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1. Dual IL-10 and PD-1 blockade in SIVmac239 infected macaques promotes sustained virologic control in absence of ART

Author

Strongin, Z., Ribeiro, S.P., Hoang, T.N., Nguyen, K., Harper, J., Estes, J.D., Micci, L., Lifson, J.D., Howell, B.J., Gorman, D., Hazuda, D.J., Paiardini, M., and Sekaly, R-P.

Subjects
Immunological research, Biological response modifiers -- Research, Interleukin-10 -- Health aspects, Cellular proteins -- Health aspects, Health
Abstract

Background: IL-10 production and PD-1 expression are both elevated during chronic HIV/SIV infection under ART. Both are associated with virus persistence and T cell impaired effector function, which leads to [...]

Published
2021
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