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From studying the bibliography and from experience we found that education issues regarding coordination abilities are addressed very vaguely and made by practical means scientifically unproven as effective. In today's sports branches, the importance of coordinative capacities is the starting point in the correct performance of motor skills but also in the ability to quickly adapt to different situations or working conditions. With the increase in the level of development of these motor capacities, in schools, through dedicated lessons, we could speak of a much better selection for certain sports branches but also for performance sports. Research presented at various scientific conferences and the published papers had a good impact on the specialists of Sport Science and Physical Education. We believe today that these studies are just the beginning to modernize the entire contents aimed at optimizing the motor capacities of the child. We know that today's young people, with problems of a motor nature, also have problems of an affective-social nature. This psychosocial imbalance is closely related to psychomotor development. In this sense, psychomotricity must be promoted as the main part of personality development.

This paper analyzes, from a spatial point of view, the places in Bihor County where we have sports associations, private clubs, small teams of children and juniors, where children and young people who have not yet reached the age of majority work. Among the research methods used and applied in carrying out this paper we mention: observation method, analytical method, the statistical-mathematical method and the method of graphic and cartographic representation and the basic tool is represented in the cartographic modeling by the ArcGis program. The Bihor football map includes 55 clubs, of which 12 have only activity with junior teams. The total number of clubs with junior teams is 31 and which totals 84 junior teams. A number of 24 clubs with senior teams 55.8% (out of 43) have no activity with junior teams. Most clubs that have junior activity are in Oradea 16, followed by Salonta 3, the rest of the localities having only one club. These clubs are distributed in 23 localities. Only 19 clubs with activity in the senior teams also have groups of children registered in official competitions. Through this study we aimed to improve the cartographic aspect the representation of the sports phenomenon in general and the football one in particular in order to show the importance of the cartographic product in the qualitative and quantitative spatial analysis, in the analytical and synthetic one.

The present paper offers a theoretical insight regarding the quality of life and health state of people with mental deficiency. Research results regarding the link between physical activity and quality of life of people with mental disorders are discussed. Literature review outlined that physical activity generates major benefits for people with mental deficiency. Conclusions point out the need to implement physical activities that can be performed by people with mental deficiency to increase their quality of life. Public and private stakeholders should cooperate in order to develop specific strategies and policies, as well as adapted programs for people with mental deficiency to maintain their health status and quality of life at a decent level.

Throughout the all known history of humanity, physical activities - regardless of type or organization - have occupied an important place in people's lives. Given these aspects, to which we can add its pedagogical, psychological, sociological valences, the body education is transformed into a higher category, which motivates the wide range of concerns related to the evolution of all the instruments designed to optimize it. On the other hand, given the special character and the particular place that the physical education and sports students occupies in relation to the mentioned category, we believe that the concern for monitoring the evolution of some components of human motility, highlighting the tendency that they register, is motivated.

Developing creativity has been a topical theme in all areas. In the field of physical activity, the term creativity is familiar, whether it is physical education or sports. However, we can see a lack of involvement, creativity in the physical education lesson, both on the part of the teachers and the students from the faculties. In view of these considerations, we believe that our intervention is opportune because in the preparatory part of the physical education lesson, it is possible to associate and realize multiple variants of walking, running, jumping, use of objects, balls, ladders, movement games, etc. and, in this way, the teacher can express his creativity in a particular way. In this regard, we propose a creative development variant, a "creative clock", to support those interested in optimizing the ways to achieve the third link in the physical education lesson.

This study examines the implications of the FDI on economy of the Republic of Moldova. Using a data approach, the results show that global financial and economic crisis of 2008-2009 has strongly influenced the dynamics of FDI. Our results also demonstrate that Moldova needs to take cardinal measures to overcome the crisis phenomenon and to direct its economy on ascending development trajectory.

Related rather to spider and scorpion, these blue-blooded, forgotten by time, Horseshoe crab own some of the most interesting secrets. This shellfish has survived on Earth for millions of years 562/450, without suffering major changes. Today, unfortunately, the problem faced extinction horseshoe crab. Measures should be taken for conservation of this species and for maintaining ecological balance, but also because of the importance of this species: the blood of this arthropod finds applications in medicine.

Veterinary pharmaceutical products intended for use in fish should comply with all usual requirements regarding approval for marketing, according to the Order of the President of the National Sanitary Veterinary Agency and for Food Safety No.187/2007, with subsequent amendments and additions. According to the legislation the technical file should containe documentation of quality, safety of animals, consumer, user and environment and demonstration of efficacy and tolerance in the target species. This paper provides the important information on requirements for demonstration on efficacy of pharmaceutical products indended for use in fish. The principal aim of the efficacy data is to prove the therapeutic value of pharmaceutical products and to establish an optimal dose and period of dose administration. In efficacity clinical trial is needed, also, to take into account, the various conditions such as climatic aspects, disease situation, water temperature and salinity, because these may influence the outcome and veracity of the studies.

Antibiotics are one of the most important therapeutic discoveries in medical history. They have revolutionized the way we treat patients with bacterial infections and have contributed to reducing the mortality and morbidity from bacterial diseases. Unfortunately, antibiotics have been liable to misuse which leads to the emergence and selection of resistant bacteria. Doctors in Europe and worldwide now are sometimes facing situations where infected patients cannot be treated adequately because the responsible bacterium is totally resistant to available antibiotics. The correct use of antimicrobials is one of the most important tools which could limit the spread of this phenomenon - resistance to antimicrobials. Specialists from Institute for Control of Biological Products and Veterinary Medicines understood to involve in this fight against antibioresistance, by tacking appropriate measures according to the european approches concerning reducing of the antibiotic consumption, correct usage and responsible of them.

Biocidal products are necessary in our lives in order to protect us against pathogenic microorganisms. But their use must be subject to a strict regulation because their harmful potential on human and animal health and environment is huge. Biocidal products must be authorized by a competent authority before placing them on the market and all active substances from their composition must be tested and certified to ensure they are in compliance with regulatory requirements in the field. Also biocides, with antimicrobials, may be involved in causing the phenomenon of antibiotic resistance. Their misuse can lead to the emergence of resistant organisms, through mechanisms similar to those that appear in incorrect treatment with antibiotics. We should, therefore, be aware of this aspect particularly important to prevent unwanted effects of cross resistance to antibiotics and biocides. The more so as, lately, there are pulled many alarm signals about the fact that, in a very short time, mankind is in danger of remaining without the main arsenal for fighting harmful microorganisms.

The present case report describes a mother and son with arrhythmogenic cardiomyopathy (ACM) with early and greater left ventricle (LV) involvement. The presence of curly hair in both, together with the resuscitated sudden cardiac death of the mother, allowed timely genetic testing, which found a pathogenic nonsense mutation of the desmoplakin gene. While asymptomatic from an arrhythmic point of view, the son’s evolution was characterized by a well-documented exercise-induced myocarditis-like stage.

The microbiological contamination of pharmaceutical products could have major consequences on the physical – chemical characteristics, safety and efficiency of the medicinal products and also on the out of specification products recall-associated costs. Quality control of the pharmaceutical products should be a major objective for both the pharmaceutical industry as well as for the official quality control laboratories and the final results of these tests should provide most accurate data regarding the safety and the efficiency of the controlled pharmaceutical products. This report is presenting the results which were obtained in 2013 in the Microbiological Control Laboratory following the quality control of the products according to their pharmaceutical form and therapeutical class.

The credit crises are the consequences of demonetization process failure of MONEY-LIABILITY. To initiate a treatment of this process more "overshadowed" by the financial-banking system, it is required a comprehensive analysis of GLOBAL DEBT; GLOBAL GDP and the ratio between them called "FINANCIAL LEVERS" [3]. The "malfunctions" of DEBT monitoring process are random, but in principle can be formalized by setting them based on statistical probability of credit crisis in the last 100 years [7, 8].

Government debt (also known as public debt and national debt) is the debt owed by a central government. (In the U.S. and other federal states, "government debt" may also refer to the debt of a state or provincial government, municipal or local government). By contrast, the annual "government deficit" refers to the difference between government receipts and spending in a single year, that is, the increase of debt over a particular year. Government debt is one method of financing government operations, but it is not the only method. Governments can also create money to monetize their debts, thereby removing the need to pay interest. But this practice simply reduces government interest costs rather than truly canceling government debt, and can result in hyperinflation if used unsparingly. Governments usually borrow by issuing securities, government bonds and bills. Less creditworthy countries sometimes borrow directly from a supranational organization (e.g. the World Bank) or international financial institutions). As the government draws its income from much of the population, government debt is an indirect debt of the taxpayers. Government debt can be categorized as internal debt (owed to lenders within the country) and external debt (owed to foreign lenders). Sovereign debt usually refers to government debt that has been issued in a foreign currency. Another common division of government debt is by duration until repayment is due. Short term debt is generally considered to be for one year or less, long term is for more than ten years. Medium term debt falls between these two boundaries. A broader definition of government debt may consider all government liabilities, including future pension payments and payments for goods and services the government has contracted but not yet paid.

The Microbiology Laboratory from the Institute for the Control of Veterinary Biological Products and Medicines participated in a collaborative study in order to determine the potency of rifamycin CRS, batch 4, according to the protocol sent by the EDQM (European Directorate for the Quality of Medicines) - coordinating of the study. The purpose of the study was to establish the potency of the batch 4 rifamycin in the characterization of the substance as reference standard. Potency was determined by microbiological method, based on comparison of the inhibition zones of growth of micro-organisms sensitive to those of a reference standard, as specified in European Pharmacopoeia, Chapter 2.7.2. - Microbiological testing of antibiotics. After analysis of received data from participants and their statistical processing by the EDQM, the potency of the batch 4, rifamycin - reference materials, was established in 870 UI/mg.

The Microbiology Laboratory from the Institute for the Control of Veterinary Biological Products and Medicines participated to a collaborative study in order to determine the potency of teicoplanin CRS, batch 2, according to the protocol sent by the EDQM (European Directorate for the Quality of Medicines) - coordinator of the study. The purpose of the study was to determine the potency of the batch 2 teicoplanin in the characterization of the substance as reference standard. Potency was determined by microbiological method, based on comparing the inhibition zones of growth of micro-organisms sensitive to those of a reference standard, as specified in European Pharmacopoeia, Chapter 2.7.2. - Microbiological testing of antibiotics. After analysis of received data from participants and their statistical processing by the EDQM, the potency of the batch 2, teicoplanin - reference materials, was established in 50150UI/fiola.

The microbiological contamination of pharmaceutical products could have major consequences on the physical – chemical characteristics, safety and efficiency of the medicinal products, on the out of specification products recall-associated costs and, very important, on the safety of the humans and animals. Quality control of the pharmaceutical products should be a major objective for both the pharmaceutical industry as well as for the official quality control laboratories and the final results of these tests should provide most accurate data regarding the safety and the efficiency of the controlled pharmaceutical products. This report is presenting the results which were obtained in 2014 in the Microbiological Control Laboratory following the quality control of the products according to their pharmaceutical form and therapeutical class.

The Microbiology Laboratory from the Institute for the Control of Veterinary Biological Products and Medicines participated to a collaborative study in order to determine the potency of kanamycin CRS, batch 3, according to the protocol sent by the EDQM (European Directorate for the Quality of Medicines) - coordinating of the study. The purpose of the study was to establish the potency of the batch 3 for in the characterization of the substance as reference standard. Potency was determined by microbiological method, based on comparison of the inhibition zones of growth of micro-organisms sensitive to those of a reference standard, as specified in European Pharmacopoeia, Chapter 2.7.2. - Microbiological testing of antibiotics. After analysis of received data from participants and their statistical processing by the EDQM, the potency of the batch 3, kanamycin - reference materials, was established in 790 UI/mg.

The microbiological contamination of pharmaceutical products could have major consequences on the physical – chemical characteristics, safety and efficiency of the medicinal products and also on the out of specification products recall-associated costs. Quality control of the pharmaceutical products should be a major objective for both the pharmaceutical industry as well as for the official quality control laboratories and the final results of these tests should provide most accurate data regarding the safety and the efficiency of the controlled pharmaceutical products. This report is presenting the results which were obtained in 2012 in the Microbiological Control Laboratory following the quality control of the products according to their pharmaceutical form and therapeutic class.

Empathy is a key factor in the dentist–patient relationship. The aim of this study was to determine empathy in dental students and educators in French hospital dental services. A cross‐sectional study was conducted among dental students and educators who practiced in 10 hospital dental services affiliated with the Faculty of Dentistry of the University of Lorraine in France. A questionnaire was self‐administered online using the Jefferson Scale of Physician Empathy (JSPE). The study included 209 participants comprising 50 students in fourth year, 66 students in fifth year, 48 students in sixth year, and 45 educators. Participants were 63.6% females, aged 27 ± 8 years. The mean empathy score was 109.40 ± 11.65. The sub‐scores of the three dimensions were 57.02 ± 6.64 for Perspective Taking, 42.56 ± 6.22 for Compassionate Care, and 9.78 ± 2.61 for Walking in the Patient's Shoes. Females showed significant higher empathy scores than males (111.36 vs. 105.84). The empathy score was correlated with age and insignificantly decreased during clinical training (from 110.06 in fourth year to 106.63 in sixth year). French dental students and educators showed high levels of empathy. [ABSTRACT FROM AUTHOR]

Veterinary medicinal products that are subject to authorization via the centralized procedure according to Regulation (EC) no. 726/2004 are included in the Community register of veterinary medicines, that is published on the European Commission website and product information of them are published on the website of the European Medicines Agency. Each competent authority involved in the linguistic review process of product information annexed to the Marketing Authorization for medicinal products authorized centrally (SPC, leaflet, information about the marketing authorization holder, product labeling conditions), approve the version in the language mother of each Member State. In the second half of 2011 have received marketing authorization via the centralized procedure a total of four veterinary medicinal products, presented above.

The present study describes the results obtained by the Microbiological Control Laboratory from Institute for Control of Biological Products and Veterinary Medicines after participating in the proficiency testing scheme study on low – level microbial enumeration from pharmaceutical products. The proficiency testing scheme was organized by LGC Standards, Great Britain, organisation with competences in managing of the proficiency testing scheme for laboratories. Membrane filtration is a microbiological technique used for the microbial enumeration test, which consist in the transfer of the appropriate amounts from the sample, prepared according to the provisions of the European Pharmacopoea, through a membrane filter, incubating it on appropriate culture media, followed by reading and interpretation of the results. The result obtained by the Microbiological Control Laboratory was 34 CFU/vial, and the value attributed by LGC Standards was 30 CFU/vial.The Z- scores were 0,16 and the performance of Microbiological Control Laboratory was very good for low –level microbial enumeration from sample

Institute for the Control of Veterinary Biological Products and Medicines participated at the collaborativestudy for determine the potency of colistimethate sodium CRS, Lot 2, according to the protocol sent by theEDQM (European Directorate for the Quality of Medicines) - coordinator of the study.The purpose of the study was to determine the potency of the batch 2 colistimethate sodium in thecharacterization of the substance as reference standard.Potency was determined by microbiological method, based on comparing the inhibition zones of growthof micro-organisms sensitive to those of a reference standard, as specified in European Pharmacopoeia"Colistimethate sodium", Chapter 2.7.2. - Microbiological testing of antibiotics.After analysis of received data from participants and their statistical processing by the EDQM, thepotency of the batch 2, colistimethate sodium - reference materials, was established in 285000UI/fiola.

The present research paper aims at comparing the similarity and remoteness of influence of the features of eight common wheat varieties and their grouping on the base of important structural indicators through the use of a mathematical approach and a cluster analysis; studying of a relationships between the examined indicators in order to make more objective evaluation using the possibilities of the factor analysis; reducing the number of correlating indicators into new factors. Two-year data were used, obtained from the examination of eight common wheat varieties. The subject of the present research were seven seven foreign varieties of wheat - Ingenio, Bologna, Dalara, Moyson, Falado, Gabrio, Pibrak, and the eighth variety - Factor - was a local Bulgarian selection. The introduction of common wheat varieties is related to the study of their productivity and ecological plasticity. For this purpose there were reported and analised yield structural elements: plant height, wheat-ear length, number of ears, number of grains per ear, weight of grains per ear, grain yield from hectare. The cluster analysis showed that the influence of wheat variety on the qualitative indicators led to their grouping into two new clusters. There was established a strong positive correlation between the number of grains per ear and the hectoliter mass (r = 0.811) as well as between the number of ears and the weight of grains per ear (r = 0.771). The correlation coefficient between the number and weight of grains - (r = 0.649). The factor analysis established the influence of three main factors influencing the group formation of wheat varieties. The first factor was related basically to plant height, ear length, number of grains per ear and hectoliter mass. The second component was basically related to the number of ears and weight of grains. The third factor was related to the mass of 1000 grains. [ABSTRACT FROM AUTHOR]

European legislation governing veterinary medicinal product is under review by the European Commission. The new legislation will cover areas for research, development and authorization of new medicinal products and determine how it will perform distribution of veterinary medicinal products for both farm animals and pets. Revision of this legislative project is expected to be posted for public consultation in this year, the final form to be adopted in 2014.

The present study describes the results obtained by the Microbiological Control Laboratory from Institute for Control of Biological Products and Veterinary Medicines after participating in the proficiency testing scheme study on microbiological assay of nystatin and tobramycin. The proficiency testing scheme was organized by European Directorate for the Quality of Medicines and Health Care. The microbiological method consisted of a cylinderplate agar diffusion assay using Bacillus subtilis ATCC 6633 for tobramycin and Saccharomyces cerevisiae for nystatin as the test microorganism. The means of results were 108.70 % of label claim for nystatin and 104.70%of label claim for tobramicin. The Z scores were 0.14 for tobramycin and 1.40 for nystatin, the assigned value used for booth samples was 105.4% for tobramycin and 101.7% for nystatin. The performance of Microbiological Control Laboratory was very good for both samples.

The centralized authorization procedure is governed by Regulation (EC) no. 726/2004 of the European Parliament and the European Council laying down Community procedures for the authorization and supervision of medicinal products (pharmaceuticals and immunological).The centralised procedure allows applicants to obtain a marketing authorisation that is valid throughout the EU. It is compulsory for medicinal products manufactured using biotechnological processes, for orphan medicinal products and for human products containing a new active substance which was not authorized in the Community before 20 May 2004 and which are intended for the treatment of AIDS, cancer,neurodegenerative disorder or diabetes. The centralized procedure is also mandatory for veterinary medicinal products intended primarily for use as performance enhancers in order to promote growth of treated animals or to increase yields from treated animals. The centralized procedure is optional for any other products containing new active substances not authorized in the Community before 20 May 2004 or for products which constitute a significant therapeutic,scientific or technical innovation or for which a Community authorization is in the interests of patients or animalhealth at Community level. When a company wishes to place on the market a medicinal product that is eligible for the centralizedprocedure, it sends an application directly to the European Medicines Agency, to be assessed by the Committee for Medicinal Products for Human Use (CHMP) or the Committee for Medicinal Products for Veterinary Use (CVMP). The procedure results in a Commission decision, which is binding on all EU Member States, to authorise the product.

The term "nutritional supplements" for animals is found first in the "Proposal for the European Parliament and of the Board amending Directive 93/74/EEC on feedingstuffs intended for particular nutritional purposes and amending Directives 74/63/EEC, 79/373/EEC and 82/471/EEC”, submitted by the European Commission to the European Parliament and Council Director for approval on July 28, 1997. The proposal was not approved, for the reasons that this category of "supplement animal nutrition” is already regulated at EU level onlegislation to feed, supplementary feed, feed premixes, food for particular nutritional purposes. In order to harmonize the conditions for the marketing and use of feed, to clarify of divergences anduncertainties due existing legislative vacuum, in order to ensure a high level of protection of public health and to provide adequate information to users and consumers, The Regulation (EC) No 767/2009 of the European Parliament and the Council on the marketing and use of feed, amending Regulation (EC) No 1831/2003 and repealing Council Directive 79/373/EEC, Council Directive 80/511/EEC, Directives 82/471/CEE, 83/228/EEC, 93/74/EEC, 93/113/EC and 96/25/EC and Commission Decision 2004/217/EC (1) aproved. The new regulation simplifies and clarifies the existing procedures and renewal the legislation for themarketing and use of feed materials, compound feed and bioproteine, including dietary feed.

Biocidal products are active substances and preparations containing one or more active substances, putin a form that is supplied to the user, with aim to destroy, to prevent the action or to exercise control over adifferent effect any harmful organism by chemical or biological means.By definition, these products are susceptible to have harmful effects on humans, animals and theenvironment as the main objective of European legislative regulations in this area is to ensure the highestlevel protection by restricting the placing on the market and use only those biocidal products which have anacceptable risk of danger to humans or the environment.The favourable opinion for the placing on the market is made after the evaluation of technicaldocumentation of biocidal products, completed by preparing a report of assessment with the formulation of theproposal to issue notice for placing on the market by the National Commission of Biocidal Products.ICBMV is designated as an authority competent to assess technical documentations on efficacy,chemistry and toxicity data of biocidal products, product type 3: Veterinary hygiene products.

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Castor bean (Ricinus communis L.) is an oil plant of great importance worldwide. It has a very low share in the structure of agricultural crops in Romania, but with a tendency to grow, due to multiple economic advantages. In the context of climate change new approach to cultivation technology is needed. Improving the effects of stressors is the benefit of using biostimulants. Under this circumstances, the aim of this paper is to present the results of the researchers performed in South Romania with respect to the application of biostimulants at castor bean crop. In the years 2019, 2020, and 2021, at Agricultural Research and Development Station Teleorman (ARDS Teleorman) located in South Romania, a multifactorial field experiment of type 2 x 2 x 2 was set up, having the following factors: Factor A - biostimulant product: a1 = product containing auxins (Kelpak); a2 = product containing amino acids (Amer Micro); Factor B - application phase: b1 = application at 4-5 leaves; b2 = application before the appearance of the main raceme; Factor C - application rate: c1 = 1 l/ha; c2 = 2 l/ha. The application of the studied biostimulants determined significant increases in seed yield at castor bean. The obtained results in the three experimental years show that the application of the biostimulants should be done before the appearance of the main raceme and in the rate of 2 l/ha. The effects determined by Amer Micro biostimulant (based on amino acids) was more consistent than those of Kelpak biostimulant (based on auxins). [ABSTRACT FROM AUTHOR]

During the period 2018-2020 a field experiment has been carried out with the oil-bearing sunflower hybrid P64LE121 (Helianthus annuus L.). It is a sulfo tolerant hybrid by ExpressSun technology. A total of 25 variants were investigated. They included untreated control, 2 herbicides applied alone in addition with adjuvant Trend 90, 10 herbicide tank mixtures and 10 herbicide combinations. Soil-applied combined herbicides were performed during after sowing before emergence period of the sunflower. Foliar-applied herbicides were performed during 3-4 leaf sunflower stage. Full control of annual broadleaved weeds in ExpressSun oil-bearing is provided by a single treatment with herbicide Fluence at a dose of 40 g/ha or with herbicide Evorelle express at a dose of 60 g/ha applied during 3-4 leaf sunflower stage. Full controls of perennial broadleaved weeds is provided by two treatments with herbicide Fluence in doses of 20+20 g/ha or with herbicide Evorelle express in doses of 30+30 g/ha, applied during 3-4 leaf and 7-8 leaf sunflower stages. In the presence of annual and perennial broadleaved and graminaceous weeds, it is necessary to apply Fluence and Evorelle express as herbicide tank mixtures together with foliar-applied antigraminaceous herbicides Fusilade forte, Stratos ultra or Targa max. In the absence of perennial graminaceous weeds, it is necessary to apply herbicides Fluence and Evorelle express as herbicide combinations with soil-applied antigraminaceous herbicides Dual gold or Indipen. The highest seed yield is obtained by herbicide tank mixture Fluence + Fusilade forte, followed by herbicide tank mixture Evorelle express + Stratos ultra. High seed yields are also obtained by use of herbicide combinations Indipen + Evorelle express and Dual gold + Fluence. [ABSTRACT FROM AUTHOR]

Castor bean is an important oil plant, which in Romania is cultivated on small areas for scientific, ornamental, industrial and medicinal purposes. Having into consideration the importance of the crop in the past, respectively up to 1989, when Romania was the sixth largest cultivator of castor bean in the world, and having in view the great importance of its oil, it can be said that in Romania the castor bean has a real potential to develop in the future. Optimizing row spacing and plant density has a significant influence on seed yield. Therefore, our research focused on determining the optimal combination of row spacing and plant density to obtain the best yield under the environmental conditions specific to the South Romania and taking into account the phenotypic expression of the cultivated variety. Researches were performed in field conditions at the Agricultural and Development Research Station Teleorman located in Teleorman County in South Romania, in the years 2019 and 2020 and on cambic chernozem soil conditions. The experiment was placed according to the method of subdivided plots into 3 replications, with the following factors: Factor A - row spacing, with 4 graduations (30, 50, 70 and 90 cm); Factor B - plant density, with 3 graduations (40,000, 60,000 and 80,000 plants/ha); Factor C - castor bean variety, with 2 graduations (Teleorman and Rivlas). The results of the performed research proved that decreasing the row spacing is associated with decreasing of yield, while increasing the plant density is associated with increasing of yield. The Rivlas variety turned out to be more productive than the Teleorman variety. [ABSTRACT FROM AUTHOR]

The improvement in survival rates of head and neck cancer patients and the increasing incidence of HPV induced cancers in young people has an important socioeconomic impact. We evaluated the rate of reemployment after having curative radiotherapy for head and neck cancer and tried to identify the barriers of successful return to work in this patient population. We performed a cross-sectional, single-institution study including 52 consecutive patients attending followup visits after curative VMAT radiotherapy for head and neck cancer between december 2022-august 2023. Eligible participants were aged 18 to 65 years at diagnosis, employed at or within 3 months before the start of the treatment and had at least 12 months of followup. Participants completed a paper-based survey to assess baseline demographics and lifestyle choices such as smoking and alcohol consumption, employment status. Mean age was 50 (22-65 years) and 75% were male. Most participants (38.5%) had nasopharynx cancer followed by oropharyngeal cancer in 25%. Successful return to work rate was 55.8%. Only 8 patients (15.4%) returned earlier than 6 months to employment. 22 patients (75.8%) of those who returned, worked full time and one patient was forced to change his profession. At the time of the analysis 23 cancer survivors (44.2%) were not working. 18 of these choose early retirement and are not planning to return, the rest of 5 patients are still on sick leave and might plan to reemploy. 77.3% reported physical symptoms being the main cause preventing reemployment. The most common physical symptom reported was fatigue in 58.9% cases. With all technical improvements in treatment delivery with the scope of reducing long term toxicity there is still an important percentage of head and neck cancer survivors not able to return to work after radiotherapy. Professional assistance in their cancer rehabilitation is needed to increase reemployment rates. The high incidence of fatigue in this population warrants further research. [ABSTRACT FROM AUTHOR]

Background: Patient adherence to follow‐up after a first episode of psychosis (FEP) is currently a major challenge. Patient's early adherence reduces the risk of relapse and improves their prognosis in the short and long term. The primary goal of our study was to determine the incidence of treatment disengagement at 1‐year follow‐up in patients with first‐episode schizophrenia, schizophreniform or schizoaffective disorder. The secondary goal was to assess the factors associated with treatment disengagement in this patient population. Methods: We conducted a monocentric retrospective study of 136 patients in France. Relevant information was collected on sociodemographic, pre‐morbidities and co‐morbidities data, as well as the management and treatment characteristics at 1.3 and 12 months. Survival analysis was used to assess the association between clinical variables, management and treatment disengagement. Results: Eighty‐four patients (62%) have interrupted their medical follow‐up at 1 year, 16% at 1 month and 34% at 3 months. A higher number of out‐patient appointments after a FEP was associated with better adherence (HR:0.85 p <.0001 95% IC = [0.0–0.9]). Initial management seems to play an important role. Involuntary admissions (HR:7.14 p =.015 95% IC = [1.48–34.52]) and total number of admissions (HR:6.86 p <.0001 95% IC = [2.47–19.05]) predict disengagement at 1 month while an increased number of out‐patient appointments at 3 months predicts adherence (HR:0.60 p <.0001 95% IC = [0.00–0.74]). Being a single parent is associated with disengagement at 3 months (HR:15.51 p =.022 95% IC = [1.49–161.65]). Conclusions: Incidence of disengagement is high. It might be necessary to change our management in order to develop out‐patient or day‐admission care and intensify care for patients at risk. [ABSTRACT FROM AUTHOR]

Castor bean (Ricinus communis L.) is a rustic, drought-resistant plant, with great adaptability to different climatic and soil conditions. Currently, it is known for the versatility of the oil extracted from its seeds, where expectations of rising demand for castor oil in the world market is high. In terms of the crop technology, it has to be considered that there are a number of variables for each growing area, especially when it is desired to adapt the castor bean crop at a certain soil tillage system. In this respect, the objective of the present paper is to put into evidence the effects of different soil tillage on the castor bean crop under the specific growing conditions from South Romania. In this respect, a field experiment was established in the years 2019 and 2020 at the Agricultural and Development Research Station Teleorman (ADRS Teleorman) located in South Romania (Teleorman county). The experimental variants were represented by the soil tillage with the following graduations: 1. Summer plowing performed at 30 cm depth + harrowing performed with a disc harrow in autumn, at 12 cm depth + 2 works of seedbed preparation performed with a seedbed cultivator in spring, before sowing, at 10 cm depth; 2. No tillage; 3. Harrowing performed with a disc harrow in spring, before sowing, at 15 cm depth; 4. Deep tillage performed with a ripper in autumn, at 35 cm depth + harrowing performed with a disc harrow for seedbed preparation in spring, before sowing, at 12 cm depth. The obtained results indicate that the conventional soil tillage is superior to the variants of minimum tillage, which implies giving up to plowing, or direct sowing, which implies no-tillage. [ABSTRACT FROM AUTHOR]