimer's disease caused by trimethyltin chloride in freshwater zebrafish. Methods. An aqueous extract of M.charantia was used to perform the primary and secondary screening. The DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay was used to determine the antioxidant capacity of crude aqueous extracts of M. charantia. Mesoporous silica nanoparticles are made using a CTAB surfactant chemical process and tetraethyl orthosilicate. UV-Vis spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscope, and EDAX were used to characterize it. Danio rerio was used to test the trimethyltin chloride for Alzheimer's disease. The M. charantia and mesoporous silica nanoparticles were then tested in the same method. Results. The extract has no adverse effects on zebrafish, indicating that M. charantia is safe for human consumption. The histopathological findings indicate that the tissues of the fish infected with the extract had no pathological modifications. Conclusion. The M. charantia showed higher antioxidant activity and anticholinesterase activity, and upon further characterization and assessment, this could be a safe and potential drug candidate for Neurotoxicity. [ABSTRACT FROM AUTHOR]

Currently, the deadly epidemic COVID-19 was exponentially spread across the world as a pandemic outbreak caused by a novel coronavirus, termed as SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). In this view, the imminent danger of a pandemic situation surge the researchers and physicians to understand the molecular mechanism and pathology of this novel virus, in order to discover promising therapeutic drugs and vaccines to cure the diseases. At present, World Health Organization (WHO) updates on 27th June, 2020 for coronavirus disease (COVID-19) outbreak situation with confirmed cases of 9,653,048 and 491,128 deaths in 211 countries, areas or territories. To control the global outbreak, robust measures have been implemented across the world to minimize COVID-19 disease spread, in specific restricting international and domestic flights, enforcing lockdowns in susceptible areas, social distancing, etc. Although, a very few broad-spectrum antiviral drugs was tested in clinical trials against COVID-19 virus, which resulted in patient recovery. Based on existing published data, this review extensively highlights the COVID-19 epidemiology, clinical manifestations, prognosis, treatment and prevention. In order to offer a detailed overview to public health officials and future readers all over the world, we explain the latest interpretation of COVID-19 and presented the current state of implementation of the medical intervention in this review. This review is hoped to help the public understand and combat with SARS-CoV-2, as well as provide a guideline for future research. [ABSTRACT FROM AUTHOR]

Cyanobacteria are rich sources of structurally novel and biologically active metabolites with antibacterial, antiviral, antifungal, and anticancer activities. The present study aimed to evaluate the antimicrobial, antioxidant, and toxicity potential of freshwater filamentous cyanobacterial species isolated from a freshwater source in Kancheepuram district and Thiruverumbur, Tamilnadu. Among the tested two cyanobacterial species, methanol-chloroform extracts of Oscillatoria sp. SSCM01 exhibits higher antibacterial activity than Phormidium sp. SSCM02. Oscillatoria sp. SSCM01 exhibited higher inhibition activity of bacterial growth at 31.2 μg/mL and 7.8 μg/mL as MIC value against Staphylococcus aureus , Salmonella typhi , respectively, and for Candida albicans at 125 μg/mL. Antioxidant activity of Oscillatoria sp. SSCM01 extract assessed by DPPH assay exhibited potent radical scavenging activity of 48% inhibition at 60 μg/mL concentration. Two cyanobacterial extracts exhibited significant activity against brine shrimp larvae (Artemia salina). The active fraction was subsequently analyzed by gas chromatography-mass spectrometry (GC-MS), bioactive compounds like hexadecanoic acid (66.3%), 1, 2-benzene dicarboxylic acid, and dibutyl phthalate were detected in Oscillatoria sp. SSCM01. Thus, our findings indicate that freshwater cyanobacteria Oscillatoria sp. SSCM01 has an inherent capability that might make it beneficial as a promising source of antimicrobial and antioxidant therapeutic agents. [ABSTRACT FROM AUTHOR]

Baseline assessments of marine microbial studies are very limited around ecologically sensitive areas of the Nuclear Power Plant (NPP) site with respect to their occurrence, distribution, role in adaptation, and their potential remediation process. The distribution and diversity of marine microbes are largely dependent on the physicochemical parameters relating to a specific area, especially spore-producing marine actinobacteria are a source for indigenous bioremediation agents. Marine actinobacterial diversity with conventional and 16 S rRNA gene analysis was done with different pre-treatment conditions and selective media. Totally, 170 different strains are identified in genera level and it belongs to 18 genera with dominant by Streptomyces sp. (75species) followed by Nocardiposis sp, (18species) Rhodococcus sp. (14species). Multiple k-dominance plots simplified the perception of marine actinobacteria according to genera level influence to standard stock. This is the first kind of study in India and the results could act as baseline inventory in terms of microbial diversity around NPP sites. Further, a potential strain of Actinomadura sp. (T5S13) produced 243.7 mg/L of EPS and remediate the Uranium radionuclides. The functional group shifting and adsorption nature were also confirmed by SEM with EDS analysis. •Baseline assessments of marine microbial diversity are very limited around ecological sensitive area. •Totally, 170 different strains were identified upto generic level, and they belong to 18 genera dominant by Streptomyces sp. •This is the first kind of study in India, and the results could act as baseline inventory in terms of actinobacterial diversity around NPP sites. • Marine actinobacterial EPS showed potential Uranium bioremediation. [ABSTRACT FROM AUTHOR]